Major interaction on record — check this product against your medications before combining. Based on 6 of 9 ingredients. Check your meds →
Dietary supplement

Project Ripped Ingredients & Drug Interactions

by Anabolic Warfare

Project Ripped label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Project Ripped against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Project Ripped is a dietary supplement by Anabolic Warfare with 9 active ingredients. Its ingredients are commonly taken for flavoring and culinary use, digestive complaints like bloating and indigestion, boosting absorption of other supplements.Based on those ingredients, 1,094 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Bioperine, 3,3 Diindolylmethane, 7-Methoxyflavone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Project Ripped by Anabolic Warfare

Ask about any prescription or over-the-counter medication and we check it for interactions with Project Ripped by Anabolic Warfare — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Project Ripped by Anabolic Warfare

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 7 of its 9 active ingredients.
  • “RipFactor Patented Blend” is a proprietary blend — the label gives one combined amount (325 mg) without saying how much of each component you get.

Project Ripped is a 9-ingredient supplement. The active ingredients include D-Aspartic Acid, Bioperine (a standardized black pepper extract), 7-Keto Dehydroepiandrosterone (a hormone-related compound), Mangifera indica bark extract, Sphaeranthus indicus flower extract, 3,3 Diindolylmethane, Acacetin, Smilax (sarsaparilla), and 7-Methoxyflavone — delivered in a proprietary blend called RipFactor.

The capsule also contains inactive ingredients: gelatin, titanium dioxide, colorants (FD&C Yellow #6 and FD&C Red #3), silicon dioxide, and magnesium stearate.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: muscle gain, strength, and body recomposition.
  • We looked for evidence on: Athletic performance, Muscle strength, Obesity, lean body mass, workout recovery, protein synthesis — and 1 related terms.
  • The closest evidence on file: Black Pepper is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Black Pepper is rated "Insufficient Reliable Evidence To Rate" for Obesity.
  • Also on file: 7-keto-dhea is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength, Obesity.

The evidence for most of these ingredients is not established in our data. Bioperine, 7-Keto-DHEA, Diindolylmethane, and Smilax all carry ratings of Insufficient Reliable Evidence for the conditions they've been studied for — meaning we don't have solid proof they work for those uses.

7-Methoxyflavone has no effectiveness ratings in our files. D-Aspartic Acid, Mangifera indica bark extract, and Acacetin also lack effectiveness data we can reference.

The evidence, ingredient by ingredient Black Pepper 7-keto-dhea Diindolylmethane Sarsaparilla Tansy 7-methoxyflavone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bioperine (black pepper) from food amounts is well tolerated; the main reported side effects are a burning aftertaste, indigestion, and reduced taste perception. Concentrated piperine supplements should be used cautiously and only with medical advice.

7-Keto-DHEA appears tolerated in short-term studies, but long-term safety isn't established; case reports include decreased red blood cell counts, nausea, and dizziness. Diindolylmethane is generally well tolerated short-term, with the most common side effects being diarrhea, gas, headache, nausea, rash, and vomiting; a rare serious reaction (DRESS) has been reported.

Sphaeranthus indicus (tansy) contains thujone, a toxic compound — serious effects include rapid pulse, irregular heartbeat, severe stomach illness, vomiting, organ damage, and death; it has been used to cause abortion and poses real risks. 7-Methoxyflavone has very limited human safety data and cannot be called clearly safe.

Side effects, ingredient by ingredient Black Pepper 7-keto-dhea Diindolylmethane Sarsaparilla Tansy 7-methoxyflavone

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Sarsaparilla, Tansy, Black Pepper, Diindolylmethane, 7-methoxyflavone.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,095 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Stop and check with your pharmacist if you take alcohol regularly, lithium, blood pressure medications (especially propranolol), heart medications (digoxin, aromatase inhibitor cancer drugs), seizure medications (phenytoin), HIV medications (nevirapine), antibiotics (rifampin), immunosuppressants (cyclosporine), sedatives (pentobarbital), cholesterol drugs (atorvastatin), breathing medications (theophylline), estrogen or hormone replacement therapy, water pills (diuretics), or drugs broken down by your liver's CYP1A2 enzyme — these are the medication types most affected by ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This is a complex multi-ingredient product with several moderate to major drug interactions and some ingredients with minimal human safety data. If you take any blood pressure, heart, seizure, HIV, antibiotic, cancer, mental health, or thyroid medications, or if you're on lithium, talk to your pharmacist before starting — your exact prescriptions need to be checked.

The thujone content from tansy extract is a significant concern; avoid if you drink alcohol regularly or take lithium.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Project Ripped, straight from the product label.

Brand Anabolic Warfare
Barcode (UPC) 812575034935
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 337977
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Project Ripped by Anabolic Warfare, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
812575034935
IngredientAmount% DV
D-Aspartic Acid750 mg--
Bioperine5 mg--
7-Keto Dehydroepiandrosterone100 mg--
Mangifera indica bark extract0 NP--
Sphaeranthus indicus flower extract0 NP--
3,3 Diindolylmethane200 mg--
Acacetin50 mg--
Smilax500 mg--
RipFactor Patented Blend325 mg--
7-Methoxyflavone25 mg--

Other ingredients: Gelatin, Titanium Dioxide, FD&C Yellow #6, FD&C red #3, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 3 capsules daily with 8-12 fl. oz. of water.

Formulation

Benefits: Recomposition formula made to deliver cuts, pumps, and density! Promotes healthy weight loss, improve lean body mass, and builds muscle. Muscle gains, power, strength, protein synthesis, and improved recovery after a workout.

Increase pumps & density Improve strength & power Support muscle recovery & joint health

Formula

DIM supports healthy hormone balance, and promotes healthy skin. 5mg of BioPerine increases the bio-availability of nutrients and enhances absorption of whole food and supplements. RipFactor promotes optimal strength, endurance, and muscle mass.

Precautions

Warning: Not intended for anyone under the age of 18.

If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.

Keep out of reach of children.

Manufactured in a facility which processes milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soybeans, and sesame.

Storage

Store in a cool, dry & dark place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Project Muscle Series

Facebook facebook.com/anabolicwarfare Instagram @anabolicwarfare

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

RipFACTOR is a trademark of PLT Health Solutions-Laila Nutraceuticals LLC. U.S. Patent # 9,907,825 and international patents pending. BioPerine is a registered trademark of Sabinsa Corporation.

Seals/Symbols

cGMP Good Manufacturing Practice Inspected Facility

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Project Ripped by Anabolic Warfare label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Project Ripped label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Project Ripped by Anabolic Warfare

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

D-Aspartic Acid

750 mg per serving

Bioperine

Interacts with
1,019 drugs
5 mg per serving Form: Black Pepper Fruit Extract

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to he...

Bioperine monograph & interactions

7-Keto Dehydroepiandrosterone

No known
interactions
100 mg per serving

7-keto-DHEA is a lab-made metabolite of the hormone DHEA that is marketed mainly for weight loss and a faster metabolism. Unlike DHEA, it is not thoug...

7-Keto Dehydroepiandrosterone monograph & interactions

3,3 Diindolylmethane

Interacts with
269 drugs
200 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

3,3 Diindolylmethane monograph & interactions

Acacetin

50 mg per serving

Smilax

Interacts with
2 drugs
500 mg per serving Form: Smilax sieboldii L. Rhizome Extract, Smilax sieboldii L. Root Extract

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited...

Smilax monograph & interactions

RipFactor Patented Blend

325 mg per serving

7-Methoxyflavone

Interacts with
12 drugs
25 mg per serving

7-Methoxyflavone is a lab-made or plant-derived flavonoid marketed mainly in testosterone-boosting and bodybuilding supplements based on the idea that...

7-Methoxyflavone monograph & interactions

Other (inactive) ingredients: Gelatin, Titanium Dioxide, FD&C Yellow #6, FD&C red #3, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Project Ripped by Anabolic Warfare Drug Interactions

Want to check YOUR meds against Project Ripped?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,094Drugs
1 Major 1,051 Moderate 42 Minor

Ingredients driving the most interactions

Bioperine 1,019
3,3 Diindolylmethane 269
7-Methoxyflavone 12
Smilax 2
Sphaeranthus indicus flower extract 1

Individual Drug Interactions

The ingredients in Project Ripped interact with 1,094 drugs. Click any drug to see the details.

5 of the 9 ingredients in Project Ripped interact with drugs. Each result below shows which ingredient is responsible. Bioperine 3,3 Diindolylmethane 7-Methoxyflavone Smilax Sphaeranthus indicus flower extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Project Ripped with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bioperine17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
Bioperine full monograph & interactions

3,3 Diindolylmethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
3,3 Diindolylmethane full monograph & interactions

7-Methoxyflavone2 drug types · 12 drugs

Aromatase Inhibitors

In vitro evidence shows that 7-methoxyflavone inhibits aromatase. Theoretically, 7-methoxyflavone might have an additive effects when used with other aromatase inhibitors, potentially increasing the therapeutic effects and adverse effects associated with these drugs. Some aromatase inhibitors include anastrozole (Arimidex), exemestane (Aromasin), and letrozole (Femara).

Likelihood Possible Evidence D
Testosterone

In vitro evidence shows that 7-methoxyflavone inhbits aromatase. Inhibiting aromatase reduces the conversion of testosterone and other androgens to estrogens. Theoretically, use of 7-methoxyflavone with testosterone might increase the effects and side effects of testosterone therapy.

Likelihood Possible Evidence D
7-Methoxyflavone full monograph & interactions

Smilax2 drug types · 2 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Sarsaparilla is thought to have diuretic properties, which could potentially cause potassium loss. Overuse or misuse of sarsaparilla with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Lithium

Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Sarsaparilla is thought to have diuretic properties. Due to these effects, sarsaparilla might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Smilax full monograph & interactions

Sphaeranthus indicus flower extract1 drug type · 1 drug

Alcohol (Ethanol)

Thujone, a constituent of tansy, can increase and alter the effects of alcohol.

Likelihood Probable Evidence D
Sphaeranthus indicus flower extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Project Ripped, from the product label.

Anabolic Warfare

See all Anabolic Warfare products
Name
Anabolic Warfare
City
Austin
State
TX
Phone Number
888-301-4002
Web Address
anabolicwarfare.com
Pharmacist Counseling Corner

Project Ripped by Anabolic Warfare: Common Questions

Does Project Ripped by Anabolic Warfare interact with any medications?
Yes. Based on its ingredients, Project Ripped has a known interaction with 1,094 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Project Ripped contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this have anything in it I should know about if I'm pregnant or breastfeeding?
Yes. The safety data advises against Sphaeranthus indicus during pregnancy and breastfeeding due to thujone toxicity — it's been used historically to cause abortion. 7-Keto-DHEA should be avoided while breastfeeding; pregnancy data is conflicting. Diindolylmethane is rated likely safe in pregnancy and lactation, and 3,3 Diindolylmethane is rated likely safe overall. If you're pregnant or nursing, talk to your doctor or pharmacist before taking this product.
What is 7-Keto-DHEA and why is it in here?
It's a hormone-related compound derived from DHEA. The evidence for what it actually does is insufficient in our data — we don't have proof it works for aging, depression, obesity, or the other conditions researchers have tested it for. Short-term use appears tolerated in small studies, but long-term safety isn't well established.
What does Bioperine do?
Bioperine is a standardized extract of black pepper that's included for absorption support. As a spice in food amounts it's well tolerated, but the supplement form in this product can increase how your body absorbs — and blood levels of — certain medications, which is why checking your prescriptions is important.
I saw this has tansy extract in it. Is that safe?
Tansy contains thujone, a toxic compound, so internal use is generally discouraged. The safety data advises against it, especially during pregnancy and breastfeeding. Deaths have been reported from small amounts of tansy oil. Talk to your pharmacist about whether this product is right for you.
What are the most common side effects I might notice?
From the black pepper ingredient, a burning aftertaste, indigestion, and reduced taste perception have been reported. From diindolylmethane, diarrhea, gas, headache, nausea, rash, and vomiting are the most common. Individual ingredients like 7-Keto-DHEA have been linked to nausea and dizziness in trial reports.
Can I take this if I drink alcohol?
No — not safely. The tansy extract in this product contains thujone, which can increase and alter the effects of alcohol. Avoid this product if you drink.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Project Ripped is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Project Ripped label
Go deeper

The Full Monographs Behind Project Ripped’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

7-keto-dhea

7-keto-DHEA is a lab-made metabolite of the hormone DHEA that is marketed mainly for weight loss and a faster metabolism. Unlike DHEA, it is not thought to convert into estrogen or testoster...

Read the full 7-keto-dhea monograph → Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph → Herb & supplement monograph

Sarsaparilla

Interacts with 2 drugs

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited and comes mostly from lab studies, so it...

Read the full Sarsaparilla monograph → Herb & supplement monograph

Tansy

Interacts with 1 drug

Tansy is a traditional bitter herb that contains thujone, a compound that can be toxic in higher amounts. Because of real safety concerns and very limited modern evidence, most people should...

Read the full Tansy monograph → Herb & supplement monograph

7-methoxyflavone

Interacts with 12 drugs

7-Methoxyflavone is a lab-made or plant-derived flavonoid marketed mainly in testosterone-boosting and bodybuilding supplements based on the idea that it blocks the aromatase enzyme. However...

Read the full 7-methoxyflavone monograph →
Sources

Sources & How We Checked

Project Ripped's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 63 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Pepper 29 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Bano G, Amla V, Raina RK, et al. The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 1987;53:568-9. PubMed
  4. Bano G, et al. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers. Eur J Clin Pharmacol 1991;41;615-7. PubMed
  5. Cohle SD, Trestrail JD III, Graham MA, et al. Fatal pepper aspiration. Am J Dis Child 1988;142:633-6. PubMed
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Diindolylmethane 14 references
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Sarsaparilla 3 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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