FDA-filed SPL labeling · retrieved through openFDA

Epinephrine / Lidocaine

Epinephrine and lidocaine is a local anesthetic combination used to numb tissue for surgical, dental, and anorectal procedures.

Brand names XylocaineLidocaine Hci And EpinephrineThe SolutionNumquick AnalgesicNumquick Topical Analgesic +11 more
Drug classes ⓘ Amide Local Anesthetic
Rx/OTC Forms 5 Routes Infiltration, Perineural · Submucosal · Infiltration; Perineural · Subcutaneous +5
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 50 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveAug 25, 2021
Clinical labels in scope ⓘ50
AvailabilityRx/OTC
Earliest approval/marketing year ⓘ1985
FDA-listed product records ⓘ156
Boxed warningNone found in compared labels
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 22, 2026
⭐ Epinephrine / Lidocaine at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Epinephrine and lidocaine is a well-established local anesthetic combination used by trained providers to numb specific areas for surgery, dental work, and other procedures, and in topical forms to relieve hemorrhoid-related discomfort. The injection forms carry real risks — including heart and brain toxicity if too much enters the bloodstream — so they are always administered and monitored by a medical professional. Topical products for anorectal symptoms are used at home as directed on the label.
How we write & review this content — our editorial policy →

📖 Epinephrine / Lidocaine: Patient Information Guide

A plain-language walkthrough of Epinephrine / Lidocaine — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Epinephrine and lidocaine products are used across several formulations to numb tissue for procedures or to relieve anorectal discomfort. Supported uses include:

  • Local or regional anesthesia for surgical, diagnostic, and therapeutic procedures in adults and children (Lidocaine Hydrochloride and Epinephrine injection, various routes)
  • Anesthesia for dental and oral surgery procedures (Lidocaine Hydrochloride and Epinephrine injection; Flavalta solution; Lidocaine subcutaneous/submucosal injection; 2% Xylocaine Dental Solutions; Lignospan Forte and Lignospan Standard solutions)
  • Obstetrical (childbirth-related) anesthesia (Lidocaine Hydrochloride and Epinephrine injection)
  • Nerve block techniques including brachial plexus, intercostal, lumbar epidural, and caudal epidural blocks (Lidocaine Hydrochloride and Epinephrine and LIDOCAINE HCl and EPINEPHRINE injections)
  • Temporary relief of anorectal itching, pain, soreness, and burning from hemorrhoids and anorectal disorders (The Solution topical spray; The Solu Tion topical inhaler/aerosol; Gold Label topical spray; Numquick Analgesic topical spray)
⚙️How it works▾

Lidocaine blocks pain by stabilizing nerve cell membranes — it prevents the tiny electrical signals that nerves use to send pain messages from starting or traveling. Epinephrine narrows the blood vessels around the injection site, which slows how quickly lidocaine is absorbed into the general bloodstream. This keeps the numbing effect working longer right where it's needed, while reducing the chance of too much lidocaine reaching the rest of the body.

💊How it's taken▾

Injection forms are always given by a trained healthcare provider — the route (infiltration, epidural, nerve block, etc.), amount, and concentration are chosen based on the procedure, patient age, weight, and health status. Topical spray and aerosol forms are applied directly to the affected skin area as directed on the product label. No injection product in this combination should be self-administered at home.

  • Injection products are not recommended for intrathecal (into spinal fluid) use
  • Children, elderly patients, and people who are seriously ill require reduced doses
  • Single-dose vials without preservatives should be discarded after one use; do not save leftover solution
🤒Side effects — in detail▾

Like all local anesthetics, side effects are generally dose-related and most common when blood levels of lidocaine are higher than intended. Common effects include:

  • Lightheadedness, dizziness, or drowsiness
  • Tingling or numbness around the mouth or lips
  • Nausea or vomiting
  • Headache or backache (especially after epidural or spinal procedures)
  • Low blood pressure
  • Shivering
  • Blurred or double vision
  • Skin reactions such as hives or rash (allergic)

Serious reactions — including seizures, loss of consciousness, severe drop in blood pressure, cardiac arrest, or bluish skin discoloration (a sign of methemoglobinemia) — require immediate emergency care. Tell your care team right away if you feel anything unusual after receiving an injection.

⚠️Warnings & precautions▾
  • Dose-related toxicity: Too much lidocaine in the bloodstream — from excessive dose, accidental blood vessel injection, or rapid absorption — can cause brain and heart toxicity. Early signs include restlessness, ringing in the ears, metallic taste, mouth tingling, tremors, or sudden drowsiness. Untreated, this can lead to seizures, cardiac arrest, or death.
  • Methemoglobinemia: A rare but dangerous blood condition where the blood can't carry oxygen properly. Watch for bluish skin or abnormal blood color. Higher-risk individuals include infants under 6 months, people with G6PD deficiency, and those taking certain other medications.
  • Sulfite allergy: The injection contains sodium metabisulfite, which can trigger severe allergic or asthma-like reactions in susceptible people, particularly those with asthma.
  • Tissue injury risk: Using epinephrine-containing products in areas with limited blood supply — fingers, toes, nose, ear, or penis — can cause ischemia (tissue damage from lack of blood flow).
  • Intra-articular use is not approved: Injecting local anesthetics into joints after surgery has been linked to chondrolysis (cartilage damage), including permanent joint damage requiring surgery.
  • Liver disease: Lidocaine is metabolized by the liver; liver impairment can lead to dangerous drug accumulation. Reduced doses and closer monitoring are needed.
🔀What it interacts with▾

Several drug combinations can cause serious problems when used with lidocaine and epinephrine injection:

  • MAO inhibitors and tricyclic antidepressants: Can cause severe, prolonged high blood pressure — combination should generally be avoided
  • Ergot-type oxytocic drugs: Combination can cause dangerous high blood pressure or stroke — avoid together
  • Nonselective beta-blockers: Can lead to severe high blood pressure and a dangerously slow heart rate — generally avoid
  • Other local anesthetics: Toxic effects add together; use with caution and careful monitoring
  • Nitrates, certain antibiotics (sulfonamides), antimalarials, anticonvulsants, acetaminophen, metoclopramide, and others: Increase the risk of methemoglobinemia
  • Potent inhaled general anesthetics: Combination with epinephrine can trigger serious heart rhythm problems
  • Phenothiazines and butyrophenones (certain antipsychotics): May blunt epinephrine's effect on blood pressure

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Do not use if you have a known allergy to lidocaine, any amide-type local anesthetic, or any other ingredient in the product
  • Tell your provider about all medications you take, especially antidepressants, blood pressure medications, and drugs used during anesthesia
  • Tell your provider if you have liver disease — lidocaine processing may be impaired, raising the risk of toxicity
  • Tell your provider if you have heart disease or poor blood vessel circulation — reduced doses and closer monitoring are needed
  • People with peripheral vascular disease or blood pressure-related vascular disease may react more strongly to epinephrine
  • Tell your provider if you have G6PD deficiency, lung problems, or any condition affecting blood oxygen — methemoglobinemia risk is higher
  • Pregnant patients: lidocaine crosses the placenta and can affect the fetus; local anesthetics used during labor may cause temporary effects in the newborn. Discuss risks with your provider.
  • Breastfeeding: lidocaine and its breakdown products appear in breast milk in small amounts; discuss timing with your provider
  • Children require doses adjusted for age, weight, and health status
  • Older adults and debilitated patients should receive reduced doses
🚑If you take too much▾

Too much lidocaine reaching the bloodstream can cause seizures, severe low blood pressure, slowed or stopped breathing, and cardiac arrest. Emergency management focuses on keeping the airway open, providing oxygen, and supporting breathing and circulation. If seizures occur and don't stop with breathing support, anti-seizure medications may be used by the treating team. Dialysis is not useful for removing lidocaine in an overdose situation.

📡Pharmacodynamics — effects in the body▾

At recommended doses, lidocaine blocks nerve conduction to produce numbness and pain relief in the targeted area. If blood levels rise too high, lidocaine can depress the cardiovascular system — lowering heart rate, blood pressure, and cardiac output. Epinephrine can stimulate the heart (beta-adrenergic effect) and narrow blood vessels (alpha-adrenergic effect), which in the context of central nerve blocks may influence blood pressure in complex ways. The net cardiovascular effect at appropriate doses is usually mild, modest low blood pressure.

🔬Pharmacokinetics — how your body processes it▾

After injection, lidocaine is completely absorbed; how fast depends on the injection site and whether epinephrine is present (epinephrine slows absorption). Between 60–80% of lidocaine in the blood is bound to proteins. It crosses both the blood-brain barrier and the placenta. The liver rapidly breaks lidocaine down into metabolites, and about 90% is excreted in the urine as metabolites, with less than 10% leaving the body unchanged. The typical half-life (the time for blood levels to fall by half) after an intravenous dose is about 1.5 to 2 hours, but this can more than double in people with liver disease. Kidney disease does not significantly affect how lidocaine itself is processed, though its metabolites may accumulate.

📦How to store it▾

stored at 20° to 25°C (68° to 77°F) . Protect from light.

📄 Written from Epinephrine / Lidocaine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Epinephrine / Lidocaine — the kind of thing our pharmacy team would talk through with you at the counter.

What is this drug actually used for? ▾
This combination is used in two main ways. When given as an injection by a healthcare provider, it numbs a specific part of your body — for example, during surgery, a dental procedure, or childbirth. The lidocaine blocks pain signals, and the epinephrine helps keep that numbing effect localized and longer-lasting. In topical spray or aerosol form, products like The Solution and Gold Label are applied around the rectum to temporarily relieve pain, itching, and burning from hemorrhoids or anorectal discomfort.
Will I feel any side effects from the injection? ▾
Some lightheadedness, drowsiness, or tingling around the mouth can happen if a little more drug than expected gets into your bloodstream — those are early warning signs your care team watches for. Headache or backache is fairly common after epidural or spinal procedures. Serious reactions like seizures or a very low blood pressure are rare but possible, which is why these injections are always given in a setting where your provider can monitor you and respond immediately.
What should I tell my doctor before getting this injection? ▾
Make sure your provider knows about all your medications — especially antidepressants called MAO inhibitors or tricyclics, any beta-blocker blood pressure medications, and anything you take for anesthesia or seizures. Also mention if you have liver disease, heart problems, poor circulation, asthma, or a history of allergic reactions to local anesthetics. If you're pregnant or breastfeeding, tell your team — lidocaine does cross to the baby and can appear in breast milk.
Are there any warning signs I should watch for after receiving an injection? ▾
Yes — and it's important to mention them to your care team right away. Early signs that too much lidocaine may be in your system include ringing in your ears, a metallic taste in your mouth, tingling or numbness around your lips, sudden dizziness, restlessness, or unusual drowsiness. If your skin turns bluish or you feel short of breath, that could signal a rare but serious blood condition called methemoglobinemia. Any of these symptoms need immediate attention — don't wait.
Can I use the topical spray at home on my own? ▾
Yes — the topical spray and aerosol products are designed for home use to relieve hemorrhoid-related symptoms like itching, pain, soreness, and burning. Apply them to the affected area as directed on the product label, and don't use more than instructed. These are very different from the injectable forms, which are only given by trained medical professionals in a clinical setting.
Is this safe if I have liver problems? ▾
You should definitely let your provider know before receiving an injection. Your liver is responsible for breaking down lidocaine, so if your liver isn't working normally, the drug can build up to higher levels in your bloodstream and increase the risk of side effects or toxicity. Your provider will likely use a lower dose and monitor you more closely. For the topical products used on the skin around the rectum, discuss with your doctor or pharmacist if you have significant liver disease.
Is Epinephrine / Lidocaine available over the counter? ▾
Both — Epinephrine / Lidocaine is sold both over the counter and by prescription, according to its FDA labeling. Lower strengths or certain forms are often available without a prescription, while higher strengths or specialized forms still require one. Ask your pharmacist which version is right for you.
When was Epinephrine / Lidocaine first available? ▾
Epinephrine / Lidocaine has been available in the United States since at least 1985, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Epinephrine / Lidocaine? ▾
Epinephrine / Lidocaine is supplied by 29 manufacturers listed in the FDA NDC Directory, including Hospira, Inc., Henry Schein, Inc., HF Acquisition Co LLC, DBA HealthFirst.

💬 Answers drafted from Epinephrine / Lidocaine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

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💊 How Epinephrine / Lidocaine comes

Epinephrine / Lidocaine is available in 5 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Injection

Infiltration · Into the epidural space · Intracaudal · Perineural · Submucosal · Under the skin
Brands Flavalta Lidocaine Hci And Epinephrine Lidocaine Hci And Epinephrine With Epinephrine Lignospan Forte Lignospan Standard Lixtraxen 1% Xylocaine
How this form is used
What it may be used for
  • Lidocaine Hydrochloride and Epinephrine injection is used to produce local or regional anesthesia for surgery, dental and oral surgery, diagnostic and therapeutic procedures, and obstetrical procedures in adults and children
  • Flavalta solution is used specifically for local anesthesia for dental procedures by nerve block or infiltration techniques
  • Lidocaine (subcutaneous/submucosal injection) is indicated for local anesthesia for dental procedures by nerve block or infiltration techniques
  • LIDOCAINE HCl and EPINEPHRINE injection is used for infiltration, peripheral nerve block, and central neural techniques including lumbar and caudal epidural blocks
Important instructions
  • Lidocaine Hydrochloride and Epinephrine injection is not recommended for intrathecal (into the spinal fluid) use
  • Multi-dose vials containing antimicrobial preservatives should not be used for epidural or caudal anesthesia — single-dose vials without preservatives are used for those techniques
  • Unused portions of preservative-free single-dose vials should be discarded after initial use
  • These injections are given only by trained healthcare providers using proper technique; the dose and route are tailored to the procedure and the patient
Available strengths 22 strengths
5 mcg/mL / 5 mg/mL 5 mcg/mL / 15 mg/mL 5 mcg/mL / 20 mg/mL 0.005 mg/mL / 20 mg/mL 10 mcg/mL / 10 mg/mL 10 mcg/mL / 20 mg/mL
Show 16 more strengths Show fewer strengths
0.01 mg/mL / 20 mg/mL 0.02 mg/mL / 20 mg/mL 20 mcg/mL / 20 mg/mL 5 mg/mL / 5 mcg/mL 5 mg/mL / 0.005 mg/mL 10 mg/mL / 10 mcg/mL 10 mg/mL / 0.01 mg/mL 15 mg/mL / 5 mcg/mL 15 mg/mL / 0.005 mg/mL 20 mg/mL / 5 mcg/mL 20 mg/mL / 10 mcg/mL 20 mg/mL / 0.01 mg/mL 20 mg/mL / 0.02 mg/mL 20 mg/mL / 20 mcg/mL 20 mg/mL / 0.005 mg/mL 0.01 mg/mL / 10 mg/mL
140 FDA-listed product records ⓘ

Topical spray

On the skin
Brands Numquick Analgesic The Solution Vasocaine
How this form is used
What it may be used for
  • The Solution spray temporarily relieves local and anorectal itching, discomfort, and pain associated with anorectal disorders or inflammation
  • Gold Label spray temporarily relieves itching, pain, soreness, and burning due to hemorrhoids, hemorrhoidal tissues, or piles
  • Numquick Analgesic spray temporarily relieves local discomfort or pain and swelling or burning associated with anorectal disorders
Important instructions
  • Apply topically to the affected anorectal area as directed on the product label
  • Use only as directed — do not exceed the recommended amount or frequency stated on the label
Available strengths 3 strengths
0.1 mg/mL / 50 mg/mL LIDOCAINE HYDROCHLORIDE 5 g/100 mL; EPINEPHRINE HYDROCHLORIDE 0.01 g/100 mL 0.01; 5 g/100 mL; g/100 mL
9 FDA-listed product records ⓘ

Inhaler

On the skin
Brands The Solu Tion
How this form is used
What it may be used for
  • The Solu Tion is used for the temporary relief of local and anorectal itching, discomfort, and pain associated with anorectal disorders or anorectal inflammation
Important instructions
  • The Solu Tion is applied topically to the affected area; follow the directions on the product label
Available strengths 1 strength
LIDOCAINE HYDROCHLORIDE 5 g/100 mL; EPINEPHRINE HYDROCHLORIDE 0.01 g/100 mL
1 FDA-listed product record ⓘ

Oral solution

By mouth
Available strengths 1 strength
20 mg/mL / 10 mcg/mL
1 FDA-listed product record ⓘ

📊 Epinephrine / Lidocaine across the U.S. market

How Epinephrine / Lidocaine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

5
Dose forms ⓘ
29
Manufacturers
20
Brand names
156
FDA-listed product records ⓘ
1985
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Hospira, Inc.15%
Henry Schein, Inc.13%
HF Acquisition Co LLC, DBA HealthFirst11%
Septodont, Inc.7%
Darby Dental Supply, LLC4%
Fresenius Kabi USA, LLC4%
Other makers46%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Epinephrine / Lidocaine is used

A general measure of how commonly Epinephrine / Lidocaine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Epinephrine / Lidocaine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

132,083
Medicaid prescriptions filled (Q1–Q4 2025)
$11.8M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Epinephrine / Lidocaine prescribed? Of the 1,596 medications we measure, Epinephrine / Lidocaine ranks #468 by Medicaid prescriptions — more than 71% of them.

Where Epinephrine / Lidocaine ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #468 of 1,596
#463 Dextromethorphan and B... 134,150 Rx #464 Desonide Topical 133,862 Rx #465 Desonide 133,862 Rx #466 Liothyronine 133,453 Rx #467 Dextroamphetamine 132,973 Rx #468 Epinephrine / Lidocain... 132,083 Rx #469 Tranexamic Acid 131,595 Rx #470 Bisoprolol 130,591 Rx #471 Miconazole 130,151 Rx #472 Bisacodyl Rectal 127,528 Rx #473 Fluphenazine 127,346 Rx

Utilization by Epinephrine / Lidocaine product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 0.01 mg/mL / 10 mg/mL injectable solution is the most-dispensed Epinephrine / Lidocaine product — about 24% of these Medicaid prescriptions.

epinephrine 0.01 MG/ML / lidocaine hydrochloride 10 MG/ML Injectable Solution Most dispensed

31,077 Medicaid prescriptions (Q1–Q4 2025) 24% of Epinephrine / Lidocaine prescriptions shown $2.9M gross reimbursement (before rebates) ≈ $93 per prescription (gross)

Summed across the 8 of 48 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1010751

epinephrine 0.01 MG/ML / lidocaine hydrochloride 20 MG/ML Injectable Solution

5,154 Medicaid prescriptions (Q1–Q4 2025) 4% of Epinephrine / Lidocaine prescriptions shown $318,868 gross reimbursement (before rebates) ≈ $62 per prescription (gross)

Summed across the 4 of 35 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1010759

30 ML epinephrine 0.005 MG/ML / lidocaine hydrochloride 10 MG/ML Injection

2,559 Medicaid prescriptions (Q1–Q4 2025) 2% of Epinephrine / Lidocaine prescriptions shown $154,896 gross reimbursement (before rebates) ≈ $61 per prescription (gross)

Summed across the 1 of 8 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1867943

20 ML epinephrine 0.005 MG/ML / lidocaine hydrochloride 20 MG/ML Injection

898 Medicaid prescriptions (Q1–Q4 2025) <1% of Epinephrine / Lidocaine prescriptions shown $85,671 gross reimbursement (before rebates) ≈ $95 per prescription (gross)

Summed across the 2 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1010688

10 ML epinephrine 0.005 MG/ML / lidocaine hydrochloride 10 MG/ML Injection

538 Medicaid prescriptions (Q1–Q4 2025) <1% of Epinephrine / Lidocaine prescriptions shown $78,024 gross reimbursement (before rebates) ≈ $145 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1867938

5 ML epinephrine 0.005 MG/ML / lidocaine hydrochloride 15 MG/ML Injection

227 Medicaid prescriptions (Q1–Q4 2025) <1% of Epinephrine / Lidocaine prescriptions shown $462 gross reimbursement (before rebates) ≈ $2.03 per prescription (gross)

Summed across the 1 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1867998

epinephrine 0.005 MG/ML / lidocaine hydrochloride 5 MG/ML Injectable Solution

191 Medicaid prescriptions (Q1–Q4 2025) <1% of Epinephrine / Lidocaine prescriptions shown $706 gross reimbursement (before rebates) ≈ $3.69 per prescription (gross)

Summed across the 2 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1010745

10 ML epinephrine 0.005 MG/ML / lidocaine hydrochloride 20 MG/ML Injection

110 Medicaid prescriptions (Q1–Q4 2025) <1% of Epinephrine / Lidocaine prescriptions shown $7,010 gross reimbursement (before rebates) ≈ $64 per prescription (gross)

Summed across the 1 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1868028

30 ML epinephrine 0.005 MG/ML / lidocaine hydrochloride 15 MG/ML Injection

60 Medicaid prescriptions (Q1–Q4 2025) <1% of Epinephrine / Lidocaine prescriptions shown $1,148 gross reimbursement (before rebates) ≈ $19 per prescription (gross)

Summed across the 1 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1867996

10 ML epinephrine 0.005 MG/ML / lidocaine hydrochloride 15 MG/ML Injection

11 Medicaid prescriptions (Q1–Q4 2025) <1% of Epinephrine / Lidocaine prescriptions shown $105 gross reimbursement (before rebates) ≈ $9.56 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1867992

Other Epinephrine / Lidocaine products — combination packs and listings not yet matched to a specific clinical product (kept visible so every prescription is accounted for)

91,258 Medicaid prescriptions (Q1–Q4 2025) 69% of Epinephrine / Lidocaine prescriptions shown $8.2M gross reimbursement (before rebates) ≈ $90 per prescription (gross)

Summed across the 17 of 39 listed NDC products with Medicaid activity.

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Epinephrine / Lidocaine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 39 of 165 listed Epinephrine / Lidocaine NDCs with Medicaid activity.

🔍 Compare Epinephrine / Lidocaine products

A representative set of FDA-listed product records for Epinephrine / Lidocaine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 156 of 156 products — FDA National Drug Code Directory. See every product, package size and price: browse all 156 Epinephrine / Lidocaine NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one exact multiple-ingredient concept (MIN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). A product with a different ingredient combination belongs on a different page.

Multiple ingredients (MIN) Epinephrine / Lidocaine RxCUI 107602 10 dose forms · 22 strengths
  3. Dose form (SCDF) Injection RxCUI 1867937 In current FDA listings
    Clinical drug / strength (SCD) 5 ML epinephrine 0.005 MG/ML / lidocaine hydrochloride 15 MG/ML RxCUI 1867998 10 ML epinephrine 0.005 MG/ML / lidocaine hydrochloride 10 MG/ML RxCUI 1867938 10 ML epinephrine 0.005 MG/ML / lidocaine hydrochloride 15 MG/ML RxCUI 1867992 10 ML epinephrine 0.005 MG/ML / lidocaine hydrochloride 20 MG/ML RxCUI 1868028 20 ML epinephrine 0.005 MG/ML / lidocaine hydrochloride 20 MG/ML RxCUI 1010688 30 ML epinephrine 0.005 MG/ML / lidocaine hydrochloride 10 MG/ML RxCUI 1867943 30 ML epinephrine 0.005 MG/ML / lidocaine hydrochloride 15 MG/ML RxCUI 1867996
  4. Dose form (SCDF) Medicated Patch RxCUI 1793094 No current FDA listing
    Clinical drug / strength (SCD) epinephrine 0.001 MG/MG / lidocaine hydrochloride 0.1 MG/MG RxCUI 1116626
  5. Dose form (SCDF) Prefilled Syringe RxCUI 1150119 No current FDA listing
    Clinical drug / strength (SCD) 3 ML epinephrine 0.01 MG/ML / lidocaine hydrochloride 10 MG/ML RxCUI 1150121
  6. Dose form (SCDF) Rectal Foam RxCUI 2749267 No current FDA listing
    Clinical drug / strength (SCD) epinephrine hydrochloride 0.1 MG/ML / lidocaine hydrochloride 50 MG/ML RxCUI 2749269

Look up RxCUI 107602 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Xylocaine Lidocaine Hci And Epinephrine The Solution Numquick Analgesic Numquick Topical Analgesic Zone 2 Vasocaine Xylocaine MPF Lidocaine Hci And Epinephrine With Epinephrine Lignospan Forte Lignospan Standard Lixtraxen 1% Minnerva II Gold Label B Numb Flavalta The Solu Tion

🏭 Manufacturers & labelers

Hospira, Inc. 23 Henry Schein, Inc. 20 HF Acquisition Co LLC, DBA HealthFirst 17 Septodont, Inc. 11 Darby Dental Supply, LLC 7 Fresenius Kabi USA, LLC 7 Dentsply Pharmaceutical 6 Benco Dental 6 General Injectables & Vaccines, Inc 6 Patterson Dental 6 Henry Schein Inc. 6 Unit Dose, Ltd. 5 Scalp Tech Inc 5 Dermal Source, Inc. 4 NDC, Inc. 3 Safco Dental Supply Co 3 The Atlanta Dental Supply Company DBA Advanced Dental Products 3 A-S Medication Solutions 2 ProPharma Distribution 2 Sportpharm LLC 2 Remedyrepack Inc. 2 Cardinal Health 107, LLC 2 General Injectables & Vaccines 2 IT3 Medical LLC 1

…and 5 more on the FDA NDC directory.

RxNorm drug class

Epinephrine / Lidocaine belongs to the alpha-Adrenergic Agonist class.

Pharmacologic class alpha-Adrenergic Agonist, beta-Adrenergic Agonist, Catecholamine
Drug family (ATC) Other agents for local oral treatment, Local hemostatics, Adrenergic and dopaminergic agents
How it works Adrenergic alpha-Agonists, Adrenergic beta-Agonists

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

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FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Aug 25, 2021
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Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Epinephrine / Lidocaine.
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Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
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Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Epinephrine / Lidocaine after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
50
NDC products indexed
156
Distinct labelers/manufacturers represented
29
Linked representative label ⓘ
Fresenius Kabi USA, LLC
Linked label effective
Aug 25, 2021
Composite sections available
22
Linked SPL Set ID
ba082c2f-64f4-419d-9c88-74f203316e17
Linked SPL Document ID
ea480a68-5927-4278-9deb-2956961da428
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 50 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Fresenius Kabi USA, LLC is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.