Arimistane + Ingenol Mebutate
Ingenol Mebutate brand name: Picato.
We found no known interaction between Arimistane and Ingenol Mebutate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Arimistane and Ingenol Mebutate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Ingenol Mebutate and Arimistane in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Arimistane safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Ingenol Mebutate
Interactions in our licensed database are recorded against drug classes, not just single drug names. Ingenol Mebutate is filed under a single classification — topical drugs. Arimistane has documented interactions with 1 drug class — the most serious being aromatase inhibitors (moderate) — and none of Ingenol Mebutate’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Arimistane Does Interact With Other Medications
Arimistane has 4 moderate known drug interactions in our database — Ingenol Mebutate isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Arimistane
We haven’t checked that one against Arimistane yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Arimistane. Pick one to open its full report.
Arimistane in Pregnancy & Breastfeeding
When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing aromatase inhibitors are dangerous. Avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Ingenol Mebutate
This page covers Arimistane only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ingenol Mebutate page lists 3 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).
By severity: 2 moderate · 1 minor.
From our pharmacist’s overview on the Ingenol Mebutate page
“Ingenol mebutate (Picato) is a gel applied to the skin for actinic keratosis, the rough precancerous patches caused by sun damage, and it is deliberately harsh, producing redness, flaking, and stinging as part of how it works. The few supplement interactions on record are all skin-level ones.”
Reviewed by 2 · Jul 18, 2026
Taking Arimistane as Part of a Dietary Supplement Product? Check It for Interactions
We hold 80 real supplement products containing Arimistane, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Arimistane. Even though Arimistane itself has no known interaction with Ingenol Mebutate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Arimistane and Ingenol Mebutate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#651 of 1,452 supplements looked up here in the last 7 days
#1,116 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Arimistane reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Arimistane and Ingenol Mebutate records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Arimistane
What is Arimistane?
- Lowering estrogen levels
- Post-cycle therapy after steroid or prohormone use
- Reducing gynecomastia ('gyno')
- Boosting testosterone
- Bodybuilding and physique support
Arimistane (sometimes sold as Estrovade) is a synthetic aromatase inhibitor marketed as a dietary supplement to lower estrogen and raise testosterone, often during or after steroid or prohormone cycles. It is not a true dietary ingredient, has very little human safety data, and U.S. regulators have warned against products containing aromatase inhibitors. Talk to a pharmacist or doctor before using it.
Not applicable (synthetic compound) · Capsules, tablets, powders
An interaction check asks whether these two react with each other — it does not ask whether Arimistane is a good idea for someone in your situation. Here is what our Arimistane record says about it on its own.
Arimistane: dosing
There is no officially established or proven safe dose for Arimistane. It has not gone through the testing that approved medicines undergo, so reliable dosing guidance does not exist.Product labels vary widely, and the actual amount in a given product may not match what is claimed. Honestly, for most people the safest choice is to avoid it.
From our Arimistane monograph — the full record covers uses, side effects and every documented interaction.
About Ingenol Mebutate Topical
What Is Ingenol Mebutate Topical Used For?
Brand name: Picato
-
Ingenol mebutate gel is used to treat actinic keratosis (flat, scaly growths on the skin caused by too much sun exposure). Ingenol mebutate is in a class of medications called cytotoxic agents. It works by killing fast-growing cells such as the abnormal cells associated with actinic keratoses.
Other Drugs & Arimistane
Browse every other medication we’ve checked against Arimistane — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
4 interactions
No interaction 2,825 drugs checked — show the list
We also checked Arimistane against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Ivermectin ›
- Abemaciclib ›
- Testosterone ›
- Sertraline ›
- Losartan Potassium ›
- Rosuvastatin ›
- Acetaminophen ›
- Aspirin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Ibuprofen ›
- Warfarin Sodium ›
- Levothyroxine, Liothyronine ›
- Docusate ›
- Amlodipine Besylate ›
- Metformin ›
- Amitriptyline ›
- Prednisone ›
- Methamphetamine ›
- Tadalafil ›
- Amphetamine ›
- Semaglutide ›
- Lisdexamfetamine ›
- Propranolol ›
- Sumatriptan ›
- Valacyclovir ›
- Hydroxyurea ›
- Amoxicillin ›
- Lisinopril ›
- Methotrexate ›
- Bupropion ›
- Azithromycin ›
- Fluoxetine ›
- Doxycycline ›
- Pregabalin ›
- Gabapentin ›
- Acetaminophen, Aspirin, Caffeine ›
- Dextroamphetamine ›
- Naproxen ›
- Lamotrigine ›
- Clonazepam ›
- Bendamustine ›
- Quetiapine ›
- Acyclovir ›
- Buspirone ›
- Omeprazole ›
- Duloxetine ›
- Citalopram ›
- Methylene Blue ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,825 medications checked with no known interaction — see the full Arimistane list.
Arimistane References
The 1 references that drive our Arimistane monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Arimistane and Ingenol Mebutate Together: Common Questions
Is it safe to take Arimistane with Ingenol Mebutate?
How was the Arimistane and Ingenol Mebutate combination checked?
Does Arimistane interact with any other medications?
Does Ingenol Mebutate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Ingenol Mebutate and Arimistane?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.