Lemon + Bupropion, Naltrexone

Lemon has 1 minor known drug interaction in our database — Bupropion, Naltrexone isn’t one of them. If you take anything else, check it against the full list below.

We haven’t checked that one against Lemon yet — ask our pharmacists directly.

Covers the 2,830 medications we’ve checked against Lemon. Pick one to open its full report.

At least one FDA label for a product containing Bupropion, Naltrexone says to take it with food. If you take Lemon on an empty stomach out of habit, keep them separate — and take Bupropion, Naltrexone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Bupropion, Naltrexone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

These two come up together because they touch the same health topic — not because they do the same job. Bupropion, Naltrexone is a prescription medicine with approved uses on its FDA label. Lemon is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Bupropion, Naltrexone is prescribed for: Contrave (naltrexone/bupropion extended-release tablets) is approved to help adults with obesity, or adults who are overweight and have at least one weight-related health condition, lose excess weight and keep it off long term. It is always used together with a reduced-calorie diet and increased physical activity — not as a stand-alone treatment. Contrave is not approved to treat depression, anxiety, or any other psychiatric condition, and it is not approved for use in anyone under 18 years of age.

Lemon has been studied for:

• Obesity studied, not established Lemon has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

  Lemon for obesity

  Although there is interest in using lemon orally for obesity, there is insufficient reliable information about the clinical effects of lemon for this condition.

• Anxiety studied, not established Lemon has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

  Lemon for anxiety

  It is unclear if aromatherapy with lemon essential oil reduces anxiety.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Bupropion, Naltrexone on your own; if you are taking Lemon for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Lemon or Bupropion, Naltrexone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

• Can You Take Passion Flower and Lemon Balm With Dofetilide? Answered by Dr. Brian Staiger, PharmD · July 2026 ›
• Does Lemon Verbena Interact With Coreg (Carvedilol)? Answered by Dr. Brian Staiger, PharmD · February 2024 ›
• Can You Drink Lemonade With Cephalexin? Answered by Dr. Brian Staiger, PharmD · May 2021 ›

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

This page covers Lemon only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bupropion, Naltrexone page lists 47 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), African Wild Potato (moderate), Artichoke (moderate) and Astaxanthin (moderate).

By severity: 1 major · 34 moderate · 12 minor.

Open the Bupropion, Naltrexone interaction page ›

We hold 1,390 real supplement products containing Lemon, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lemon. Even though Lemon itself has no known interaction with Bupropion, Naltrexone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Natural Medicines records Bupropion, Naltrexone as a medicine that can lower these. This is not an interaction with Lemon — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:

• SODIUM›

Read the full Bupropion, Naltrexone nutrient depletion report ›

Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.