Can You Take Prednisone With Zarbee's Cough?

In our latest question and answer, our pharmacist discusses whether or not prednisone is safe to take with Zarbee's Cough medicine.

1 min read Updated Jun 2026 Read by 5,103 people
Can You Take Prednisone With Zarbee's Cough?
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Daniella asked

Hi, my child has bronchitis and was prescribed a few things, including prednisone. It is okay to give prednisone with Zarbee's cough medicine?

Jul 30, 2022
The quick answer
  • It is perfectly safe to take prednisone and Zarbee's Cough syrup together with no known interactions between them.
  • There are no known interactions between Zarbee's Cough and any prescription medication.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.

Answer

Thanks for reaching out to us! We've answered a few questions recently about Zarbee's products and we're more than happy to answer more.

It is perfectly safe to take (or give to your child in this case) prednisone and Zarbee's Cough syrup together. There is no known interaction between them, and based on the ingredients in Zarbee's, we wouldn't expect any interactions.

This applies to other steroids as well, not just prednisone. Methylprednisolone and prednisolone are also safe to take with Zarbee's Cough.

What Is In Zarbee's Cough Syrup?

Zarbees Cough and supplement facts

Zarbee's Cough syrup for children contains:

  • Dark honey
  • Grapefruit seed extract
  • Citric acid
  • Ascorbic acid
  • Water
  • Natural flavors
  • Zinc gluconate

As mentioned, none of the above ingredients interact with prednisone.

In fact, there are no known interactions between Zarbee's cough and any prescription medication. While grapefruit is somewhat notorious for its role in a multitude of drug interactions, the very small amount of grapefruit seed extract contained here is not thought to be of concern.

Final Words

Thanks again for your question and I hope your little guy starts to feel better soon!

References & sources
  1. Prednisone Monograph — PubChem
  2. Honey Monograph — Natural Standard (Subscription Required)
Glossary — Terms in This Answer
Prednisone
A prescription steroid medication used to reduce inflammation and suppress the immune system.
Steroids
Medications that reduce inflammation and immune system activity in the body.
Methylprednisolone
A prescription steroid medication similar to prednisone used to treat inflammation and immune-related conditions.
Prednisolone
A prescription steroid medication related to prednisone that reduces inflammation and immune response.
Drug interactions
When two or more medications affect each other in ways that change how they work in your body.
Grapefruit seed extract
A substance derived from grapefruit seeds that can interfere with how certain medications are processed in the body.
Ascorbic acid
A form of vitamin C that supports immune function and acts as an antioxidant.
Zinc gluconate
A form of the mineral zinc used to support immune health and wound healing.
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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