Andro-Plexx Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Andro-Plexx against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Andro-Plexx is a dietary supplement by Soto Supplements with 4 active ingredients. Its ingredients are commonly taken for lowering estrogen levels, post-cycle therapy after steroid or prohormone use, reducing gynecomastia ('gyno').Based on those ingredients, 4 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Androsta-3,5-Diene-7,17-Dione. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Andro-Plexx by Soto Supplements
Ask about any prescription or over-the-counter medication and we check it for interactions with Andro-Plexx by Soto Supplements — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Andro-Plexx by Soto Supplements
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Andro-Plexx is a liquid supplement with 4 active ingredients, all of which are prohormones or hormone-related compounds meant to support muscle and athletic function. The main one we have data on is Arimistane, which works by inhibiting an enzyme (aromatase) involved in estrogen production.
The other three active ingredients — 17 beta-[1-ketoethyl]-androstane-3-one,17a-ol, 6-Ketoprogesterone, and 17beta-[1-ketoethyl]-androsta-1,4-diene-3-one,17a-ol — are also hormone precursors, though we don't hold detailed information on them. The product also contains several inactive ingredients including water, glycerol, citric acid, sodium benzoate, and sucralose as a sweetener.
Does it work?
Insufficient evidence
The evidence we hold doesn't establish that Arimistane works for any of the purposes this product is marketed for — athletic performance, muscle strength, erectile dysfunction, sexual arousal, or weight loss. All five effectiveness ratings are marked as insufficient reliable evidence to rate.
That means the research to prove it works simply isn't in our data. It's a gap worth knowing about before you buy.
How safe is it?
Some data gaps
Arimistane carries significant safety concerns. It's a hormone-altering compound with very little safety data, and regulatory authorities warn against aromatase inhibitor supplements.
The product should be avoided during pregnancy — lowering estrogen at that time could be harmful — and there's no safety data to support use while breastfeeding either. For the other three active ingredients, safety data isn't on file with us, so we can't speak to their side-effect profile.
No adverse effects are documented in the trial data we hold for Arimistane, but the absence of reported side effects doesn't mean none occur — it reflects limited study of the ingredient.
Meds to double-check
Moderate interaction found
Anyone taking aromatase inhibitors — usually prescribed for hormone-sensitive breast cancer — should not use Andro-Plexx without checking with their oncologist first. The Moderate interaction could increase the risk of low estrogen side effects and liver problems.
Because we can't check three of the four active ingredients, mention this product to your pharmacist before you start it if you take any prescription medication.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.
This is a prohormone supplement meant for muscle and athletic support, but the evidence doesn't show it works for those goals. More importantly, it contains ingredients regulators warn against, carries pregnancy and breastfeeding safety concerns, and three of its four actives haven't been fully checked for interactions.
If you're on any hormone-related medication or pregnant or breastfeeding, talk with your pharmacist or doctor before considering this one.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Andro-Plexx, straight from the product label.
| Brand | Soto Supplements |
|---|---|
| Net contents | 4 fl. Oz.; 120 mL |
| Market status | On market |
| Date entered into DSLD | Oct 23, 2020 |
| DSLD ID | 233470 |
| Product type | Other Combinations |
| Supplement form | Liquid |
| Dietary claims / uses | Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Andro-Plexx by Soto Supplements, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| 17 beta-[1-ketoethyl]-androstane-3-one,17a-ol | 0 NP | -- |
| Andro-Plexx Proprietary Blend | 150 mg | -- |
| 6-Ketoprogesterone | 0 NP | -- |
| Androsta-3,5-Diene-7,17-Dione | 0 NP | -- |
| 17beta-[1-ketoethyl]-androsta-1,4-diene-3-one,17a-ol | 0 NP | -- |
Other ingredients: Water, Glycerol, HPBCD, Citric Acid, Sodium Benzoate, Ca EDTA, Natural and Artificial flavors, Sucralose, Glycyrrhizic Acid
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Platinum label
Quadstack
Formulation
Boosts anabolic performance Promotes recovery Promotes muscle and strength gains
60 servings
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Andro-Plexx by Soto Supplements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Andro-Plexx by Soto Supplements
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Andro-Plexx Proprietary Blend
- › 17 beta-[1-ketoethyl]-androstane-3-one,17a-ol
- › 6-Ketoprogesterone
- › Androsta-3,5-Diene-7,17-Dione
- › 17beta-[1-ketoethyl]-androsta-1,4-diene-3-one,17a-ol
Other (inactive) ingredients: Water, Glycerol, HPBCD, Citric Acid, Sodium Benzoate, Ca EDTA, Natural and Artificial flavors, Sucralose, Glycyrrhizic Acid. These complete the product’s ingredient list but are not active constituents.
Andro-Plexx by Soto Supplements Drug Interactions
HelloPharmacist Interaction Report
Andro-Plexx by Soto Supplements contains one ingredient we can check for drug interactions: Arimistane (Androsta-3,5-Diene-7,17-Dione).
It has a documented Moderate interaction with aromatase inhibitors — a class of drugs used mainly in hormone-sensitive cancers. Arimistane is believed to inhibit the same enzyme these medications target, which could increase the risk of low estrogen side effects or liver toxicity.
Read the full breakdown — every affected drug type, severity by severity
Additionally, the product contains three other active ingredients that we cannot check — we hold no interaction data for 17 beta-[1-ketoethyl]-androstane-3-one,17a-ol, 6-Ketoprogesterone, or 17beta-[1-ketoethyl]-androsta-1,4-diene-3-one,17a-ol. Altogether, these interactions span 4 individual medications.
If you take any prescription medication — especially aromatase inhibitors or other hormone-related drugs — run your full medication list through the checker below before you start Andro-Plexx. We may not have checked all the ingredients in this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Andro-Plexx?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Andro-Plexx interact with 4 drugs. Click any drug to see the details.
1 of the 4 ingredients in Andro-Plexx interact with drugs. Each result below shows which ingredient is responsible. Androsta-3,5-Diene-7,17-Dione
AnastrozoleArimidex
How Anastrozole interacts with Andro-Plexx — through 1 ingredient. Tap an ingredient for the detail:
Androsta-3,5-diene-7,17-dioneAromatase Inhibitors Moderate
Interaction Summary
It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors.
Read the full Androsta-3,5-diene-7,17-dione + Anastrozole interactionExemestaneAromasin
How Exemestane interacts with Andro-Plexx — through 1 ingredient. Tap an ingredient for the detail:
Androsta-3,5-diene-7,17-dioneAromatase Inhibitors Moderate
Interaction Summary
It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors.
Read the full Androsta-3,5-diene-7,17-dione + Exemestane interactionLetrozoleFemara
How Letrozole interacts with Andro-Plexx — through 1 ingredient. Tap an ingredient for the detail:
Androsta-3,5-diene-7,17-dioneAromatase Inhibitors Moderate
Interaction Summary
It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors.
Read the full Androsta-3,5-diene-7,17-dione + Letrozole interactionLetrozole, Ribociclib SuccinateKisqali Femara Co-Pack
How Letrozole, Ribociclib Succinate interacts with Andro-Plexx — through 1 ingredient. Tap an ingredient for the detail:
Androsta-3,5-diene-7,17-dioneAromatase Inhibitors Moderate
Interaction Summary
It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors.
Read the full Androsta-3,5-diene-7,17-dione + Letrozole, Ribociclib Succinate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Andro-Plexx with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Androsta-3,5-Diene-7,17-Dione
Aromatase Inhibitors
It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors. This interaction could potentially increase the risk of side effects associated with low estrogen levels or from additive side effects, such as an increased risk of liver toxicity. It is recommended to consult with a healthcare provider before combining Arimistane with other aromatase inhibitors to assess the potential risks and benefits.
Brand information
Manufacturer and brand details for Andro-Plexx, from the product label.
Andro-Plexx by Soto Supplements: Common Questions
Does Andro-Plexx by Soto Supplements interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does Andro-Plexx actually work for muscle building or athletic performance?
Can I take this if I'm pregnant or breastfeeding?
What does Arimistane do?
What are the side effects?
Why is this product hard to find?
Is this safe to take with my other medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Andro-Plexx is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Andro-Plexx’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Andro-Plexx's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 1 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Arimistane 1 reference
- Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC