Isochrome Ingredients & Drug Interactions
by Isotonix
What is this page for?
First and foremost: checking Isochrome against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Isochrome is a dietary supplement by Isotonix with 8 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 463 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Coenzyme Q10, Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Isochrome by Isotonix
Ask about any prescription or over-the-counter medication and we check it for interactions with Isochrome by Isotonix — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Isochrome by Isotonix
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Isochrome contains eight active ingredients: vitamin B6, lipase (a digestive enzyme), coenzyme Q10, riboflavin, boron, potassium, L-carnitine, and chromium. Each plays a different role—B vitamins and coenzyme Q10 support energy and cellular function, lipase aids digestion, potassium and chromium support heart and blood sugar regulation, boron supports bone health, and L-carnitine supports energy production and heart function.
The product also contains inactive ingredients including fructose, citric acid, apple fiber, and flavorings.
Does it work?
Strong evidence
The evidence for effectiveness varies by ingredient. Vitamin B6 is effective for sideroblastic anemia and B6 deficiency, and possibly effective for pregnancy-induced nausea.
Coenzyme Q10 is possibly effective for fibromyalgia, migraines, congestive heart failure, and diabetic nerve pain. Riboflavin has no established effectiveness ratings in our data.
Boron is likely effective for boron deficiency and possibly effective for vaginal yeast infections. L-carnitine is effective for L-carnitine deficiency and possibly effective for high cholesterol and congestive heart failure.
Chromium is likely effective for chromium deficiency and possibly effective for type 2 diabetes. Lipase lacks sufficient evidence to rate its effectiveness for the conditions it's used for.
How safe is it?
Well-documented data
Most ingredients are generally well tolerated at typical doses. Vitamin B6 is safe at normal levels, but high doses over time can damage nerves (sensory neuropathy), especially above 1,000 mg daily.
Coenzyme Q10, riboflavin, and L-carnitine are generally well tolerated; common mild side effects include nausea, diarrhea, and gastrointestinal upset. Potassium can cause serious problems at high levels, including irregular heartbeats and dangerously low blood pressure, especially in people with kidney disease.
Chromium and boron are generally safe at typical doses. There is insufficient pregnancy and breastfeeding safety data for most ingredients; talk with your doctor or pharmacist before use if you are pregnant or nursing, especially since boron should be avoided in pregnancy and breastfeeding.
Meds to double-check
Moderate interaction found
Before taking Isochrome, double-check with your pharmacist if you take blood pressure medications (antihypertensive drugs, ACE inhibitors, ARBs, or potassium-sparing diuretics), diabetes or insulin medications, blood thinners like warfarin or acenocoumarol, thyroid hormone (levothyroxine), seizure medications (phenobarbital or phenytoin), heart rhythm drugs like amiodarone, tetracycline antibiotics, or NSAIDs or aspirin. No interactions are documented for lipase among the ingredients we could check.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Isochrome is a multisupplement designed to support energy, digestion, and overall health. If you take blood pressure medications, blood thinners, thyroid medicine, seizure drugs, diabetes medications, or antibiotics, check your specific prescriptions with the tool on this page before starting.
Pregnant or nursing women should speak with their pharmacist first. It's generally well tolerated, but stop if you notice unusual symptoms like nerve tingling, irregular heartbeats, or severe stomach upset.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 8 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Isochrome, straight from the product label.
| Brand | Isotonix |
|---|---|
| Barcode (UPC) | 848570004987 |
| Net contents | 3.5 Ounce(s); 100 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Jun 20, 2024 |
| DSLD ID | 313393 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Isochrome by Isotonix, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin B6 | 2 mg | 118% |
| Calories | 10 Calorie(s) | -- |
| Total Sugars | 2 Gram(s) | -- |
| added Sugars | 2 Gram(s) | 4% |
| Lipase | 5 mg | -- |
| Coenzyme Q10 | 60 mg | -- |
| Total Carbohydrates | 2 Gram(s) | 1% |
| Riboflavin | 3.26 mg | 251% |
| Boron | 2 mg | -- |
| Potassium | 95 mg | 2% |
| L-Carnitine-L-Tartrate | 20 mg | -- |
| Chromium | 215 mcg | 614% |
Other ingredients: Fructose, Citric Acid, Apple Fiber, Silicon Dioxide, Rebaudioside A, Calcium Sulfate, Maltodextrin, Glucose, Luo Han Guo fruit extract, Lemon flavor, Lime flavor, Stearic Acid
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Helps maintain healthy blood sugar levels Increases energy and stamina Supports healthy insulin activity Helps maintain cardiovascular health
This vegan product contains no added wheat, soy, yeast, gluten, starch, salt, preservatives or milk.
Gluten free
Vegan
Brand IP Statement(s)
Isotonix The world's most advanced nutraceuticals
US Patent No. 4,315,927
FDA Statement of Identity
An Isotonic-Capable Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions for use: Pour 1 level, white bottle capful of powder into the overcap. Add water to the line on the overcap (2 fl oz/60ml) and stir. As a dietary supplement, take once daily or as directed by your healthcare provider. Maximum absorption occurs when taken with a meal. This product is isotonic only if the specified amounts of powder and water are used.
Precautions
Warning: If you are currently using prescription drugs or have an ongoing medical condition, consult your healthcare provider before using this product. If you are pregnant or breastfeeding, do not use this product.
Keep out of the reach of children.
Do not use if safety seal is broken or missing. Resale on third-party websites is strictly prohibited unless specifically authorized by Market America or its corporate affiliates. If barcodes are altered or you purchase this product from an unauthorized third-party website, the product is not guaranteed by Market America or its corporate affiliates.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Isochrome by Isotonix label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Isochrome by Isotonix
These are the 8 active ingredients this product is made of. Select any to open its full monograph.
Serving size3.3 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Vitamin B6
Interacts with210 drugs
Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...
Vitamin B6 monograph & interactionsLipase
No knowninteractions
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...
Lipase monograph & interactionsCoenzyme Q10
Interacts with198 drugs
CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...
Coenzyme Q10 monograph & interactionsRiboflavin
Interacts with20 drugs
Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...
Riboflavin monograph & interactionsBoron
No knowninteractions
Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence f...
Boron monograph & interactionsPotassium
Interacts with62 drugs
Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...
Potassium monograph & interactionsL-Carnitine-L-Tartrate
Interacts with19 drugs
L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most...
L-Carnitine-L-Tartrate monograph & interactionsChromium
Interacts with178 drugs
Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...
Chromium monograph & interactionsOther (inactive) ingredients: Fructose, Citric Acid, Apple Fiber, Silicon Dioxide, Rebaudioside A, Calcium Sulfate, Maltodextrin, Glucose, Luo Han Guo fruit extract, Lemon flavor, Lime flavor, Stearic Acid. These complete the product’s ingredient list but are not active constituents.
Isochrome by Isotonix Drug Interactions
HelloPharmacist Interaction Report
Isochrome by Isotonix contains eight active ingredients, and several of them interact with medications.
The most serious interaction is between chromium and antidiabetic drugs (including insulin), which carries Moderate severity and raises the risk of low blood sugar (hypoglycemia). Chromium may also interact with levothyroxine, a thyroid hormone, by reducing how much of it your body absorbs.
Read the full breakdown — every affected drug type, severity by severity
Vitamin B6 in this product interacts with blood pressure medications (antihypertensive drugs), the heart rhythm drug amiodarone, and seizure medications like phenobarbital and phenytoin—all Moderate severity. Coenzyme Q10 and L-carnitine both interact with blood thinners: coenzyme Q10 may decrease warfarin's effectiveness, while L-carnitine may increase it.
Potassium interacts with several blood pressure and heart medications (potassium-sparing diuretics, ACE inhibitors, and angiotensin receptor blockers), raising the risk of dangerously high potassium levels. Riboflavin may reduce the potency of tetracycline antibiotics.
Boron has no documented interactions with medications. NSAIDs and aspirin may increase chromium absorption slightly (Minor severity).
Altogether, these interactions span 460 individual medications.
Use the medication checker below to search your exact prescriptions before starting Isochrome.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Isochrome?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Isochrome interact with 463 drugs. Click any drug to see the details.
6 of the 8 ingredients in Isochrome interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Coenzyme Q10 Chromium Potassium Riboflavin L-Carnitine-L-Tartrate
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Isochrome — through 1 ingredient. Tap an ingredient for the detail:
ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Isochrome — through 2 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Acebutolol interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Isochrome — through 1 ingredient. Tap an ingredient for the detail:
L-carnitine-l-tartrateAcenocoumarol (sintrom) Moderate
Interaction Summary
Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
Read the full L-carnitine-l-tartrate + Acenocoumarol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Isochrome — through 2 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Acetazolamide interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Isochrome — through 1 ingredient. Tap an ingredient for the detail:
ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Isochrome — through 1 ingredient. Tap an ingredient for the detail:
ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium + Albiglutide interactionAliskirenTekturna
How Aliskiren interacts with Isochrome — through 2 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Aliskiren interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Isochrome — through 1 ingredient. Tap an ingredient for the detail:
ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Isochrome — through 1 ingredient. Tap an ingredient for the detail:
ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Isochrome — through 1 ingredient. Tap an ingredient for the detail:
ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium + Alogliptin, Pioglitazone interactionAltretamineHexalen
How Altretamine interacts with Isochrome — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10Alkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10 + Altretamine interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Isochrome — through 2 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Ambrisentan interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Isochrome — through 3 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amiloride interactionPotassiumPotassium-sparing Diuretics Moderate
Interaction Summary
Concomitant use increases the risk of hyperkalemia.
Read the full Potassium + Amiloride interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Isochrome — through 3 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amiloride, Hydrochlorothiazide interactionPotassiumPotassium-sparing Diuretics Moderate
Interaction Summary
Concomitant use increases the risk of hyperkalemia.
Read the full Potassium + Amiloride, Hydrochlorothiazide interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Amiloride, Hydrochlorothiazide interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Isochrome — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Amiodarone (cordarone) Moderate
Interaction Summary
Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Read the full Vitamin B6 + Amiodarone interactionAmlodipineNorliqva
How Amlodipine interacts with Isochrome — through 2 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amlodipine interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Isochrome — through 2 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amlodipine Benzoate interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Isochrome — through 2 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amlodipine Besilate interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Isochrome — through 2 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amlodipine Besylate interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Isochrome — through 3 ingredients. Tap an ingredient for the detail:
PotassiumAce Inhibitors (aceis) Moderate
Interaction Summary
Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
Read the full Potassium + Amlodipine Besylate, Benazepril interactionVitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amlodipine Besylate, Benazepril interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Isochrome — through 3 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amlodipine, Celecoxib interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Amlodipine, Celecoxib interactionChromiumNonsteroidal Anti-inflammatory Drugs (nsaids) Minor
Interaction Summary
NSAIDs might increase chromium levels in the body.
Read the full Chromium + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Isochrome — through 2 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Ammonium Chloride interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Ammonium Chloride interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Isochrome — through 1 ingredient. Tap an ingredient for the detail:
RiboflavinTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
Read the full Riboflavin + Amphotericin, Tetracycline interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Isochrome — through 1 ingredient. Tap an ingredient for the detail:
ChromiumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Read the full Chromium + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with Isochrome — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Aprobarbital, Butabarbital, Phenobarbital interactionAprocitentanTryvio
How Aprocitentan interacts with Isochrome — through 2 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Aprocitentan interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Aprocitentan interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with Isochrome — through 2 ingredients. Tap an ingredient for the detail:
Vitamin B6Phenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Vitamin B6 + Aspirin, Codeine Phosphate, Phenobarbital interactionChromiumAspirin, Nonsteroidal Anti-inflammatory Drugs (nsaids) Minor
Interaction Summary
Theoretically, aspirin might increase chromium absorption.
Read the full Chromium + Aspirin, Codeine Phosphate, Phenobarbital interactionAtenololAtenix, Tenormin
How Atenolol interacts with Isochrome — through 2 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Atenolol interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Isochrome — through 2 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Atenolol, Chlortalidone interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Isochrome — through 2 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Atenolol, Chlorthalidone interactionCoenzyme Q10Antihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Atenolol, Chlorthalidone interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Isochrome with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin B6
Amiodarone (Cordarone)
Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.
Antihypertensive Drugs
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.
Phenobarbital (Luminal)
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.
Phenytoin (Dilantin)
High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.
Levodopa
Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.
Coenzyme Q10
Alkylating Agents
Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.
Warfarin (Coumadin)
Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.
Antihypertensive Drugs
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.
Chromium
Antidiabetes Drugs
Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.
Insulin
Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,
Levothyroxine (Synthroid, Others)
Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.
Aspirin
Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)
NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.
Potassium
Ace Inhibitors (Aceis)
Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Angiotensin Receptor Blockers (Arbs)
Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Potassium-Sparing Diuretics
Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.
Riboflavin
Tetracycline Antibiotics
Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.
L-Carnitine-L-Tartrate
Acenocoumarol (Sintrom)
Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.
Thyroid Hormone
Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.
Warfarin (Coumadin)
Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.
Brand information
Manufacturer and brand details for Isochrome, from the product label.
Isotonix
See all Isotonix products- Name
- Market America, Inc.
- Street Address
- 1302 Pleasant Ridge Road
- City
- Greensboro
- State
- NC
- ZipCode
- 27409
Isochrome by Isotonix: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Isochrome’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Vitamin B6
Interacts with 210 drugsVitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...
Read the full Vitamin B6 monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographCoenzyme Q10
Interacts with 198 drugsCoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...
Read the full Coenzyme Q10 monograph → Herb & supplement monographRiboflavin
Interacts with 20 drugsRiboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...
Read the full Riboflavin monograph → Herb & supplement monographBoron
Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...
Read the full Boron monograph → Herb & supplement monographPotassium
Interacts with 62 drugsPotassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...
Read the full Potassium monograph → Herb & supplement monographL-carnitine
Interacts with 19 drugsL-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most clearly useful for people with a true ca...
Read the full L-carnitine monograph → Herb & supplement monographChromium
Interacts with 178 drugsChromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...
Read the full Chromium monograph →Sources & How We Checked
Isochrome's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 190 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin B6 32 references
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- Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
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Lipase 1 reference
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Coenzyme Q10 40 references
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- Engelsen J, Nielsen JD, Winther K. Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial. Thromb Haemost 2002;87:1075-6. DOI
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Riboflavin 5 references
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Boron 6 references
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Potassium 12 references
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L-carnitine 41 references
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