Herb & supplement monograph

7-methoxyflavone Drug Interactions, Uses, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated June 2026

What is this page for?

First and foremost: how 7-methoxyflavone interacts with medications. The heart of this page is the interaction list — every drug 7-methoxyflavone is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what 7-methoxyflavone is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

Check 7-methoxyflavone against your medication

Add one medication

✓ Supplement

7-methoxyflavone

1 Your medication

Start typing any prescription or over-the-counter drug name.

Reviewed by licensed pharmacists Sourced from Natural Medicines

On this page

7-methoxyflavone Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated August 2026

Based on the available evidence, the overall risk of a clinically significant 7-methoxyflavone drug interaction appears low for most people, since every listed interaction rests on lab research rather than proof in humans. None of the interactions are rated major, and all of them are graded as only possible, meaning they come from laboratory findings, not human studies.

Interactions deserving the most attention

The medications that deserve the most attention are aromatase inhibitors such as anastrozole, exemestane, and letrozole, and testosterone therapy. Lab studies suggest 7-methoxyflavone may block aromatase, an enzyme the body uses to turn testosterone into estrogen. In theory, this could add to the effects and side effects of aromatase inhibitor drugs, or boost the effects of testosterone treatment. Because these medicines are often used for serious conditions like breast cancer, we think anyone taking them should mention this supplement to their care team.

What the rest of the list means

The dozen medications on this list all fall into these two related groups, and every concern is theoretical so far. A predicted effect in a test tube does not always translate into a meaningful change in people, and no human studies have confirmed these interactions.

Check your medications against 7-methoxyflavone

Based on HelloPharmacist’s 7-methoxyflavone interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with 7-methoxyflavone

12 medications have a known interaction with 7-methoxyflavone, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against 7-methoxyflavone using our pharmacist-reviewed interaction data.

AI summaries are generated from our 7-methoxyflavone interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact 7-methoxyflavone combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs 7-methoxyflavone affects

Every type of medication (drug category) 7-methoxyflavone is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 2 drug categories 7-methoxyflavone interacts with

Aromatase InhibitorsTestosterone

Aromatase Inhibitors

In vitro evidence shows that 7-methoxyflavone inhibits aromatase. Theoretically, 7-methoxyflavone might have an additive effects when used with other aromatase inhibitors, potentially increasing the therapeutic effects and adverse effects associated with these drugs. Some aromatase inhibitors include anastrozole (Arimidex), exemestane (Aromasin), and letrozole (Femara).

Likelihood Possible Evidence D

Testosterone

In vitro evidence shows that 7-methoxyflavone inhbits aromatase. Inhibiting aromatase reduces the conversion of testosterone and other androgens to estrogens. Theoretically, use of 7-methoxyflavone with testosterone might increase the effects and side effects of testosterone therapy.

Likelihood Possible Evidence D

Monograph

7-methoxyflavone: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed June 2026 ·

The bottom line

7-Methoxyflavone is a lab-made or plant-derived flavonoid marketed mainly in testosterone-boosting and bodybuilding supplements based on the idea that it blocks the aromatase enzyme. However, solid human evidence that it raises testosterone, improves performance, or builds muscle is essentially lacking, and its long-term safety has not been well studied. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Part used: Isolated flavonoid compound (synthesized or extracted from plants)
Common forms: Capsules, tablets, powders (often in combination supplements)

People commonly use it for

Boosting testosterone
Reducing estrogen (aromatase inhibition)
Athletic and bodybuilding performance
Muscle building support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallLimited data

Human safety data are very limited, so it cannot be called clearly safe.

PregnancyBest avoided

Avoid because of unknown safety and possible effects on hormones.

BreastfeedingBest avoided

Avoid due to lack of safety data and potential hormonal activity.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

7-Methoxyflavone (also written as 7-methoxy-2-phenylchromen-4-one) is a type of plant compound called a flavonoid. Flavonoids are natural substances found in many fruits, vegetables, and herbs. This particular one has a small chemical change (a "methoxy" group) that makes it slightly different from the flavonoids you would get from food.

It can be made in a laboratory through chemical synthesis, or pulled from certain plants. It has been reported in plants such as Zornia brasiliensis and in some species from the Meliaceae and Rutaceae plant families.

You will mostly find 7-methoxyflavone inside dietary supplements aimed at men, athletes, and bodybuilders. These products are marketed with claims about raising testosterone, lowering estrogen, and helping build muscle. It is not a traditional herbal remedy with a long history of use.

Uses & effectiveness

People take 7-methoxyflavone mainly because supplement makers claim it can raise testosterone and support muscle growth and athletic performance. The idea is that by blocking an enzyme called aromatase, the body would keep more testosterone and make less estrogen.

The evidence to support these claims in people is very weak. Most of what is known comes from laboratory (test-tube) and limited animal research, not from well-designed human studies. We do not have good clinical trials showing that taking 7-methoxyflavone actually raises testosterone, improves muscle size, or boosts exercise performance in people.

Because of this, it is fair to say the effectiveness of 7-methoxyflavone for any health or performance goal is unproven. If a product promises big results, treat those claims with caution.

How it works

The main proposed mechanism is that 7-methoxyflavone may act as an aromatase inhibitor. Aromatase is an enzyme that converts testosterone and similar androgens into estrogens. In theory, blocking this enzyme could leave more testosterone in the body and lower estrogen.

Some flavonoids have shown this kind of activity in laboratory settings. However, an effect seen in a test tube does not always carry over to the human body, where the compound has to be absorbed, survive digestion, and reach the right tissues in meaningful amounts.

It is important to understand that the aromatase-blocking idea for 7-methoxyflavone is mostly based on early, non-human research. How well (or whether) it works this way in people who take it as a supplement has not been clearly shown.

Safety & precautions

The safety of 7-methoxyflavone in humans has not been well studied. Because it is a relatively niche supplement ingredient, there is little information about how much is safe, what happens with long-term use, or who might be at higher risk.

Anything that may affect hormone levels, like an aromatase inhibitor, deserves extra caution. Lowering estrogen too much can have unwanted effects, and people with hormone-sensitive conditions, those taking hormone-related medicines, and teenagers (whose hormones are still developing) should be especially careful.

Supplements are not tested by the FDA the way medicines are, so product quality and exact contents can vary. Pregnant and breastfeeding people should avoid 7-methoxyflavone because its safety is unknown and it may have hormonal activity. Always check with your pharmacist or doctor before starting any new supplement, especially one marketed to change hormone levels.

Side effects

Because human studies are lacking, the full side effect profile of 7-methoxyflavone is not well known.

With compounds that may lower estrogen, possible concerns can include changes in mood, joint discomfort, changes in libido, and—over the long term—effects on bone health, although these have not been clearly demonstrated for 7-methoxyflavone specifically. As with any supplement, mild digestive upset is also possible.

If you notice any unusual symptoms after taking a product that contains 7-methoxyflavone, stop using it and talk to a healthcare professional.

Dosing

There is no established, science-based dose for 7-methoxyflavone. It has not been studied enough in people to know a safe and effective amount.

Most products that contain it provide it as part of a blend, and amounts vary widely from brand to brand. If you choose to use a product despite the limited evidence, follow the dose printed on the label and do not exceed it.

Because the science is so thin, the best step is to talk with your pharmacist or doctor first. They can help you weigh whether the product makes sense for you and check for any concerns based on your health and other medicines.

References & further reading

The 1 references that drive our 7-methoxyflavone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Ta N, Walle T. Aromatase inhibition by bioavailable flavones. J Steroid Biochem Mol Biol 2007;107(1-2):127-9.

Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

Brand directory

Brands that make products with 7-methoxyflavone

11 brands in our database make a supplement containing 7-methoxyflavone.

Anabolic Warfare 65 products Anovite 17 products ANS Performance 12 products Applied Nutriceuticals 30 products ATS Labs 19 products Biotivia 51 products Chaotic-Labz 37 products EST 12 products iForce Nutrition 6 products Nutra Innovations 23 products XL Xero Limits 5 products

Product directory

Supplement products with 7-methoxyflavone

20 products in our database contain 7-methoxyflavone. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

7-methoxyflavone: Common Questions

Does 7-methoxyflavone interact with prescription medications?

Yes. We list 12 medications with a known interaction with 7-methoxyflavone. Use the checker above to see how 7-methoxyflavone interacts with a specific drug.

How are 7-methoxyflavone interactions rated?

Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.

Is it safe to take 7-methoxyflavone with my medications?

It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.

Where does this 7-methoxyflavone interaction information come from?

Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.

What is 7-methoxyflavone used for?

It is mostly used in supplements marketed to raise testosterone, lower estrogen, and support muscle building and athletic performance. However, there is little solid human evidence that it actually does any of these things.

Does 7-methoxyflavone really boost testosterone?

This claim is based on the idea that it blocks the aromatase enzyme, but that comes mainly from lab and animal research. Good human studies showing it raises testosterone are lacking.

Is 7-methoxyflavone safe to take?

Its safety has not been well studied in people, so it cannot be called clearly safe. Because it may affect hormones, it is best to check with your pharmacist or doctor before using it.

Can I take 7-methoxyflavone if I am pregnant or breastfeeding?

No. Its safety is unknown and it may have hormonal activity, so it should be avoided during pregnancy and breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain 7-methoxyflavone

A rotating sample of real supplements in our database that list 7-methoxyflavone — open any to see its full ingredients and every drug interaction we check.

See all 20 products with 7-methoxyflavone →

Where next

Supplement interaction checkerCheck any supplement or product against your medications Drug–drug interactionsCheck two or more of your medications against each other Browse medications A–ZEvery drug we’ve checked against herbs & supplements NDC & pricing lookupFind a drug’s NDCs, packaging and costs Ask a pharmacistFree, personal answer from our licensed team

Have a question about 7-methoxyflavone?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist