7-methoxyflavone + Conjugated Estrogens, Methyltestosterone
Conjugated Estrogens, Methyltestosterone brand name: Premarin with Methyltestosterone.
7-methoxyflavone has a moderate interaction with Conjugated Estrogens, Methyltestosterone. In vitro evidence shows that 7-methoxyflavone inhbits aromatase.
Read the full interaction report7-methoxyflavone and Conjugated Estrogens, Methyltestosterone
Here is the interaction we found between these two, with the evidence behind it.
TESTOSTERONE
Why this applies to Conjugated Estrogens, Methyltestosterone
Conjugated Estrogens, Methyltestosterone falls under TESTOSTERONE — the group 7-methoxyflavone interacts with.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combo pill contains methyltestosterone, a form of testosterone, paired with conjugated estrogens. Your body normally turns some of that testosterone into estrogen using an enzyme called aromatase. The idea behind 7-methoxyflavone is that it may block aromatase, so in theory less of your methyltestosterone would convert to estrogen, leaving more active testosterone around.
If that happened, you could see stronger testosterone-type effects: things like acne, oily skin, facial or body hair changes, voice deepening, or mood shifts. Keep in mind this is theoretical, based only on lab (test-tube) data, not real human studies, so the actual risk is uncertain. Still, since you're already on a hormone product, please run 7-methoxyflavone by your pharmacist or doctor before adding it.
- Ta N, Walle T. Aromatase inhibition by bioavailable flavones. J Steroid Biochem Mol Biol 2007;107(1-2):127-9.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
7-methoxyflavone Also Interacts With Other Medications
7-methoxyflavone has 11 moderate known drug interactions in our database — the Conjugated Estrogens, Methyltestosterone one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against 7-methoxyflavone
We haven’t checked that one against 7-methoxyflavone yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against 7-methoxyflavone. Pick one to open its full report.
See Every Supplement That Interacts With Conjugated Estrogens, Methyltestosterone
This page covers 7-methoxyflavone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Conjugated Estrogens, Methyltestosterone page lists 226 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).
By severity: 6 major · 184 moderate · 36 minor.
From our pharmacist’s overview on the Conjugated Estrogens, Methyltestosterone page
“If you take conjugated estrogens with methyltestosterone (Premarin with Methyltestosterone), a hormone combination used for menopausal symptoms, read the six major-rated entries here before adding any supplement. Most of the 226 ingredients on file change how your body handles the hormones themselves.”
Reviewed by 2 · Jul 18, 2026
Open the Conjugated Estrogens, Methyltestosterone interaction page
Taking 7-methoxyflavone as Part of a Dietary Supplement Product? Check It for Interactions
We hold 20 real supplement products containing 7-methoxyflavone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 7-methoxyflavone. Your product may carry other ingredients that interact with Conjugated Estrogens, Methyltestosterone too, on top of 7-methoxyflavone — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where 7-methoxyflavone and Conjugated Estrogens, Methyltestosterone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#545 of 1,452 supplements looked up here in the last 7 days
#1,443 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About 7-methoxyflavone
What is 7-methoxyflavone?
- Boosting testosterone
- Reducing estrogen (aromatase inhibition)
- Athletic and bodybuilding performance
- Muscle building support
7-Methoxyflavone is a lab-made or plant-derived flavonoid marketed mainly in testosterone-boosting and bodybuilding supplements based on the idea that it blocks the aromatase enzyme. However, solid human evidence that it raises testosterone, improves performance, or builds muscle is essentially lacking, and its long-term safety has not been well studied. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
Other Drugs & 7-methoxyflavone
Browse every other medication we’ve checked against 7-methoxyflavone — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
11 interactions
No interaction 2,818 drugs checked — show the list
We also checked 7-methoxyflavone against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Ibuprofen ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
Showing the 60 most looked-up of 2,818 medications checked with no known interaction — see the full 7-methoxyflavone list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Conjugated Estrogens, Methyltestosterone Is Linked to Lower Levels of 5 Nutrients
Natural Medicines records Conjugated Estrogens, Methyltestosterone as a medicine that can lower these. This is not an interaction with 7-methoxyflavone — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Conjugated Estrogens, Methyltestosterone nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking 7-methoxyflavone and Conjugated Estrogens, Methyltestosterone Together: Common Questions
Can you take 7-methoxyflavone with Conjugated Estrogens, Methyltestosterone?
How serious is the 7-methoxyflavone and Conjugated Estrogens, Methyltestosterone interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Conjugated Estrogens, Methyltestosterone and 7-methoxyflavone?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.