Arimistane + Anastrozole
Anastrozole brand name: Arimidex.
Arimistane has a moderate interaction with Anastrozole. It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors.
Read the full interaction reportArimistane and Anastrozole
Here is the interaction we found between these two, with the evidence behind it.
Aromatase Inhibitors
Why this applies to Anastrozole
Anastrozole falls under Aromatase Inhibitors — the group Arimistane interacts with.
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
Here's the thing about pairing these two: Anastrozole (Arimidex) and Arimistane do the same job. Both are aromatase inhibitors, meaning they block the enzyme that makes estrogen. Stacking them doesn't make your treatment work better, it just piles on more of the same effect. That can push your estrogen too low and stack the side effects on top of each other.
With Anastrozole, that could mean worse hot flashes, joint and bone aches, fatigue, or mood changes, and possibly more strain on your liver. Since you're taking Anastrozole for a serious reason like breast cancer, adding an unregulated supplement with little safety data isn't worth the risk. Please don't start or stop anything on your own. Talk with your oncologist or pharmacist first.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Arimistane Also Interacts With Other Medications
Arimistane has 3 moderate known drug interactions in our database — the Anastrozole one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Arimistane
We haven’t checked that one against Arimistane yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Arimistane. Pick one to open its full report.
Questions About Arimistane or Anastrozole
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Arimistane or Anastrozole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Anastrozole
This page covers Arimistane only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Anastrozole page lists 22 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), 7-methoxyflavone (moderate), Atractylodes (moderate), Chrysin (moderate) and Coffee Charcoal (moderate).
By severity: 1 major · 12 moderate · 9 minor.
From our pharmacist’s overview on the Anastrozole page
“Activated charcoal carries the one major rating on the anastrozole (Arimidex) list, because it can soak up the drug in the gut and cut how much your body absorbs. For a medicine that treats hormone-sensitive breast cancer by keeping estrogen suppressed, anything that lowers its level deserves real concern, and I would act on this list…”
Reviewed by 2 · Jul 18, 2026
Taking Arimistane as Part of a Dietary Supplement Product? Check It for Interactions
We hold 80 real supplement products containing Arimistane, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Arimistane. Your product may carry other ingredients that interact with Anastrozole too, on top of Arimistane — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Arimistane and Anastrozole Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#596 of 1,452 supplements looked up here in the last 7 days
#401 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Arimistane
What is Arimistane?
- Lowering estrogen levels
- Post-cycle therapy after steroid or prohormone use
- Reducing gynecomastia ('gyno')
- Boosting testosterone
- Bodybuilding and physique support
Arimistane (sometimes sold as Estrovade) is a synthetic aromatase inhibitor marketed as a dietary supplement to lower estrogen and raise testosterone, often during or after steroid or prohormone cycles. It is not a true dietary ingredient, has very little human safety data, and U.S. regulators have warned against products containing aromatase inhibitors. Talk to a pharmacist or doctor before using it.
About Anastrozole
What Is Anastrozole Used For?
Brand name: Arimidex
Anastrozole (also sold as Arimidex) is used in postmenopausal women to treat hormone receptor-positive breast cancer at several stages. This includes early breast cancer after surgery (adjuvant therapy), locally advanced or metastatic breast cancer as a first treatment, and advanced breast cancer that has continued to grow after tamoxifen therapy.
For the second-line use in advanced breast cancer, women whose cancer did not respond to estrogen receptor (ER) testing or who did not respond to tamoxifen rarely benefited from anastrozole.
Other Drugs & Arimistane
Browse every other medication we’ve checked against Arimistane — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
3 interactions
No interaction 2,826 drugs checked — show the list
We also checked Arimistane against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Losartan Potassium ›
- Acetaminophen ›
- Aspirin ›
- Metoprolol ›
- Rosuvastatin ›
- Escitalopram ›
- Rivaroxaban ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Methamphetamine ›
- Tirzepatide ›
- Tadalafil ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Amitriptyline ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Isotretinoin ›
- Lisinopril ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Amphetamine ›
- Bupropion ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Codeine ›
- Naproxen ›
- Quetiapine ›
- Clonazepam ›
- Omeprazole ›
- Duloxetine ›
- Citalopram ›
- Methylene Blue ›
- Buspirone ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,826 medications checked with no known interaction — see the full Arimistane list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Taking Arimistane and Anastrozole Together: Common Questions
Can you take Arimistane with Anastrozole?
How serious is the Arimistane and Anastrozole interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.