Arimistane + Bupropion, Naltrexone
Bupropion, Naltrexone brand name: Contrave.
We found no known interaction between Arimistane and Bupropion, Naltrexone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Bupropion, Naltrexone states a food rule worth keeping to.
Arimistane and Bupropion, Naltrexone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Bupropion, Naltrexone and Arimistane in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Arimistane safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Bupropion, Naltrexone
Interactions in our licensed database are recorded against drug classes, not just single drug names. Bupropion, Naltrexone is filed under 7 classifications — including antidepressant drugs, cytochrome p450 2b6 (cyp2b6) substrates, cytochrome p450 2d6 (cyp2d6) inhibitors. Arimistane has documented interactions with 1 drug class — the most serious being aromatase inhibitors (moderate) — and none of Bupropion, Naltrexone’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Arimistane Does Interact With Other Medications
Arimistane has 4 moderate known drug interactions in our database — Bupropion, Naltrexone isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Arimistane
We haven’t checked that one against Arimistane yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Arimistane. Pick one to open its full report.
Arimistane in Pregnancy & Breastfeeding
When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing aromatase inhibitors are dangerous. Avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Bupropion, Naltrexone Products Have a Food Rule — Arimistane Should Not Break It
At least one FDA label for a product containing Bupropion, Naltrexone says to take it with food. If you take Arimistane on an empty stomach out of habit, keep them separate — and take Bupropion, Naltrexone with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Bupropion, Naltrexone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
In clinical trials, CONTRAVE was administered with meals.
From the Dosage and Administration section of the FDA label we read for Bupropion, Naltrexone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Bupropion, Naltrexone Is Prescribed For, and What Arimistane Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Bupropion, Naltrexone is a prescription medicine with approved uses on its FDA label. Arimistane is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Bupropion, Naltrexone is prescribed for: Contrave (naltrexone and bupropion) is used with a reduced-calorie diet and more physical activity. It helps adults lose excess body weight and maintain that weight loss long term. It is for adults with obesity, or with overweight plus at least one weight-related condition. Its effect on heart disease and death from heart problems has not been established.
Arimistane has been studied for:
-
Obesity studied, not established Arimistane has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Arimistane for obesity
Although there is interest in using oral arimistane for obesity, there is insufficient reliable information about the clinical effects of arimistane for this condition.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Bupropion, Naltrexone on your own; if you are taking Arimistane for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Bupropion, Naltrexone
This page covers Arimistane only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bupropion, Naltrexone page lists 47 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), African Wild Potato (moderate), Artichoke (moderate) and Astaxanthin (moderate).
By severity: 1 major · 34 moderate · 12 minor.
From our pharmacist’s overview on the Bupropion, Naltrexone page
“Anyone taking Contrave (bupropion with naltrexone) for weight management should treat this list with genuine care, starting with the single major-rated entry, activated charcoal, which can soak up the medication in the gut and sharply blunt its effect. Beyond that, two themes dominate.”
Reviewed by 2 · Jul 18, 2026
Taking Arimistane as Part of a Dietary Supplement Product? Check It for Interactions
We hold 80 real supplement products containing Arimistane, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Arimistane. Even though Arimistane itself has no known interaction with Bupropion, Naltrexone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Arimistane and Bupropion, Naltrexone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#394 of 1,452 supplements looked up here in the last 7 days
#455 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Arimistane reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Arimistane and Bupropion, Naltrexone records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Arimistane
What is Arimistane?
- Lowering estrogen levels
- Post-cycle therapy after steroid or prohormone use
- Reducing gynecomastia ('gyno')
- Boosting testosterone
- Bodybuilding and physique support
Arimistane (sometimes sold as Estrovade) is a synthetic aromatase inhibitor marketed as a dietary supplement to lower estrogen and raise testosterone, often during or after steroid or prohormone cycles. It is not a true dietary ingredient, has very little human safety data, and U.S. regulators have warned against products containing aromatase inhibitors. Talk to a pharmacist or doctor before using it.
Not applicable (synthetic compound) · Capsules, tablets, powders
An interaction check asks whether these two react with each other — it does not ask whether Arimistane is a good idea for someone in your situation. Here is what our Arimistane record says about it on its own.
Arimistane: dosing
There is no officially established or proven safe dose for Arimistane. It has not gone through the testing that approved medicines undergo, so reliable dosing guidance does not exist.Product labels vary widely, and the actual amount in a given product may not match what is claimed. Honestly, for most people the safest choice is to avoid it.
From our Arimistane monograph — the full record covers uses, side effects and every documented interaction.
About Naltrexone and Bupropion
What Is Naltrexone and Bupropion Used For?
Brand name: Contrave
Contrave (naltrexone and bupropion) is used with a reduced-calorie diet and more physical activity. It helps adults lose excess body weight and maintain that weight loss long term.
It is for adults with obesity, or with overweight plus at least one weight-related condition. Its effect on heart disease and death from heart problems has not been established.
Other Drugs & Arimistane
Browse every other medication we’ve checked against Arimistane — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
4 interactions
No interaction 2,825 drugs checked — show the list
We also checked Arimistane against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Sertraline ›
- Losartan Potassium ›
- Acetaminophen ›
- Aspirin ›
- Rosuvastatin ›
- Escitalopram ›
- Metoprolol ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Warfarin Sodium ›
- Tirzepatide ›
- Ibuprofen ›
- Amlodipine Besylate ›
- Methamphetamine ›
- Docusate ›
- Tadalafil ›
- Hydroxyurea ›
- Metformin ›
- Valacyclovir ›
- Prednisone ›
- Sumatriptan ›
- Semaglutide ›
- Amitriptyline ›
- Lisdexamfetamine ›
- Amphetamine ›
- Levothyroxine, Liothyronine ›
- Propranolol ›
- Methotrexate ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Bendamustine ›
- Pregabalin ›
- Doxycycline ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Acyclovir ›
- Naproxen ›
- Acetaminophen, Aspirin, Caffeine ›
- Quetiapine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Duloxetine ›
- Citalopram ›
- Methylene Blue ›
- Acetaminophen, Codeine ›
Showing the 60 most looked-up of 2,825 medications checked with no known interaction — see the full Arimistane list.
Arimistane References
The 1 references that drive our Arimistane monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Bupropion, Naltrexone Is Linked to Lower Levels of One Nutrient
Natural Medicines records Bupropion, Naltrexone as a medicine that can lower these. This is not an interaction with Arimistane — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Bupropion, Naltrexone nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Arimistane and Bupropion, Naltrexone Together: Common Questions
Is it safe to take Arimistane with Bupropion, Naltrexone?
Should I take Arimistane and Bupropion, Naltrexone at the same time of day?
Are Arimistane and Bupropion, Naltrexone used for the same thing?
How was the Arimistane and Bupropion, Naltrexone combination checked?
Does Arimistane interact with any other medications?
Does Bupropion, Naltrexone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.