Drug & supplement interaction

Lunasin + Bupropion, Naltrexone

Bupropion, Naltrexone brand name: Contrave.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Lunasin and Bupropion, Naltrexone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Bupropion, Naltrexone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Lunasin and Bupropion, Naltrexone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Bupropion, Naltrexone and Lunasin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Lunasin at all — not against Bupropion, Naltrexone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lunasin safety at a glance

Lunasin overall Not established Lunasin is found in common foods, but the safety of concentrated supplements has not been well studied.
Pregnancy Avoid There is not enough safety data, so concentrated supplements should be avoided during pregnancy.
Breastfeeding Avoid There is not enough safety data, so concentrated supplements should be avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Bupropion, Naltrexone and Lunasin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Lunasin and Bupropion, Naltrexone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Bloating or gas / Constipation / Stomach pain / Diarrhea / Nausea Additional detail

    Lunasin

    “There is currently a limited amount of information on the adverse effects of lunasin. Orally, adverse effects reported in clinical research include nausea, constipation (including obstipation), diarrhea, early satiety, decreased appetite, bloating, abdominal pain, and flatulence.”

    Lunasin · Natural Medicines adverse-effect record, reported in constipation.

    2 sources cited
    1. 104526. Bedlack RS, Wicks P, Vaughan T, et al. Lunasin does not slow ALS progression: results of an open-label, single-center, hybrid-virtual 12-month trial. Amyotroph Lateral Scler Frontotemporal Degener. 2019 May;20(3-4):285-293. PubMed
    2. 104527. Haddad Tabrizi S, Haddad E, Rajaram S, Oda K, Kaur A, Sabaté J. The effect of soybean lunasin on cardiometabolic risk factors: A randomized clinical trial. Subst Use Misuse. 2019;54(9):1530-1540. PubMed

    “Orally, lunasin can cause nausea, constipation, diarrhea, early satiety, decreased appetite, bloating, abdominal pain, and flatulence. Two cases of obstipation requiring hospitalization have been reported following administration of lunasin.”

    Lunasin · Natural Medicines adverse-effect record, reported in constipation.

    2 sources cited
    1. 104526. Bedlack RS, Wicks P, Vaughan T, et al. Lunasin does not slow ALS progression: results of an open-label, single-center, hybrid-virtual 12-month trial. Amyotroph Lateral Scler Frontotemporal Degener. 2019 May;20(3-4):285-293. PubMed
    2. 104527. Haddad Tabrizi S, Haddad E, Rajaram S, Oda K, Kaur A, Sabaté J. The effect of soybean lunasin on cardiometabolic risk factors: A randomized clinical trial. Subst Use Misuse. 2019;54(9):1530-1540. PubMed

    Bupropion, Naltrexone

    Listed in the ADVERSE REACTIONS section of the FDA label for Bupropion, Naltrexone. Read the label on DailyMed ›

Reported for Lunasin but not commonly for Bupropion, Naltrexone: reduced appetite.

Effects for Bupropion, Naltrexone come from the ADVERSE REACTIONS section of its FDA label; effects for Lunasin come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Bupropion, Naltrexone Products Have a Food Rule — Lunasin Should Not Break It

At least one FDA label for a product containing Bupropion, Naltrexone says to take it with food. If you take Lunasin on an empty stomach out of habit, keep them separate — and take Bupropion, Naltrexone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Bupropion, Naltrexone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

In clinical trials, CONTRAVE was administered with meals.

From the Dosage and Administration section of the FDA label we read for Bupropion, Naltrexone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Bupropion, Naltrexone Is Prescribed For, and What Lunasin Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Bupropion, Naltrexone is a prescription medicine with approved uses on its FDA label. Lunasin is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Bupropion, Naltrexone is prescribed for: Contrave (naltrexone and bupropion) is used with a reduced-calorie diet and more physical activity. It helps adults lose excess body weight and maintain that weight loss long term. It is for adults with obesity, or with overweight plus at least one weight-related condition. Its effect on heart disease and death from heart problems has not been established.

Lunasin has been studied for:

  • Obesity studied, not established Lunasin has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Lunasin for obesity

    Preliminary clinical research in adults with multiple cardiometabolic risk factors (e.g., low levels of high-density lipoprotein [HDL] or elevated low-density lipoprotein [LDL], triglycerides, fasting blood glucose, blood pressure, or body mass index [BMI]) suggests that taking 168 mg of lunasin-enriched soy extract twice daily for 8 weeks does not affect BMI, waist circumference, or fasting blood glucose when compar…

    1 source cited
    1. 104527. Haddad Tabrizi S, Haddad E, Rajaram S, Oda K, Kaur A, Sabaté J. The effect of soybean lunasin on cardiometabolic risk factors: A randomized clinical trial. Subst Use Misuse. 2019;54(9):1530-1540. PubMed

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Bupropion, Naltrexone on your own; if you are taking Lunasin for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Bupropion, Naltrexone

This page covers Lunasin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bupropion, Naltrexone page lists 47 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), African Wild Potato (moderate), Artichoke (moderate) and Astaxanthin (moderate).

By severity: 1 major · 34 moderate · 12 minor.

From our pharmacist’s overview on the Bupropion, Naltrexone page

“Anyone taking Contrave (bupropion with naltrexone) for weight management should treat this list with genuine care, starting with the single major-rated entry, activated charcoal, which can soak up the medication in the gut and sharply blunt its effect. Beyond that, two themes dominate.”

Reviewed by 2 · Jul 18, 2026

Open the Bupropion, Naltrexone interaction page

How much people look this up

Where Lunasin and Bupropion, Naltrexone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lunasin
Steady interest

#1,377 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bupropion, Naltrexone
Top 25%

#650 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lunasin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Lunasin and Bupropion, Naltrexone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lunasin

What is Lunasin?

  • Cholesterol and heart health
  • General immune support
  • Antioxidant support
  • Anti-inflammatory support
  • Cancer-prevention interest (unproven)

Lunasin is a small protein (peptide) found naturally in soybeans and some other seeds and grains. Laboratory and animal studies suggest it may have antioxidant, anti-inflammatory, and cholesterol-related effects, but solid human evidence is very limited. Talk with your pharmacist or doctor before using a lunasin supplement.

Seeds (most studied in soybean) · Capsules, powders, and protein extracts (often soy-derived)

An interaction check asks whether these two react with each other — it does not ask whether Lunasin is a good idea for someone in your situation. Here is what our Lunasin record says about it on its own.

Lunasin: dosing

There is no established standard dose for lunasin supplements. The amounts used in research vary, and product labels differ from brand to brand.If you choose to try a product, follow the directions on the label and do not exceed them. Because quality and purity of supplements can vary, look for brands that use independent third-party testing.

From our Lunasin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lunasin monograph & all interactions
Medication

About Naltrexone and Bupropion

What Is Naltrexone and Bupropion Used For?

Brand name: Contrave

Contrave (naltrexone and bupropion) is used with a reduced-calorie diet and more physical activity. It helps adults lose excess body weight and maintain that weight loss long term.

It is for adults with obesity, or with overweight plus at least one weight-related condition. Its effect on heart disease and death from heart problems has not been established.

See full Naltrexone and Bupropion drug information
Keep checking

Other Drugs & Lunasin

Browse every other medication we’ve checked against Lunasin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Lunasin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Lunasin list.

See the full Lunasin interactions page
See every supplement checked against Bupropion, Naltrexone, ranked by severity
Evidence & sources

Lunasin References

The 2 references that drive our Lunasin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Bedlack RS, Wicks P, Vaughan T, et al. Lunasin does not slow ALS progression: results of an open-label, single-center, hybrid-virtual 12-month trial. Amyotroph Lateral Scler Frontotemporal Degener. 2019 May;20(3-4):285-293. PubMed
  2. Haddad Tabrizi S, Haddad E, Rajaram S, Oda K, Kaur A, Sabaté J. The effect of soybean lunasin on cardiometabolic risk factors: A randomized clinical trial. Subst Use Misuse. 2019;54(9):1530-1540. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lunasin and Bupropion, Naltrexone Together: Common Questions

Is it safe to take Lunasin with Bupropion, Naltrexone?
We do not list a known interaction between Lunasin and Bupropion, Naltrexone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Lunasin and Bupropion, Naltrexone have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Lunasin and Bupropion, Naltrexone at the same time of day?
At least one FDA label for a product containing Bupropion, Naltrexone says to take it with food. If you take Lunasin on an empty stomach out of habit, keep them separate and take Bupropion, Naltrexone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Bupropion, Naltrexone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Lunasin and Bupropion, Naltrexone used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Lunasin in each. That is a conversation for your prescriber, especially if Bupropion, Naltrexone is being adjusted to a target.
Does Bupropion, Naltrexone interact with any supplements?
Yes. Bupropion, Naltrexone has documented interactions with 47 supplements in our database — Lunasin is not one of them. The Bupropion, Naltrexone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lunasin monograph Uses, safety profile, and every drug interaction in one place Naltrexone and Bupropion drug information The full plain-English guide to this medication Bupropion, Naltrexone supplement interactions Every supplement checked against Bupropion, Naltrexone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Bupropion, Naltrexone and Lunasin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.