Mercury Herb Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Mercury Herb interacts with medications. The heart of this page is the interaction list — every drug Mercury Herb is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Mercury Herb is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Mercury Herb against your medication
Add one medicationDrugs that interact with Mercury Herb
0 medications have a known interaction with Mercury Herb, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Mercury Herb. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Mercury Herb combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Mercury Herb: Uses, Safety & Side Effects
Mercury Herb (Mercurialis annua) is a traditional European plant once used as a mild laxative and topical remedy, but it has very little modern scientific support and is considered potentially toxic. Because the plant can cause serious poisoning when misused, most herbal experts no longer recommend it, and you should talk to a pharmacist or doctor before considering it.
- Scientific name
- Mercurialis annua
- Family
- Euphorbiaceae
- Part used
- Leaves and aerial (above-ground) parts
- Common forms
- Dried herb, tea/infusion, poultice, traditional topical preparations
- Constipation
- Mild skin irritation
- Swelling or inflammation (topical)
- Traditional folk remedy
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
The plant is considered potentially toxic and has poorly defined safe doses.
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Mercury Herb usually refers to Mercurialis annua, also called annual mercury, a small flowering weed in the spurge family (Euphorbiaceae). Despite its name, it is a plant and is not related to the metal mercury.
It grows widely across Europe, the Mediterranean region, and parts of Asia, often in gardens, fields, and waste areas. In old herbal traditions, the leaves and above-ground parts were used as a gentle laxative and were sometimes applied to the skin.
Today, the plant is rarely used and is far better known as a garden weed than as a remedy. Modern herbalists generally treat it with caution because the plant has a reputation for being toxic.
Uses & effectiveness
Historically, Mercury Herb was used as a mild laxative for constipation and as a topical preparation for skin irritation, swelling, and minor wounds. These uses come from traditional folk medicine, not from solid scientific testing.
There is very little modern research on Mercury Herb in humans. There are no high-quality clinical trials that show it works for any condition, and the evidence that exists is mostly historical or based on its known chemistry. Because of this, we cannot say it is effective or safe for any health problem.
Given the lack of evidence and the potential for toxicity, the overall picture is that the risks likely outweigh any unproven benefits.
How it works
Plants in the spurge family, including Mercurialis, can contain irritating and potentially toxic compounds. The mild laxative effect attributed to Mercury Herb may come from substances that irritate the gut lining and increase bowel movement.
The plant has also been reported to contain compounds such as volatile oils, alkaloid-like substances, and saponins, along with components that can be irritating to tissues. Some of these substances may explain both its traditional uses and its toxicity.
It is important to understand that these proposed mechanisms are based on old reports and laboratory observations, not on well-designed human studies. The exact way it affects the body is not clearly established.
Safety & precautions
Mercury Herb is considered potentially toxic. Historical and toxicology reports describe cases of poisoning, particularly when larger amounts were eaten. For this reason, most experts advise against using it as a remedy.
People who are older, have kidney or liver problems, or have digestive conditions should be especially careful and should not use it. Children should never be given this plant.
Pregnancy and breastfeeding: Avoid Mercury Herb completely if you are pregnant or breastfeeding. There is no reliable safety information, and a laxative-acting, potentially toxic plant could be harmful to you or your baby.
Because safe amounts are not defined and the plant can cause harm, talk with a pharmacist or doctor before using any product containing Mercury Herb. If you suspect poisoning, contact a poison control center or seek emergency care.
Side effects
Reported and expected side effects include stomach cramps, nausea, vomiting, and diarrhea, which fit with its irritant and laxative properties. Topical use may cause skin irritation in some people.
More serious effects have been linked to eating larger amounts of the plant, and may include severe gastrointestinal upset and signs of poisoning. Because of these risks, any unusual or severe symptoms after using Mercury Herb should be taken seriously and checked by a medical professional.
Mercury Herb: Reported Adverse Effects
Documented safety reports on Mercury Herb from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, mercury herb might cause diarrhea and overactive bladder. Symptoms of poisoning might include nerve paralysis, liver and kidney failure, and death. The pollen has shown to be allergenic, and may be responsible for rhinitis and asthmatic symptoms. Mercury herb might also cause allergic reactions in individuals allergic to ash, castor bean plant, mugwort, olive, pellitory-of-the-wall, and Salsola kali.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Vallverdu A, Garcia-Ortega P, Martinez J, et al. Mercurialis annua: characterization of main allergens and cross- reactivity with other species. Int Arch Allergy Immunol 1997;112:356-64.
- Garcia-Ortega P, Martinez J, Martinez A, et al. Mercurialis annua pollen: a new source of allergic sensitization and respiratory disease. J Allergy Clin Immunol 1992;89:987-93.
Diarrhea Gastrointestinal
Orally, mercury herb might cause diarrhea.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Overactive bladder Genitourinary
Orally, mercury herb might cause overactive bladder.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Poisoning Hepatic
Orally, mercury herb poisoning might cause liver failure.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Poisoning Neurologic/CNS
Orally, mercury herb poisoning might cause nerve paralysis.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Poisoning Renal
Orally, mercury herb poisoning might cause kidney failure.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no established or standardized safe dose for Mercury Herb. Because of its toxicity concerns and the lack of modern research, no reliable amount can be recommended.
We do not provide specific dosing for this plant. If you are considering any product that contains Mercury Herb, follow the product label exactly and, more importantly, check first with a pharmacist or doctor. In most cases, safer and better-studied options are available for constipation and skin concerns.
Mercury Herb & Pregnancy
Mercury Herb & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 3 references that drive our Mercury Herb monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Vallverdu A, Garcia-Ortega P, Martinez J, et al. Mercurialis annua: characterization of main allergens and cross- reactivity with other species. Int Arch Allergy Immunol 1997;112:356-64. PubMed
- Garcia-Ortega P, Martinez J, Martinez A, et al. Mercurialis annua pollen: a new source of allergic sensitization and respiratory disease. J Allergy Clin Immunol 1992;89:987-93.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Mercury Herb: Common Questions
Does Mercury Herb interact with prescription medications?
How are Mercury Herb interactions rated?
Is it safe to take Mercury Herb with my medications?
Where does this Mercury Herb interaction information come from?
Is Mercury Herb the same as the metal mercury?
What was Mercury Herb traditionally used for?
Is Mercury Herb safe to take?
Can I use Mercury Herb during pregnancy or breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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