Interactions on record — worth a quick check against your medications. Based on 6 of 8 ingredients. Check your meds →
Dietary supplement

Project Bulk Ingredients & Drug Interactions

by Anabolic Warfare

Project Bulk label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Project Bulk against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Project Bulk is a dietary supplement by Anabolic Warfare with 8 active ingredients. Its ingredients are commonly taken for bone health, joint and arthritis support, hormone (testosterone/estrogen) support.Based on those ingredients, 1,050 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bioperine, Dehydroepiandrosterone, Maral Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Project Bulk by Anabolic Warfare

Ask about any prescription or over-the-counter medication and we check it for interactions with Project Bulk by Anabolic Warfare — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Project Bulk by Anabolic Warfare

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Project Bulk contains 8 active ingredients. Boron supports healthy bone and muscle function.

Bioperine (black pepper extract) is included to enhance absorption and nutrient bioavailability. Dehydroepiandrosterone (DHEA) is a hormone precursor.

Maral root extract is an adaptogenic herb traditionally used for athletic performance. The product also contains epicatechin (a plant compound), eucommia ulmoides bark extract, sarsaparilla root extract, and ajuga turkestanica.

The capsules also contain inactive ingredients: gelatin, rice flour, silicon dioxide, and magnesium stearate.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: muscle gains, power, strength, and recovery.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Fatigue, Muscle strength, Physical performance, Protein synthesis — and 1 related terms.
  • The closest evidence on file: Dhea is rated "Possibly Ineffective" for Muscle strength (Natural Medicines).
  • Also on file: Dhea is rated "Possibly Ineffective" for Physical performance.
  • Also on file: Boron is rated "Possibly Ineffective" for Athletic performance.

Boron is likely effective for correcting boron deficiency and possibly effective for vaginal candidiasis and radiation dermatitis, though it's possibly ineffective for athletic performance. DHEA is likely effective for vaginal atrophy and possibly effective for infertility, aging skin, and depression.

For the other ingredients in this product—bioperine, maral root extract, sarsaparilla, and the remaining actives—the evidence for athletic performance or other uses is insufficient or not established in our data.

The evidence, ingredient by ingredient Boron Black Pepper Dhea Maral Root Sarsaparilla Ajuga Nipponensis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boron is generally well tolerated at doses below 20 mg daily, with common side effects being loss of appetite, skin irritation, and indigestion. At chronic high doses (1 gram daily of boric acid or 25 grams daily of boric tartrate), boron can cause hair loss and severe skin effects; acute poisoning from larger amounts can cause nausea, vomiting, diarrhea, and in severe cases dehydration and shock.

Avoid boron supplements in pregnancy and while breastfeeding. Bioperine from black pepper is generally well tolerated as a food spice; concentrated supplements should be used cautiously.

Common side effects are burning aftertaste, indigestion, and reduced taste. A rare allergic reaction is possible.

DHEA is well tolerated short-term at typical doses, but long-term use carries theoretical concern for increased cancer risk. Common side effects include acne, headache, insomnia, mood changes, and nausea; in women, masculinizing effects like voice deepening and irregular periods can occur; in men, aggression and breast changes.

DHEA is possibly unsafe in pregnancy and should be avoided while breastfeeding. Maral root and sarsaparilla have limited human safety data; avoid both during pregnancy and breastfeeding.

No adverse effects are on file for epicatechin, eucommia ulmoides bark extract, or ajuga turkestanica.

Side effects, ingredient by ingredient Boron Black Pepper Dhea Maral Root Sarsaparilla Ajuga Nipponensis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 6 matched ingredients can interact with medications — Dhea, Sarsaparilla, Black Pepper, Maral Root.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,051 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Project Bulk, check with your pharmacist or doctor if you take any blood thinners (anticoagulants or antiplatelet drugs), seizure medications, heart medications (beta-blockers, digoxin), antidepressants, HIV or TB drugs, cholesterol medications, cancer medications, lithium, sleep medications, or asthma/breathing medications—all have documented moderate interactions with one or more ingredients here.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Project Bulk is marketed for athletic performance and muscle building, though evidence for most ingredients is limited or insufficient. If you take a beta-blocker, seizure medication, blood thinner, HIV or TB drug, heart medication, or mood stabilizer, you'll need to discuss this product with your pharmacist or doctor—it has significant interactions with those drug types.

DHEA is a hormone and should only be used under medical guidance. Pregnant women or those breastfeeding should avoid boron, DHEA, maral root, and sarsaparilla.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Project Bulk, straight from the product label.

Brand Anabolic Warfare
Barcode (UPC) 812575035178
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 307031
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Project Bulk by Anabolic Warfare, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
812575035178
IngredientAmount% DV
Boron10 mg--
Bioperine5 mg--
Dehydroepiandrosterone100 mg--
Maral Root Extract100 mg--
Epicatechin250 mg--
Eucommia ulmoides Bark Extract500 mg--
Smilax Rhizome, Root Extract500 mg--
Ajuga turkestanica500 mg--

Other ingredients: Gelatin, Rice Flour, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 3 capsules with 8-12 fl. oz. of water.

Formulation

Benefits: Our most advanced mass building formula. Muscle gains, power, strength, protein synthesis, and improved recovery. Project Bulk supports normal blood flow, muscle growth and strength.

Bulk formula Mass building Increase muscle protein synthesis

Formula

Ajuga turkestanica supports strength and protein synthesis while building lean muscle mass and promoting faster recovery. 5 mg of BioPerine increases the bio-availability of nutrients and supports the absorption of whole foods and supplements.

Precautions

Warning: Not intended for anyone under the age of 18.

If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.

Keep out of the reach of children.

Storage

Keep container tightly closed in a cool, dry & dark place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Project muscle series

Facebook facebook.com/anabolicwarfare Instagram @anabolicwarfare

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

BioPerine is a registered trademark of Sabinsa Corporation.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Project Bulk by Anabolic Warfare label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Project Bulk label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Project Bulk by Anabolic Warfare

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Boron

No known
interactions
10 mg per serving Form: Boron Citrate

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence f...

Boron monograph & interactions

Bioperine

Interacts with
1,019 drugs
5 mg per serving Form: Black Pepper Fruit Extract

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to he...

Bioperine monograph & interactions

Dehydroepiandrosterone

Interacts with
776 drugs
100 mg per serving

DHEA is a natural hormone that the body makes and that declines with age, and it is sold as a supplement claiming many benefits. The evidence is mixed...

Dehydroepiandrosterone monograph & interactions

Maral Root Extract

Interacts with
122 drugs
100 mg per serving

Maral Root (Rhaponticum carthamoides) is a Siberian herb used as an 'adaptogen' and is popular among athletes for stamina and muscle building, largely...

Maral Root Extract monograph & interactions

Epicatechin

250 mg per serving

Eucommia ulmoides Bark Extract

500 mg per serving

Smilax Rhizome, Root Extract

Interacts with
2 drugs
500 mg per serving Form: Smilax sieboldii Rhizome Extract, Smilax sieboldii Root Extract

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited...

Smilax Rhizome, Root Extract monograph & interactions

Ajuga turkestanica

No known
interactions
500 mg per serving Form: Turkesterone

Ajuga nipponensis is a perennial plant from East Asia used in traditional medicine for cough and respiratory complaints. There is very little human re...

Ajuga turkestanica monograph & interactions

Other (inactive) ingredients: Gelatin, Rice Flour, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Project Bulk by Anabolic Warfare Drug Interactions

Want to check YOUR meds against Project Bulk?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,050Drugs
1,001 Moderate 49 Minor

Ingredients driving the most interactions

Bioperine 1,019
Dehydroepiandrosterone 776
Maral Root Extract 122
Smilax Rhizome, Root Extract 2

Individual Drug Interactions

The ingredients in Project Bulk interact with 1,050 drugs. Click any drug to see the details.

4 of the 8 ingredients in Project Bulk interact with drugs. Each result below shows which ingredient is responsible. Bioperine Dehydroepiandrosterone Maral Root Extract Smilax Rhizome, Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Project Bulk with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bioperine17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
Bioperine full monograph & interactions

Dehydroepiandrosterone10 drug types · 776 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Human and laboratory research show that DHEA and DHEA-S can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, DHEA might increase the risk of psychiatric adverse events when used with antidepressants.
In a human case report, the use of a selective serotonin reuptake inhibitor (SSRI) with DHEA caused a manic episode. Concern for this interaction may be greater in younger individuals with higher baseline DHEA levels.

Likelihood Possible Evidence D
Aromatase Inhibitors

Theoretically, DHEA might interfere with the clinical effects of aromatase inhibitors.
DHEA is a potent estrogen agonist, which may antagonize the anti-estrogen activity of aromatase inhibitors.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Some preliminary evidence shows that DHEA may inhibit CYP3A4; however, the clinical significance of this potential interaction is not known.

Likelihood Possible Evidence D
Fulvestrant (Faslodex)

Theoretically, DHEA might interfere with the anti-estrogen effects of fulvestrant.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist action of fulvestrant in estrogen-receptor positive cancer cells.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, DHEA might interfere with the anti-estrogen effects of tamoxifen.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist activity of tamoxifen in estrogen-receptor positive cancer cells.

Likelihood Possible Evidence D
Triazolam (Halcion)

DHEA can increase blood levels of triazolam.
Administration of DHEA 200 mg daily for two weeks was shown to inhibit the cytochrome P450 3A4 (CYP3A4) metabolism of triazolam. This inhibition appears to be due to DHEA-S, rather than DHEA.

Likelihood Probable Evidence D
Tuberculosis Vaccine

DHEA might reduce the effectiveness of the tuberculosis vaccine.
Animal research shows that high doses of DHEA can reduce the efficacy of the Bacillus Calmette-Guérin (BCG) tuberculosis vaccine.

Likelihood Possible Evidence D
Estrogens

Theoretically, DHEA might increase the effects and adverse effects of estrogen therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. Also, in clinical research, estrogen-progestin oral contraceptives and conjugated estrogens reduce blood levels of DHEA and DHEA-S. The clinical significance of these findings is unclear.

Likelihood Possible Evidence D
Testosterone

Theoretically, DHEA might increase the effects and side effects of testosterone therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. The clinical significance of these findings is unclear.

Likelihood Possible Evidence D
Dehydroepiandrosterone full monograph & interactions

Maral Root Extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

In vitro research shows that maral root tincture can reduce platelet aggregation. Theoretically, maral root might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs. Some of these drugs include aspirin, clopidogrel (Plavix), nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Maral Root Extract full monograph & interactions

Smilax Rhizome, Root Extract2 drug types · 2 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Sarsaparilla is thought to have diuretic properties, which could potentially cause potassium loss. Overuse or misuse of sarsaparilla with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Lithium

Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Sarsaparilla is thought to have diuretic properties. Due to these effects, sarsaparilla might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Smilax Rhizome, Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Project Bulk, from the product label.

Anabolic Warfare

See all Anabolic Warfare products
Name
Anabolic Warfare
City
Austin
State
TX
Phone Number
888-301-4002
Web Address
anabolicwarfare.com
Pharmacist Counseling Corner

Project Bulk by Anabolic Warfare: Common Questions

Does Project Bulk by Anabolic Warfare interact with any medications?
Yes. Based on its ingredients, Project Bulk has a known interaction with 1,050 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Project Bulk contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is boron safe to take if I'm pregnant or breastfeeding?
No. The safety data advises against boron supplements in pregnancy—high amounts may harm the fetus. There's not enough safety information to use boron while breastfeeding either. Talk with your doctor about whether this product is right for you if you're pregnant, planning pregnancy, or breastfeeding.
What are the most common side effects of Project Bulk?
Boron may cause loss of appetite, skin irritation, or indigestion. DHEA commonly causes acne, headache, insomnia, and mood changes. Bioperine may cause a burning aftertaste or indigestion. In women taking DHEA, voice deepening and irregular periods can occur.
Does DHEA affect hormones, and is it safe long-term?
Yes—DHEA is a hormone precursor and alters hormone levels, so it should only be used under medical guidance. While it's well tolerated short-term at normal doses, long-term oral use carries theoretical concern for increased cancer risk. It's not safe in pregnancy and should be avoided while breastfeeding.
Why does this product contain boron if it's not effective for athletic performance?
The data shows boron is likely effective for boron deficiency and possibly effective for some skin and vaginal conditions, but possibly ineffective for athletic performance. The manufacturer chose these ingredients for their proposed effects; the evidence supporting them for muscle building varies.
What does Bioperine do in this product?
Bioperine is black pepper extract included to enhance the absorption and bioavailability of other nutrients in the formula. However, it also has moderate interactions with several medications—including heart, seizure, HIV, TB, and asthma drugs—so it's important to check with your pharmacist if you take any of those.
Are there any ingredients in Project Bulk that we don't have interaction data for?
Yes. We could not check epicatechin, eucommia ulmoides bark extract, or ajuga turkestanica—we hold no monograph data for those ingredients. If you take medications, mention the full product label to your pharmacist for a complete safety review.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Project Bulk is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Project Bulk label
Go deeper

The Full Monographs Behind Project Bulk’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boron

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...

Read the full Boron monograph → Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

Dhea

Interacts with 776 drugs

DHEA is a natural hormone that the body makes and that declines with age, and it is sold as a supplement claiming many benefits. The evidence is mixed and limited for most uses, and because...

Read the full Dhea monograph → Herb & supplement monograph

Maral Root

Interacts with 122 drugs

Maral Root (Rhaponticum carthamoides) is a Siberian herb used as an 'adaptogen' and is popular among athletes for stamina and muscle building, largely because it contains plant compounds cal...

Read the full Maral Root monograph → Herb & supplement monograph

Sarsaparilla

Interacts with 2 drugs

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited and comes mostly from lab studies, so it...

Read the full Sarsaparilla monograph → Herb & supplement monograph

Ajuga Nipponensis

Ajuga nipponensis is a perennial plant from East Asia used in traditional medicine for cough and respiratory complaints. There is very little human research to confirm any health benefits, s...

Read the full Ajuga Nipponensis monograph →
Sources

Sources & How We Checked

Project Bulk's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 139 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boron 6 references
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
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See these in context on the Dhea monograph →

Maral Root 2 references
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See these in context on the Maral Root monograph →

Sarsaparilla 3 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
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See these in context on the Sarsaparilla monograph →

Ajuga Nipponensis 1 reference
  1. Liao SC, Chiu TF, Chen JC, Lin CC. Ajuga nipponensis Makino poisoning. Clin Toxicol (Phila) 2005;43:583-5.

See these in context on the Ajuga Nipponensis monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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