Yew Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Yew interacts with medications. The heart of this page is the interaction list — every drug Yew is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Yew is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Yew against your medication
Add one medicationDrugs that interact with Yew
0 medications have a known interaction with Yew, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Yew. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Yew combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Yew: Uses, Safety & Side Effects
Yew is a highly poisonous plant, and nearly all parts can be deadly even in small amounts. It is famous mainly because pharmaceutical drugs like paclitaxel (Taxol) are made from yew compounds in a controlled lab setting — but yew itself should never be taken as a supplement, tea, or home remedy.
- Scientific name
- Taxus baccata
- Family
- Taxaceae
- Part used
- Needles (leaves), bark, and seeds (all highly toxic); semi-synthetic drugs are derived from yew compounds
- Common forms
- Not used as a home remedy; yew-derived compounds are used only as prescription chemotherapy drugs (paclitaxel, docetaxel)
- Source of cancer chemotherapy drugs
- Historical folk and ornamental use
- Traditional remedies (now considered unsafe)
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Yew is highly toxic and can cause sudden death; it should never be used as a supplement or home remedy.
When the needles are used orally. Yew needles have been used as an abortifacient.
Read the full pregnancy detailWhen the needles are used orally. Yew needles have been used as an abortifacient.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Yew is an evergreen tree or shrub (most often Taxus baccata, the European yew) found in Europe, Asia, and North America. It has dark green needle-like leaves and produces a soft red berry-like structure called an aril, which surrounds a hard, toxic seed.
Yew is commonly grown as a hedge or ornamental plant in gardens and graveyards. Despite its long history in folklore and traditional medicine, yew is extremely poisonous. Almost every part of the plant contains dangerous compounds.
Today, yew's main importance in medicine is as a natural source of taxane compounds, which scientists use to make prescription cancer drugs in carefully controlled laboratory settings. The raw plant is not a safe dietary supplement.
Uses & effectiveness
There is no proven safe use of raw yew as a dietary supplement or herbal remedy. People have historically tried yew preparations for various ailments, but these uses are dangerous and are not supported by evidence.
Yew's true medical value comes from taxane drugs like paclitaxel (Taxol) and docetaxel (Taxotere), which are derived or semi-synthesized from yew compounds. These prescription chemotherapy medicines are well studied and effective for cancers such as breast, ovarian, and lung cancer — but they are given by oncologists at precise doses, not as herbal products.
It is important to understand that taking yew plant, tea, or extracts will not give you the benefits of these cancer drugs. Instead, it can cause severe poisoning or death.
How it works
Yew contains a group of poisonous compounds called taxine alkaloids (such as taxine A and B). These alkaloids interfere with the heart's electrical activity and can cause dangerous, sometimes fatal, heart rhythm problems.
Yew also contains taxanes, including the parent compound used to develop paclitaxel. In the lab, taxanes work by binding to structures inside cells called microtubules and stopping cancer cells from dividing. This anti-cancer action only works safely when isolated and dosed as a controlled pharmaceutical drug.
The key point is that the same plant holds both deadly heart toxins and the raw material for life-saving drugs — which is why it must be processed by professionals and never used as a home remedy.
Safety & precautions
Yew is one of the most poisonous plants in the world. Eating even a small amount of needles or seeds can cause severe poisoning and sudden death, sometimes with little warning. Poisonings have occurred in both people and animals, including livestock and pets.
No one should consume yew leaves, bark, seeds, teas, tinctures, or homemade extracts. The red flesh of the aril is sometimes said to be less toxic, but the seed inside is deadly, so the whole plant should be treated as dangerous.
Pregnancy and breastfeeding: Yew must be completely avoided. It is poisonous and may cause miscarriage, harm to the baby, or death of the mother.
Keep yew plants and clippings away from children and pets. If you suspect anyone has eaten any part of a yew plant, call your local poison control center or emergency services immediately.
Side effects
Yew poisoning can come on quickly and may include:
- Nausea, vomiting, and abdominal pain
- Dizziness, weakness, and trembling
- Difficulty breathing
- Slow, fast, or irregular heartbeat
- Sudden collapse, seizures, or death
Because the toxins affect the heart, a person may appear well one moment and become critically ill very quickly. There is no reliable safe dose, and poisoning can be fatal even with medical treatment.
Yew: Reported Adverse Effects
Documented safety reports on Yew from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, symptoms of yew poisoning include queasiness, dry mouth, vomiting, vertigo, severe abdominal pain, weakness, nervousness, trembling, dyspnea, incoordination, tachycardia, bradycardia, arrhythmias, ventricular fibrillation, hypotension, unconsciousness, coma, dizziness, seizures, respiratory depression, mydriasis, reddening of the lips, pale and cyanotic skin, and death secondary to cardiac arrest. Usually, gastrointestinal and neurological symptoms occur early, within 30-90 minutes, followed by cardiovascular symptoms and death within 24 hours. Some people are allergic to yew following airborne exposure.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Van IG, Visser R, Peltenburg H, et al. Sudden unexpected death due to Taxus poisoning. A report of five cases, with review of the literature. Forensic Sci Int 1992;56:81-7.
- Krenzelok EP, Jacobsen TD, Aronis J. Is the yew really poisonous to you? J Toxicol Clin Toxicol 1998;36:219-23.
- Persico A, Bacis G, Uberti F, et al. Identification of taxine derivatives in biological fluids from a patient after attempted suicide by ingestion of yew (Taxus baccata) leaves. J Anal Toxicol. 2011;35(4):238-41.
- Pilija V, Djurendic-Brenesel M, Miletic S. Fatal poisoning by ingestion of Taxus Baccata leaves. Forensic Sci Int. 2018;290:e1-e4.
- Farag M, Badowski D, Koschny R, Skopp G, Brcic A, Szabo GB. Extracorporeal life support and digoxin-specific Fab fragments for successful management of Taxus baccata intoxication with low output and ventricular arrhythmia. Am J Emerg Med. 2017;35(12):1987
- Vardon Bounes F, Tardif E, Ruiz S, Gallart JC, Conil JM, Delmas C. Suicide attempt with self-made Taxus baccata leaf capsules: survival following the application of extracorporeal membrane oxygenation for ventricular arrythmia and refractory cardiogenic s
- Baum C, Bohnen S, Sill B, et al. Prolonged resuscitation and cardiogenic shock after intoxication with European yew (Taxus baccata): Complete recovery after intermittent mechanical circulatory support. Int J Cardiol. 2015;181:176-8.
- Hermes-Laufer J, Meyer M, Rudiger A, et al. Extracorporeal life support as bridge to recovery in yew poisoning: case reports and literature review. ESC Heart Fail. 2021 Feb;8(1):705-709.
- G N, Chan M, Gue YX, Gorog DA. Fatal heart block from intentional yew tree (Taxus baccata) ingestion: a case report. Eur Heart J Case Rep. 2019 Dec 23;4(1):1-4.
- Sinn LE, Porterfield JF. Fatal taxine poisoning from yew leaf ingestion. J Forensic Sci 1991;36:599-601.
- Willaert, W., Claessens, P., Vankelecom, B., and Vanderheyden, M. Intoxication with taxus baccata: cardiac arrhythmias following yew leaves ingestion. Pacing Clin.Electrophysiol. 2002;25(4 Pt 1):511-512.
- Yersin, B., Frey, J. G., Schaller, M. D., Nicod, P., and Perret, C. Fatal cardiac arrhythmias and shock following yew leaves ingestion. Ann.Emerg.Med. 1987;16(12):1396-1397.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Maguchi, S. and Fukuda, S. Taxus cuspidata (Japanese yew) pollen nasal allergy. Auris Nasus Larynx 2001;28 Suppl:S43-S47.
- de Vos FYFL, van Laarhoven HMW. Taxus baccata allergy in a breast cancer patient. Neth J Med. 2012;70(5):249-0.
Allergic rhinitis (hay fever) Immunologic
There is at least one known case of a patient with yew allergy associated with airborne exposure to yew trees. Based on this case report, it was also determined that people who are allergic to yew might become hypersensitive to docetaxel, which is derived from yew. Pollen from yew has caused nasal allergy in 18 patients.
Arrhythmia Cardiovascular
Orally, symptoms of yew poisoning include tachycardia, bradycardia, arrhythmias, hypotension, ventricular fibrillation, and death due to cardiac arrest. Usually, gastrointestinal and neurological symptoms occur early, within 30-90 minutes, followed by cardiovascular symptoms and death within 24 hours.
Treatment is usually related to supportive care, however, arrhythmias are often resistant to standard pharmacologic treatments and transvenous or external pacemakers. Lipid emulsion therapy and digoxin-binding antibodies have also been used to treat yew poisoning, but the effects are unclear. Veno-arterial extracorporeal membrane oxygenation (VA ECMO) has been used as a bridge during taxine elimination and cardiac recovery. VA ECMO has typically been used for 72 hours or less.
- Van IG, Visser R, Peltenburg H, et al. Sudden unexpected death due to Taxus poisoning. A report of five cases, with review of the literature. Forensic Sci Int 1992;56:81-7.
- Willaert, W., Claessens, P., Vankelecom, B., and Vanderheyden, M. Intoxication with taxus baccata: cardiac arrhythmias following yew leaves ingestion. Pacing Clin.Electrophysiol. 2002;25(4 Pt 1):511-512.
- Yersin, B., Frey, J. G., Schaller, M. D., Nicod, P., and Perret, C. Fatal cardiac arrhythmias and shock following yew leaves ingestion. Ann.Emerg.Med. 1987;16(12):1396-1397.
- Persico A, Bacis G, Uberti F, et al. Identification of taxine derivatives in biological fluids from a patient after attempted suicide by ingestion of yew (Taxus baccata) leaves. J Anal Toxicol. 2011;35(4):238-41.
- Farag M, Badowski D, Koschny R, Skopp G, Brcic A, Szabo GB. Extracorporeal life support and digoxin-specific Fab fragments for successful management of Taxus baccata intoxication with low output and ventricular arrhythmia. Am J Emerg Med. 2017;35(12):1987
- Vardon Bounes F, Tardif E, Ruiz S, Gallart JC, Conil JM, Delmas C. Suicide attempt with self-made Taxus baccata leaf capsules: survival following the application of extracorporeal membrane oxygenation for ventricular arrythmia and refractory cardiogenic s
- Baum C, Bohnen S, Sill B, et al. Prolonged resuscitation and cardiogenic shock after intoxication with European yew (Taxus baccata): Complete recovery after intermittent mechanical circulatory support. Int J Cardiol. 2015;181:176-8.
- Hermes-Laufer J, Meyer M, Rudiger A, et al. Extracorporeal life support as bridge to recovery in yew poisoning: case reports and literature review. ESC Heart Fail. 2021 Feb;8(1):705-709.
- G N, Chan M, Gue YX, Gorog DA. Fatal heart block from intentional yew tree (Taxus baccata) ingestion: a case report. Eur Heart J Case Rep. 2019 Dec 23;4(1):1-4.
Depression Neurologic/CNS
Orally, symptoms of yew poisoning include vertigo, weakness, nervousness, trembling, loss of coordination, unconsciousness, coma, dizziness, seizures, respiratory depression, and mydriasis. Usually, gastrointestinal and neurological symptoms occur early, within 30-90 minutes, followed by cardiovascular symptoms and death within 24 hours.
- Van IG, Visser R, Peltenburg H, et al. Sudden unexpected death due to Taxus poisoning. A report of five cases, with review of the literature. Forensic Sci Int 1992;56:81-7.
- Sinn LE, Porterfield JF. Fatal taxine poisoning from yew leaf ingestion. J Forensic Sci 1991;36:599-601.
- Persico A, Bacis G, Uberti F, et al. Identification of taxine derivatives in biological fluids from a patient after attempted suicide by ingestion of yew (Taxus baccata) leaves. J Anal Toxicol. 2011;35(4):238-41.
- G N, Chan M, Gue YX, Gorog DA. Fatal heart block from intentional yew tree (Taxus baccata) ingestion: a case report. Eur Heart J Case Rep. 2019 Dec 23;4(1):1-4.
- Farag M, Badowski D, Koschny R, Skopp G, Brcic A, Szabo GB. Extracorporeal life support and digoxin-specific Fab fragments for successful management of Taxus baccata intoxication with low output and ventricular arrhythmia. Am J Emerg Med. 2017;35(12):1987
- Hermes-Laufer J, Meyer M, Rudiger A, et al. Extracorporeal life support as bridge to recovery in yew poisoning: case reports and literature review. ESC Heart Fail. 2021 Feb;8(1):705-709.
- Pilija V, Djurendic-Brenesel M, Miletic S. Fatal poisoning by ingestion of Taxus Baccata leaves. Forensic Sci Int. 2018;290:e1-e4.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Dry mouth Gastrointestinal
Orally, initial symptoms of yew poisoning include queasiness, dry mouth, nausea, vomiting, and severe abdominal pain. Usually, gastrointestinal and neurological symptoms occur early, within 30-90 minutes, followed by cardiovascular symptoms and death within 24 hours.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Van IG, Visser R, Peltenburg H, et al. Sudden unexpected death due to Taxus poisoning. A report of five cases, with review of the literature. Forensic Sci Int 1992;56:81-7.
- Krenzelok EP, Jacobsen TD, Aronis J. Is the yew really poisonous to you? J Toxicol Clin Toxicol 1998;36:219-23.
- Persico A, Bacis G, Uberti F, et al. Identification of taxine derivatives in biological fluids from a patient after attempted suicide by ingestion of yew (Taxus baccata) leaves. J Anal Toxicol. 2011;35(4):238-41.
- Pilija V, Djurendic-Brenesel M, Miletic S. Fatal poisoning by ingestion of Taxus Baccata leaves. Forensic Sci Int. 2018;290:e1-e4.
- Farag M, Badowski D, Koschny R, Skopp G, Brcic A, Szabo GB. Extracorporeal life support and digoxin-specific Fab fragments for successful management of Taxus baccata intoxication with low output and ventricular arrhythmia. Am J Emerg Med. 2017;35(12):1987
- Vardon Bounes F, Tardif E, Ruiz S, Gallart JC, Conil JM, Delmas C. Suicide attempt with self-made Taxus baccata leaf capsules: survival following the application of extracorporeal membrane oxygenation for ventricular arrythmia and refractory cardiogenic s
- Baum C, Bohnen S, Sill B, et al. Prolonged resuscitation and cardiogenic shock after intoxication with European yew (Taxus baccata): Complete recovery after intermittent mechanical circulatory support. Int J Cardiol. 2015;181:176-8.
- Hermes-Laufer J, Meyer M, Rudiger A, et al. Extracorporeal life support as bridge to recovery in yew poisoning: case reports and literature review. ESC Heart Fail. 2021 Feb;8(1):705-709.
- G N, Chan M, Gue YX, Gorog DA. Fatal heart block from intentional yew tree (Taxus baccata) ingestion: a case report. Eur Heart J Case Rep. 2019 Dec 23;4(1):1-4.
Poisoning Pulmonary/Respiratory
Orally, symptoms of yew poisoning include dyspnea.
Poisoning Dermatologic
Orally, symptoms of yew poisoning include reddening of the lips and pale and cyanotic skin.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Krenzelok EP, Jacobsen TD, Aronis J. Is the yew really poisonous to you? J Toxicol Clin Toxicol 1998;36:219-23.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no safe dose of yew as a supplement or herbal product. It should never be taken by mouth in any form.
The cancer drugs derived from yew (paclitaxel and docetaxel) are completely different products. They are given only by cancer specialists, in a hospital or clinic, at carefully calculated doses based on a person's body size and condition.
If you are looking for a natural product for any health concern, talk with your pharmacist or doctor about safe, well-studied options instead of yew.
Yew & Pregnancy
Yew & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 17 references that drive our Yew monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Sinn LE, Porterfield JF. Fatal taxine poisoning from yew leaf ingestion. J Forensic Sci 1991;36:599-601. DOI
- Van IG, Visser R, Peltenburg H, et al. Sudden unexpected death due to Taxus poisoning. A report of five cases, with review of the literature. Forensic Sci Int 1992;56:81-7. PubMed
- Krenzelok EP, Jacobsen TD, Aronis J. Is the yew really poisonous to you? J Toxicol Clin Toxicol 1998;36:219-23. PubMed
- Maguchi, S. and Fukuda, S. Taxus cuspidata (Japanese yew) pollen nasal allergy. Auris Nasus Larynx 2001;28 Suppl:S43-S47. PubMed
- Willaert, W., Claessens, P., Vankelecom, B., and Vanderheyden, M. Intoxication with taxus baccata: cardiac arrhythmias following yew leaves ingestion. Pacing Clin.Electrophysiol. 2002;25(4 Pt 1):511-512.
- Yersin, B., Frey, J. G., Schaller, M. D., Nicod, P., and Perret, C. Fatal cardiac arrhythmias and shock following yew leaves ingestion. Ann.Emerg.Med. 1987;16(12):1396-1397. PubMed
- de Vos FYFL, van Laarhoven HMW. Taxus baccata allergy in a breast cancer patient. Neth J Med. 2012;70(5):249-0.
- Persico A, Bacis G, Uberti F, et al. Identification of taxine derivatives in biological fluids from a patient after attempted suicide by ingestion of yew (Taxus baccata) leaves. J Anal Toxicol. 2011;35(4):238-41. PubMed
- Pilija V, Djurendic-Brenesel M, Miletic S. Fatal poisoning by ingestion of Taxus Baccata leaves. Forensic Sci Int. 2018;290:e1-e4. PubMed
- Farag M, Badowski D, Koschny R, Skopp G, Brcic A, Szabo GB. Extracorporeal life support and digoxin-specific Fab fragments for successful management of Taxus baccata intoxication with low output and ventricular arrhythmia. Am J Emerg Med. 2017;35(12):1987 PubMed
- Vardon Bounes F, Tardif E, Ruiz S, Gallart JC, Conil JM, Delmas C. Suicide attempt with self-made Taxus baccata leaf capsules: survival following the application of extracorporeal membrane oxygenation for ventricular arrythmia and refractory cardiogenic s
- Baum C, Bohnen S, Sill B, et al. Prolonged resuscitation and cardiogenic shock after intoxication with European yew (Taxus baccata): Complete recovery after intermittent mechanical circulatory support. Int J Cardiol. 2015;181:176-8. PubMed
- Hermes-Laufer J, Meyer M, Rudiger A, et al. Extracorporeal life support as bridge to recovery in yew poisoning: case reports and literature review. ESC Heart Fail. 2021 Feb;8(1):705-709. PubMed
- G N, Chan M, Gue YX, Gorog DA. Fatal heart block from intentional yew tree (Taxus baccata) ingestion: a case report. Eur Heart J Case Rep. 2019 Dec 23;4(1):1-4. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Yew
3 brands in our database make a supplement containing Yew.
Supplement products with Yew
8 products in our database contain Yew. Open any to see its full ingredient list and every drug interaction we check.
Yew: Common Questions
Does Yew interact with prescription medications?
How are Yew interactions rated?
Is it safe to take Yew with my medications?
Where does this Yew interaction information come from?
Is Yew safe to take as a supplement or tea?
If cancer drugs come from Yew, can I use Yew to fight cancer?
What should I do if my child or pet swallows Yew?
Are Yew berries dangerous?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Yew
A rotating sample of real supplements in our database that list Yew — open any to see its full ingredients and every drug interaction we check.
- Montana YewTip Oil by Bighorn Botanicals
- Montana YewTip Oil by Bighorn Botanicals
- Montana YewTip Tincture by Bighorn Botanicals
- 22 Reishis by Ron Teeguarden's Dragon Herbs
- Never-Say-Die Powder by Ron Teeguarden's Dragon Herbs
- Montana YewTip Oil by Bighorn Botanicals
- 22 Reishis by Ron Teeguarden's Dragon Herbs
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