Tylenol With Bactrim - Interaction Detail
In our latest question and answer, the pharmacist discusses if it is safe to combine Tylenol and Bactrim.

Question
I was prescribed Bactrim for a skin infection that I have. I have a little bit of a headache and wanted to take Tylenol. Is that safe?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 18, 2025
Key points
- There is no known interaction between Bactrim and Tylenol.
Answer
There is no known drug interaction between Tylenol (acetaminophen) and Bactrim (sulfamethoxazole; trimethoprim). They are considered safe to take together.
In fact, most pain relievers are safe to take with Bactrim. In addition to Tylenol, Bactrim is safe to combine with these other over-the-counter analgesics:
- Advil/Motrin (ibuprofen)
- Aleve (naproxen)
It is important to remember that in addition to being a pain reliever, Tylenol is also a fever reducer and can be helpful if you also have a temperature.
Additional Drug Information
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Final Words
Thanks for reaching out!
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Dr. Brian Staiger, PharmD
- 4759 views