Major interaction on record — check this product against your medications before combining. Based on 6 of 10 ingredients. Check your meds →
Dietary supplement

100% Hydrolyzed Whey Protein Alpine Vanilla Ingredients & Drug Interactions

by NutraBio

100% Hydrolyzed Whey Protein Alpine Vanilla label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 100% Hydrolyzed Whey Protein Alpine Vanilla against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

100% Hydrolyzed Whey Protein Alpine Vanilla is a dietary supplement by NutraBio with 10 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 2,047 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Xanthan Gum, Sodium, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against 100% Hydrolyzed Whey Protein Alpine Vanilla by NutraBio

Ask about any prescription or over-the-counter medication and we check it for interactions with 100% Hydrolyzed Whey Protein Alpine Vanilla by NutraBio — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of 100% Hydrolyzed Whey Protein Alpine Vanilla by NutraBio

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • “Flavoring” is listed as a grouped ingredient — the label gives one combined amount (1 Gram(s)) without saying how much of each component you get.

This product contains 8 ingredients, with several active ones. The main ingredient is hydrolyzed whey protein — whey that's been broken down into smaller pieces for easier digestion and absorption.

You also get sodium, potassium, and calcium, which are minerals your body needs for muscle function, nerve signals, and bone health. Xanthan gum is a thickener derived from a bacterium; it's used to control texture.

Natural vanilla flavor provides taste. The remaining ingredients are the sweetener sucralose and additional flavoring.

The product contains no other inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle building and protein intake support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, HIV/AIDS-related wasting, Sarcopenia, Muscle recovery, Protein supplementation — and 2 related terms.
  • The strongest evidence on file: Whey Protein is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Calcium is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.
  • Also on file: Whey Protein is rated "Insufficient Reliable Evidence To Rate" for HIV/AIDS-related wasting, HIV/AIDS, Sarcopenia, Exercise-induced muscle damage.

The whey protein in here is possibly effective for athletic performance — it supports muscle growth and recovery when you're training. The calcium is likely effective for osteoporosis prevention.

Sodium, potassium, and calcium are all essential minerals, though they're not being added to "treat" a deficiency in a typical serving of protein powder — they're there in amounts you'd encounter in food. The evidence on whey protein for bone health suggests it may actually be ineffective, so don't count on this as an osteoporosis treatment by itself.

The evidence, ingredient by ingredient Sodium Potassium Calcium Xanthan Gum Vanilla Whey Protein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Whey protein is generally well tolerated in healthy adults when used as directed. Common side effects are mild and dose-related — bloating, cramps, diarrhea, nausea, headache, and in some people, acne.

The minerals (sodium, potassium, calcium) are safe in the amounts normally eaten, but this product isn't a supplement designed to boost them; they're just naturally present in whey. High sodium intake is linked to high blood pressure and heart strain over time, and high potassium or calcium from supplements can cause problems if you have kidney disease or certain medical conditions.

Xanthan gum is safe in food amounts for most people; it can rarely cause allergic reactions topically.

Side effects, ingredient by ingredient Sodium Potassium Calcium Xanthan Gum Vanilla Whey Protein

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Xanthan Gum, Calcium, Whey Protein, Potassium, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 2,048 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take levodopa (Parkinson disease), blood pressure or heart drugs (ACE inhibitors, ARBs, antihypertensives, diltiazem, sotalol), thyroid medication (levothyroxine), quinolone or tetracycline antibiotics, bisphosphonates (osteoporosis), corticosteroids, lithium, or didanosine. No interactions are documented for natural vanilla flavor.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a whey protein powder suitable for healthy adults looking to support muscle recovery and athletic performance. If you take any blood pressure medications, heart drugs, thyroid medication, antibiotics, lithium, or osteoporosis drugs, run your medications through the interaction checker below before using this product.

Talk with your pharmacist if you have kidney disease, since the minerals and protein load may need adjustment.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 100% Hydrolyzed Whey Protein Alpine Vanilla, straight from the product label.

Brand NutraBio
Barcode (UPC) 649908255404
Net contents 2 lbs; 907 Gram(s)
Market status On market
Date entered into DSLD Oct 22, 2015
DSLD ID 51156
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 100% Hydrolyzed Whey Protein Alpine Vanilla by NutraBio, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
32.5 Gram(s)
Maximum serving Sizes:
32.5 Gram(s)
Servings per container
28
UPC/BARCODE
649908255404
IngredientAmount% DV
Calories120 {Calories}--
Total Carbohydrates2 Gram(s)1%
Sugar2 Gram(s)--
Calories from Fat10 {Calories}--
Protein25 Gram(s)50%
Saturated Fat1 Gram(s)4%
Sodium60 mg3%
Potassium20 mg1%
Cholesterol15 mg4%
Calcium15 mg2%
Salt65 mg--
Xanthan Gum100 mg--
natural Vanilla flavor610 mg--
Sucralose68 mg--
Total Fat1.5 Gram(s)2%
Flavoring1 Gram(s)--
hydrolyzed Whey Protein31.6 Gram(s)--

Other ingredients: Absolutely None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

1 serving Mixed with favorite beverage 8 oz. shake well 1-3 servings based on protein needs daily Suggested Use: Add 1 scoop with 8 ounces of cold water or your favorite beverage to a shaker cup or blender and mix for 25-30 seconds. Vary the amount of liquid to meet your desired taste and consistency. Drink 1-4 servings daily as needed to satisfy your protein requirements. Using nonfat milk instead of water will give you a thicker, creamier shake.

Formula

100% WHEY ISOLATE – for 100% RESULTS!

Each serving contains 25 grams of complete protein derived solely from 100% Whey Protein Isolate.

HIGH CONCENTRATION OF BCAAs & AMINO ACIDS

Typical amino acid profile per serving: {Chart} Essential Amino Acids (EAAs) Tryptophan 411mg Valine** 1392mg Threonine 1614mg Isoleucine** 1487mg Leucine** 2563mg Lysine 2563mg Phenylalanine 759mg Methionine 506mg Conditionally Essential Amino Acids (CAAs) Arginine 570mg Cysteine 696mg Tyrosine 823mg Histidine 380mg Proline 1487mg Glutamic Acid (Glutamine Precursor) 4209mg Nonessential Amino Acids (NAAs) Aspartic Acid 2595mg Serine 1266mg Glycine 411mg Alanine 1266mg ** Branch Chain Amino Acids

Fast absorbing hydrolyzed whey

High Concentration of BCAAs

25g Protein 5.4g BCAAs

Allergens: Milk.

Kosher, Soy Free, Gluten Free & BSE/TSE Free

Formulation

This supplement has NOT been amino or nitrogen spiked and contains NO whey concentrate, maltodextrin, dextrose, creamer or other fillers.

NO AMINO SPIKING NO WHEY CONCENTRATE NO ION OR ACID WHEY NO PROPRIETARY BLENDS NO HIDDEN INGREDIENTS NO BANNED SUBSTANCES LOW FAT & CHOLESTEROL NO DEXTROSE/MALTODEXTRIN NO FILLERS or EXCIPIENTS NO GLUTEN, SOY or BSE/TSE

No fillers No amino spiking No excipients

Kosher, Soy Free, Gluten Free & BSE/TSE Free

General Statements

This whey protein isolate provides the perfect amino acid profile required for optimum nitrogen retention, protein synthesis and muscle growth.

Shown is the typical amino acid profile per serving which is derived from whey protein isolate only. Absolutely no ingredients have been added to spike protein values.

Quality and purity since 1996. NutraBio manufactures in our own FDA registered & inspected GMP facility complying with FDA 21 CFR Part 111 regulations.

Manufactured in our GMP & FDA inspected facility FDA Registration: 16906175560

BUILD ~ REPAIR ~ GROW

Maximizes Protein Synthesis High Biological Value (BV)

Made in our GMP & FDA inspected facility

This product is intended as a dietary supplement only. Do not use as a sole source of nutrition.

SERVING SCOOP INCLUDED (MAY SETTLE TO THE BOTTOM DURING SHIPPING.)

Without compromise since 1996

Made in USA

Full label disclosure No proprietary blends Every ingredient disclosed with dosage Absolutely no amino acid spiking

Seals/Symbols

NO AMINO SPIKING SPIKE FREE

TRUE LABEL FULL LABEL DISCLOSURE

OU D

FDA Statement of Identity

Dietary Supplement

Precautions

Allergens: Milk.

Storage

STORE IN A COOL DRY PLACE.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

25540-005 B20425-002

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

100% Hydrolyzed Whey Protein Alpine Vanilla by NutraBio label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

100% Hydrolyzed Whey Protein Alpine Vanilla label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 100% Hydrolyzed Whey Protein Alpine Vanilla by NutraBio

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size32.5 Gram(s) Dosage formPowder Servings per container28 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

2 Gram(s) per serving

Protein

25 Gram(s) per serving

Sodium

Interacts with
205 drugs
60 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
20 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Calcium

Interacts with
168 drugs
15 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Flavoring

1 Gram(s) per serving

Hydrolyzed Whey Protein

Interacts with
53 drugs
31.6 Gram(s) per serving Form: Sunflower Lecithin

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined...

Hydrolyzed Whey Protein monograph & interactions

Other (inactive) ingredients: Absolutely None. These complete the product’s ingredient list but are not active constituents.

Interaction report

100% Hydrolyzed Whey Protein Alpine Vanilla by NutraBio Drug Interactions

Want to check YOUR meds against 100% Hydrolyzed Whey Protein Alpine Vanilla?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,047Drugs
12 Major 301 Moderate 1,734 Minor

Ingredients driving the most interactions

Xanthan Gum 2,022
Sodium 205
Calcium 168
Potassium 62
hydrolyzed Whey Protein 53

Individual Drug Interactions

The ingredients in 100% Hydrolyzed Whey Protein Alpine Vanilla interact with 2,047 drugs. Click any drug to see the details.

5 of the 10 ingredients in 100% Hydrolyzed Whey Protein Alpine Vanilla interact with drugs. Each result below shows which ingredient is responsible. Xanthan Gum Sodium Calcium Potassium hydrolyzed Whey Protein

Each ingredient & the kinds of drugs it affects

For each ingredient in 100% Hydrolyzed Whey Protein Alpine Vanilla with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Xanthan Gum1 drug type · 2,022 drugs

Oral Drugs

Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities. Xanthan gum slows gastric emptying and has been used to control the release of drugs in tablet formulations. To avoid any alterations in drug absorption, xanthan gum should be taken 30-60 minutes after oral medications.

Likelihood Possible Evidence D
Xanthan Gum full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

hydrolyzed Whey Protein4 drug types · 53 drugs

Levodopa

Theoretically, whey protein might decrease levodopa absorption.
Small clinical studies show that concomitant ingestion of protein or high doses of leucine or isoleucine (100 mg/kg) and levodopa can exacerbate tremor, rigidity, and the "on-off" syndrome in patients with Parkinson disease.

Likelihood Probable Evidence D
Bisphosphonates

Theoretically, whey protein might reduce the absorption of bisphosphonates.
Whey protein contains minerals such as calcium that bind bisphosphonates in the gut. Advise patients to take bisphosphonates at least 30 minutes before whey protein, but preferably at a different time of day.

Likelihood Probable Evidence D
Quinolone Antibiotics

Theoretically, whey protein might decrease quinolone absorption.
Whey protein contains minerals, such as calcium, that can bind to quinolones in the gut. To avoid this interaction, advise patients to take oral quinolones at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, whey protein might decrease tetracycline absorption.
Whey protein contains minerals, such as calcium, that bind to tetracyclines in the gut. To avoid this interaction, advise patients to take oral tetracyclines at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
hydrolyzed Whey Protein full monograph & interactions
The maker

Brand information

Manufacturer and brand details for 100% Hydrolyzed Whey Protein Alpine Vanilla, from the product label.

NutraBio

See all NutraBio products
Name
NutraBio Labs, Inc.
Street Address
564 Lincoln Blvd.
City
Middlesex
State
NJ
ZipCode
08846
Phone Number
732-748-8606
Web Address
www.nutrabio.com
Pharmacist Counseling Corner

100% Hydrolyzed Whey Protein Alpine Vanilla by NutraBio: Common Questions

Does 100% Hydrolyzed Whey Protein Alpine Vanilla by NutraBio interact with any medications?
Yes. Based on its ingredients, 100% Hydrolyzed Whey Protein Alpine Vanilla has a known interaction with 2,047 medications, including 12 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
100% Hydrolyzed Whey Protein Alpine Vanilla contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this protein powder work if I take my thyroid medication at the same time?
No — calcium in this product can reduce how much thyroid medication your body absorbs. Take your levothyroxine at least 4 hours apart from this powder. Talk with your pharmacist about the exact timing that works best for your schedule.
What are the most common side effects?
Bloating, cramps, diarrhea, nausea, and headache are most common and are usually dose-related — they often go away if you use less or let your stomach adjust. Some people report acne when using whey protein; if that happens, stopping usually clears it up.
Does it contain any fillers or unnecessary ingredients?
No — the product has no other inactive ingredients. What you see is what you get: whey protein, minerals, xanthan gum for texture, vanilla flavor, and sucralose as sweetener.
Is it safe to use during pregnancy?
Whey protein itself has no pregnancy safety data on file, so there isn't enough to know either way. Calcium is likely safe in pregnancy at recommended amounts. Talk with your doctor or midwife before starting any supplement during pregnancy.
Can I use this if I have high blood pressure?
If you take blood pressure medication, the sodium in this product could theoretically reduce how well your drug works. High sodium intake can also raise blood pressure. Check with your doctor or pharmacist about whether this product fits your needs.
Is this powder good for bone health?
The calcium may help with bone strength, and calcium is rated likely effective for osteoporosis. However, the whey protein itself is rated possibly ineffective for bone health, so don't rely on this powder alone to protect your bones.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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100% Hydrolyzed Whey Protein Alpine Vanilla label
Go deeper

The Full Monographs Behind 100% Hydrolyzed Whey Protein Alpine Vanilla’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Xanthan Gum

Interacts with 2,022 drugs

Xanthan gum is a fermentation-made fiber widely used to thicken and stabilize foods and to thicken liquids for people with swallowing difficulties. It is generally recognized as safe in the...

Read the full Xanthan Gum monograph → Herb & supplement monograph

Vanilla

Vanilla is best known and very safe as a food flavoring, and small amounts used in cooking are not a concern for most people. As a health supplement, evidence for any specific medical benefi...

Read the full Vanilla monograph → Herb & supplement monograph

Whey Protein

Interacts with 53 drugs

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined with exercise. It is generally safe for...

Read the full Whey Protein monograph →
Sources

Sources & How We Checked

100% Hydrolyzed Whey Protein Alpine Vanilla's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 153 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
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  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
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  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
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  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
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  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
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  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
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  32. Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
  33. Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
  34. Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
  35. Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
  37. George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Potassium 12 references
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  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
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  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Calcium 62 references
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See these in context on the Calcium monograph →

Xanthan Gum 11 references
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  2. van der Reijden WA, van der Kwaak, Vissink A, et al. Treatment of xerostomia with polymer-based saliva substitutes in patients with Sjogren's syndrome. Arthritis Rheum 1996;39:57-63.
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  6. Llamas-Moreno JF, Baiza-Durán LM, Saucedo-Rodríguez LR, Alaníz-De la O JF. Efficacy and safety of chondroitin sulfate/xanthan gum versus polyethylene glycol/propylene glycol/hydroxypropyl guar in patients with dry eye. Clin Ophthalmol 2013;7:995-9. PubMed
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See these in context on the Xanthan Gum monograph →

Vanilla 5 references
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See these in context on the Vanilla monograph →

Whey Protein 25 references
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See these in context on the Whey Protein monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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