Drug & supplement interaction

Hemlock + Clopidogrel

Clopidogrel brand name: Plavix.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Hemlock and Clopidogrel in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Hemlock and Clopidogrel

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Clopidogrel and Hemlock in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Hemlock at all — not against Clopidogrel, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hemlock safety at a glance

Hemlock overall Avoid Hemlock is a deadly poison and should never be taken in any amount.
Pregnancy Unsafe When used orally because ingestion can be lethal; avoid using. Read the full pregnancy detail
Breastfeeding Unsafe When used orally because ingestion can be lethal; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Clopidogrel and Hemlock? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Hemlock Itself Has Been Linked To

This is not an interaction — nothing below involves Clopidogrel. It is the side-effect record for Hemlock on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Hemlock, this list is the first place to look. 5 entries are worth acting on rather than waiting out — marked below.

  • Severe muscle breakdown Worth acting on Additional detail

    “Hemlock is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. Orally, hemlock can cause burning of the mouth, throat, and abdomen, nausea, vomiting, excessive urination, salivation, drowsiness, mydriasis, muscle pain, rapid muscle swelling and stiffness, rhabdomyolysis, and tachycardia followed by bradycardia.”

    Hemlock · Natural Medicines adverse-effect record, reported in muscle breakdown.

    6 sources cited
    1. 6340. Drummer OH, Roberts AN, Bedford PJ, et al. Three deaths from hemlock poisoning. Med J Aust 1995;162:592-3. PubMed
    2. 6341. Frank BS, Panter KE. Ingestion of poison hemlock (Conium maculatum). West J Med 1995;163:573-4.
    3. 54709. Biberci, E., Altuntas, Y., Cobanoglu, A., and Alpinar, A. Acute respiratory arrest following hemlock (Conium maculatum) intoxication. J.Toxicol.Clin.Toxicol. 2002;40(4):517-518.
    4. 54711. Foster, P. F., McFadden, R., Trevino, R., Galliardt, S., Kopczewski, L. A., Gugliuzza, K., Gonzalez, Z., and Wright, F. Successful transplantation of donor organs from a hemlock poisoning victim. Transplantation 9-15-2003;76(5):874-876. PubMed
    5. 54712. Vetter, J. Poison hemlock (Conium maculatum L.). Food Chem.Toxicol. 2004;42(9):1373-1382. PubMed
    6. 54716. Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Scatizzi, A., De Marco, S., and Smialek, J. E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephr PubMed

    “Orally, hemlock can cause muscle pain, rapid muscle swelling and stiffness, and rhabdomyolysis. Plasma exchange effectively improved the signs of rhabdomyolysis in one case of hemlock poisoning.”

    Hemlock · Natural Medicines adverse-effect record, reported in muscle breakdown.

    5 sources cited
    1. 6340. Drummer OH, Roberts AN, Bedford PJ, et al. Three deaths from hemlock poisoning. Med J Aust 1995;162:592-3. PubMed
    2. 6341. Frank BS, Panter KE. Ingestion of poison hemlock (Conium maculatum). West J Med 1995;163:573-4.
    3. 54712. Vetter, J. Poison hemlock (Conium maculatum L.). Food Chem.Toxicol. 2004;42(9):1373-1382. PubMed
    4. 110410. Boskabadi J, Askari Z, Zakariaei Z, Fakhar M, Tabaripour R. Mild-to-severe poisoning due to Conium maculatum as toxic herb: A case series. Clin Case Rep. 2021 Jul 23;9(7):e04509.
    5. 54727. Montemurro, N. E., Di Maggio, A., Strippoli, P., Coviello, F., Godino, F., Miloro, G., and Scatizzi, A. Combined dialysis and plasma-exchange in acute renal failure. Biomater.Artif.Cells Immobilization Biotechnol. 1993;21(2):283-287. PubMed
  • A slow heartbeat Worth acting on Additional detail

    “Orally, hemlock can cause tachycardia followed by bradycardia, cardiovascular collapse, and death. In one case report, a 6-year old girl had prolonged coagulation tests after accidental ingestion of hemlock. It can also cause hypertension.

    Intravenously, hemlock resulted in a brief cardiac arrest followed by return of spontaneous circulation in one case report.”

    Hemlock · Natural Medicines adverse-effect record, reported in cardiac arrest.

    6 sources cited
    1. 6340. Drummer OH, Roberts AN, Bedford PJ, et al. Three deaths from hemlock poisoning. Med J Aust 1995;162:592-3. PubMed
    2. 6341. Frank BS, Panter KE. Ingestion of poison hemlock (Conium maculatum). West J Med 1995;163:573-4.
    3. 54712. Vetter, J. Poison hemlock (Conium maculatum L.). Food Chem.Toxicol. 2004;42(9):1373-1382. PubMed
    4. 96877. Konca C, Kahramaner Z, Bosnak M, Kocamaz H. Hemlock (Conium Maculatum) poisoning in a child. Turk J Emerg Med. 2016;14(1):34-6. DOI
    5. 110410. Boskabadi J, Askari Z, Zakariaei Z, Fakhar M, Tabaripour R. Mild-to-severe poisoning due to Conium maculatum as toxic herb: A case series. Clin Case Rep. 2021 Jul 23;9(7):e04509.
    6. 96876. Brtalik D, Stopyra J, Hannum J. Intravenous poison hemlock injection resulting in prolonged respiratory failure and encephalopathy. J Med Toxicol. 2017;13(2):180-182. PubMed
  • Seizures Worth acting on Additional detail

    “Orally, hemlock can cause drowsiness, fatigue, lethargy, dizziness, numbness, loss of speech, tremors, paralysis, seizures, encephalopathy, unconsciousness, and death. Death from hemlock toxicity is usually due to respiratory paralysis.

    A case report describes prolonged status epilepticus in a 41-year-old, previously healthy female who mistook hemlock root for parsnip.”

    Hemlock · Natural Medicines adverse-effect record, reported in epilepsy.

    6 sources cited
    1. 6340. Drummer OH, Roberts AN, Bedford PJ, et al. Three deaths from hemlock poisoning. Med J Aust 1995;162:592-3. PubMed
    2. 6341. Frank BS, Panter KE. Ingestion of poison hemlock (Conium maculatum). West J Med 1995;163:573-4.
    3. 10778. Carod-Artal FJ. [Neurological syndromes linked with the intake of plants and fungi containing a toxic component (I). Neurotoxic syndromes caused by the ingestion of plants, seeds and fruits]. Rev Neurol 2003;36:860-71.
    4. 54711. Foster, P. F., McFadden, R., Trevino, R., Galliardt, S., Kopczewski, L. A., Gugliuzza, K., Gonzalez, Z., and Wright, F. Successful transplantation of donor organs from a hemlock poisoning victim. Transplantation 9-15-2003;76(5):874-876. PubMed
    5. 54712. Vetter, J. Poison hemlock (Conium maculatum L.). Food Chem.Toxicol. 2004;42(9):1373-1382. PubMed
    6. 54716. Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Scatizzi, A., De Marco, S., and Smialek, J. E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephr PubMed
  • Kidney problems Worth acting on Additional detail

    “Orally, hemlock has been reported to cause myoglobinuria, acute tubular necrosis, and acute renal failure. Plasma exchange effectively improved the signs of renal failure in one case of hemlock poisoning.”

    Hemlock · Natural Medicines adverse-effect record, reported in poisoning.

    5 sources cited
    1. 54716. Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Scatizzi, A., De Marco, S., and Smialek, J. E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephr PubMed
    2. 54717. Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Bruno, S., Scatizzi, A., and De Marco, S. Rhabdomyolysis and acute tubular necrosis in coniine (hemlock) poisoning. Lancet 12-16-1989;2(8677):1461-1462. PubMed
    3. 54718. Rizzi, D., Introna, F., Jr., Gagliano, Candela R., Di Nunno, C., Ricco, R., Recchia, R., and De, Michele, V. [Toxic rhabdomyolysis and tubular necrosis in hemlock poisoning. 4 case reports]. Clin.Ter. 2-15-1988;124(3):193-201.
    4. 54728. Scatizzi, A., Di Maggio, A., Rizzi, D., Sebastio, A. M., and Basile, C. Acute renal failure due to tubular necrosis caused by wildfowl-mediated hemlock poisoning. Ren Fail. 1993;15(1):93-96. PubMed
    5. 54727. Montemurro, N. E., Di Maggio, A., Strippoli, P., Coviello, F., Godino, F., Miloro, G., and Scatizzi, A. Combined dialysis and plasma-exchange in acute renal failure. Biomater.Artif.Cells Immobilization Biotechnol. 1993;21(2):283-287. PubMed
  • Raised blood pressure Worth acting on Additional detail

    Recorded for Hemlock in the same Natural Medicines adverse-effect record shown under A slow heartbeat above.

  • A fast or pounding heartbeat Additional detail

    Recorded for Hemlock in the same Natural Medicines adverse-effect record shown under Severe muscle breakdown above.

  • Numbness or tingling Additional detail

    Recorded for Hemlock in the same Natural Medicines adverse-effect record shown under Seizures above.

  • Drowsiness Additional detail

    Recorded for Hemlock in the same Natural Medicines adverse-effect record shown under Severe muscle breakdown above.

  • Muscle pain / Swelling Additional detail

    Recorded for Hemlock in the same Natural Medicines adverse-effect record shown under Severe muscle breakdown above.

Showing the 10 most notable of 14 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Hemlock — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Clopidogrel’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Clopidogrel column appears here.

Special populations

Hemlock in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally because ingestion can be lethal; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Hemlock or Clopidogrel

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Hemlock or Clopidogrel, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Clopidogrel

This page covers Hemlock only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Clopidogrel page lists 309 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Grapefruit (major), Piracetam (major) and St. John's Wort (major).

By severity: 5 major · 258 moderate · 46 minor.

From our pharmacist’s overview on the Clopidogrel page

“Clopidogrel (Plavix) keeps platelets from sticking together after a stent, heart attack, or stroke, which makes this a list to take carefully. Of the 309 supplements and herbs on file, 202 carry blood-thinning or antiplatelet activity of their own and can stack bleeding risk on top of the drug's, while most of the rest change how the l…”

Reviewed by 2 · Jul 18, 2026

Open the Clopidogrel interaction page

One more smart check

Taking Hemlock as Part of a Dietary Supplement Product? Check It for Interactions

We hold 9 real supplement products containing Hemlock, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hemlock. Even though Hemlock itself has no known interaction with Clopidogrel, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hemlock and Clopidogrel Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hemlock
Steady interest

#1,086 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Clopidogrel
Top 1%

#14 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hemlock reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Hemlock and Clopidogrel records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hemlock

What is Hemlock?

  • Historical sedative or pain reliever
  • Traditional treatment for muscle spasms
  • Folk use for joint and nerve pain
  • Historical execution poison
  • Homeopathic preparations

Hemlock (Conium maculatum) is a highly poisonous plant that has no safe or proven medicinal use today. Even small amounts can cause paralysis and death, so it should never be consumed or applied to the body. Do not use hemlock or any product containing it.

Conium maculatum · Apiaceae · Whole plant, including leaves, seeds, stems, and roots (all parts are poisonous) · Not safely used in any form; historically prepared as extracts, tinctures, or poultices

An interaction check asks whether these two react with each other — it does not ask whether Hemlock is a good idea for someone in your situation. Here is what our Hemlock record says about it on its own.

Hemlock: dosing

There is no safe dose of hemlock. It is not a supplement and should never be measured out or taken. Even a small amount of plant material or seeds can be fatal to humans and animals.Do not buy, prepare, or consume any product that contains Conium maculatum.

From our Hemlock monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hemlock monograph & all interactions
Medication

About Clopidogrel

What Is Clopidogrel Used For?

Brand name: Plavix

Clopidogrel tablets are used to reduce the risk of heart attack and stroke in people with acute coronary syndrome (ACS) — including unstable angina and non-ST-elevation or ST-elevation heart attacks — and in people with a history of recent heart attack, recent stroke, or established peripheral arterial disease. For ACS, it is typically given alongside aspirin.

It works by preventing platelets (blood cells that trigger clotting) from clumping together, which helps keep arteries open and lowers the chance of a dangerous clot forming.

Most-Reported Side Effects for Clopidogrel

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 10,950 reports
Myocardial infarction 10,227 reports
Fatigue 9,428 reports
Gastrointestinal haemorrhage 8,776 reports
Nausea 8,686 reports
See full Clopidogrel drug information
Keep checking

Other Drugs & Hemlock

Browse every other medication we’ve checked against Hemlock — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Hemlock against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Hemlock list.

See the full Hemlock interactions page
See every supplement checked against Clopidogrel, ranked by severity
Evidence & sources

Hemlock References

The 18 references that drive our Hemlock monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Lopez TA, Cid MS, Bianchini ML. Biochemistry of hemlock (Conium maculatum L.) alkaloids and their acute and chronic toxicity in livestock. A review. Toxicon 1999;37:841-65. PubMed
  2. Drummer OH, Roberts AN, Bedford PJ, et al. Three deaths from hemlock poisoning. Med J Aust 1995;162:592-3. PubMed
  3. Frank BS, Panter KE. Ingestion of poison hemlock (Conium maculatum). West J Med 1995;163:573-4.
  4. Carod-Artal FJ. [Neurological syndromes linked with the intake of plants and fungi containing a toxic component (I). Neurotoxic syndromes caused by the ingestion of plants, seeds and fruits]. Rev Neurol 2003;36:860-71.
  5. Biberci, E., Altuntas, Y., Cobanoglu, A., and Alpinar, A. Acute respiratory arrest following hemlock (Conium maculatum) intoxication. J.Toxicol.Clin.Toxicol. 2002;40(4):517-518.
  6. Foster, P. F., McFadden, R., Trevino, R., Galliardt, S., Kopczewski, L. A., Gugliuzza, K., Gonzalez, Z., and Wright, F. Successful transplantation of donor organs from a hemlock poisoning victim. Transplantation 9-15-2003;76(5):874-876. PubMed
  7. Vetter, J. Poison hemlock (Conium maculatum L.). Food Chem.Toxicol. 2004;42(9):1373-1382. PubMed
  8. Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Scatizzi, A., De Marco, S., and Smialek, J. E. Clinical spectrum of accidental hemlock poisoning: neurotoxic manifestations, rhabdomyolysis and acute tubular necrosis. Nephr PubMed
  9. Rizzi, D., Basile, C., Di Maggio, A., Sebastio, A., Introna, F., Jr., Rizzi, R., Bruno, S., Scatizzi, A., and De Marco, S. Rhabdomyolysis and acute tubular necrosis in coniine (hemlock) poisoning. Lancet 12-16-1989;2(8677):1461-1462. PubMed
  10. Rizzi, D., Introna, F., Jr., Gagliano, Candela R., Di Nunno, C., Ricco, R., Recchia, R., and De, Michele, V. [Toxic rhabdomyolysis and tubular necrosis in hemlock poisoning. 4 case reports]. Clin.Ter. 2-15-1988;124(3):193-201.
  11. Montemurro, N. E., Di Maggio, A., Strippoli, P., Coviello, F., Godino, F., Miloro, G., and Scatizzi, A. Combined dialysis and plasma-exchange in acute renal failure. Biomater.Artif.Cells Immobilization Biotechnol. 1993;21(2):283-287. PubMed
  12. Scatizzi, A., Di Maggio, A., Rizzi, D., Sebastio, A. M., and Basile, C. Acute renal failure due to tubular necrosis caused by wildfowl-mediated hemlock poisoning. Ren Fail. 1993;15(1):93-96. PubMed
  13. Brtalik D, Stopyra J, Hannum J. Intravenous poison hemlock injection resulting in prolonged respiratory failure and encephalopathy. J Med Toxicol. 2017;13(2):180-182. PubMed
  14. Konca C, Kahramaner Z, Bosnak M, Kocamaz H. Hemlock (Conium Maculatum) poisoning in a child. Turk J Emerg Med. 2016;14(1):34-6. DOI
  15. Chen HY, Horng H, Rowley F, Smollin C. Rapid respiratory arrest after ingestion of poison hemlock mistaken for wild celery. Clin Toxicol (Phila). 2017;55(2):155-156. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hemlock and Clopidogrel Together: Common Questions

Is it safe to take Hemlock with Clopidogrel?
We do not list a known interaction between Hemlock and Clopidogrel. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Clopidogrel interact with any supplements?
Yes. Clopidogrel has documented interactions with 309 supplements in our database — Hemlock is not one of them. The Clopidogrel interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hemlock monograph Uses, safety profile, and every drug interaction in one place Clopidogrel drug information The full plain-English guide to this medication Clopidogrel supplement interactions Every supplement checked against Clopidogrel, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 18 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Clopidogrel and Hemlock?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.