Drug & supplement interaction

Arimistane + Piroxicam

Piroxicam brand names: Feldene, Feldene Gel.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Arimistane and Piroxicam in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Arimistane and Piroxicam

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Piroxicam and Arimistane in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Arimistane safety at a glance

Arimistane overall Avoid It is a hormone-altering drug with little safety data, and regulators warn against aromatase inhibitor supplements.
Pregnancy Possibly Unsafe When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing aromatase inhibit... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing aromatase inhibit... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Piroxicam and Arimistane? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Piroxicam

Interactions in our licensed database are recorded against drug classes, not just single drug names. Piroxicam is filed under 9 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), cytochrome p450 2c9 (cyp2c9) substrates, anticoagulant/antiplatelet drugs. Arimistane has documented interactions with 1 drug class — the most serious being aromatase inhibitors (moderate) — and none of Piroxicam’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Arimistane Does Interact With Other Medications

Arimistane has 4 moderate known drug interactions in our database — Piroxicam isn’t one of them. If you take anything else, check it against the full list below.

Moderate 4 No known interaction 2,826 (incl. Piroxicam)
Taking anything else?

Check Another of Your Medications Against Arimistane

Covers the 2,830 medications we’ve checked against Arimistane. Pick one to open its full report.

What to actually watch for

What Piroxicam’s Own FDA Label Lists

This is not an interaction — none of it involves Arimistane. These are the most notable effects listed in the ADVERSE REACTIONS section of Piroxicam’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Pain or burning when passing urine Worth acting on
  • Bleeding in the gut Worth acting on
  • High potassium Worth acting on
  • Low blood sugar Worth acting on
  • A heart attack Worth acting on
  • Hallucinations Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Heart failure Worth acting on
  • An allergic reaction Worth acting on mentioned in 15.4% of FDA reports for Piroxicam

Showing the 10 most notable of 59 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Piroxicam. Read the label on DailyMed › Where a percentage is shown, it is the share of 6,275 voluntary FDA FAERS reports for Piroxicam that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Arimistane’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Arimistane side to compare — that is a limit of the record, not a statement that Arimistane has no side effects.

Special populations

Arimistane in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing aromatase inhibitors are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Arimistane or Piroxicam

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Arimistane or Piroxicam, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Piroxicam

This page covers Arimistane only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Piroxicam page lists 285 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 242 moderate · 36 minor.

From our pharmacist’s overview on the Piroxicam page

“Piroxicam (Feldene) is a potent, long-acting NSAID for arthritis pain, and since it already carries real stomach-bleeding risk on its own, my honest read is that this page calls for genuine caution rather than a quick skim. Most of the 285 interacting supplements share a single problem: they thin the blood or blunt platelets, stacking…”

Reviewed by 2 · Jul 18, 2026

Open the Piroxicam interaction page

One more smart check

Taking Arimistane as Part of a Dietary Supplement Product? Check It for Interactions

We hold 80 real supplement products containing Arimistane, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Arimistane. Even though Arimistane itself has no known interaction with Piroxicam, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Arimistane and Piroxicam Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Arimistane
Top half

#569 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Piroxicam
Steady interest

#1,638 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Arimistane reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Arimistane and Piroxicam records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Arimistane

What is Arimistane?

Arimistane
  • Lowering estrogen levels
  • Post-cycle therapy after steroid or prohormone use
  • Reducing gynecomastia ('gyno')
  • Boosting testosterone
  • Bodybuilding and physique support

Arimistane (sometimes sold as Estrovade) is a synthetic aromatase inhibitor marketed as a dietary supplement to lower estrogen and raise testosterone, often during or after steroid or prohormone cycles. It is not a true dietary ingredient, has very little human safety data, and U.S. regulators have warned against products containing aromatase inhibitors. Talk to a pharmacist or doctor before using it.

Not applicable (synthetic compound) · Capsules, tablets, powders

An interaction check asks whether these two react with each other — it does not ask whether Arimistane is a good idea for someone in your situation. Here is what our Arimistane record says about it on its own.

Arimistane: dosing

There is no officially established or proven safe dose for Arimistane. It has not gone through the testing that approved medicines undergo, so reliable dosing guidance does not exist.Product labels vary widely, and the actual amount in a given product may not match what is claimed. Honestly, for most people the safest choice is to avoid it.

From our Arimistane monograph — the full record covers uses, side effects and every documented interaction.

Read the full Arimistane monograph & all interactions
Medication

About Piroxicam

What Is Piroxicam Used For?

Brand names: Feldene, Feldene Gel

Piroxicam capsules are used to relieve pain, swelling, and stiffness caused by osteoarthritis and rheumatoid arthritis. It targets inflammation at the source to help improve day-to-day comfort and movement.

Piroxicam is not a cure for either condition — it manages symptoms. Your prescriber will weigh the benefits against the risks and aim for the lowest effective dose for the shortest time needed.

Most-Reported Side Effects for Piroxicam

From FAERS, the FDA’s public side-effect reporting system (6,347 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug hypersensitivity 980 reports
Rash 921 reports
Arthralgia 915 reports
Rheumatoid arthritis 856 reports
Fatigue 855 reports
See full Piroxicam drug information
Keep checking

Other Drugs & Arimistane

Browse every other medication we’ve checked against Arimistane — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
4Moderate
0Minor
2,825No known interaction
4 Moderate 2,825 No interaction
Moderate

4 interactions

No interaction 2,825 drugs checked — show the list

We also checked Arimistane against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,825 medications checked with no known interaction — see the full Arimistane list.

See the full Arimistane interactions page
See every supplement checked against Piroxicam, ranked by severity
Evidence & sources

Arimistane References

The 1 references that drive our Arimistane monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Arimistane and Piroxicam Together: Common Questions

Is it safe to take Arimistane with Piroxicam?
We do not list a known interaction between Arimistane and Piroxicam. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Arimistane and Piroxicam combination checked?
Interactions in our licensed database are recorded against drug classes. Piroxicam is filed under 9 classifications, and Arimistane has documented interactions with 1 drug class — none of Piroxicam's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Arimistane interact with any other medications?
Yes. Arimistane has 4 documented drug interactions in our database — Piroxicam is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Piroxicam interact with any supplements?
Yes. Piroxicam has documented interactions with 285 supplements in our database — Arimistane is not one of them. The Piroxicam interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Arimistane monograph Uses, safety profile, and every drug interaction in one place Piroxicam drug information The full plain-English guide to this medication Piroxicam supplement interactions Every supplement checked against Piroxicam, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Piroxicam and Arimistane?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.