Beef Tallow Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Beef Tallow interacts with medications. The heart of this page is the interaction list — every drug Beef Tallow is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Beef Tallow is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Beef Tallow against your medication
Add one medicationDrugs that interact with Beef Tallow
0 medications have a known interaction with Beef Tallow, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Beef Tallow. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Beef Tallow combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Beef Tallow: Uses, Safety & Side Effects
Beef tallow is rendered fat from cattle used as a cooking fat and, more recently, as a natural skin moisturizer. It is mostly saturated and monounsaturated fat, so it is calorie-dense and should be used in moderation; strong human evidence for health benefits beyond being a cooking fat is limited. Talk with your pharmacist or doctor before using it as a supplement, especially if you have heart or cholesterol concerns.
- Part used
- Rendered fat from cattle (Bos taurus), usually from around the kidneys (suet) or other fatty tissue
- Common forms
- Solid cooking fat, cooking oil, skin balms and salves, soaps, and some capsules or supplements
- Cooking and frying fat
- Skin moisturizer and balm
- Homemade skin care and soaps
- Part of ancestral or traditional diets
- Lip balm and body care
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally recognized as safe as a food, but it is high in saturated fat, so use in moderation.
When used orally in the amounts commonly found in foods. There is insufficient reliable information available about the safety of using beef tallow in...
Read the full pregnancy detailWhen used orally in the amounts commonly found in foods. There is insufficient reliable information available about the safety of using beef tallow in...
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Beef tallow is fat from cattle that has been melted down and purified in a process called rendering. The most prized type comes from suet, the hard fat found around the kidneys and loins. After rendering, tallow becomes a firm, creamy, off-white fat that is solid at room temperature.
Tallow has been used for centuries as a cooking fat, a candle and soap ingredient, and a skin salve. It fell out of favor when vegetable oils became popular, but it has seen a comeback among people interested in traditional or "ancestral" cooking and in natural skin care.
Today people use beef tallow mainly in two ways: as a heat-stable fat for frying and cooking, and as a moisturizer applied to the skin. It is a food ingredient rather than an herb, and it is not a vitamin or a standardized supplement.
How it works
Beef tallow is made almost entirely of fat (triglycerides). It contains a mix of saturated fats (such as palmitic and stearic acid) and monounsaturated fats (mainly oleic acid, the same fat found in olive oil). It also has small amounts of fat-soluble vitamins.
As a cooking fat, its high proportion of saturated fat makes it resistant to breaking down under heat. As a skin product, its fatty acids may help form a barrier that slows water loss from the skin and softens rough patches. These effects are based mostly on the general behavior of fats rather than on detailed clinical studies of tallow itself.
Because it is a whole fat rather than a single active compound, most claims about how tallow "works" are based on the properties of its fats and on laboratory or traditional-use reasoning, not on strong human trials.
Does Beef Tallow work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Beef Tallow, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 7 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Acne
Although there has been interest in using topical beef tallow for acne, there is insufficient reliable information about the clinical effects of beef tallow for this purpose.
Insufficient Reliable Evidence To Rate Aging skin
Although there has been interest in using topical beef tallow for aging skin, there is insufficient reliable information about the clinical effects of beef tallow for this purpose.
Insufficient Reliable Evidence To Rate Atopic dermatitis (eczema)
Although there has been interest in using topical beef tallow for atopic dermatitis, there is insufficient reliable information about the clinical effects of beef tallow for this purpose.
Insufficient Reliable Evidence To Rate Dry skin
Although there has been interest in using topical beef tallow for dry skin, there is insufficient reliable information about the clinical effects of beef tallow for this purpose.
Insufficient Reliable Evidence To Rate Obesity
Although there has been interest in using oral beef tallow for weight loss, there is insufficient reliable information about the clinical effects of beef tallow for this purpose.
Insufficient Reliable Evidence To Rate Osteoarthritis
It is unclear if oral beef tallow is beneficial for osteoarthritis.
Insufficient Reliable Evidence To Rate Wound healing
Although there has been interest in using topical beef tallow for wound healing, there is insufficient reliable information about the clinical effects of beef tallow for this purpose.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
As a food, beef tallow is generally recognized as safe when eaten in normal amounts. The main concern is that it is very high in saturated fat and calories. Eating large amounts of saturated fat is linked to higher LDL ("bad") cholesterol in many people, which is a risk factor for heart disease.
People with high cholesterol, heart disease, or a doctor's advice to limit saturated fat should be especially careful and talk with their healthcare provider. People with a beef or meat allergy should avoid it.
Pregnancy and breastfeeding: Using tallow occasionally as a cooking fat is generally acceptable, but there is no reason to take it as a supplement, and it has not been studied for this purpose. When in doubt, choose a balanced diet and check with your doctor or pharmacist.
When applied to the skin, tallow is usually well tolerated, but do a small patch test first, since any topical product can cause irritation or breakouts in some people.
Side effects
For most people, beef tallow used in normal cooking amounts causes no direct side effects. Because it is calorie-dense, eating a lot of it can contribute to weight gain and, over time, higher cholesterol in some people.
Eating very large or greasy amounts at once may cause an upset stomach, nausea, or loose stools in sensitive people.
On the skin, tallow can occasionally cause clogged pores, breakouts, redness, or irritation, especially in those prone to acne. Anyone with a beef allergy could have an allergic reaction. Stop use and seek care if you notice rash, swelling, or trouble breathing.
Beef Tallow: Reported Adverse Effects
Documented safety reports on Beef Tallow from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Reports by conditionCardiovascular disease (CVD) Cardiovascular
Beef tallow is rich in saturated and monounsaturated fatty acids. Population research has found an increased risk for heart disease with increased dietary consumption of saturated fats. Both the 2020 Dietary Guidelines for Americans and The American Heart Association/American College of Cardiology guidelines strongly recommend reducing intake of saturated fatty acids to less than 10% of total daily energy. Both clinical and observational research show that a reduced intake of saturated fatty acids, especially from animal fat, along with increased intake of polyunsaturated fatty acids, reduces levels of low-density lipoprotein (LDL) cholesterol. In small clinical studies, consuming beef tallow increased levels of total and LDL cholesterol, as well as the ratio of total cholesterol to high-density lipoprotein (HDL) cholesterol, when compared with consuming unsaturated oils such as canola, corn, and olive.
- Zhou L, Zheng M, Zhang T, et al. Chemical property, bioactive constituent and volatile compound changes of beef tallow during an improved flavor-retaining refining approach. Food Chem 2025;477:143491.
- Limmatvapirat C, Limmatvapirat S, Krongrawa W, et al. Beef tallow: Extraction, physicochemical property, fatty acid composition, antioxidant activity, and formulation of lotion bars. J. Appl. Pharm. Sci. 2021;11(9):18-28.
- Kawahara S, Takenoyama SI, Nagato C, Muguruma M, Ito T, Yamauchi K. Evaluation of beef tallow as a natural source of conjugated linoleic acid. Animal Sci. J. 2002;73(6):533-8.
- US Department of Agriculture (USDA). Fat, beef tallow. April 2018. Available at: https://fdc.nal.usda.gov/food-details/171400/nutrients. Accessed April 9, 2025.
- Sacks FM, Lichtenstein AH, Wu JHY, et al.; American Heart Association. Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association. Circulation 2017;136(3):e1-e23.
- Shen X, Miao S, Zhang Y, et al. Stearic acid metabolism in human health and disease. Clin Nutr 2025;44:222-238.
- Petersen KS, Maki KC, Calder PC, et al. Perspective on the health effects of unsaturated fatty acids and commonly consumed plant oils high in unsaturated fat. Br J Nutr 2024;132(8):1039-1050.
- Denke MA, Grundy SM. Effects of fats high in stearic acid on lipid and lipoprotein concentrations in men. Am J Clin Nutr 1991;54(6):1036-40.
- Schwab US, Vogel S, Lammi-Keefe CJ, et al. Varying dietary fat type of reduced-fat diets has little effect on the susceptibility of LDL to oxidative modification in moderately hypercholesterolemic subjects. J Nutr 1998;128(10):1703-9.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no established medicinal dose for beef tallow. It is used as a cooking fat in the same way you would use butter or oil, and portion sizes should follow normal dietary guidelines for fats.
Because it is high in saturated fat, most health authorities suggest limiting total saturated fat intake. If you use tallow for cooking, use it in moderation as part of a balanced diet.
For skin use, follow the directions on the specific product you buy. If you are considering any tallow-based capsule or supplement, check the product label and talk with your pharmacist or doctor first, since these are not standardized.
Beef Tallow & Pregnancy
Beef Tallow & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 9 references that drive our Beef Tallow monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Sacks FM, Lichtenstein AH, Wu JHY, et al.; American Heart Association. Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association. Circulation 2017;136(3):e1-e23.
- Denke MA, Grundy SM. Effects of fats high in stearic acid on lipid and lipoprotein concentrations in men. Am J Clin Nutr 1991;54(6):1036-40. PubMed
- Schwab US, Vogel S, Lammi-Keefe CJ, et al. Varying dietary fat type of reduced-fat diets has little effect on the susceptibility of LDL to oxidative modification in moderately hypercholesterolemic subjects. J Nutr 1998;128(10):1703-9. PubMed
- Shen X, Miao S, Zhang Y, et al. Stearic acid metabolism in human health and disease. Clin Nutr 2025;44:222-238. PubMed
- Petersen KS, Maki KC, Calder PC, et al. Perspective on the health effects of unsaturated fatty acids and commonly consumed plant oils high in unsaturated fat. Br J Nutr 2024;132(8):1039-1050. PubMed
- Zhou L, Zheng M, Zhang T, et al. Chemical property, bioactive constituent and volatile compound changes of beef tallow during an improved flavor-retaining refining approach. Food Chem 2025;477:143491. PubMed
- Limmatvapirat C, Limmatvapirat S, Krongrawa W, et al. Beef tallow: Extraction, physicochemical property, fatty acid composition, antioxidant activity, and formulation of lotion bars. J. Appl. Pharm. Sci. 2021;11(9):18-28. DOI
- Kawahara S, Takenoyama SI, Nagato C, Muguruma M, Ito T, Yamauchi K. Evaluation of beef tallow as a natural source of conjugated linoleic acid. Animal Sci. J. 2002;73(6):533-8. DOI
- US Department of Agriculture (USDA). Fat, beef tallow. April 2018. Available at: https://fdc.nal.usda.gov/food-details/171400/nutrients. Accessed April 9, 2025.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Beef Tallow: Common Questions
What is Beef Tallow used for, and does it work?
Does Beef Tallow interact with prescription medications?
How are Beef Tallow interactions rated?
Is it safe to take Beef Tallow with my medications?
Where does this Beef Tallow interaction information come from?
What is Beef Tallow used for?
Is Beef Tallow healthy?
Can I put Beef Tallow on my skin?
Is Beef Tallow safe during pregnancy or breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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