Medication interaction hub

What Supplements Interact with Bupropion, Naltrexone?

Bupropion, Naltrexone brand name: Contrave. Every interaction below applies to the brands too.

47 Interactions 1 Major 34 Moderate 12 Minor
Curated & coded by · Clinical Pharmacist · Updated October 1, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Bupropion, Naltrexone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Bupropion, Naltrexone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Anyone taking Contrave (bupropion with naltrexone) for weight management should treat this list with genuine care, starting with the single major-rated entry, activated charcoal, which can soak up the medication in the gut and sharply blunt its effect. Beyond that, two themes dominate. Fibers and charcoal-type products can cut absorption of anything swallowed, and a large cluster of herbs alters the liver enzyme that clears bupropion, letting its level drift up or down. St. John's wort has actual human data showing it lowers bupropion levels.

The absorption issue hits close to home here, since glucomannan is a common weight loss fiber; space it well apart from your dose. A handful of entries also add to seizure risk, and bupropion already lowers that threshold on its own. Of the 47 ingredients on file, 34 rate moderate and 12 minor, with charcoal the lone major.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 34 Minor 12 No known interaction 1,405

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Bupropion, Naltrexone: Top Interactions at a Glance

The Bupropion, Naltrexone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 47 interacting ingredients — plus 1,405 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Bupropion, Naltrexone Combinations Today

The Bupropion, Naltrexone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Kratom + Bupropion, Naltrexonei

Taking kratom in combination with naltrexone might precipitate withdrawal.

Read the full interaction Minor Likelihood Possible Rhodiola + Bupropion, Naltrexonei

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.

Read the full interaction Minor Likelihood Possible Black Psyllium + Bupropion, Naltrexonei

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full interaction Moderate Likelihood Possible Melatonin + Bupropion, Naltrexonei

Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Read the full interaction Major Likelihood Probable Activated Charcoal + Bupropion, Naltrexonei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Moderate Likelihood Probable Coffee Charcoal + Bupropion, Naltrexonei

Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two hours.

Read the full interaction
The complete list

Every Supplement Checked Against Bupropion, Naltrexone

All 1,452 ingredients in our database, ranked by severity — 47 with a Bupropion, Naltrexone interaction on file and 1,405 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Bupropion, Naltrexone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Kratom with Bupropion, Naltrexone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking kratom in combination with naltrexone might precipitate withdrawal.

Full Kratom + Bupropion, Naltrexone answer

Can you take Rhodiola with Bupropion, Naltrexone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.

Full Rhodiola + Bupropion, Naltrexone answer

Can you take Black Psyllium with Bupropion, Naltrexone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Bupropion, Naltrexone answer

Can you take Melatonin with Bupropion, Naltrexone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Bupropion, Naltrexone answer

Can you take Licorice with Bupropion, Naltrexone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase levels of drugs metabolized by CYP2B6.

Full Licorice + Bupropion, Naltrexone answer

Can you take Milk Thistle with Bupropion, Naltrexone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, milk thistle might inhibit CYP2B6.

Full Milk Thistle + Bupropion, Naltrexone answer

Can you take Rauwolscine with Bupropion, Naltrexone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Bupropion, Naltrexone answer

Can you take Slippery Elm with Bupropion, Naltrexone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Bupropion, Naltrexone answer

Can you take Sweet Annie with Bupropion, Naltrexone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP2B6.

Full Sweet Annie + Bupropion, Naltrexone answer

Can you take Thuja with Bupropion, Naltrexone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Bupropion, Naltrexone answer

Can you take Tragacanth with Bupropion, Naltrexone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Bupropion, Naltrexone answer

Can you take Wine with Bupropion, Naltrexone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may increase the risk of adverse effects from alcohol.

Full Wine + Bupropion, Naltrexone answer

Can you take Thyroid Extract with Bupropion, Naltrexone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Bupropion, Naltrexone answer

Can you take Agar with Bupropion, Naltrexone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Bupropion, Naltrexone answer

Can you take Algin with Bupropion, Naltrexone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Bupropion, Naltrexone answer

Can you take Blond Psyllium with Bupropion, Naltrexone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Bupropion, Naltrexone answer

Can you take Carob with Bupropion, Naltrexone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Bupropion, Naltrexone answer

Can you take Ginger with Bupropion, Naltrexone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ginger might increase the levels of CYP2B6 substrates.

Full Ginger + Bupropion, Naltrexone answer

Can you take Hibiscus Sabdariffa with Bupropion, Naltrexone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP2B6 substrates.

Full Hibiscus Sabdariffa + Bupropion, Naltrexone answer

Can you take Karaya Gum with Bupropion, Naltrexone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Bupropion, Naltrexone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Bupropion, Naltrexone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Bupropion, Naltrexone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Bupropion, Naltrexone sits in 7 interaction categories. Open any one to see what the group means:

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Bupropion, Naltrexone through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Bupropion, Naltrexone through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Bupropion, Naltrexone through this category.

Antidepressant Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Bupropion, Naltrexone through this category.

Bupropion (Wellbutrin) 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Bupropion, Naltrexone through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Bupropion, Naltrexone through this category.

Naltrexone (Vivitrol) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Bupropion, Naltrexone through this category.

About Bupropion, Naltrexone

Naltrexone and bupropion is a combination medicine, sold as Contrave, used along with diet and exercise to help adults with obesity or overweight (who also have a weight-related health condition) lose weight and keep it off.

Generic name: Bupropion, Naltrexone  ·  Brand name: Contrave.

See the full Naltrexone and Bupropion drug information

Related: does Bupropion, Naltrexone deplete any nutrients?

Bupropion, Naltrexone has 1 reported nutrient association in the research literature — see the Bupropion, Naltrexone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Bupropion, Naltrexone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Bupropion, Naltrexone.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Products that contain Bupropion, Naltrexone-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Bupropion, Naltrexone.

Standardized St. John's Wort 600 mg by Nature's Truth contains St. John's Wort St. John's Wort-IMT by SP Standard Process contains St. John's Wort St John's Wort Extract by SuperSmart contains St. John's Wort St John's Wort 400 mg by Signature Supplements contains St. John's Wort
Pharmacist Counseling Corner

Bupropion, Naltrexone & Supplements: Common Questions

What supplements interact with Bupropion, Naltrexone?
More than you might expect — 47 in total, though they are far from equal: 1 are rated major, 34 moderate, and 12 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, Coffee Charcoal, European Mandrake.
Which Bupropion, Naltrexone supplement interactions are the most serious?
The 1 major-rated combination — led by Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Bupropion, Naltrexone?
Usually yes — most people on Bupropion, Naltrexone can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Contrave have the same supplement interactions as Bupropion, Naltrexone?
Yes — Contrave all contain Bupropion, Naltrexone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Bupropion, Naltrexone deplete any vitamins or nutrients?
It might — Bupropion, Naltrexone has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Bupropion, Naltrexone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Bupropion, Naltrexone and my other medications?
This page covers Bupropion, Naltrexone against supplements and herbal ingredients. Checking Bupropion, Naltrexone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Naltrexone and Bupropion drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 1, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.