Drug & supplement interaction

Vitamin B6 + Bisoprolol

Bisoprolol brand name: Zebeta.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Vitamin B6 has a moderate interaction with Bisoprolol. Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Vitamin B6 and Bisoprolol

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIHYPERTENSIVE DRUGS

Why this applies to Bisoprolol

Bisoprolol falls under ANTIHYPERTENSIVE DRUGS — the group Vitamin B6 interacts with.

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the short version: bisoprolol already lowers your blood pressure and slows your heart rate. The interesting part with vitamin B6 is that high doses may gently nudge blood pressure down too, possibly by lowering some of the stress hormones (like adrenaline) that keep pressure up. So the two together could have a small added blood-pressure-lowering effect.

If your pressure drops a little too far, you might feel dizzy, lightheaded, or extra tired, especially when standing up quickly. The evidence here is fairly mild and mostly tied to high-dose B6, not the B6 you get from food, which is unlikely to matter. This isn't a reason to stop anything. Just check with your pharmacist or doctor before starting a high-dose B6 supplement so they can keep an eye on your numbers.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  2. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  3. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  4. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Vitamin B6 Also Interacts With Other Medications

Vitamin B6 has 204 moderate, 5 minor known drug interactions in our database — the Bisoprolol one above is one of them. If you take anything else, check it against the full list below.

Moderate 204 Minor 5 No known interaction 2,621 (incl. Bisoprolol)
Taking anything else?

Check Another of Your Medications Against Vitamin B6

Covers the 2,830 medications we’ve checked against Vitamin B6. Pick one to open its full report.

From our Q&A

Questions About Vitamin B6 or Bisoprolol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Vitamin B6 or Bisoprolol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Bisoprolol

This page covers Vitamin B6 only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bisoprolol page lists 183 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Indian Snakeroot (major) and Tyramine (major).

By severity: 5 major · 151 moderate · 27 minor.

From our pharmacist’s overview on the Bisoprolol page

“Bisoprolol (Zebeta) slows your heart and lowers your blood pressure, so treat these 183 supplement interactions as a genuine concern rather than fine print, and learn the five rated major first. Most of the list, 119 ingredients in all, either adds to bisoprolol's pressure-lowering effect or works against it, so your numbers can drift…”

Reviewed by 2 · Jul 18, 2026

Open the Bisoprolol interaction page

One more smart check

Taking Vitamin B6 as Part of a Dietary Supplement Product? Check It for Interactions

We hold 24,838 real supplement products containing Vitamin B6, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Vitamin B6. Your product may carry other ingredients that interact with Bisoprolol too, on top of Vitamin B6 — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Vitamin B6 and Bisoprolol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Vitamin B6
Top 10

#3 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bisoprolol
Top 5%

#62 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Vitamin B6

What is Vitamin B6?

  • Morning sickness in pregnancy
  • Premenstrual syndrome (PMS)
  • Preventing or treating B6 deficiency
  • Nerve health and metabolism support
  • Nausea

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-related nausea and may help some people with PMS, but taking very high doses for long periods can cause nerve damage. Get most of your B6 from food, and check with a pharmacist or doctor before taking high-dose supplements.

Read the full Vitamin B6 monograph & all interactions
Medication

About Bisoprolol

What Is Bisoprolol Used For?

Brand name: Zebeta

Bisoprolol fumarate tablets are used to manage high blood pressure (hypertension). Lowering blood pressure reduces the strain on the heart and blood vessels, helping prevent serious complications over time.

It can be used on its own or combined with other blood pressure-lowering medicines, such as thiazide diuretics. All supported products — including those labeled as Bisoprolol and Bisoprolol Fumarate — share this indication.

See full Bisoprolol drug information
Keep checking

Other Drugs & Vitamin B6

Browse every other medication we’ve checked against Vitamin B6 — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
204Moderate
5Minor
2,620No known interaction
204 Moderate 5 Minor 2,620 No interaction
Moderate

204 interactions

Showing 60 of 204 moderate interactions — see all 204 on the Vitamin B6 page.

Minor

5 interactions

No interaction 2,620 drugs checked — show the list

We also checked Vitamin B6 against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,620 medications checked with no known interaction — see the full Vitamin B6 list.

See the full Vitamin B6 interactions page
See every supplement checked against Bisoprolol, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Vitamin B6 monograph › Uses, safety, and every drug interaction in one place Bisoprolol supplement interactions › Every supplement checked against Bisoprolol, ranked by severity Bisoprolol drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Vitamin B6 and Bisoprolol Together: Common Questions

Can you take Vitamin B6 with Bisoprolol?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Vitamin B6 and Bisoprolol interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Bisoprolol and Vitamin B6?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.