Butea Superba + Zileuton
Zileuton brand names: Zyflo, Zyflo CR.
We found no known interaction between Butea Superba and Zileuton in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Zileuton states a food rule worth keeping to.
Butea Superba and Zileuton
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Zileuton and Butea Superba in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Butea Superba safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Zileuton
Interactions in our licensed database are recorded against drug classes, not just single drug names. Zileuton is filed under 8 classifications — including cytochrome p450 1a2 (cyp1a2) inhibitors, cytochrome p450 2c9 (cyp2c9) substrates, cytochrome p450 3a4 (cyp3a4) inhibitors. Butea Superba has documented interactions with 1 drug class — the most serious being phosphodiesterase-5 inhibitors (moderate) — and none of Zileuton’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Butea Superba Does Interact With Other Medications
Butea Superba has 7 moderate known drug interactions in our database — Zileuton isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Butea Superba
We haven’t checked that one against Butea Superba yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Butea Superba. Pick one to open its full report.
Some Zileuton Products Have a Food Rule — Butea Superba Should Not Break It
At least one FDA label for a product containing Zileuton says to take it with food. If you take Butea Superba on an empty stomach out of habit, keep them separate — and take Zileuton with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Zileuton products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
For ease of administration, ZYFLO may be taken with meals and at bedtime.
From the Dosage and Administration section of the FDA label we read for Zileuton — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Zileuton
This page covers Butea Superba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Zileuton page lists 213 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).
By severity: 6 major · 163 moderate · 44 minor.
Taking Butea Superba as Part of a Dietary Supplement Product? Check It for Interactions
We hold 23 real supplement products containing Butea Superba, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Butea Superba. Even though Butea Superba itself has no known interaction with Zileuton, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Butea Superba and Zileuton Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#681 of 1,452 supplements looked up here in the last 7 days
#2,472 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Butea Superba reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Butea Superba and Zileuton records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Butea Superba
What is Butea Superba?
- Erectile dysfunction
- Low libido
- Male sexual performance
- General vitality and energy
- Traditional tonic
Butea superba is a Thai herb traditionally used to support male sexual health, but the human evidence is very limited and mostly small or low-quality. Its safety has not been well studied, so caution is advised, and you should talk with a pharmacist or doctor before trying it—especially if you have a medical condition or take other medicines.
Butea superba · Fabaceae · Root (tuber) · Capsules, tablets, powder, tinctures, topical gels
An interaction check asks whether these two react with each other — it does not ask whether Butea Superba is a good idea for someone in your situation. Here is what our Butea Superba record says about it on its own.
Butea Superba: dosing
There is no well-established or standardized dose for Butea superba. Studies have used different amounts and preparations, so it is hard to recommend a specific, reliable dose.If you choose to use it, follow the directions on the product label and do not exceed them.
From our Butea Superba monograph — the full record covers uses, side effects and every documented interaction.
About Zileuton
What Is Zileuton Used For?
Brand names: Zyflo, Zyflo CR
Zileuton is used for the ongoing prevention and treatment of asthma in adults and adolescents aged 12 and older. It is a maintenance medicine — meaning it is taken regularly to keep asthma under control, not to stop an asthma attack once it has started.
Zyflo (the tablet form) and zileuton extended-release tablets are both approved for this same purpose. Neither form should be used to treat a sudden asthma attack. However, both can be continued during a flare-up of asthma while you also use your rescue inhaler.
Other Drugs & Butea Superba
Browse every other medication we’ve checked against Butea Superba — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
7 interactions
No interaction 2,822 drugs checked — show the list
We also checked Butea Superba against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Valacyclovir ›
- Warfarin Sodium ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,822 medications checked with no known interaction — see the full Butea Superba list.
Butea Superba References
The 2 references that drive our Butea Superba monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Cherdshewasart W, Nimsakul N. Clinical trial of Butea superba, an alternative herbal treatment for erectile dysfunction. Asian J Androl 2003;5:243-6.
- Cortés-González JR, Arratia-Maqueo JA, Gómez-Guerra LS, Holmberg AR. The use of Butea superba (Roxb.) compared to sildenafil for treating erectile dysfunction. BJU Int 2010;105(2):225-8. doi: 10.1111/j.1464-410X.2009.08748.x.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Butea Superba and Zileuton Together: Common Questions
Is it safe to take Butea Superba with Zileuton?
Should I take Butea Superba and Zileuton at the same time of day?
How was the Butea Superba and Zileuton combination checked?
Does Butea Superba interact with any other medications?
Does Zileuton interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.