Beta-sitosterol + Bupropion, Naltrexone
Bupropion, Naltrexone brand name: Contrave.
We found no known interaction between Beta-sitosterol and Bupropion, Naltrexone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Bupropion, Naltrexone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Beta-sitosterol and Bupropion, Naltrexone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Bupropion, Naltrexone and Beta-sitosterol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Beta-sitosterol at all — not against Bupropion, Naltrexone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Beta-sitosterol safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Bupropion, Naltrexone Products Have a Food Rule — Beta-sitosterol Should Not Break It
At least one FDA label for a product containing Bupropion, Naltrexone says to take it with food. If you take Beta-sitosterol on an empty stomach out of habit, keep them separate — and take Bupropion, Naltrexone with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Bupropion, Naltrexone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
In clinical trials, CONTRAVE was administered with meals.
From the Dosage and Administration section of the FDA label we read for Bupropion, Naltrexone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Bupropion, Naltrexone Is Prescribed For, and What Beta-sitosterol Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Bupropion, Naltrexone is a prescription medicine with approved uses on its FDA label. Beta-sitosterol is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Bupropion, Naltrexone is prescribed for: Contrave (naltrexone/bupropion extended-release tablets) is approved to help adults with obesity, or adults who are overweight and have at least one weight-related health condition, lose excess weight and keep it off long term. It is always used together with a reduced-calorie diet and increased physical activity — not as a stand-alone treatment. Contrave is not approved to treat depression, anxiety, or any other psychiatric condition, and it is not approved for use in anyone under 18 years of age.
Beta-sitosterol has been studied for:
-
Obesity studied, not established Beta-sitosterol has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Beta-sitosterol for obesity
It is unclear if oral beta-sitosterol is beneficial for obesity.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Bupropion, Naltrexone on your own; if you are taking Beta-sitosterol for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Bupropion, Naltrexone
This page covers Beta-sitosterol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bupropion, Naltrexone page lists 47 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), African Wild Potato (moderate), Artichoke (moderate) and Astaxanthin (moderate).
By severity: 1 major · 34 moderate · 12 minor.
From our pharmacist’s overview on the Bupropion, Naltrexone page
“Anyone taking Contrave (bupropion with naltrexone) for weight management should treat this list with genuine care, starting with the single major-rated entry, activated charcoal, which can soak up the medication in the gut and sharply blunt its effect. Beyond that, two themes dominate.”
Reviewed by 2 · Jul 18, 2026
Taking Beta-sitosterol as Part of a Dietary Supplement Product? Check It for Interactions
We hold 7 real supplement products containing Beta-sitosterol, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Beta-sitosterol. Even though Beta-sitosterol itself has no known interaction with Bupropion, Naltrexone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Beta-sitosterol and Bupropion, Naltrexone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#305 of 1,452 supplements looked up here in the last 7 days
#650 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Beta-sitosterol reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Beta-sitosterol and Bupropion, Naltrexone records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Beta-sitosterol
What is Beta-sitosterol?
- High cholesterol
- Enlarged prostate (BPH)
- Heart health
- Immune support
- Hair loss
Beta-sitosterol is a plant sterol that may modestly lower LDL ('bad') cholesterol and may help ease urinary symptoms from an enlarged prostate. Evidence is moderate for these uses and weaker for others, and it is generally well tolerated, but you should talk with your pharmacist or doctor before starting it.
Plant sterol found in seeds, nuts, vegetable oils, and many plants · Capsules, tablets, softgels, and fortified foods
An interaction check asks whether these two react with each other — it does not ask whether Beta-sitosterol is a good idea for someone in your situation. Here is what our Beta-sitosterol record says about it on its own.
Beta-sitosterol: dosing
There is no single official dose of beta-sitosterol for all uses. The amount used in studies varies depending on the condition being studied, and product strengths differ between brands.The best approach is to follow the directions on the product label and not take more than recommended.
From our Beta-sitosterol monograph — the full record covers uses, side effects and every documented interaction.
About Naltrexone and Bupropion
What Is Naltrexone and Bupropion Used For?
Brand name: Contrave
Contrave (naltrexone and bupropion) is used with a reduced-calorie diet and more physical activity. It helps adults lose excess body weight and maintain that weight loss long term.
It is for adults with obesity, or with overweight plus at least one weight-related condition. Its effect on heart disease and death from heart problems has not been established.
Other Drugs & Beta-sitosterol
Browse every other medication we’ve checked against Beta-sitosterol — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Beta-sitosterol against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Sertraline ›
- Losartan Potassium ›
- Acetaminophen ›
- Aspirin ›
- Rosuvastatin ›
- Escitalopram ›
- Metoprolol ›
- Clopidogrel ›
- Rivaroxaban ›
- Atorvastatin ›
- Isotretinoin ›
- Warfarin Sodium ›
- Tirzepatide ›
- Amlodipine Besylate ›
- Ibuprofen ›
- Methamphetamine ›
- Docusate ›
- Tadalafil ›
- Hydroxyurea ›
- Valacyclovir ›
- Metformin ›
- Sumatriptan ›
- Prednisone ›
- Semaglutide ›
- Amitriptyline ›
- Lisdexamfetamine ›
- Amphetamine ›
- Levothyroxine, Liothyronine ›
- Propranolol ›
- Methotrexate ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Bendamustine ›
- Pregabalin ›
- Doxycycline ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Acyclovir ›
- Naproxen ›
- Acetaminophen, Aspirin, Caffeine ›
- Quetiapine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Duloxetine ›
- Letrozole ›
- Citalopram ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Beta-sitosterol list.
Beta-sitosterol References
The 7 references that drive our Beta-sitosterol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 1995;345:1529-32.
- Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427-32.
- Wilt TJ, MacDonald R, Ishani A. beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int 1999;83:976-83. PubMed
- Oster P, Schlierf G, Heuck CC, et al. [Sitosterol in familial hyperlipoproteinemia type II. A randomized, double-blind, cross-over study]. Dtsch Med Wochenschr 1976;101:1308-11.
- Becker M, Staab D, Von Bergman K. Long-term treatment of severe familial hypercholesterolemia in children: effect of sitosterol and bezafibrate. Pediatrics 1992;89:138-42. DOI
- Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
- Lorenze A, Hsueh W, Nasr J. Beta-sitosterol-induced acute pancreatitis: A case report and review of the literature. Cureus. 2020;12(3):e7407. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Bupropion, Naltrexone Is Linked to Lower Levels of One Nutrient
Natural Medicines records Bupropion, Naltrexone as a medicine that can lower these. This is not an interaction with Beta-sitosterol — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Bupropion, Naltrexone nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Beta-sitosterol and Bupropion, Naltrexone Together: Common Questions
Is it safe to take Beta-sitosterol with Bupropion, Naltrexone?
Do Beta-sitosterol and Bupropion, Naltrexone have any of the same side effects?
Should I take Beta-sitosterol and Bupropion, Naltrexone at the same time of day?
Are Beta-sitosterol and Bupropion, Naltrexone used for the same thing?
Does Bupropion, Naltrexone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.