Tylenol With Bactrim - Interaction Detail
In our latest question and answer, the pharmacist discusses if it is safe to combine Tylenol and Bactrim.
I was prescribed Bactrim for a skin infection that I have. I have a little bit of a headache and wanted to take Tylenol. Is that safe?
Nov 03, 2022- Tylenol and Bactrim are safe to take together with no known drug interaction.
- Most over-the-counter pain relievers including ibuprofen and naproxen are also safe to combine with Bactrim.
- Tylenol can help reduce both pain and fever if you have a temperature.
Answer
There is no known drug interaction between Tylenol (acetaminophen) and Bactrim (sulfamethoxazole; trimethoprim). They are considered safe to take together.
In fact, most pain relievers are safe to take with Bactrim. In addition to Tylenol, Bactrim is safe to combine with these other over-the-counter analgesics:
- Advil/Motrin (ibuprofen)
- Aleve (naproxen)
It is important to remember that in addition to being a pain reliever, Tylenol is also a fever reducer and can be helpful if you also have a temperature.
Additional Drug Information
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Final Words
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References & sources
Glossary — Terms in This Answer
- Acetaminophen
- An over-the-counter pain reliever and fever reducer commonly known by the brand name Tylenol.
- Bactrim
- A prescription antibiotic medication used to treat bacterial infections.
- Sulfamethoxazole
- One of the two active ingredients in Bactrim that helps fight bacterial infections.
- Trimethoprim
- The second active ingredient in Bactrim that works with sulfamethoxazole to treat infections.
- Drug interaction
- A situation where two medications affect each other's effectiveness or safety when taken together.
- Analgesics
- Medications that relieve pain.
- Ibuprofen
- An over-the-counter pain reliever and anti-inflammatory medication sold under brand names like Advil or Motrin.
- Naproxen
- An over-the-counter pain reliever and anti-inflammatory medication sold under the brand name Aleve.
Dr. Brian Staiger, PharmD
Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified
Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...
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