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Bisoprolol

Bisoprolol is a beta-blocker tablet used to treat high blood pressure (hypertension), alone or alongside other blood pressure medicines.

Brand name Zebeta
Drug classes Adrenergic Beta-antagonists
Rx Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 32 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 5, 2026
Bisoprolol at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Bisoprolol (Zebeta) is a once-daily beta-blocker for high blood pressure that mainly targets the heart, slowing its rate and easing how hard it pumps; on the market since about 1992 and available generically, it is usually an add-on rather than a first choice. Most people tolerate it well, and tiredness, a slower pulse and mild dizziness are the usual complaints, often easing after a few weeks. The rule that matters most is never stopping it suddenly, which can trigger chest pain, heart rhythm problems or a heart attack, so any stop should be a slow, planned taper. With asthma or COPD it needs real caution.

Clinical pearls

  • If you have diabetes, it can hide the racing heartbeat of low blood sugar, so watch for sweating and check your glucose.
  • If you take clonidine too and both are being stopped, bisoprolol comes off first to avoid a dangerous blood pressure spike.
  • Verapamil, diltiazem and digoxin can slow the heart too much alongside it, so make sure every prescriber knows you take it.
  • Before major surgery, tell your surgeon and anesthesiologist, and know an epinephrine pen may work less well while you take it.
How we write & review this content — our editorial policy →
How you get itPrescription only
Comes asTablet
Earliest FDA record1992
Companies listing it with the FDA23
FDA label last updatedJan 14, 2021
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Bisoprolol, written from its FDA label.

What Bisoprolol is used for

▾

Bisoprolol fumarate tablets are approved for one main use across all supported products:

  • High blood pressure (hypertension) — both Bisoprolol and Bisoprolol Fumarate tablets are indicated for this, used alone or alongside other antihypertensive (blood pressure-lowering) medicines such as thiazide diuretics

How Bisoprolol works

▾

Bisoprolol works by blocking beta-1 receptors — chemical switches found mainly in the heart. When these receptors are blocked, the heart beats more slowly and with less force, which lowers blood pressure. It may also reduce blood pressure by decreasing the release of a kidney hormone called renin and by dialing down nerve signals that would otherwise raise blood pressure.

Bisoprolol is considered cardioselective — it preferentially targets the heart over the lungs and blood vessels. However, this selectivity is not absolute at higher doses, so the lowest effective dose is always preferred, especially in people with breathing conditions.

Bisoprolol dosage

▾

Bisoprolol fumarate tablets are taken once daily by mouth, with or without food. Absorption is not affected by eating. Dose is individualized — your prescriber will decide the right amount for you and may adjust it over time based on your response.

  • Steady blood pressure control is typically reached within a few days of consistent once-daily dosing
  • People with significant kidney impairment (creatinine clearance below 40 mL/min) or liver disease (hepatitis or cirrhosis) should start at a lower dose with careful increases
  • Elderly patients generally do not need a dose adjustment unless kidney or liver function is significantly reduced
  • There is no established dosing experience for children

Dosing details from the FDA-approved label

From the Bisoprolol prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Hypertension (usual starting dose)
    • The usual starting dose is 5 mg once daily
    • In some patients, 2.5 mg may be an appropriate starting dose
    • If the antihypertensive effect of 5 mg is inadequate, the dose may be increased to 10 mg and then, if necessary, to 20 mg once daily
    • Maximum: 20 mg once daily
    • Dose must be individualized to the needs of the patient.
  • Patients with renal or hepatic impairment (hepatitis or cirrhosis, or creatinine clearance less than 40 mL/min)
    • The initial daily dose should be 2.5 mg and caution should be used in dose-titration
    • Limited data suggest bisoprolol is not dialyzable, so drug replacement is not necessary in patients undergoing dialysis.
  • Geriatric patients
    • It is not necessary to adjust the dose in the elderly, unless there is also significant renal or hepatic dysfunction
    • Adjust only if significant renal or hepatic dysfunction is present.
  • Pediatric patients
    • There is no pediatric experience with bisoprolol fumarate tablets
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION The dose of bisoprolol fumarate tablets must be individualized to the needs of the patient. The usual starting dose is 5 mg once daily. In some patients, 2.5 mg may be an appropriate starting dose (see Bronchospastic Disease in WARNINGS ). If the antihypertensive effect of 5 mg is inadequate, the dose may be increased to 10 mg and then, if necessary, to 20 mg once daily. Patients with Renal or Hepatic Impairment In patients with hepatic impairment (hepatitis or cirrhosis) or renal dysfunction (creatinine clearance less than 40 mL/min), the initial daily dose should be 2.5 mg and caution should be used in dose-titration. Since limited data suggest that bisoprolol fumarate is not dialyzable, drug replacement is not necessary in patients undergoing dialysis. Geriatric Patients It is not necessary to adjust the dose in the elderly, unless there is also significant renal or hepatic dysfunction (see above and Geriatric Use in PRECAUTIONS ). Pediatric Patients There is no pediatric experience with bisoprolol fumarate tablets.

Read the full Dosage and Administration section on DailyMed →

Bisoprolol side effects

▾

Most people tolerate bisoprolol well. The most commonly reported side effects include:

Common side effects

  • Fatigue or low energy
  • Headache
  • Dizziness
  • Diarrhea
  • Cough
  • Runny or stuffy nose (rhinitis)
  • Slow heartbeat (bradycardia)
  • Swelling in the hands or feet
  • Dry mouth
  • Insomnia or vivid dreams

When to get medical help

  • Call your doctor if you notice signs of worsening heart failure: new or increasing shortness of breath, rapid weight gain, or swelling
  • Do not stop bisoprolol suddenly — abrupt stopping can trigger chest pain (angina), abnormal heart rhythms, or heart attack, especially if you have coronary artery disease
  • Seek emergency help if you have a severe allergic reaction: swelling of the face or throat, difficulty breathing
  • Tell your doctor right away if you feel your heart beating very slowly or if you faint
  • If you have diabetes, be aware that bisoprolol can mask a fast heartbeat that normally warns you of low blood sugar

Serious reactions — including signs of worsening heart failure (sudden shortness of breath, leg swelling), a dangerously slow or irregular heartbeat, or severe allergic reactions (throat swelling, trouble breathing) — need immediate medical attention.

Bisoprolol warnings and precautions

▾
  • Never stop bisoprolol suddenly if you have coronary artery disease. Abrupt discontinuation can cause chest pain (angina), heart attack, or dangerous heart rhythms. Taper slowly under your doctor's supervision.
  • Heart failure: Beta-blockers can worsen pump function. Bisoprolol should generally be avoided in overt heart failure; it can be used cautiously only in stable, compensated cases under close monitoring.
  • Breathing conditions: Bisoprolol is generally not recommended for people with asthma or COPD. If it must be used, the lowest possible dose should be prescribed and a bronchodilator (rescue inhaler) kept on hand.
  • Diabetes: Bisoprolol can mask the fast heartbeat that warns you of low blood sugar. Diabetic patients on insulin or oral diabetes medicines should be aware of this and monitor carefully.
  • Thyroid disease: Bisoprolol can hide the symptoms of an overactive thyroid. Stopping it abruptly when thyroid disease is present can trigger a dangerous condition called thyroid storm.
  • Surgery: Tell your anesthesiologist and surgeon you take bisoprolol. It should not be routinely stopped before major surgery, but it can affect how your heart responds to anesthesia.
  • Severe allergies: People with a history of severe anaphylactic reactions may not respond to the normal dose of epinephrine used in an emergency while on bisoprolol.

Bisoprolol interactions

▾

Bisoprolol can interact with several medications that also affect the heart or blood pressure:

  • Other beta-blockers — never combine; additive effects are dangerous
  • Verapamil and diltiazem (certain calcium channel blockers) — can cause excessive slowing of the heart and conduction problems
  • Digoxin — both drugs slow the heart; combining them raises the risk of bradycardia (dangerously slow heartbeat)
  • Clonidine — if both are being stopped, bisoprolol should be tapered first; stopping clonidine first can cause a sudden dangerous rise in blood pressure
  • Reserpine / guanethidine — combined use can cause an excessive drop in heart rate and blood pressure
  • Disopyramide (an antiarrhythmic drug) — additive effects on heart conduction
  • Rifampin — speeds up the body's clearance of bisoprolol, potentially reducing its blood pressure-lowering effect
  • Epinephrine — people taking bisoprolol who have a history of severe allergic reactions may not respond to the usual doses of epinephrine used in emergencies

Interactions listed in the FDA-approved label

From the Bisoprolol prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Other beta-blocking agents: The label states bisoprolol fumarate should not be combined with other beta-blocking agents. Should not be combined.
  • Catecholamine-depleting drugs (reserpine, guanethidine): The added beta-adrenergic blocking action of bisoprolol may produce excessive reduction of sympathetic activity. Patients should be closely monitored.
  • Clonidine: Concurrent therapy with clonidine is addressed in the label for when therapy is to be discontinued. If therapy is to be discontinued, it is suggested that bisoprolol be discontinued for several days before the withdrawal of clonidine.
  • Myocardial depressants or inhibitors of AV conduction (certain calcium antagonists such as verapamil and diltiazem; antiarrhythmics such as disopyramide): These drugs are myocardial depressants or inhibitors of AV conduction when used concurrently with bisoprolol. Use bisoprolol with care.
  • Digitalis glycosides: Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate; concomitant use can increase the risk of bradycardia.
  • Rifampin: Rifampin increases the metabolic clearance of bisoprolol, resulting in a shortened elimination half-life. Initial dose modification is generally not necessary.
  • Thiazide diuretics and cimetidine: Pharmacokinetic studies document no clinically relevant interactions.
  • Warfarin: There was no effect of bisoprolol on prothrombin time in patients on stable doses of warfarin.
  • Epinephrine / allergens (risk of anaphylactic reaction): While taking beta-blockers, patients with a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge, and may be unresponsive to the usual doses of epinephrine used to treat allergic reactions.
Read the label’s full interactions text

Drug Interactions Bisoprolol fumarate should not be combined with other beta-blocking agents. Patients receiving catecholamine-depleting drugs, such as reserpine or guanethidine, should be closely monitored, because the added beta-adrenergic blocking action of bisoprolol fumarate tablets may produce excessive reduction of sympathetic activity. In patients receiving concurrent therapy with clonidine, if therapy is to be discontinued, it is suggested that bisoprolol fumarate tablets be discontinued for several days before the withdrawal of clonidine. Bisoprolol fumarate should be used with care when myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists [particularly of the phenylalkylamine (verapamil) and benzothiazepine (diltiazem) classes], or antiarrhythmic agents, such as disopyramide, are used concurrently. Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia. Concurrent use of rifampin increases the metabolic clearance of bisoprolol fumarate, resulting in a shortened elimination half-life of bisoprolol fumarate. However, initial dose modification is generally not necessary. Pharmacokinetic studies document no clinically relevant interactions with other agents given concomitantly, including thiazide diuretics and cimetidine. There was no effect of bisoprolol fumarate on prothrombin time in patients on stable doses of warfarin. Risk of Anaphylactic Reaction While taking beta-blockers, patients with a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge, either accidental, diagnostic or therapeutic. Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reactions.

Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿183 supplements and herbs with documented Bisoprolol interactions, ranked by severity Check Bisoprolol against a supplement or herb →

Before taking Bisoprolol

▾
  • Do not take bisoprolol if you have cardiogenic shock, overt heart failure, a second- or third-degree heart conduction block, or a marked resting slow heartbeat (sinus bradycardia)
  • Tell your doctor if you have asthma or COPD — bisoprolol is generally not recommended; if used at all, it requires extra caution and close monitoring
  • Tell your doctor about any kidney or liver problems — those with significant impairment need a lower starting dose
  • Tell your doctor if you have diabetes — bisoprolol can hide low blood sugar warning signs
  • Tell your doctor about any thyroid conditions — bisoprolol masks hyperthyroid symptoms and should not be stopped abruptly if thyroid disease is present
  • Tell your doctor about peripheral vascular disease (poor leg or arm circulation) — bisoprolol may worsen symptoms
  • Alert your surgeon and anesthesiologist before any procedure
  • Children: No established experience with bisoprolol fumarate tablets in pediatric patients
  • Older adults: No routine dose adjustment needed unless kidney or liver function is significantly reduced

Bisoprolol overdose

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Taking too much bisoprolol can cause a dangerously slow heartbeat, very low blood pressure, worsening heart failure, bronchospasm (airway tightening), and low blood sugar. If you suspect an overdose, stop the medicine and seek emergency medical care immediately. Bisoprolol is not removed effectively by dialysis, so supportive hospital treatment is the primary approach.

What Bisoprolol does in the body

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Bisoprolol's most prominent effect on the body is slowing the heart rate — both at rest and during exercise. It also reduces how much blood the heart pumps out with each minute (cardiac output), without significantly changing the amount pumped per beat (stroke volume). Its effects on blood pressure last for a full 24 hours with once-daily dosing, and the peak effect on heart rate occurs within 1 to 4 hours after a dose. Bisoprolol also slows electrical conduction through the heart's AV node, which is why it is contraindicated in people who already have significant conduction block.

How your body processes Bisoprolol

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Taken by mouth, bisoprolol is well absorbed — about 80% of the dose reaches the bloodstream — and food does not affect this. It reaches peak blood levels within 2 to 4 hours of dosing, and its effects last long enough to make once-daily dosing effective. The body clears bisoprolol about equally through the kidneys and through the liver (as inactive breakdown products), with a half-life of roughly 9 to 12 hours in most adults. In people with significant kidney impairment or liver disease such as cirrhosis, the drug stays in the body longer, which is why lower starting doses and careful monitoring are needed in those groups.

How to store Bisoprolol

▾

Store at 20 o C to 25 o C (68 o Fto 77 o F); excursions permitted to 15 o C to 30 o C (59 o Fto 86 o F) . Protect from moisture. Dispense in tight, light resistant containers.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

183

Supplements & herbs that interact with Bisoprolol

183 supplements and herbal products have documented interactions with Bisoprolol in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 5
  • Moderate · 151
  • Minor · 27
ACTIVATED CHARCOAL Major AMERICAN HELLEBORE Major AMERICAN MISTLETOE Major INDIAN SNAKEROOT Major TYRAMINE Major 1,3-DMAA Moderate ACACIA RIGIDULA Moderate ACTIVE HEXOSE CORRELATED COMPOUND (AHCC) Moderate +175 more
Every supplement checked against Bisoprolol — ranked by severity The full interaction hub: 5 major · 151 moderate · 27 minor · every one linked to its full report. Check Bisoprolol against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

1

Nutrient depletion considerations

Bisoprolol has been associated with lower levels of 1 nutrient in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

COENZYME Q10 Insufficient Evidence
See the full Bisoprolol nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Bisoprolol: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Bisoprolol — the kind of thing our pharmacy team would talk through with you at the counter.

What is bisoprolol actually used for?

▾
Bisoprolol is used to lower high blood pressure (hypertension). It works by slowing your heart rate and reducing the force of each heartbeat, which takes pressure off your arteries. It can be used on its own or combined with other blood pressure medicines. Keeping blood pressure under control reduces your long-term risk of serious complications.

Can I stop taking bisoprolol if I feel fine?

▾
Please don't stop it suddenly without talking to your doctor first. Even if you feel great, stopping bisoprolol abruptly — especially if you have any underlying heart disease — can trigger chest pain, an abnormal heart rhythm, or even a heart attack. If you and your doctor decide to stop it, the plan is usually to taper the dose down gradually over about a week while keeping a close eye on how you feel.

Is it okay to take bisoprolol if I have asthma or a breathing condition?

▾
Beta-blockers like bisoprolol generally aren't recommended if you have asthma or COPD because they can cause airway tightening (bronchospasm). That said, bisoprolol is more heart-selective than many other beta-blockers, so in some cases where other options have failed, a doctor may cautiously consider it at the lowest possible dose — with a bronchodilator (rescue inhaler) kept close by. This is a conversation worth having openly with your prescriber.

I have diabetes. Does bisoprolol affect my blood sugar?

▾
Bisoprolol won't directly raise or lower your blood sugar, but it can hide one of the warning signs of low blood sugar — a fast heartbeat. If you take insulin or diabetes pills, you should be extra alert to other low blood sugar symptoms like sweating, shakiness, or feeling faint. Let your doctor know you're on bisoprolol so they can factor this into your diabetes management.

What side effects should I actually watch out for?

▾
Most people tolerate bisoprolol well. Fatigue, dizziness, and headache are the most common complaints, especially early on. A slower heart rate is expected — that's actually part of how it works. What you'd want to call your doctor about right away is if you feel your heart beating very slowly, notice sudden shortness of breath or swelling in your legs, or feel like you might pass out. A severe allergic reaction — swelling of the face or throat, difficulty breathing — is a medical emergency.

Are there medications I should avoid while taking bisoprolol?

▾
A few important ones: don't take another beta-blocker at the same time. Certain heart medicines — like verapamil, diltiazem, digoxin, or disopyramide — can slow your heart too much when combined with bisoprolol, so your doctor will monitor you carefully if those are needed. If you're also on clonidine for blood pressure and need to stop both, bisoprolol should be stopped first. And if you take rifampin (an antibiotic), it can reduce how well bisoprolol works. Always share your full medication list with every provider and pharmacist.

Is Bisoprolol available over the counter?

▾
No. Bisoprolol is a prescription medicine: every Bisoprolol product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Bisoprolol first available?

▾
The earliest FDA record we hold for Bisoprolol is from 1992: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Bisoprolol was first used.

Who makes Bisoprolol?

▾
23 companies currently list Bisoprolol products in the FDA's NDC Directory, including Bryant Ranch Prepack, Advagen Pharma Ltd, TruPharma, LLC. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Bisoprolol on HelloPharmacist

📊Bisoprolol supplement interactions183 checked — ranked by severity 🌿Drug & Supplement CheckerBisoprolol vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Bisoprolol NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Bisoprolol Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Bisoprolol forms and strengths (how it comes)

Bisoprolol is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Tablet

By mouth
How this form is used
What it may be used for
  • Bisoprolol Fumarate tablets are used to manage high blood pressure (hypertension)
  • Bisoprolol tablets are used to manage high blood pressure (hypertension)
  • Both Bisoprolol and Bisoprolol Fumarate tablets may be used alone or combined with other blood pressure medicines
Important instructions
  • Take Bisoprolol and Bisoprolol Fumarate tablets by mouth once a day
  • Bisoprolol and Bisoprolol Fumarate tablets can be taken with or without food
  • Do not stop Bisoprolol or Bisoprolol Fumarate tablets suddenly — always follow your doctor's guidance on tapering
  • For patients with significant kidney or liver problems, Bisoprolol Fumarate tablet dosing should start lower and be increased with caution under medical supervision
Available strengths 3 strengths
2.5 mg 5 mg 10 mg
75 FDA-listed product records ⓘ

Bisoprolol on the U.S. market: products, makers and brands

How Bisoprolol appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

23 companies list 49 Bisoprolol product records with the FDA, mostly as tablet; the earliest marketing or approval year on record is 1992. Brand names on the directory include Zebeta; the rest are generics.

1
Dose forms ⓘ
23
Labelers (makers, repackagers, distributors)
2
Brand names
49
FDA-listed product records ⓘ
1992
Earliest FDA record ⓘ

Also listed with the FDA, not a patient dose form: Powder (12) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack14%
Advagen Pharma Ltd6%
TruPharma, LLC6%
Alembic Pharmaceuticals Inc.4%
Alembic Pharmaceuticals Limited4%
Aurobindo Pharma Limited4%
Other makers61%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Bisoprolol is used (Medicaid data)

A general measure of how commonly Bisoprolol is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Bisoprolol is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

130,591
Medicaid prescriptions filled (Q1–Q4 2025)
$2.5M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Bisoprolol prescribed? Of the 1,601 medications we measure, Bisoprolol ranks #471 by Medicaid prescriptions — more than 71% of them.

Where Bisoprolol ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #471 of 1,601
#466 Liothyronine 133,453 Rx #467 Dextroamphetamine 132,973 Rx #468 Epinephrine / Lidocain... 132,083 Rx #469 Tranexamic Acid 131,595 Rx #470 Olanzapine / Samidorph... 130,976 Rx #471 Bisoprolol 130,591 Rx #472 Miconazole 130,151 Rx #473 Bisacodyl Rectal 127,528 Rx #474 Fluphenazine 127,346 Rx #475 Adapalene 126,305 Rx #476 Misoprostol 125,269 Rx

Utilization by Bisoprolol product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 5 mg oral tablet is the most-dispensed Bisoprolol product — about 78% of these Medicaid prescriptions.

bisoprolol fumarate 5 MG Oral Tablet Most dispensed

102,214 Medicaid prescriptions (Q1–Q4 2025) 78% of Bisoprolol prescriptions shown $1.8M gross reimbursement (before rebates) ≈ $18 per prescription (gross)

Summed across the 17 of 72 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 854905

bisoprolol fumarate 10 MG Oral Tablet

27,217 Medicaid prescriptions (Q1–Q4 2025) 21% of Bisoprolol prescriptions shown $574,405 gross reimbursement (before rebates) ≈ $21 per prescription (gross)

Summed across the 16 of 60 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 854901

bisoprolol fumarate 2.5 MG Oral Tablet

1,160 Medicaid prescriptions (Q2–Q4 2025) <1% of Bisoprolol prescriptions shown $148,501 gross reimbursement (before rebates) ≈ $128 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 865155

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Bisoprolol, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 34 of 134 listed Bisoprolol NDCs with Medicaid activity.

Compare Bisoprolol products

A representative set of FDA-listed product records for Bisoprolol — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 49 of 49 products — FDA National Drug Code Directory. See every product, package size and price: browse all 49 Bisoprolol NDCs →

Bisoprolol side effects reported to the FDA (FAERS)

After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Bisoprolol — a signal of what to watch for, not proof the drug caused it.

The effects most often named in FDA reports that mention Bisoprolol are dyspnoea, acute kidney injury, fatigue; about 97% of the reports were classed as serious. These are voluntary reports, so they show what people report, not how often it happens.

135,644
Reports mentioning it
97%
Reported as serious
12
Distinct effects shown
Most reported effects
Dyspnoea
9,192
Acute Kidney Injury
7,221
Fatigue
7,175
Diarrhoea
6,669
Nausea
6,461
Dizziness
6,225
Drug Interaction
5,803
Hypotension
5,463
Fall
5,417
Vomiting
5,032
Age groups
Elderly · 18,365Adult · 7,987Neonate · 219Adolescent · 50Child · 30Infant · 26

Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Bisoprolol in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.

Bisoprolol FDA approval history

How Bisoprolol went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.

Bisoprolol was first approved by the FDA in 1992 (Brand: ZEBETA · Teva Branded Pharm); the first generic version was approved in 2000. It remains available in U.S. pharmacies today.

1992
Brand approved
Brand: ZEBETA · Teva Branded Pharm
2000
First generic approved
Lower-cost ANDA competition begins
2026
Available today
Active in U.S. pharmacies

Source: Drugs@FDA.

Bisoprolol recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Bisoprolol recalls since July 2021.

✅No Bisoprolol recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Bisoprolol RxCUI 19484 1 dose form · 6 strengths
  1. Dose form (SCDF) Oral Tablet RxCUI 371104 In current FDA listings
    Clinical drug / strength (SCD) fumarate 1.25 MG RxCUI 865154 fumarate 10 MG RxCUI 854901 fumarate 2.5 MG RxCUI 865155 fumarate 3.75 MG RxCUI 865157 fumarate 5 MG RxCUI 854905 fumarate 7.5 MG RxCUI 865159

Look up RxCUI 19484 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Bisoprolol costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Tablet, Film Coated · Oral 5 mg $0.114 per tablet NDC details & price history
Tablet, Film Coated · Oral 10 mg $0.160 per tablet NDC details & price history
Tablet, Film Coated · Oral 2.5 mg $2.52 per tablet NDC details & price history
Tablet · Oral 5 mg $0.114 per tablet NDC details & price history
Tablet · Oral 10 mg $0.160 per tablet NDC details & price history
Tablet, Film Coated 5 mg $0.114 per tablet NDC details & price history
Tablet, Film Coated 10 mg $0.160 per tablet NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Bisoprolol brand names

Bisoprolol is sold under one brand name in the FDA directory — Zebeta. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Zebeta

Who makes Bisoprolol: manufacturers and labelers

23 companies list Bisoprolol products with the FDA. By number of product records, the largest are Bryant Ranch Prepack, Advagen Pharma Ltd, TruPharma, LLC. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Bryant Ranch Prepack 7 Advagen Pharma Ltd 3 TruPharma, LLC 3 Alembic Pharmaceuticals Inc. 2 Alembic Pharmaceuticals Limited 2 Aurobindo Pharma Limited 2 Golden State Medical Supply, Inc. 2 Harman Finochem Limited 2 Micro Labs Limited 2 Natco Pharma USA LLC 2 NorthStar Rx LLC 2 Novitium Pharma LLC 2 PD-Rx Pharmaceuticals, Inc. 2 Rising Pharma Holdings, Inc. 2 Solco Healthcare US, LLC 2 Sun Pharmaceutical Industries Limited 2 Unichem Pharmaceuticals (USA), Inc. 2 Viona Pharmaceuticals Inc 2 Zydus Lifesciences Limited 2 American Health Packaging 1 AvPAK 1 Preferred Pharmaceuticals Inc. 1 Proficient Rx LP 1

Bisoprolol drug class (RxNorm)

Bisoprolol belongs to the beta-Adrenergic Blocker class.

Pharmacologic class beta-Adrenergic Blocker
Drug family (ATC) Beta blocking agents, selective
How it works Adrenergic beta-Antagonists

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Bisoprolol page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jan 14, 2021
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Bisoprolol.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Bisoprolol after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
32
Finished products in the current FDA directory
49
Companies listing them (makers, repackagers, distributors)
23
FDA labeler codes behind them ⓘ
25
Linked representative label ⓘ
TruPharma, LLC
Linked label effective
Jan 14, 2021
Composite sections available
17
Linked SPL Set ID
bba0bc2b-602f-4df1-a761-85bd3c80c7de
Linked SPL Document ID
2a9e4180-cb1c-f924-e063-6394a90a60c6
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. TruPharma, LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →