Boron Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Boron interacts with medications. The heart of this page is the interaction list — every drug Boron is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Boron is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Boron against your medication
Add one medicationDrugs that interact with Boron
0 medications have a known interaction with Boron, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Boron. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Boron combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Boron: Uses, Safety & Side Effects
Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or preliminary, and most people get enough boron from a normal diet. It appears generally safe in low amounts, but high doses can be toxic, so check with your pharmacist or doctor before using it.

- Part used
- Trace mineral (not a plant part)
- Common forms
- Capsules, tablets, liquids; forms include boron citrate, boron glycinate, boron aspartate, and sodium borate
- Bone health
- Joint and arthritis support
- Hormone (testosterone/estrogen) support
- Cognitive function
- Menstrual discomfort
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally safe in small amounts from food and low-dose supplements, but high doses can be toxic.
When used orally and appropriately. Boron is safe in amounts that do not exceed the UL during pregnancy or lactation, which is 20 mg daily in those 19...
Read the full pregnancy detailWhen used orally and appropriately. Boron is safe in amounts that do not exceed the UL during pregnancy or lactation, which is 20 mg daily in those 19...
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Boron is a trace mineral found naturally in soil, water, and many plant foods. It is not made by the body, so the boron you have comes from your diet. Good food sources include fruits (like apples, raisins, and prunes), vegetables, nuts, legumes, and some beverages such as coffee and wine.
Because boron is present in so many common foods, most people get enough through a normal diet and true deficiency is rare. As a supplement, boron is sold in capsules, tablets, and liquids, often in forms like boron citrate, boron glycinate, or sodium borate.
People most often take boron supplements for bone health, joint comfort, and to support hormone levels, though the science behind these uses is still developing.
How it works
Scientists do not fully understand exactly how boron works in the body. One leading idea is that boron influences how the body processes minerals involved in bone health, such as calcium, magnesium, phosphorus, and vitamin D.
Boron may also affect the activity of certain hormones, including sex and steroid hormones, and some laboratory research suggests it may influence inflammation and the way certain enzymes work.
It is important to know that much of this is based on laboratory and animal studies or small human trials. These proposed mechanisms do not guarantee that taking boron supplements will produce a noticeable health benefit.
Does Boron work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
Likely Effective Boron deficiency
Oral boron treats and prevents boron deficiency.
Possibly Effective Radiation dermatitis
Topical application of sodium pentaborate pentahydrate gel to radiation sites may reduce the risk of dermatitis in patients with breast cancer who are receiving radiotherapy.
Possibly Effective Vaginal candidiasis
Boric acid applied intravaginally seems to reduce vaginal candidiasis.
Possibly Ineffective Athletic performance
Oral boron does not seem to improve athletic performance.
Also studied for 10 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Age-related cognitive decline
It is unclear if oral boron is beneficial for age-related cognitive decline.
Insufficient Reliable Evidence To Rate Diabetic foot ulcers
It is unclear if topical boron is beneficial for use in diabetic foot ulcers.
Insufficient Reliable Evidence To Rate Dysmenorrhea
It is unclear if oral boron is beneficial for reducing pain during menstruation.
Insufficient Reliable Evidence To Rate Kidney stones (nephrolithiasis)
It is unclear if boron is beneficial for medical expulsive therapy after extracorporeal shockwave lithotripsy.
Insufficient Reliable Evidence To Rate Kidney transplant
It is unclear if oral boron is beneficial in patients receiving a kidney transplant.
Insufficient Reliable Evidence To Rate Obesity
Although there has been interest in using oral boron for obesity, there is insufficient reliable information about the clinical effects of boron for this purpose.
Insufficient Reliable Evidence To Rate Osteoarthritis
It is unclear if oral boron is beneficial for osteoarthritis symptoms.
Insufficient Reliable Evidence To Rate Osteoporosis
It is unclear if oral boron is beneficial for osteoporosis.
Insufficient Reliable Evidence To Rate Periodontitis
Small clinical studies suggest that adding topical boric acid to scaling and root planing treatment may be beneficial in periodontitis.
Insufficient Reliable Evidence To Rate Tooth extraction
It is unclear if boron is beneficial for use in periodontal healing after impacted third molar surgery.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
The small amounts of boron found in food and in low-dose supplements are generally considered safe for most healthy adults. However, boron can be toxic at high doses, so it should not be taken in large amounts.
Health authorities have set a tolerable upper intake level for adults. Staying within that limit is important, and you should not take more than the product label recommends without medical advice.
People with kidney problems should be especially careful, because the kidneys clear boron from the body. Children and people who are ill should not take boron supplements without guidance from a healthcare professional.
Pregnancy and breastfeeding: Avoid boron supplements during pregnancy and while breastfeeding. High amounts of boron may be harmful to a developing baby, and there is not enough safety data to support supplement use during these times. Getting boron from a normal, balanced diet is fine.
Always talk with your pharmacist or doctor before starting boron, especially if you have a medical condition or take other medications or supplements.
Side effects
At low doses, boron usually causes few or no side effects. At higher doses, it can cause nausea, vomiting, diarrhea, stomach upset, and skin irritation.
Very high or toxic amounts of boron can lead to more serious problems such as headache, restlessness, tremors, and other signs of poisoning. These effects are linked to large overdoses, not normal dietary intake.
If you notice unusual symptoms after taking boron, stop and contact a healthcare provider.
Boron: Reported Adverse Effects
Documented safety reports on Boron from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, boron is generally well tolerated when used in doses below the tolerable upper intake level (UL) of 20 mg. Vaginally, boron is well tolerated.
Most Common Adverse Effects:
Orally: Anorexia, dermatitis, erythema, indigestion.
Vaginally: Burning and pain.
Alopecia Dermatologic
Orally, chronic use of 1 gram daily of boric acid or 25 grams daily of boric tartrate can cause dermatitis and alopecia.
Larger doses can result in acute poisoning. Symptoms of poisoning in adults and children may include skin erythema, desquamation, and exfoliation.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
Anorexia Gastrointestinal
Orally, chronic use of 1 gram daily of boric acid or 25 grams daily of boric tartrate can cause anorexia and indigestion.
Larger doses can result in acute poisoning. Children who have ingested 5 grams or more of borates can have persistent nausea, vomiting, and diarrhea leading to acute dehydration, shock, and coma. Adults who have ingested 15-20 grams of borate can exhibit nausea, vomiting, diarrhea, epigastric pain, hematemesis, and a blue-green discoloration of feces and vomit.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
Cough Pulmonary/Respiratory
Exposure to boric acid and boron oxide dust has been reported to cause mouth and nasal passage irritation, sore throat, and productive cough.
Poisoning Neurologic/CNS
Orally, large doses can result in acute poisoning. Poisoning with boron can cause hyperexcitability, irritability, tremors, convulsions, weakness, lethargy, and headaches.
- Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no official recommended dietary allowance (RDA) for boron, and a standardized supplement dose has not been firmly established. Most people already get boron from foods like fruits, vegetables, nuts, and legumes.
Supplements are usually sold in small milligram amounts. Health authorities have set a safe upper limit for adults, and you should not exceed it. The safest approach is to follow the dose on the product label and not take more than directed.
Before starting boron, check with your pharmacist or doctor to make sure the dose is appropriate for you and that you are not already getting enough from your diet and other supplements.
Boron & Pregnancy
Boron & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 6 references that drive our Boron monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Thai L, Hart LL. Boric acid vaginal suppositories. Ann Pharmacother 1993;27:1355-7.
- Acs N, Banhidy F, Puho E, Czeizel AE. Teratogenic effects of vaginal boric acid treatment during pregnancy. Int J Gynaecol Obstet 2006;93:55-6. PubMed
- Garabrant, D. H., Bernstein, L., Peters, J. M., and Smith, T. J. Respiratory and eye irritation from boron oxide and boric acid dusts. J Occup Med 1984;26(8):584-586. PubMed
- Hjelm C, Harari F, Vahter M. Pre- and postnatal environmental boron exposure and infant growth: results from a mother-child cohort in northern Argentina. Environ Res 2019;171:60-8. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Boron
1,009 brands in our database make a supplement containing Boron.
Supplement products with Boron
9,031 products in our database contain Boron. Open any to see its full ingredient list and every drug interaction we check.
Boron: Common Questions
What is Boron used for, and does it work?
Does Boron interact with prescription medications?
How are Boron interactions rated?
Is it safe to take Boron with my medications?
Where does this Boron interaction information come from?
What is Boron used for?
Do I need a Boron supplement?
Is Boron safe to take?
Can I take Boron during pregnancy or breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Boron
A rotating sample of real supplements in our database that list Boron — open any to see its full ingredients and every drug interaction we check.
- Isochrome by Isotonix
- Basic Nutrient Support Tablet by Pathway To Healing
- Multi-Vita-Min Senior by Wonder Laboratories
- Maximin Pack by Nature Made
- Max For Men Iron Free by Country Life
- Fast & Be Clear by Allergy Research Group
- Focus Factor by Focus Factor
- Prenatal by care/of
- Bone Defense by KAL
- Two-Per-Day Tablets by Life Extension
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