Gumweed Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Gumweed interacts with medications. The heart of this page is the interaction list — every drug Gumweed is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Gumweed is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Gumweed against your medication
Add one medicationDrugs that interact with Gumweed
0 medications have a known interaction with Gumweed, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Gumweed. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Gumweed combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Gumweed: Uses, Safety & Side Effects
Gumweed is a traditional North American plant used mostly for coughs, chest congestion, and skin irritation such as poison ivy rashes. Good-quality human studies are lacking, so its benefits are not well proven, and it should be used cautiously and avoided during pregnancy and breastfeeding.
- Scientific name
- Grindelia robusta
- Family
- Asteraceae
- Part used
- Dried leaves and flowering tops
- Common forms
- Tea, tincture, liquid extract, capsules, topical preparations
- Cough and bronchitis
- Asthma-related breathing problems
- Skin irritation from poison ivy or poison oak
- Minor wounds and rashes
- Upper respiratory congestion
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally used in small amounts traditionally, but human safety data are limited.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Gumweed is the common name for several plants in the Grindelia group, which belong to the daisy (Asteraceae) family. The name comes from the sticky, gummy resin found on its yellow flower heads. It grows in dry, sunny areas across the western and central parts of North America.
Native American peoples and early herbalists used gumweed mainly as a remedy for coughs and chest congestion, and they applied it to the skin to soothe rashes from poison ivy and poison oak. Today it is sold as a tea, tincture, liquid extract, capsule, or topical product, often in cough and respiratory blends.
Uses & effectiveness
Gumweed is most often used as an expectorant, meaning people take it to help loosen mucus and ease coughs from colds, bronchitis, and asthma. It is also applied to the skin for irritation, such as poison ivy or poison oak rashes, insect bites, and minor wounds.
It is important to be honest about the evidence: most of what we know about gumweed comes from traditional use and laboratory research, not from well-designed human studies. There is not enough reliable clinical evidence to say how well it works for any of these conditions. People with asthma or ongoing breathing problems should rely on treatments proven to work and not use gumweed as a substitute.
How it works
Gumweed contains a sticky resin made up of compounds such as grindelic acid and related diterpenes, along with flavonoids and small amounts of plant volatile oils. These substances are thought to be responsible for its traditional effects.
The resin may help thin and loosen mucus in the airways, which is the basis for its use as an expectorant. Some compounds in the plant have shown mild anti-inflammatory and soothing actions in laboratory studies when applied to skin. Keep in mind that these proposed mechanisms come mostly from test-tube and animal research, and they do not prove the plant works the same way in people.
Safety & precautions
Gumweed has a long history of traditional use, but modern safety data in humans are limited. Because it belongs to the daisy (Asteraceae) family, people who are allergic to ragweed, marigolds, chrysanthemums, or related plants may react to it.
The plant can take up selenium from soil, and large or long-term amounts could in theory deliver too much of this mineral. For this reason it is best used in modest amounts and for short periods. People with kidney problems, heart conditions, or other chronic illnesses should check with a doctor or pharmacist first.
Pregnancy and breastfeeding: There is not enough information to consider gumweed safe during pregnancy or while breastfeeding, so it should be avoided during these times. Always talk to a healthcare professional before using it.
Side effects
When used in small, traditional amounts, gumweed is usually well tolerated, but research on side effects is limited. Possible problems include stomach upset, nausea, or diarrhea, especially with larger doses.
Allergic reactions are possible, particularly in people sensitive to other plants in the daisy family. Skin use may cause irritation in some people. Because the plant can concentrate selenium, taking large amounts over a long time could lead to selenium-related effects. Stop using it and seek medical care if you develop a rash, swelling, or trouble breathing.
Gumweed: Reported Adverse Effects
Documented safety reports on Gumweed from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, gumweed seems to be well tolerated. It can cause gastric mucosal irritation, diarrhea, and kidney irritation.
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Diarrhea Gastrointestinal
Orally, gumweed can cause gastric mucosal irritation and diarrhea.
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no well-established, standardized dose for gumweed. Traditional preparations include teas, tinctures, and liquid extracts, but the strength of commercial products varies widely.
The safest approach is to follow the directions on the product label and not exceed the suggested amount. Because reliable dosing studies are lacking, it is a good idea to check with a pharmacist or doctor before starting, especially if you take other medicines or have a health condition.
Gumweed & Pregnancy
Gumweed & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 3 references that drive our Gumweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Gumweed
6 brands in our database make a supplement containing Gumweed.
Supplement products with Gumweed
18 products in our database contain Gumweed. Open any to see its full ingredient list and every drug interaction we check.
Gumweed: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Gumweed
A rotating sample of real supplements in our database that list Gumweed — open any to see its full ingredients and every drug interaction we check.
- Kids Herbal Cough Elixir by Eclectic Herb
- Grindelia by TerraVita
- Kids Herbal Cough Elixir Black Cherry Flavored by Eclectic Institute
- Kids Herbal Cough Elixir Black Cherry Flavored by Eclectic Institute
- Black Elderberry NightTime Syrup by Gaia Herbs
- Mighty Lungs by Gaia Herbs
- Kid's Herbal Cough Elixir by Eclectic Herb
- Grindelia Chocolate Flavor by TerraVita
- Grindelia by Herbal Terra
- Grindelia by Hawaii Pharm
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