Herb & supplement monograph

Rye Grass Drug Interactions, Uses, Effectiveness, Safety & More

Check Rye Grass against your medication

Add one medication
Rye Grass
+
Start typing any prescription or over-the-counter drug name.
Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Rye Grass

0 medications have a known interaction with Rye Grass, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Rye Grass. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Rye Grass combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Rye Grass: Uses, Safety & Side Effects

The bottom line

Rye grass pollen extract is most often used as a supplement for prostate-related urinary symptoms, where some small studies suggest a possible benefit, but the overall evidence is limited and not conclusive. It is generally well tolerated, but it is not a proven treatment, and you should talk to your doctor or pharmacist before using it, especially if you have prostate or urinary problems.

Scientific name
Secale cereale
Family
Poaceae
Part used
Pollen extract, grass (leaves), and seeds/grain
Common forms
Tablets, capsules, pollen extracts, and dried grass powders
People commonly use it for
  • Prostate symptoms (BPH)
  • Chronic prostatitis
  • Urinary symptoms
  • General wellness/nutrition
  • Allergy desensitization (research only)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated in studies, but long-term safety is not well established.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using rye grass pollen extract.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using rye grass pollen extract.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Rye grass comes from the cereal rye plant (Secale cereale), a grass grown widely around the world as a grain crop and cover crop. The supplement most people mean by "rye grass" is a pollen extract made from rye and sometimes other grasses, which has been studied mainly for prostate health.

Rye grass pollen extracts are sold as tablets and capsules, often under branded names. The young grass and grain are also used in some general nutrition or "green" supplement products. People most commonly take rye grass pollen extract hoping to ease urinary symptoms linked to an enlarged prostate.

How it works

The exact way rye grass pollen extract might help is not fully understood. Laboratory studies suggest it may have anti-inflammatory effects and may relax smooth muscle in the bladder and prostate area, which could in theory ease urinary symptoms.

Researchers have also suggested it may affect prostate cell growth and reduce swelling. It is important to know that much of this information comes from laboratory and animal studies, and these proposed mechanisms have not been clearly confirmed in humans.

Effectiveness

Does Rye Grass work?

Evidence overview · 3 uses evaluated
2 Possibly effective 1 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Benign prostatic hyperplasia (BPH)
Rating & evidence shown verbatim from Natural Medicines

Taking rye grass pollen extract orally seems to improve symptoms such as frequency, nocturia, urgency, flow rate, dribbling, and pain in patients with mild to moderate BPH.

Possibly Effective Chronic Prostatitis and chronic pelvic pain syndrome (CP/CPPS)
Rating & evidence shown verbatim from Natural Medicines

Some research shows that taking rye grass pollen extract might relieve some symptoms of CP/CPPS.

Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Constipation
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral rye grass is beneficial in patients with constipation.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Rye grass pollen extract has generally been well tolerated in the studies done so far, with mostly mild side effects. However, long-term safety has not been carefully studied, and supplement quality can vary from product to product.

People with grass or pollen allergies should be cautious, since pollen-based products could trigger an allergic reaction. Men with urinary symptoms should not assume rye grass is treating the underlying cause; symptoms of an enlarged prostate can overlap with more serious conditions, so it is important to get a proper evaluation from a doctor.

Because there is not enough safety information, rye grass should be avoided during pregnancy and breastfeeding. Always check with your pharmacist or doctor before starting any new supplement, especially if you have an existing health condition.

Side effects

When side effects occur, they are usually mild and may include stomach upset, nausea, or mild digestive discomfort. Some people may notice headache or other minor effects.

Rare but more serious reactions could include allergic reactions, especially in people sensitive to grass or pollen. Stop taking the product and seek medical care if you have signs of a serious allergic reaction such as rash, swelling, trouble breathing, or dizziness.

Rye Grass: Reported Adverse Effects

Documented safety reports on Rye Grass from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, rye grass and rye grass pollen are well tolerated.

Most Common Adverse Effects:

Orally: Abdominal distention, heartburn, nausea.

Reports by condition
Dyspepsia Gastrointestinal
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official or standardized dose for rye grass pollen extract. The amount used varies between different products and study formulas, so a single recommended dose cannot be given reliably.

The best approach is to follow the directions on the product label and to talk with your pharmacist or doctor before starting. They can help you decide whether it is appropriate for you and review it alongside your other medicines and conditions.

Pregnancy & Breastfeeding

Rye Grass & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using rye grass pollen extract.

Rye Grass & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using rye grass pollen extract.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 references that drive our Rye Grass monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Rugendorff EW, Weidner W, Ebeling L, Buck AC. Results of treatment with pollen extract (Cernilton N) in chronic prostatitis and prostatodynia. Br J Urol 1993;71:433-8.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Rye Grass: Common Questions

What is Rye Grass used for, and does it work?
People use Rye Grass for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Rye Grass for Benign prostatic hyperplasia (BPH) and Chronic Prostatitis and chronic pelvic pain syndrome (CP/CPPS). For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Rye Grass interact with prescription medications?
We do not currently list any known drug interactions for Rye Grass. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Rye Grass interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Rye Grass with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Rye Grass interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Rye Grass used for?
It is most often used as a supplement for urinary symptoms related to an enlarged prostate (BPH) and for chronic prostatitis, though the evidence for these uses is limited and not conclusive.
Does Rye Grass pollen extract actually work for prostate problems?
Some small studies suggest it may modestly improve urinary symptoms, but the research is limited and it is not a proven treatment. See your doctor for proper evaluation of any prostate or urinary symptoms.
Is Rye Grass safe to take?
It has generally been well tolerated in studies, but long-term safety is not well established. People with grass or pollen allergies should be cautious, and you should check with your pharmacist or doctor first.
Can I take Rye Grass during pregnancy or while breastfeeding?
There is not enough safety information, so it is best to avoid Rye Grass supplements during pregnancy and breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Have a question about Rye Grass?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist