7-methoxyflavone + Exemestane
Exemestane brand name: Aromasin.
7-methoxyflavone has a moderate interaction with Exemestane. In vitro evidence shows that 7-methoxyflavone inhibits aromatase.
Read the full interaction report7-methoxyflavone and Exemestane
Here is the interaction we found between these two, with the evidence behind it.
AROMATASE INHIBITORS
Why this applies to Exemestane
Exemestane falls under AROMATASE INHIBITORS — the group 7-methoxyflavone interacts with.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing about Exemestane (Aromasin): it's already an aromatase inhibitor, meaning its whole job is to block the enzyme that makes estrogen. The supplement 7-methoxyflavone is marketed as doing the very same thing. So stacking them isn't a metabolism issue, it's an overlap. In lab dishes the supplement blocks aromatase too, so in theory you'd be doubling up on the same action.
If estrogen drops even lower than your cancer treatment intends, you could see more of Exemestane's usual side effects, things like hot flashes, joint and muscle aches, fatigue, or bone thinning. Honestly, this is theoretical and based on test-tube data, not real patients. But since you're on cancer therapy, please loop in your oncologist or pharmacist before adding it.
- Ta N, Walle T. Aromatase inhibition by bioavailable flavones. J Steroid Biochem Mol Biol 2007;107(1-2):127-9.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
7-methoxyflavone Also Interacts With Other Medications
7-methoxyflavone has 11 moderate known drug interactions in our database — the Exemestane one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against 7-methoxyflavone
We haven’t checked that one against 7-methoxyflavone yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against 7-methoxyflavone. Pick one to open its full report.
See Every Supplement That Interacts With Exemestane
This page covers 7-methoxyflavone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Exemestane page lists 141 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 98 moderate · 40 minor.
From our pharmacist’s overview on the Exemestane page
“Exemestane (Aromasin) is an aromatase inhibitor for hormone-sensitive breast cancer, and because its job is keeping estrogen suppressed, anything that shifts its blood level puts the treatment itself at risk. This list deserves real care.”
Reviewed by 2 · Jul 18, 2026
Taking 7-methoxyflavone as Part of a Dietary Supplement Product? Check It for Interactions
We hold 20 real supplement products containing 7-methoxyflavone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 7-methoxyflavone. Your product may carry other ingredients that interact with Exemestane too, on top of 7-methoxyflavone — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where 7-methoxyflavone and Exemestane Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#777 of 1,452 supplements looked up here in the last 7 days
#1,308 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About 7-methoxyflavone
What is 7-methoxyflavone?
- Boosting testosterone
- Reducing estrogen (aromatase inhibition)
- Athletic and bodybuilding performance
- Muscle building support
7-Methoxyflavone is a lab-made or plant-derived flavonoid marketed mainly in testosterone-boosting and bodybuilding supplements based on the idea that it blocks the aromatase enzyme. However, solid human evidence that it raises testosterone, improves performance, or builds muscle is essentially lacking, and its long-term safety has not been well studied. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
About Exemestane
What Is Exemestane Used For?
Brand name: Aromasin
Exemestane is used in postmenopausal women with breast cancer that is fueled by estrogen. It has two uses.
The first is early breast cancer that is estrogen-receptor positive, after two to three years of tamoxifen. Exemestane then completes a total of five consecutive years of hormone therapy. The second is advanced breast cancer that has progressed after tamoxifen. These uses are listed for Aromasin and for exemestane tablets.
Other Drugs & 7-methoxyflavone
Browse every other medication we’ve checked against 7-methoxyflavone — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
11 interactions
- Testosterone ›
- Methyltestosterone ›
- Testosterone Undecanoate ›
- Methyltestosterone Buccal ›
- Anastrozole ›
- Letrozole ›
- Testosterone Enanthate ›
- Conjugated Estrogens, Methyltestosterone ›
- Diethylstilbestrol, Methyltestosterone ›
- Esterified Estrogens, Methyltestosterone ›
- Letrozole, Ribociclib Succinate ›
No interaction 2,818 drugs checked — show the list
We also checked 7-methoxyflavone against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Abemaciclib ›
- Ivermectin ›
- Sertraline ›
- Losartan Potassium ›
- Acetaminophen ›
- Aspirin ›
- Rosuvastatin ›
- Escitalopram ›
- Metoprolol ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Warfarin Sodium ›
- Tirzepatide ›
- Ibuprofen ›
- Amlodipine Besylate ›
- Methamphetamine ›
- Docusate ›
- Tadalafil ›
- Hydroxyurea ›
- Metformin ›
- Valacyclovir ›
- Sumatriptan ›
- Prednisone ›
- Semaglutide ›
- Amitriptyline ›
- Lisdexamfetamine ›
- Amphetamine ›
- Levothyroxine, Liothyronine ›
- Propranolol ›
- Methotrexate ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Bendamustine ›
- Pregabalin ›
- Doxycycline ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Acyclovir ›
- Naproxen ›
- Acetaminophen, Aspirin, Caffeine ›
- Quetiapine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Duloxetine ›
- Citalopram ›
- Methylene Blue ›
- Acetaminophen, Codeine ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,818 medications checked with no known interaction — see the full 7-methoxyflavone list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Taking 7-methoxyflavone and Exemestane Together: Common Questions
Can you take 7-methoxyflavone with Exemestane?
How serious is the 7-methoxyflavone and Exemestane interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Exemestane and 7-methoxyflavone?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.