Major interaction on record — check this product against your medications before combining. Based on 8 of 10 ingredients. Check your meds →
Dietary supplement

Nuclear Armageddon Fruit Explosion Ingredients & Drug Interactions

by Anabolic Warfare

Nuclear Armageddon Fruit Explosion label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nuclear Armageddon Fruit Explosion against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Nuclear Armageddon Fruit Explosion is a dietary supplement by Anabolic Warfare with 10 active ingredients. Its ingredients are commonly taken for athletic performance and endurance, high-intensity exercise capacity, reducing muscle fatigue.Based on those ingredients, 1,100 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Rauvolfia vomitoria Root Extract, Caffeine Anhydrous, L-Arginine Pyroglutamate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Nuclear Armageddon Fruit Explosion by Anabolic Warfare

Ask about any prescription or over-the-counter medication and we check it for interactions with Nuclear Armageddon Fruit Explosion by Anabolic Warfare — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Nuclear Armageddon Fruit Explosion by Anabolic Warfare

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 7 of its 10 active ingredients.
  • “Stimulant Blend” is a proprietary blend — the label gives one combined amount (397 mg) without saying how much of each component you get.

Nuclear Armageddon Fruit Explosion contains 10 ingredients, several of which are active compounds. Beta-alanine supports athletic and physical performance.

Caffeine anhydrous is a central nervous system stimulant included for mental alertness and athletic performance. L-arginine pyroglutamate and L-citrulline malate are amino acids that promote blood vessel dilation and may support athletic performance.

Potassium is an electrolyte. Betaine anhydrous supports cellular function.

Toothed clubmoss aerial parts extract contains compounds that may affect nervous-system function. The product also includes Cluster Dextrin (a carbohydrate), Nitrosigine (a proprietary ingredient we could not check), and a Stimulant Blend.

The remaining ingredients are inactive — citric acid, silicon dioxide, natural and artificial flavors, sucralose, and acesulfame potassium — which serve as fillers, binders, and flavoring agents in the powder form.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: pre-workout muscle performance and pumps.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle soreness, Exercise-induced muscle breakdown, Physical performance, Muscle strength, Mental alertness — and 4 related terms.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Caffeine is rated "Likely Effective" for Mental alertness.
  • Also on file: Beta-alanine is rated "Possibly Effective" for Athletic performance, Physical performance.

Beta-alanine is possibly effective for athletic performance and physical performance, though evidence for cognitive benefits, COPD, or menopausal symptoms is insufficient. Caffeine anhydrous is likely effective for mental alertness and athletic performance, and effective for a specific newborn breathing condition (neonatal apnea).

L-citrulline malate is possibly effective for athletic performance. Betaine anhydrous is effective for a rare genetic disorder (homocystinuria) and possibly effective for elevated homocysteine, but evidence for NASH, depression, GERD, or colorectal adenoma is insufficient.

L-arginine pyroglutamate, potassium, toothed clubmoss, and Rauvolfia vomitoria have no established effectiveness ratings in our data for typical supplement uses.

The evidence, ingredient by ingredient Beta-alanine Betaine Anhydrous L-arginine L-citrulline Potassium Caffeine Toothed Clubmoss Rauvolfia Vomitoria

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-alanine is generally well tolerated but commonly causes harmless tingling and flushing of the skin, usually starting on the scalp within 20 minutes and lasting about an hour—this is dose-dependent and mild at lower doses. The safety data advises against it during pregnancy and breastfeeding.

Caffeine anhydrous is generally safe in moderate amounts but high doses can cause serious side effects; it may increase pregnancy risks, so ask your doctor about safe limits, and small amounts pass into breast milk but moderate intake is usually considered acceptable. Betaine anhydrous is generally well tolerated in studied doses but may cause body odor, diarrhea, nausea, vomiting, GI distress, or elevated cholesterol; insufficient safety data exists for pregnancy and breastfeeding.

L-citrulline malate is generally well tolerated but may cause gastrointestinal discomfort or heartburn; the safety data advises against it in pregnancy and breastfeeding. Potassium is generally well tolerated from food, but supplements can cause dangerously high blood levels in some people, especially those with kidney disease.

L-arginine pyroglutamate can lower blood pressure and may cause abdominal pain, bloating, nausea, diarrhea, headache, or insomnia; insufficient safety information exists for pregnancy and breastfeeding. Toothed clubmoss may cause dizziness, nausea, and sweating, with not enough safety information for pregnancy or breastfeeding.

Rauvolfia vomitoria contains potent alkaloids that can cause low blood pressure, depression, and other significant effects, and the safety data advises against it in pregnancy and breastfeeding.

Side effects, ingredient by ingredient Beta-alanine Betaine Anhydrous L-arginine L-citrulline Potassium Caffeine Toothed Clubmoss Rauvolfia Vomitoria

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 8 matched ingredients can interact with medications — Toothed Clubmoss, Potassium, L-arginine, Caffeine, L-citrulline, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 1,100 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you use stimulant drugs, antipsychotics, MAOIs or other antidepressants, levodopa (for Parkinson's disease), barbiturates, ephedrine, blood thinners, potassium-sparing diuretics or ACE inhibitors / ARBs, blood pressure medications, erectile dysfunction drugs, diabetes medications, anticholinergic drugs, or cholinergic drugs. The most serious risks involve stimulants and antipsychotics.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is intended for athletic performance and mental alertness in healthy adults without kidney disease, high blood pressure, diabetes, or psychiatric conditions — but it carries substantial medication interactions, especially with stimulants, antipsychotics, antidepressants, and blood pressure or diabetes drugs. Before you try it, check all your current medications with the tool on this page, and talk to your pharmacist if you take anything for heart, blood pressure, mood, seizures, or blood sugar.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nuclear Armageddon Fruit Explosion, straight from the product label.

Brand Anabolic Warfare
Barcode (UPC) 812575033723
Net contents 13.97 Ounce(s); 396 Gram(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 307029
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nuclear Armageddon Fruit Explosion by Anabolic Warfare, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
13.2 Gram(s)
Maximum serving Sizes:
13.2 Gram(s)
Servings per container
30
UPC/BARCODE
812575033723
IngredientAmount% DV
Beta-Alanine1500 mg--
Caffeine Anhydrous0 NP--
Betaine Anhydrous2000 mg--
L-Arginine Pyroglutamate1000 mg--
L-Citrulline Malate4000 mg--
Potassium20 mg1%
Toothed Clubmoss Aerial Parts Extract0 NP--
Cluster Dextrin1000 mg--
Stimulant Blend397 mg--
Nitrosigine500 mg--
Rauvolfia vomitoria Root Extract0 NP--

Other ingredients: Citric Acid, Silicon Dioxide, Natural Flavors, Artificial Flavors, Sucralose, Acesulfame Potassium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions Mix 1 scoop of Nuclear Armageddon with 6-8 fl. oz. of water, 15 minutes prior to exercise. Do not take within 4 hours prior to bedtime.

Formula

Benefits 4 g of L-Citrulline Malate to promote nitric oxide production and increase muscle pumps. 1.5 g of Beta-Alanine to enhance performance by increasing endurance and decreasing muscle fatigue. 2 g of Betaine Anhydrous to promote liver health, improve athletic performance, and support protein synthesis. 395 mg of caffeine to increase energy & focus.

Fruit Explosion Naturally and artificially flavored

Nitrosigine Bonded Arginine Silicate

Precautions

Warning: not intended for anyone under the age of 18. Keep out of reach of children.

If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.

Warning: Consuming this product can expose you to chemicals including lead which is known by the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov/food.

Manufactured in a facility which processes milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soybeans, and sesame.

Storage

Store in a cool, dry & dark place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

All-in-one pre-workout Increase muscle pumps Support protein synthesis Promote nitric oxide

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

cGMP Good Manufacturing Practices Inspected Facility

Brand IP Statement(s)

Nitrosigine, including the Nitrosigine logo, is a trademark of Nutrition 21, LLC. Nitrosigine is patent protected.

General Statements

Facebook facebook.com/anabolicwarfare Instagram @anabolicwarfare

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nuclear Armageddon Fruit Explosion by Anabolic Warfare label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nuclear Armageddon Fruit Explosion label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nuclear Armageddon Fruit Explosion by Anabolic Warfare

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size13.2 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Beta-Alanine

No known
interactions
1500 mg per serving

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-int...

Beta-Alanine monograph & interactions

Betaine Anhydrous

No known
interactions
2000 mg per serving

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

Betaine Anhydrous monograph & interactions

L-Arginine Pyroglutamate

Interacts with
403 drugs
1000 mg per serving

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...

L-Arginine Pyroglutamate monograph & interactions

L-Citrulline Malate

Interacts with
178 drugs
4000 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline Malate monograph & interactions

Potassium

Interacts with
62 drugs
20 mg per serving Form: Nitrosigine

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Cluster Dextrin

1000 mg per serving Form: Highly Branched Cyclic Dextrin

Nitrosigine

500 mg per serving Form: Inositol-Stabilized Arginine Silicate

Other (inactive) ingredients: Citric Acid, Silicon Dioxide, Natural Flavors, Artificial Flavors, Sucralose, Acesulfame Potassium. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nuclear Armageddon Fruit Explosion by Anabolic Warfare Drug Interactions

Want to check YOUR meds against Nuclear Armageddon Fruit Explosion?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,100Drugs
230 Major 809 Moderate 61 Minor

Ingredients driving the most interactions

Rauvolfia vomitoria Root Extract 840
Caffeine Anhydrous 655
L-Arginine Pyroglutamate 403
Toothed Clubmoss Aerial Parts Extract 219
L-Citrulline Malate 178

Individual Drug Interactions

The ingredients in Nuclear Armageddon Fruit Explosion interact with 1,100 drugs. Click any drug to see the details.

6 of the 10 ingredients in Nuclear Armageddon Fruit Explosion interact with drugs. Each result below shows which ingredient is responsible. Rauvolfia vomitoria Root Extract Caffeine Anhydrous L-Arginine Pyroglutamate Toothed Clubmoss Aerial Parts Extract L-Citrulline Malate Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Nuclear Armageddon Fruit Explosion with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Rauvolfia vomitoria Root Extract11 drug types · 840 drugs

Antipsychotic Drugs

Theoretically, concomitant use might increase the risk of adverse effects.
Concomitant use of neuroleptics with Rauvolfia vomitoria may potentiate the effects of these drugs and the rauwolfia alkaloids.

Likelihood Probable Evidence D
Levodopa

Theoretically, Rauvolfia vomitoria might reduce the effects of levodopa.
Avoid using Rauvolfia vomitoria with levodopa; concomitant use may reduce drug effectiveness and increase extrapyramidal motor symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might cause additive effects.
Yohimbine, a constituent of Rauvolfia vomitoria, has MAO inhibitory effects. At high doses, yohimbine is a non-selective inhibitor of MAO.

Likelihood Probable Evidence D
Stimulant Drugs

Theoretically, concomitant use might cause additive effects.
Yohimbine, a constituent of Rauvolfia vomitoria, has sympathomimetic effects and increases blood pressure in a dose-dependent manner. Theoretically, taking Rauvolfia vomitoria with stimulant drugs can have additive stimulant and hypertensive effects.

Likelihood Probable Evidence D
Antidiabetes Drugs

Theoretically, taking Rauvolfia vomitoria with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical research shows that drinking a beverage containing Rauvolfia vomitoria foliage and bitter orange fruit lowers blood glucose levels. Hypoglycemic effects of Rauvolfia vomitoria have also been demonstrated in an animal diabetic model.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, Rauvolfia vomitoria might increase the risk of hypotension.
Rauvolfia vomitoria contains a very small amount of the drug reserpine. Reserpine can reduce both systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking Rauvolfia vomitoria might cause additive sedative effects.
Rauvolfia vomitoria has sedative effects in animal research.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Rauvolfia vomitoria might increase the levels and clinical effects of CYP2D6 substrates.
Rauvolfia vomitoria contains small amounts of the drug yohimbine. In vitro research shows that yohimbine inhibits CYP2D6 enzyme activity.

Likelihood Possible Evidence D
Ephedrine

Theoretically, Rauvolfia vomitoria might alter the effects and side effects of ephedrine.
Rauvolfia vomitoria contains resperine, which might reduce indirect-sympathomimetic drug activity. However, another constituent of Rauvolfia vomitoria, yohimbine, has stimulant activity and may increase the risk of adverse effects with ephedrine.

Likelihood Probable Evidence D
Tricyclic Antidepressants (Tcas)

Theoretically, concomitant use might alter the effects of Rauvolfia vomitoria and increase the risk for adverse effects.
A small clinical study in patients taking TCAs for at least 4 weeks shows that receiving doses of intravenous yohimbine, a constituent of Rauvolfia vomitoria, 2.5-20 mg daily for up to 7 days precipitates severe anxiety, agitation, and tremor. Also, concomitant use of TCAs with Rauvolfia vomitoria may decrease the effects of rauwolfia alkaloids.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, combining Rauvolfia vomitoria with antiplatelet or anticoagulant drugs might have additive effects.
Rauvolfia vomitoria contains small amounts of yohimbine. Research in healthy adults shows that taking yohimbine in doses of 8 mg or more seems to inhibit platelet aggregation in vitro by binding to the alpha-2 adrenoceptor. The effects of Rauvolfia vomitoria itself are unclear.

Likelihood Possible Evidence D
Rauvolfia vomitoria Root Extract full monograph & interactions

Caffeine Anhydrous41 drug types · 655 drugs

Ephedrine

Theoretically, concomitant use might increase the risk for stimulant adverse effects.
Use of ephedrine with caffeine can increase the risk of stimulatory adverse effects. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, caffeine might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Some evidence shows that caffeine is a competitive inhibitor of adenosine and can reduce the vasodilatory effects of adenosine in humans. However, other research shows that caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, caffeine may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Caffeine is reported to have antiplatelet activity. Theoretically, it might increase the risk of bleeding when used concomitantly with these agents; however, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Beta-Adrenergic Agonists

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Carbamazepine (Tegretol)

Theoretically, caffeine might reduce the effects of carbamazepine and increase the risk for convulsions.
Animal research suggests that taking caffeine can lower the anticonvulsant effects of carbamazepine and can induce seizures when taken in doses above 400 mg/kg. Human research has shown that taking caffeine 300 mg in three divided doses along with carbamazepine 200 mg reduces the bioavailability of carbamazepine by 32% and prolongs the plasma half-life of carbamazepine 2-fold in healthy individuals.

Likelihood Possible Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the levels and adverse effects of caffeine.
Cimetidine decreases the rate of caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Caffeine might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Caffeine might increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg per day inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Although researchers speculate that caffeine might inhibit CYP1A2, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients more sensitive to an interaction between clozapine and caffeine. In one case report, severe, life-threatening clozapine toxicity and multiorgan system failure occurred in a patient with schizophrenia stabilized on clozapine who consumed caffeine 600 mg daily.

Likelihood Possible Evidence B
Dipyridamole (Persantine)

Theoretically, caffeine might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Caffeine inhibits dipyridamole-induced vasodilation. It is recommended that methylxanthines and methylxanthine-containing products be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram use might increase the levels and adverse effects of caffeine.
Disulfiram decreases the rate of caffeine clearance.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Ethosuximide (Zarontin)

Theoretically, caffeine might reduce the effects of ethosuximide and increase the risk for convulsions.
Animal research suggests that caffeine 92.4 mg/kg can decrease the anticonvulsant activity of ethosuximide. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Felbamate (Felbatol)

Theoretically, caffeine might reduce the effects of felbamate and increase the risk for convulsions.
Animal research suggests that a high dose of caffeine 161.7 mg/kg can decreases the anticonvulsant activity of felbamate. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Flutamide (Eulexin)

Theoretically, caffeine might increase the levels and adverse effects of flutamide.
In vitro evidence suggests that caffeine can inhibit the metabolism of flutamide. However, this effect has not been reported in humans.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence D
Lithium

Abrupt caffeine withdrawal might increase the levels and adverse effects of lithium.
Caffeine has diuretic activity. When abruptly discontinued, caffeine may alter the clearance of lithium. There are two case reports of lithium tremor that worsened upon abrupt coffee withdrawal and 6 case reports of elevated serum lithium levels after reducing or eliminating caffeine intake. In one case, a male with schizoaffective disorder stabilized on lithium had an elevated lithium level after reducing his caffeine intake by 87%. At a later date, he increased his caffeine intake by 6-fold, resulting in a subtherapeutic lithium level and a recurrence of psychiatric symptoms.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, caffeine might decrease the effects of pentobarbital.
Caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

Theoretically, caffeine might reduce the effects of phenobarbital and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenobarbital. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, caffeine might reduce the effects of phenytoin and increase the risk for convulsions.
Animal research suggests that caffeine can decrease the anticonvulsant activity of phenytoin. The effect does not seem to be related to the seizure threshold-lowering effects of caffeine. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Pioglitazone (Actos)

Theoretically, caffeine might increase the levels and clinical effects of pioglitazone.
Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Quinolones (also called fluoroquinolones) can decrease caffeine clearance by inhibiting cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce the metabolism of one or both agents.

Likelihood Possible Evidence D
Caffeine Anhydrous full monograph & all 41 interactions

L-Arginine Pyroglutamate9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine Pyroglutamate full monograph & interactions

Toothed Clubmoss Aerial Parts Extract2 drug types · 219 drugs

Anticholinergic Drugs

In animal models, toothed clubmoss and huperzine A, an active constituent of toothed clubmoss, reversed cognitive deficits induced by scopolamine. Theoretically, concurrent use of anticholinergic drugs and toothed clubmoss might decrease the effectiveness of toothed clubmoss or the anticholinergic drug.
Some anticholinergic drugs include atropine, benztropine (Cogentin), biperiden (Akineton), procyclidine (Kemadrin), and trihexyphenidyl (Artane).

Likelihood Possible Evidence D
Cholinergic Drugs

Huperzine A, a constituent of toothed clubmoss, has demonstrated acetylcholinesterase inhibitory properties. Theoretically, concurrent use of toothed clubmoss with cholinergic drugs might have additive effects and increase the risk of cholinergic side effects.
Cholinergic drugs include bethanechol (Urecholine), donepezil (Aricept), echothiophate (Phospholine Iodide), edrophonium (Enlon, Reversol, Tensilon), neostigmine (Prostigmin), physostigmine (Antilirium), pyridostigmine (Mestinon, Regonol), succinylcholine (Anectine, Quelicin), and tacrine (Cognex).

Likelihood Possible Evidence D
Toothed Clubmoss Aerial Parts Extract full monograph & interactions

L-Citrulline Malate2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline Malate full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nuclear Armageddon Fruit Explosion, from the product label.

Anabolic Warfare

See all Anabolic Warfare products
Name
Anabolic Warfare
City
Austin
State
TX
Phone Number
888-301-4002
Web Address
anabolicwarfare.com
Pharmacist Counseling Corner

Nuclear Armageddon Fruit Explosion by Anabolic Warfare: Common Questions

Does Nuclear Armageddon Fruit Explosion by Anabolic Warfare interact with any medications?
Yes. Based on its ingredients, Nuclear Armageddon Fruit Explosion has a known interaction with 1,100 medications, including 230 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nuclear Armageddon Fruit Explosion contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's the beta-alanine tingling I've heard about?
That's paresthesia — a harmless pins-and-needles feeling that beta-alanine commonly causes. It usually starts on your scalp within 20 minutes of taking it, spreads across your body, and lasts about an hour. It's dose-dependent: at lower doses, only about a quarter of people experience it, and it's very mild. At higher doses it can feel more pronounced but isn't dangerous.
Can I use this during pregnancy or while breastfeeding?
No. Beta-alanine, L-citrulline malate, and toothed clubmoss advise against use in pregnancy and breastfeeding due to insufficient safety data. Caffeine may increase pregnancy risks — ask your doctor about safe limits — and small amounts pass into breast milk. L-arginine pyroglutamate and Rauvolfia vomitoria also lack sufficient safety data for these times. Talk with your doctor or pharmacist before using any of these ingredients if you're pregnant or nursing.
Does this have any fillers?
Yes. The inactive ingredients include citric acid, silicon dioxide, natural and artificial flavors, sucralose, and acesulfame potassium — these are the fillers, binders, and flavorings that make up the powder.
Will this help me build muscle or get stronger?
Beta-alanine and L-citrulline malate are possibly effective for athletic performance, and caffeine is likely effective for it. But this product is not rated for muscle growth or strength-building specifically — the evidence we hold supports performance during activity rather than muscle building over time. Results vary by person and depend on your training.
What about the caffeine content — how much is in a serving?
The product facts don't list the specific dose of caffeine anhydrous per serving, so you'll need to check the nutrition label on the package or contact the manufacturer directly.
Are there any ingredients you couldn't check for interactions?
Yes. We could not check Cluster Dextrin, Nitrosigine, or the full component breakdown of the Stimulant Blend — we hold no interaction data for those. If any of those are new to you or you're on medications, ask your pharmacist about them specifically.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nuclear Armageddon Fruit Explosion label
Go deeper

The Full Monographs Behind Nuclear Armageddon Fruit Explosion’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph → Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Caffeine

Interacts with 655 drugs

Caffeine is a natural stimulant found in coffee, tea, and many other plants and products. In moderate amounts it can boost alertness and reduce tiredness for most healthy adults, but too muc...

Read the full Caffeine monograph → Herb & supplement monograph

Toothed Clubmoss

Interacts with 219 drugs

Toothed Clubmoss is a moss-like plant best known as the natural source of huperzine A, a compound studied mainly for memory and Alzheimer's disease. Some early research is promising, but the...

Read the full Toothed Clubmoss monograph → Herb & supplement monograph

Rauvolfia Vomitoria

Interacts with 840 drugs

Rauvolfia vomitoria is an African shrub whose root contains powerful alkaloids, including reserpine, that have historically been used for high blood pressure and agitation. Because these com...

Read the full Rauvolfia Vomitoria monograph →
Sources

Sources & How We Checked

Nuclear Armageddon Fruit Explosion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 395 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-alanine 13 references
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  2. Hill CA, Harris RC, Kim HJ, et al. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids 2007;32:225-33.
  3. Bellinger PM, Minahan CL. The effect of ß-alanine supplementation on cycling time trials of different length. Eur J Sport Sci 2016;16(7):829-36.
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  5. Glenn JM, Gray M, Stewart R, et al. Incremental effects of 28 days of beta-alanine supplementation on high-intensity cycling performance and blood lactate in masters female cyclists. Amino Acids 2015;47(12):2593-600. PubMed
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  7. Howe ST, Bellinger PM, Driller MW, Shing CM, Fell JW. The effect of beta-alanine supplementation on isokinetic force and cycling performance in highly trained cyclists. Int J Sport Nutr Exerc Metab 2013;23(6):562-70. PubMed
  8. Sweeney KM, Wright GA, Glenn Brice A, Doberstein ST. The effect of beta-alanine supplementation on power performance during repeated sprint activity. J Strength Cond Res 2010;24(1):79-87.
  9. Décombaz J, Beaumont M, Vuichoud J, Bouisset F, Stellingwerff T. Effect of slow-release ß-alanine tablets on absorption kinetics and paresthesia. Amino Acids 2012;43(1):67-76. Erratum in: Amino Acids 2013;45(4):1015.
  10. Stellingwerff T, Anwander H, Egger A, et al. Effect of two ß-alanine dosing protocols on muscle carnosine synthesis and washout. Amino Acids 2012;42(6):2461-72. PubMed
  11. da Silva RP, de Oliveira LF, Saunders B, et al. Effects of ß-alanine and sodium bicarbonate supplementation on the estimated energy system contribution during high-intensity intermittent exercise. Amino Acids. 2019;51(1):83-96. PubMed
  12. Varanoske AN, Hoffman JR, Church DD, et al. Comparison of sustained-release and rapid-release ß-alanine formulations on changes in skeletal muscle carnosine and histidine content and isometric performance following a muscle-damaging protocol. Amino Acids. PubMed
  13. Perim P, Gobbi N, Duarte B, et al. Beta-alanine did not improve high-intensity performance throughout simulated road cycling. Eur J Sport Sci 2021. PubMed

See these in context on the Beta-alanine monograph →

Caffeine 236 references
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Betaine Anhydrous 11 references
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L-arginine 66 references
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L-citrulline 8 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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