Herb & supplement monograph

Gumweed Drug Interactions, Uses, Safety & More

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Interaction report

Drugs that interact with Gumweed

0 medications have a known interaction with Gumweed, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Gumweed. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Gumweed combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Gumweed: Uses, Safety & Side Effects

The bottom line

Gumweed is a traditional North American plant used mostly for coughs, chest congestion, and skin irritation such as poison ivy rashes. Good-quality human studies are lacking, so its benefits are not well proven, and it should be used cautiously and avoided during pregnancy and breastfeeding.

Scientific name
Grindelia robusta
Family
Asteraceae
Part used
Dried leaves and flowering tops
Common forms
Tea, tincture, liquid extract, capsules, topical preparations
People commonly use it for
  • Cough and bronchitis
  • Asthma-related breathing problems
  • Skin irritation from poison ivy or poison oak
  • Minor wounds and rashes
  • Upper respiratory congestion

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally used in small amounts traditionally, but human safety data are limited.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Gumweed is the common name for several plants in the Grindelia group, which belong to the daisy (Asteraceae) family. The name comes from the sticky, gummy resin found on its yellow flower heads. It grows in dry, sunny areas across the western and central parts of North America.

Native American peoples and early herbalists used gumweed mainly as a remedy for coughs and chest congestion, and they applied it to the skin to soothe rashes from poison ivy and poison oak. Today it is sold as a tea, tincture, liquid extract, capsule, or topical product, often in cough and respiratory blends.

Uses & effectiveness

Gumweed is most often used as an expectorant, meaning people take it to help loosen mucus and ease coughs from colds, bronchitis, and asthma. It is also applied to the skin for irritation, such as poison ivy or poison oak rashes, insect bites, and minor wounds.

It is important to be honest about the evidence: most of what we know about gumweed comes from traditional use and laboratory research, not from well-designed human studies. There is not enough reliable clinical evidence to say how well it works for any of these conditions. People with asthma or ongoing breathing problems should rely on treatments proven to work and not use gumweed as a substitute.

How it works

Gumweed contains a sticky resin made up of compounds such as grindelic acid and related diterpenes, along with flavonoids and small amounts of plant volatile oils. These substances are thought to be responsible for its traditional effects.

The resin may help thin and loosen mucus in the airways, which is the basis for its use as an expectorant. Some compounds in the plant have shown mild anti-inflammatory and soothing actions in laboratory studies when applied to skin. Keep in mind that these proposed mechanisms come mostly from test-tube and animal research, and they do not prove the plant works the same way in people.

Safety & precautions

Gumweed has a long history of traditional use, but modern safety data in humans are limited. Because it belongs to the daisy (Asteraceae) family, people who are allergic to ragweed, marigolds, chrysanthemums, or related plants may react to it.

The plant can take up selenium from soil, and large or long-term amounts could in theory deliver too much of this mineral. For this reason it is best used in modest amounts and for short periods. People with kidney problems, heart conditions, or other chronic illnesses should check with a doctor or pharmacist first.

Pregnancy and breastfeeding: There is not enough information to consider gumweed safe during pregnancy or while breastfeeding, so it should be avoided during these times. Always talk to a healthcare professional before using it.

Side effects

When used in small, traditional amounts, gumweed is usually well tolerated, but research on side effects is limited. Possible problems include stomach upset, nausea, or diarrhea, especially with larger doses.

Allergic reactions are possible, particularly in people sensitive to other plants in the daisy family. Skin use may cause irritation in some people. Because the plant can concentrate selenium, taking large amounts over a long time could lead to selenium-related effects. Stop using it and seek medical care if you develop a rash, swelling, or trouble breathing.

Gumweed: Reported Adverse Effects

Documented safety reports on Gumweed from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, gumweed seems to be well tolerated. It can cause gastric mucosal irritation, diarrhea, and kidney irritation.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Reports by condition
Diarrhea Gastrointestinal

Orally, gumweed can cause gastric mucosal irritation and diarrhea.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established, standardized dose for gumweed. Traditional preparations include teas, tinctures, and liquid extracts, but the strength of commercial products varies widely.

The safest approach is to follow the directions on the product label and not exceed the suggested amount. Because reliable dosing studies are lacking, it is a good idea to check with a pharmacist or doctor before starting, especially if you take other medicines or have a health condition.

Pregnancy & Breastfeeding

Gumweed & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Gumweed & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 3 references that drive our Gumweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Gumweed

18 products in our database contain Gumweed. Open any to see its full ingredient list and every drug interaction we check.

Black Elderberry NightTime Syrup by Gaia Herbs Liquid 3 Fluid Ounce(s) · 89 Milliliter(s) View ingredients & interactions Grindelia by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Grindelia by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Grindelia by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Grindelia by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Grindelia Chocolate Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Grindelia Mint Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Grindelia Non-Alcohol by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Grindelia Strawberry Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Grindelia Vanilla Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Kid's Herbal Cough Elixir by Eclectic Herb Liquid 2 Fluid Ounce(s) · 30 Milliliter(s) View ingredients & interactions Kids Herbal Cough Elixir by Eclectic Herb Liquid 1 Fluid Ounce(s) · 30 Milliliter(s) View ingredients & interactions Kids Herbal Cough Elixir Black Cherry Flavored by Eclectic Institute Liquid 1 fl. Oz. · 30 mL View ingredients & interactions Kids Herbal Cough Elixir Black Cherry Flavored by Eclectic Institute Liquid 2 fl. Oz. · 60 mL View ingredients & interactions Mighty Lungs by Gaia Herbs Capsule 60 Vegan Liquid Phyto-Cap(s)(R) View ingredients & interactions Bronchial Wellness Syrup by Gaia Herbs Liquid 5.4 Fluid Ounce(s) · 160 mL Off market View ingredients & interactions Lung Support 400 mg by Eclectic Institute Capsule 45 Capsule(s) Off market View ingredients & interactions Mighty Lungs by Gaia Herbs Capsule 60 Vegan Liquid Phyto-Cap(s)(R) Off market View ingredients & interactions
Pharmacist Counseling Corner

Gumweed: Common Questions

Does Gumweed interact with prescription medications?
We do not currently list any known drug interactions for Gumweed. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Gumweed interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Gumweed with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Gumweed interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Gumweed used for?
It is used most often as a traditional remedy for coughs and chest congestion, and it is applied to the skin to soothe rashes such as those from poison ivy or poison oak. Strong human evidence for these uses is lacking.
Is Gumweed safe to take?
In small, traditional amounts it is generally well tolerated, but human safety data are limited. People allergic to ragweed and related daisy-family plants should be cautious, and it is best used only short term.
Can I use Gumweed if I'm pregnant or breastfeeding?
No reliable safety information is available, so Gumweed should be avoided during pregnancy and breastfeeding. Talk to your doctor or pharmacist before using any herbal product during these times.
How is Gumweed taken?
It is commonly taken as a tea, tincture, or liquid extract, or applied to the skin in topical products. Because there is no standardized dose, follow the product label and ask a pharmacist if you are unsure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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