7-methoxyflavone + Esterified Estrogens, Methyltestosterone
Esterified Estrogens, Methyltestosterone brand name: Estratest.
7-methoxyflavone has a moderate interaction with Esterified Estrogens, Methyltestosterone. In vitro evidence shows that 7-methoxyflavone inhbits aromatase.
Read the full interaction report7-methoxyflavone and Esterified Estrogens, Methyltestosterone
Here is the interaction we found between these two, with the evidence behind it.
TESTOSTERONE
Why this applies to Esterified Estrogens, Methyltestosterone
Esterified Estrogens, Methyltestosterone falls under TESTOSTERONE — the group 7-methoxyflavone interacts with.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Estratest combines an estrogen with methyltestosterone, a synthetic form of testosterone. Normally your body turns some testosterone into estrogen using an enzyme called aromatase. The idea here is that 7-methoxyflavone may block that enzyme, so less of the testosterone part gets converted away. In theory, that could leave a bit more active testosterone hanging around, which may nudge up both the wanted and unwanted effects.
For methyltestosterone, that could mean more acne, oily skin, unwanted hair growth, voice changes, or mood shifts, and in women, masculinizing effects. That said, this is only a theory based on lab dish studies, not real human data, so I wouldn't lose sleep over it. Still, since I see little proven benefit from this supplement, please run it by your pharmacist or doctor first.
- Ta N, Walle T. Aromatase inhibition by bioavailable flavones. J Steroid Biochem Mol Biol 2007;107(1-2):127-9.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
7-methoxyflavone Also Interacts With Other Medications
7-methoxyflavone has 11 moderate known drug interactions in our database — the Esterified Estrogens, Methyltestosterone one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against 7-methoxyflavone
We haven’t checked that one against 7-methoxyflavone yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against 7-methoxyflavone. Pick one to open its full report.
See Every Supplement That Interacts With Esterified Estrogens, Methyltestosterone
This page covers 7-methoxyflavone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Esterified Estrogens, Methyltestosterone page lists 221 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).
By severity: 6 major · 177 moderate · 38 minor.
From our pharmacist’s overview on the Esterified Estrogens, Methyltestosterone page
“Start with grapefruit. For anyone taking Estratest (esterified estrogens, methyltestosterone) for menopausal symptoms, grapefruit juice blocks the enzyme that clears these hormones, letting levels and side effects climb, while St.”
Reviewed by 2 · Jul 18, 2026
Open the Esterified Estrogens, Methyltestosterone interaction page
Taking 7-methoxyflavone as Part of a Dietary Supplement Product? Check It for Interactions
We hold 20 real supplement products containing 7-methoxyflavone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 7-methoxyflavone. Your product may carry other ingredients that interact with Esterified Estrogens, Methyltestosterone too, on top of 7-methoxyflavone — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where 7-methoxyflavone and Esterified Estrogens, Methyltestosterone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#545 of 1,452 supplements looked up here in the last 7 days
#2,168 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About 7-methoxyflavone
What is 7-methoxyflavone?
- Boosting testosterone
- Reducing estrogen (aromatase inhibition)
- Athletic and bodybuilding performance
- Muscle building support
7-Methoxyflavone is a lab-made or plant-derived flavonoid marketed mainly in testosterone-boosting and bodybuilding supplements based on the idea that it blocks the aromatase enzyme. However, solid human evidence that it raises testosterone, improves performance, or builds muscle is essentially lacking, and its long-term safety has not been well studied. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
Other Drugs & 7-methoxyflavone
Browse every other medication we’ve checked against 7-methoxyflavone — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
11 interactions
No interaction 2,818 drugs checked — show the list
We also checked 7-methoxyflavone against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Ibuprofen ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
Showing the 60 most looked-up of 2,818 medications checked with no known interaction — see the full 7-methoxyflavone list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Esterified Estrogens, Methyltestosterone Is Linked to Lower Levels of 5 Nutrients
Natural Medicines records Esterified Estrogens, Methyltestosterone as a medicine that can lower these. This is not an interaction with 7-methoxyflavone — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Esterified Estrogens, Methyltestosterone nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking 7-methoxyflavone and Esterified Estrogens, Methyltestosterone Together: Common Questions
Can you take 7-methoxyflavone with Esterified Estrogens, Methyltestosterone?
How serious is the 7-methoxyflavone and Esterified Estrogens, Methyltestosterone interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Esterified Estrogens, Methyltestosterone and 7-methoxyflavone?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.