Herb & supplement monograph

Arimistane Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated June 2026

What is this page for?

First and foremost: how Arimistane interacts with medications. The heart of this page is the interaction list — every drug Arimistane is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Arimistane is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Arimistane Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Arimistane drug interaction appears low for most people, because it interacts with only a small number of medications. None of the known interactions are rated major, and all of them involve a single group of medicines rated moderate.

Interactions deserving the most attention

The interactions that matter most involve aromatase inhibitors, prescription medicines that lower estrogen and are often used in breast cancer treatment. Arimistane is thought to block the same estrogen-making enzyme, so combining them could add up, raising the chance of low-estrogen side effects and possibly stress on the liver. Human evidence for this is reasonably supported, though not from large controlled studies, so we treat it as a real concern for anyone taking these medicines.

What the rest of the list means

Outside of that one group, Arimistane has very few known interactions, which suggests most common medications are not expected to be affected. The concern that does exist rests largely on how Arimistane works on the body's estrogen-making enzyme rather than on proof of harm in large human studies.

Check your medications against Arimistane

Based on HelloPharmacist’s Arimistane interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Arimistane

4 medications have a known interaction with Arimistane, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Arimistane using our pharmacist-reviewed interaction data.

AI summaries are generated from our Arimistane interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Arimistane combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Arimistane affects

Every type of medication (drug category) Arimistane is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Arimistane interacts with

Aromatase Inhibitors

It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors. This interaction could potentially increase the risk of side effects associated with low estrogen levels or from additive side effects, such as an increased risk of liver toxicity. It is recommended to consult with a healthcare provider before combining Arimistane with other aromatase inhibitors to assess the potential risks and benefits.

Likelihood Probable Evidence C

Monograph

Arimistane: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed June 2026 ·

The bottom line

Arimistane (sometimes sold as Estrovade) is a synthetic aromatase inhibitor marketed as a dietary supplement to lower estrogen and raise testosterone, often during or after steroid or prohormone cycles. It is not a true dietary ingredient, has very little human safety data, and U.S. regulators have warned against products containing aromatase inhibitors. Talk to a pharmacist or doctor before using it.

Part used: Not applicable (synthetic compound)
Common forms: Capsules, tablets, powders

People commonly use it for

Lowering estrogen levels
Post-cycle therapy after steroid or prohormone use
Reducing gynecomastia ('gyno')
Boosting testosterone
Bodybuilding and physique support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallBest avoided

It is a hormone-altering drug with little safety data, and regulators warn against aromatase inhibitor supplements.

PregnancyPossibly Unsafe

When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing aromata...

Read the full pregnancy detail

BreastfeedingPossibly Unsafe

When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing aromata...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Arimistane (also sold under names like Estrovade) is a man-made compound related to androstane steroids. It is not an herb or a plant — it is a synthetic chemical that is marketed as a dietary supplement, even though it acts more like a drug.

It is most often sold to bodybuilders and athletes. People typically use it to lower estrogen, especially while taking or after stopping anabolic steroids or prohormones. This is sometimes called 'post-cycle therapy.'

Because it changes hormone levels, Arimistane is not a typical vitamin or herbal supplement. Many health authorities consider aromatase inhibitors like this to be unapproved drugs rather than legitimate dietary ingredients.

How it works

Arimistane is described as an aromatase inhibitor. Aromatase is an enzyme in the body that converts testosterone and similar hormones into estrogen. By blocking this enzyme, Arimistane is thought to lower estrogen levels and, indirectly, allow testosterone to stay higher.

Lower estrogen may also signal the brain to increase hormones that support natural testosterone production. This is the reasoning behind using it after steroid or prohormone cycles, when the body's own testosterone may be suppressed.

It is important to know that much of this is based on how aromatase inhibitors work in general and on laboratory reasoning, not on strong human studies of Arimistane itself.

Effectiveness

Does Arimistane work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 6 uses evaluated

6 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

For Arimistane, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 6 conditions — evidence insufficient to rate

Insufficient Reliable Evidence To Rate Athletic performance