Drug & supplement interaction

Chuchuhuasi + Bupropion, Naltrexone

Bupropion, Naltrexone brand name: Contrave.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Chuchuhuasi and Bupropion, Naltrexone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Bupropion, Naltrexone states a food rule worth keeping to.

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Interaction report

Chuchuhuasi and Bupropion, Naltrexone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Bupropion, Naltrexone and Chuchuhuasi in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Chuchuhuasi at all — not against Bupropion, Naltrexone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chuchuhuasi safety at a glance

Chuchuhuasi overall Use caution It has a long history of traditional use but very little modern safety or quality testing, so use cautiously.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid it to be safe.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Bupropion, Naltrexone and Chuchuhuasi? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Bupropion, Naltrexone’s Own FDA Label Lists

This is not an interaction — none of it involves Chuchuhuasi. These are the most notable effects listed in the ADVERSE REACTIONS section of Bupropion, Naltrexone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Memory problems Worth acting on
  • Dehydration Worth acting on
  • Unsteadiness Worth acting on
  • A heart attack Worth acting on
  • Fainting Worth acting on
  • A severe skin reaction Worth acting on
  • Seizures Worth acting on
  • Low mood Worth acting on
  • Kidney problems Worth acting on
  • Anemia Worth acting on

Showing the 10 most notable of 41 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Bupropion, Naltrexone. Read the label on DailyMed › Chuchuhuasi’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Chuchuhuasi side to compare — that is a limit of the record, not a statement that Chuchuhuasi has no side effects.

How to take them

Some Bupropion, Naltrexone Products Have a Food Rule — Chuchuhuasi Should Not Break It

At least one FDA label for a product containing Bupropion, Naltrexone says to take it with food. If you take Chuchuhuasi on an empty stomach out of habit, keep them separate — and take Bupropion, Naltrexone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Bupropion, Naltrexone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

In clinical trials, CONTRAVE was administered with meals.

From the Dosage and Administration section of the FDA label we read for Bupropion, Naltrexone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Bupropion, Naltrexone

This page covers Chuchuhuasi only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bupropion, Naltrexone page lists 47 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), African Wild Potato (moderate), Artichoke (moderate) and Astaxanthin (moderate).

By severity: 1 major · 34 moderate · 12 minor.

From our pharmacist’s overview on the Bupropion, Naltrexone page

“Anyone taking Contrave (bupropion with naltrexone) for weight management should treat this list with genuine care, starting with the single major-rated entry, activated charcoal, which can soak up the medication in the gut and sharply blunt its effect. Beyond that, two themes dominate.”

Reviewed by 2 · Jul 18, 2026

Open the Bupropion, Naltrexone interaction page

One more smart check

Taking Chuchuhuasi as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Chuchuhuasi, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chuchuhuasi. Even though Chuchuhuasi itself has no known interaction with Bupropion, Naltrexone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chuchuhuasi and Bupropion, Naltrexone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chuchuhuasi
Steady interest

#787 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bupropion, Naltrexone
Top half

#1,356 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Chuchuhuasi is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chuchuhuasi reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Chuchuhuasi and Bupropion, Naltrexone records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chuchuhuasi

What is Chuchuhuasi?

  • Arthritis and joint pain
  • Back pain and muscle aches
  • Inflammation
  • Menstrual cramps
  • General tonic and energy
  • Digestive complaints

Chuchuhuasi is an Amazonian tree bark traditionally used for joint pain, inflammation, and as a general tonic. Solid human studies are lacking, so its benefits remain unproven, and you should talk to your pharmacist or doctor before trying it—especially if you are pregnant, breastfeeding, or taking other medicines.

Maytenus krukovii · Celastraceae · Bark (mainly the inner bark) and roots · Tinctures, capsules, dried bark for tea/decoction, liquid extracts, and bark soaked in aguardiente (local rum)

An interaction check asks whether these two react with each other — it does not ask whether Chuchuhuasi is a good idea for someone in your situation. Here is what our Chuchuhuasi record says about it on its own.

Chuchuhuasi: dosing

There is no established or standardized dose for chuchuhuasi. Because human studies are lacking, no one has determined a safe and effective amount.If you choose to try it, the safest approach is to follow the directions on the product label and not exceed them. Choose products from reputable companies that test for quality and purity.

From our Chuchuhuasi monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chuchuhuasi monograph & all interactions
Medication

About Naltrexone and Bupropion

What Is Naltrexone and Bupropion Used For?

Brand name: Contrave

Contrave (naltrexone/bupropion extended-release tablets) is approved to help adults with obesity, or adults who are overweight and have at least one weight-related health condition, lose excess weight and keep it off long term. It is always used together with a reduced-calorie diet and increased physical activity — not as a stand-alone treatment.

Contrave is not approved to treat depression, anxiety, or any other psychiatric condition, and it is not approved for use in anyone under 18 years of age.

See full Naltrexone and Bupropion drug information
Keep checking

Other Drugs & Chuchuhuasi

Browse every other medication we’ve checked against Chuchuhuasi — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Chuchuhuasi against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Chuchuhuasi list.

See the full Chuchuhuasi interactions page
See every supplement checked against Bupropion, Naltrexone, ranked by severity
Evidence & sources

Chuchuhuasi References

The 3 sources that drive our Chuchuhuasi monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Chuchuhuasi is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH National Center for Complementary and Integrative Health (NCCIH) Source
  2. Herbs and Supplements — MedlinePlus (U.S. National Library of Medicine) Source
  3. About Herbs, Botanicals & Other Products — Memorial Sloan Kettering Cancer Center Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chuchuhuasi and Bupropion, Naltrexone Together: Common Questions

Is it safe to take Chuchuhuasi with Bupropion, Naltrexone?
We do not list a known interaction between Chuchuhuasi and Bupropion, Naltrexone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Chuchuhuasi and Bupropion, Naltrexone at the same time of day?
At least one FDA label for a product containing Bupropion, Naltrexone says to take it with food. If you take Chuchuhuasi on an empty stomach out of habit, keep them separate and take Bupropion, Naltrexone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Bupropion, Naltrexone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Bupropion, Naltrexone interact with any supplements?
Yes. Bupropion, Naltrexone has documented interactions with 47 supplements in our database — Chuchuhuasi is not one of them. The Bupropion, Naltrexone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chuchuhuasi monograph Uses, safety profile, and every drug interaction in one place Naltrexone and Bupropion drug information The full plain-English guide to this medication Bupropion, Naltrexone supplement interactions Every supplement checked against Bupropion, Naltrexone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Bupropion, Naltrexone and Chuchuhuasi?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.