Drug & supplement interaction

Poppy Seed + Clopidogrel

Clopidogrel brand name: Plavix.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Poppy Seed and Clopidogrel in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Poppy Seed and Clopidogrel

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Clopidogrel and Poppy Seed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Poppy Seed at all — not against Clopidogrel, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Poppy Seed safety at a glance

Poppy Seed overall Use caution Safe as a food, but large amounts may contain trace opiate residue and can trigger positive drug tests.
Pregnancy Likely Safe When used as a spice or flavoring in amounts commonly found in foods. Poppy seed has Generally Recognized as Safe (GRAS) status in the US for use as a spice or... Read the full pregnancy detail
Breastfeeding Likely Safe When used as a spice or flavoring in amounts commonly found in foods. Poppy seed has Generally Recognized as Safe (GRAS) status in the US for use as a spice or... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Clopidogrel and Poppy Seed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Poppy Seed Itself Has Been Linked To

This is not an interaction — nothing below involves Clopidogrel. It is the side-effect record for Poppy Seed on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Poppy Seed, this list is the first place to look. 4 entries are worth acting on rather than waiting out — marked below.

  • An electrolyte imbalance / Dehydration / An irregular heartbeat Worth acting on Additional detail

    “Orally, poppy seed can cause intestinal obstruction with fecal impaction when used in very large amounts. A case of bowel obstruction and subsequent death due to complications of bowel obstruction has been reported for a 54-year-old female who ingested at least 900 grams of poppy seed.”

    Poppy Seed · Natural Medicines adverse-effect record, reported in arrhythmia.

    1 source cited
    1. 96901. Schuppener LM, Corliss RF. Death due to complications of bowel obstruction following raw poppy seed ingestion. J Forensic Sci. 2018;63(2):614-618. PubMed
  • A bowel blockage Worth acting on Additional detail

    “Orally, poppy seeds are generally well tolerated when consumed in food amounts. Poppy seeds also seem to be well tolerated when used short-term in medicinal amounts. Consuming a large amount of poppy seeds or poppy seed tea may be unsafe.

    Most Common Adverse Effects:

    Orally: Allergic reactions, including dyspnea, mucosal swelling, and urticaria, in sensitive individuals.

    Serious Adverse Effects (Rare):

    Orally: Intest…”

    Poppy Seed · Natural Medicines adverse-effect record, reported in acute respiratory distress syndrome (ards).

  • Shortness of breath Worth acting on Additional detail

    “Three fatalities attributed to morphine overdose have been reported in individuals who consumed poppy seed tea. Symptoms and complications of overdose included slow breathing, pulmonary edema, acute respiratory distress syndrome, and aspiration pneumonitis.”

    Poppy Seed · Natural Medicines adverse-effect record, reported in acute respiratory distress syndrome (ards).

    2 sources cited
    1. 96900. Powers D, Erickson S, Swortwood MJ. Quantification of morphine, codeine, and thebaine in home-brewed poppy seed tea by LC-MS/MS. J Forensic Sci. 2018;63(4):1229-1235.
    2. 96902. Poponea N, Kashlan MT, Vollstaedt J. Opium poppy seed tea: A lesser known but deadly cocktail. Am J Respir Crit Care Med. 2018;197:A6895.
  • Hives / An allergic reaction Worth acting on Additional detail

    “Orally, allergic reactions to poppy seed have included vomiting and swelling of the oral mucosa, urticaria, respiratory distress, and dyspnea.”

    Poppy Seed · Natural Medicines adverse-effect record, reported in acute respiratory distress syndrome (ards).

    1 source cited
    1. 27282. Braun, W. and Kovary, P. M. [Poppy seed allergy]. Z.Hautkr 1988;63(4):344.
  • Numbness or tingling / Anxiety or restlessness Additional detail

    “Orally, poppy seed may cause symptoms of opiate impairment when large amounts are sucked or prepared as poppy seed tea. Although poppy seeds do not naturally contain opiates, poppy seeds can become coated with opiates during harvesting or by insect damage.”

    Poppy Seed · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    6 sources cited
    1. 27274. Braye, K., Harwood, T., Inder, R., Beasley, R., and Robinson, G. Poppy seed tea and opiate abuse in New Zealand. Drug Alcohol Rev 2007;26(2):215-219. PubMed
    2. 90847. Pettitt BC Jr, Dyszel SM, Hood LV. Opiates in poppy seed: effect on urinalysis results after consumption of poppy seed cake-filling. Clin Chem 1987;33(7):1251-2. DOI
    3. 90848. Bjerver K, Jonsson J, Kilsson A. Morphine intake from poppy seed food. J Pharma Pharmacol 2011;34(12):798-801. DOI
    4. 90849. Facchini PJ, De Luca V. Phloem-Specific Expression of Tyrosine/Dopa Decarboxylase Genes and the Biosynthesis of Isoquinoline Alkaloids in Opium Poppy. The Plant Cell 1995;7(11):1811-1821. PubMed
    5. 27261. Kaplan, R. Poppy seed dependence. Med J Aust 1994;161(2):176. PubMed
    6. 27275. Lloyd-Jones, D. M. and Bonomo, Y. Unusual presentations for pharmacotherapy-poppy seed dependence. Drug Alcohol Rev 2006;25(4):375-376. PubMed
  • Swelling Additional detail

    Recorded for Poppy Seed in the same Natural Medicines adverse-effect record shown under A bowel blockage above.

Showing the 10 most notable of 11 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Poppy Seed — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Clopidogrel’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Clopidogrel column appears here.

Special populations

Poppy Seed in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used as a spice or flavoring in amounts commonly found in foods. Poppy seed has Generally Recognized as Safe (GRAS) status in the US for use as a spice or flavoring. There is insufficient reliable information available about the safety of poppy seed when used in medicinal amounts during pregnancy and lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Poppy Seed or Clopidogrel

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Poppy Seed or Clopidogrel, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Clopidogrel

This page covers Poppy Seed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Clopidogrel page lists 309 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Grapefruit (major), Piracetam (major) and St. John's Wort (major).

By severity: 5 major · 258 moderate · 46 minor.

From our pharmacist’s overview on the Clopidogrel page

“Clopidogrel (Plavix) keeps platelets from sticking together after a stent, heart attack, or stroke, which makes this a list to take carefully. Of the 309 supplements and herbs on file, 202 carry blood-thinning or antiplatelet activity of their own and can stack bleeding risk on top of the drug's, while most of the rest change how the l…”

Reviewed by 2 · Jul 18, 2026

Open the Clopidogrel interaction page

How much people look this up

Where Poppy Seed and Clopidogrel Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Poppy Seed
Steady interest

#1,010 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Clopidogrel
Top 1%

#14 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Poppy Seed reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Poppy Seed and Clopidogrel records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Poppy Seed

What is Poppy Seed?

  • Culinary flavoring and baking
  • Source of dietary fat and minerals
  • Traditional digestive remedy
  • Skin and cooking oil
  • Mild sleep or relaxation folk use

Poppy seeds are a common food ingredient harvested from the opium poppy, and the seeds themselves contain very little of the plant's opium compounds. They are generally safe as food, but eating large amounts can leave trace opiate residues that may show up on drug tests. There is little solid evidence supporting poppy seed as a medicinal supplement.

Papaver somniferum · Papaveraceae · Seeds (and seed oil) · Whole seeds, ground seeds, seed oil, baked goods, paste fillings

An interaction check asks whether these two react with each other — it does not ask whether Poppy Seed is a good idea for someone in your situation. Here is what our Poppy Seed record says about it on its own.

Poppy Seed: dosing

There is no established medicinal dose for poppy seed. It is normally consumed as a food ingredient in amounts found in breads, pastries, and dressings, which is considered safe for most people.No supplement form has a proven, standardized therapeutic dose. If you choose to use a poppy seed product, follow the label and avoid large amounts or homemade tea preparations.

From our Poppy Seed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Poppy Seed monograph & all interactions
Medication

About Clopidogrel

What Is Clopidogrel Used For?

Brand name: Plavix

Clopidogrel tablets are used to reduce the risk of heart attack and stroke in people with acute coronary syndrome (ACS) — including unstable angina and non-ST-elevation or ST-elevation heart attacks — and in people with a history of recent heart attack, recent stroke, or established peripheral arterial disease. For ACS, it is typically given alongside aspirin.

It works by preventing platelets (blood cells that trigger clotting) from clumping together, which helps keep arteries open and lowers the chance of a dangerous clot forming.

Most-Reported Side Effects for Clopidogrel

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 10,950 reports
Myocardial infarction 10,227 reports
Fatigue 9,428 reports
Gastrointestinal haemorrhage 8,776 reports
Nausea 8,686 reports
See full Clopidogrel drug information
Keep checking

Other Drugs & Poppy Seed

Browse every other medication we’ve checked against Poppy Seed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Poppy Seed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Poppy Seed list.

See the full Poppy Seed interactions page
See every supplement checked against Clopidogrel, ranked by severity
Evidence & sources

Poppy Seed References

The 13 references that drive our Poppy Seed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Meneely KD. Poppy seed ingestion: the Oregon perspective. J Forensic Sci 1992;37(4):1158-1162. DOI
  3. Kaplan, R. Poppy seed dependence. Med J Aust 1994;161(2):176. PubMed
  4. Braye, K., Harwood, T., Inder, R., Beasley, R., and Robinson, G. Poppy seed tea and opiate abuse in New Zealand. Drug Alcohol Rev 2007;26(2):215-219. PubMed
  5. Lloyd-Jones, D. M. and Bonomo, Y. Unusual presentations for pharmacotherapy-poppy seed dependence. Drug Alcohol Rev 2006;25(4):375-376. PubMed
  6. Braun, W. and Kovary, P. M. [Poppy seed allergy]. Z.Hautkr 1988;63(4):344.
  7. Pettitt BC Jr, Dyszel SM, Hood LV. Opiates in poppy seed: effect on urinalysis results after consumption of poppy seed cake-filling. Clin Chem 1987;33(7):1251-2. DOI
  8. Bjerver K, Jonsson J, Kilsson A. Morphine intake from poppy seed food. J Pharma Pharmacol 2011;34(12):798-801. DOI
  9. Facchini PJ, De Luca V. Phloem-Specific Expression of Tyrosine/Dopa Decarboxylase Genes and the Biosynthesis of Isoquinoline Alkaloids in Opium Poppy. The Plant Cell 1995;7(11):1811-1821. PubMed
  10. Powers D, Erickson S, Swortwood MJ. Quantification of morphine, codeine, and thebaine in home-brewed poppy seed tea by LC-MS/MS. J Forensic Sci. 2018;63(4):1229-1235.
  11. Schuppener LM, Corliss RF. Death due to complications of bowel obstruction following raw poppy seed ingestion. J Forensic Sci. 2018;63(2):614-618. PubMed
  12. Poponea N, Kashlan MT, Vollstaedt J. Opium poppy seed tea: A lesser known but deadly cocktail. Am J Respir Crit Care Med. 2018;197:A6895.
  13. Tan YPA, Alexander PDG, Knowles S. Acute cardiotoxicity following 'poppy seed tea' consumption. Anaesth Rep 2021;9(2):e12130. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Poppy Seed and Clopidogrel Together: Common Questions

Is it safe to take Poppy Seed with Clopidogrel?
We do not list a known interaction between Poppy Seed and Clopidogrel. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Clopidogrel interact with any supplements?
Yes. Clopidogrel has documented interactions with 309 supplements in our database — Poppy Seed is not one of them. The Clopidogrel interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Poppy Seed monograph Uses, safety profile, and every drug interaction in one place Clopidogrel drug information The full plain-English guide to this medication Clopidogrel supplement interactions Every supplement checked against Clopidogrel, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 13 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Clopidogrel and Poppy Seed?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.