Herb & supplement monograph

Boron Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Boron

0 medications have a known interaction with Boron, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Boron. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Boron combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Boron: Uses, Safety & Side Effects

The bottom line

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or preliminary, and most people get enough boron from a normal diet. It appears generally safe in low amounts, but high doses can be toxic, so check with your pharmacist or doctor before using it.

Boron
Part used
Trace mineral (not a plant part)
Common forms
Capsules, tablets, liquids; forms include boron citrate, boron glycinate, boron aspartate, and sodium borate
People commonly use it for
  • Bone health
  • Joint and arthritis support
  • Hormone (testosterone/estrogen) support
  • Cognitive function
  • Menstrual discomfort

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally safe in small amounts from food and low-dose supplements, but high doses can be toxic.

PregnancyLikely Safe

When used orally and appropriately. Boron is safe in amounts that do not exceed the UL during pregnancy or lactation, which is 20 mg daily in those 19...

Read the full pregnancy detail
BreastfeedingLikely Safe

When used orally and appropriately. Boron is safe in amounts that do not exceed the UL during pregnancy or lactation, which is 20 mg daily in those 19...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Boron is a trace mineral found naturally in soil, water, and many plant foods. It is not made by the body, so the boron you have comes from your diet. Good food sources include fruits (like apples, raisins, and prunes), vegetables, nuts, legumes, and some beverages such as coffee and wine.

Because boron is present in so many common foods, most people get enough through a normal diet and true deficiency is rare. As a supplement, boron is sold in capsules, tablets, and liquids, often in forms like boron citrate, boron glycinate, or sodium borate.

People most often take boron supplements for bone health, joint comfort, and to support hormone levels, though the science behind these uses is still developing.

How it works

Scientists do not fully understand exactly how boron works in the body. One leading idea is that boron influences how the body processes minerals involved in bone health, such as calcium, magnesium, phosphorus, and vitamin D.

Boron may also affect the activity of certain hormones, including sex and steroid hormones, and some laboratory research suggests it may influence inflammation and the way certain enzymes work.

It is important to know that much of this is based on laboratory and animal studies or small human trials. These proposed mechanisms do not guarantee that taking boron supplements will produce a noticeable health benefit.

Effectiveness

Does Boron work?

Evidence overview · 14 uses evaluated
1 Likely effective 2 Possibly effective 1 Leans ineffective 10 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Likely Effective Boron deficiency
Rating & evidence shown verbatim from Natural Medicines

Oral boron treats and prevents boron deficiency.

Possibly Effective Radiation dermatitis
Rating & evidence shown verbatim from Natural Medicines

Topical application of sodium pentaborate pentahydrate gel to radiation sites may reduce the risk of dermatitis in patients with breast cancer who are receiving radiotherapy.

Possibly Effective Vaginal candidiasis
Rating & evidence shown verbatim from Natural Medicines

Boric acid applied intravaginally seems to reduce vaginal candidiasis.

Possibly Ineffective Athletic performance
Rating & evidence shown verbatim from Natural Medicines

Oral boron does not seem to improve athletic performance.

Also studied for 10 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Age-related cognitive decline
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral boron is beneficial for age-related cognitive decline.

Insufficient Reliable Evidence To Rate Diabetic foot ulcers
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical boron is beneficial for use in diabetic foot ulcers.

Insufficient Reliable Evidence To Rate Dysmenorrhea
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral boron is beneficial for reducing pain during menstruation.

Insufficient Reliable Evidence To Rate Kidney stones (nephrolithiasis)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if boron is beneficial for medical expulsive therapy after extracorporeal shockwave lithotripsy.

Insufficient Reliable Evidence To Rate Kidney transplant
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral boron is beneficial in patients receiving a kidney transplant.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral boron for obesity, there is insufficient reliable information about the clinical effects of boron for this purpose.

Insufficient Reliable Evidence To Rate Osteoarthritis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral boron is beneficial for osteoarthritis symptoms.

Insufficient Reliable Evidence To Rate Osteoporosis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral boron is beneficial for osteoporosis.

Insufficient Reliable Evidence To Rate Periodontitis
Rating & evidence shown verbatim from Natural Medicines

Small clinical studies suggest that adding topical boric acid to scaling and root planing treatment may be beneficial in periodontitis.

Insufficient Reliable Evidence To Rate Tooth extraction
Rating & evidence shown verbatim from Natural Medicines

It is unclear if boron is beneficial for use in periodontal healing after impacted third molar surgery.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

The small amounts of boron found in food and in low-dose supplements are generally considered safe for most healthy adults. However, boron can be toxic at high doses, so it should not be taken in large amounts.

Health authorities have set a tolerable upper intake level for adults. Staying within that limit is important, and you should not take more than the product label recommends without medical advice.

People with kidney problems should be especially careful, because the kidneys clear boron from the body. Children and people who are ill should not take boron supplements without guidance from a healthcare professional.

Pregnancy and breastfeeding: Avoid boron supplements during pregnancy and while breastfeeding. High amounts of boron may be harmful to a developing baby, and there is not enough safety data to support supplement use during these times. Getting boron from a normal, balanced diet is fine.

Always talk with your pharmacist or doctor before starting boron, especially if you have a medical condition or take other medications or supplements.

Side effects

At low doses, boron usually causes few or no side effects. At higher doses, it can cause nausea, vomiting, diarrhea, stomach upset, and skin irritation.

Very high or toxic amounts of boron can lead to more serious problems such as headache, restlessness, tremors, and other signs of poisoning. These effects are linked to large overdoses, not normal dietary intake.

If you notice unusual symptoms after taking boron, stop and contact a healthcare provider.

Boron: Reported Adverse Effects

Documented safety reports on Boron from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, boron is generally well tolerated when used in doses below the tolerable upper intake level (UL) of 20 mg. Vaginally, boron is well tolerated.

Most Common Adverse Effects:

Orally: Anorexia, dermatitis, erythema, indigestion.

Vaginally: Burning and pain.

Reports by condition
Alopecia Dermatologic

Orally, chronic use of 1 gram daily of boric acid or 25 grams daily of boric tartrate can cause dermatitis and alopecia.

Larger doses can result in acute poisoning. Symptoms of poisoning in adults and children may include skin erythema, desquamation, and exfoliation.

  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
Anorexia Gastrointestinal

Orally, chronic use of 1 gram daily of boric acid or 25 grams daily of boric tartrate can cause anorexia and indigestion.

Larger doses can result in acute poisoning. Children who have ingested 5 grams or more of borates can have persistent nausea, vomiting, and diarrhea leading to acute dehydration, shock, and coma. Adults who have ingested 15-20 grams of borate can exhibit nausea, vomiting, diarrhea, epigastric pain, hematemesis, and a blue-green discoloration of feces and vomit.

  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
Cough Pulmonary/Respiratory

Exposure to boric acid and boron oxide dust has been reported to cause mouth and nasal passage irritation, sore throat, and productive cough.

  1. Garabrant, D. H., Bernstein, L., Peters, J. M., and Smith, T. J. Respiratory and eye irritation from boron oxide and boric acid dusts. J Occup Med 1984;26(8):584-586.
Poisoning Neurologic/CNS

Orally, large doses can result in acute poisoning. Poisoning with boron can cause hyperexcitability, irritability, tremors, convulsions, weakness, lethargy, and headaches.

  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official recommended dietary allowance (RDA) for boron, and a standardized supplement dose has not been firmly established. Most people already get boron from foods like fruits, vegetables, nuts, and legumes.

Supplements are usually sold in small milligram amounts. Health authorities have set a safe upper limit for adults, and you should not exceed it. The safest approach is to follow the dose on the product label and not take more than directed.

Before starting boron, check with your pharmacist or doctor to make sure the dose is appropriate for you and that you are not already getting enough from your diet and other supplements.

Pregnancy & Breastfeeding

Boron & Pregnancy

Likely Safe

When used orally and appropriately. Boron is safe in amounts that do not exceed the UL during pregnancy or lactation, which is 20 mg daily in those 19-50 years of age or 17 mg daily for those 14-18 years of age.

  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Possibly Unsafe

When used orally in doses exceeding the UL. Higher doses might impair growth and cause adverse effects in the developing fetus. ...when used vaginally. Intravaginal boric acid has been associated with a 2.7- to 2.8-fold increased risk of birth defects when used during the first 4 months of pregnancy.

  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Hjelm C, Harari F, Vahter M. Pre- and postnatal environmental boron exposure and infant growth: results from a mother-child cohort in northern Argentina. Environ Res 2019;171:60-8.
  3. Thai L, Hart LL. Boric acid vaginal suppositories. Ann Pharmacother 1993;27:1355-7.
  4. Acs N, Banhidy F, Puho E, Czeizel AE. Teratogenic effects of vaginal boric acid treatment during pregnancy. Int J Gynaecol Obstet 2006;93:55-6.

Boron & Breastfeeding

Likely Safe

When used orally and appropriately. Boron is safe in amounts that do not exceed the UL during pregnancy or lactation, which is 20 mg daily in those 19-50 years of age or 17 mg daily for those 14-18 years of age.

  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
Possibly Unsafe

When used orally in doses exceeding the UL. Higher doses might impair growth and cause adverse effects in the developing fetus. ...when used vaginally. Intravaginal boric acid has been associated with a 2.7- to 2.8-fold increased risk of birth defects when used during the first 4 months of pregnancy.

  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Hjelm C, Harari F, Vahter M. Pre- and postnatal environmental boron exposure and infant growth: results from a mother-child cohort in northern Argentina. Environ Res 2019;171:60-8.
  3. Thai L, Hart LL. Boric acid vaginal suppositories. Ann Pharmacother 1993;27:1355-7.
  4. Acs N, Banhidy F, Puho E, Czeizel AE. Teratogenic effects of vaginal boric acid treatment during pregnancy. Int J Gynaecol Obstet 2006;93:55-6.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 6 references that drive our Boron monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Thai L, Hart LL. Boric acid vaginal suppositories. Ann Pharmacother 1993;27:1355-7.
  4. Acs N, Banhidy F, Puho E, Czeizel AE. Teratogenic effects of vaginal boric acid treatment during pregnancy. Int J Gynaecol Obstet 2006;93:55-6. PubMed
  5. Garabrant, D. H., Bernstein, L., Peters, J. M., and Smith, T. J. Respiratory and eye irritation from boron oxide and boric acid dusts. J Occup Med 1984;26(8):584-586. PubMed
  6. Hjelm C, Harari F, Vahter M. Pre- and postnatal environmental boron exposure and infant growth: results from a mother-child cohort in northern Argentina. Environ Res 2019;171:60-8. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Boron

9,031 products in our database contain Boron. Open any to see its full ingredient list and every drug interaction we check.

A.M. by Thorne Capsule 90 Capsule(s) View ingredients & interactions A.M. by EXOS Performance Nutrition Capsule 90 Capsule(s) View ingredients & interactions A.M. by EXOS Performance Nutrition Capsule 30 Single Serving Packet(s) View ingredients & interactions A.M. Activator by ProCaps Laboratories Capsule 180 Easy-To-Swallow Capsule(s) View ingredients & interactions A.M. Activator by ProCaps Laboratories Capsule 180 Easy-To-Swallow Capsule(s) View ingredients & interactions ABC Plus by Nature's Bounty Tablet Or Pill 100 Tablet(s) View ingredients & interactions ABC Plus Multi by Puritan's Pride Tablet Or Pill 100 Coated Tablet(s) View ingredients & interactions ABC Plus Senior by Esmond Natural Other (e.g. Tea Bag) 100 Caplet(s) View ingredients & interactions ABC Plus Senior by Nature's Bounty Other (e.g. Tea Bag) 60 Caplet(s) View ingredients & interactions ABC Plus Senior by Nature's Bounty Other (e.g. Tea Bag) 120 Caplet(s) View ingredients & interactions ABC Plus Senior by Nature's Bounty Other (e.g. Tea Bag) 100 Caplet(s) View ingredients & interactions ABC Plus Senior Iron Free by Vitamin World Other (e.g. Tea Bag) 240 Coated Caplet(s) View ingredients & interactions ABC Plus Senior Iron Free by Vitamin World Other (e.g. Tea Bag) 120 Coated Caplet(s) View ingredients & interactions ABC Plus Senior Multi by Puritan's Pride Other (e.g. Tea Bag) 30 Coated Caplet(s) View ingredients & interactions ABC Plus Senior Multi by Puritan's Pride Other (e.g. Tea Bag) 240 Coated Caplet(s) View ingredients & interactions ABC Plus Senior Multi by Puritan's Pride Other (e.g. Tea Bag) 30 Coated Caplet(s) View ingredients & interactions ABC Plus Senior Multi by Puritan's Pride Tablet Or Pill 120 Coated Caplet(s) View ingredients & interactions ABC Plus Senior Multi by Puritan's Pride Other (e.g. Tea Bag) 60 Coated Caplet(s) View ingredients & interactions ABC Plus Senior Multi by Puritan's Pride Other (e.g. Tea Bag) 120 Coated Caplet(s) View ingredients & interactions ABC Plus Senior Multi by Puritan's Pride Other (e.g. Tea Bag) 240 Coated Caplet(s) View ingredients & interactions ABC Plus Senior Multi by Puritan's Pride Other (e.g. Tea Bag) 30 Coated Caplet(s) View ingredients & interactions ABC Plus Senior Multi by Puritan's Pride Other (e.g. Tea Bag) 60 Coated Caplet(s) View ingredients & interactions Acid Neutralizer Mild Grape Flavor by Greens First Pro Powder 4.29 Oz(s) · 121.8 Gram(s) View ingredients & interactions Activated Coral Calcium by NaturesPlus Capsule 90 Vegetarian Capsule(s) View ingredients & interactions
Pharmacist Counseling Corner

Boron: Common Questions

What is Boron used for, and does it work?
People use Boron for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Boron for Boron deficiency, Radiation dermatitis and Vaginal candidiasis. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Boron interact with prescription medications?
We do not currently list any known drug interactions for Boron. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Boron interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Boron with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Boron interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Boron used for?
People most commonly take Boron for bone health, joint and arthritis support, and to influence hormone levels. The human evidence for these uses is limited, so it is not proven to work for any specific condition.
Do I need a Boron supplement?
Most people get enough Boron from a normal diet rich in fruits, vegetables, nuts, and legumes, and true deficiency is rare. A supplement is usually not necessary unless a healthcare provider recommends one.
Is Boron safe to take?
Small amounts from food and low-dose supplements are generally considered safe for healthy adults, but high doses can be toxic and cause nausea, vomiting, and other problems. Stay within the recommended upper limit and check with your pharmacist.
Can I take Boron during pregnancy or breastfeeding?
It is best to avoid Boron supplements during pregnancy and breastfeeding, since high amounts may be harmful and safety data is limited. Getting Boron from a normal balanced diet is fine.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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