7-methoxyflavone + Testosterone Undecanoate
Testosterone Undecanoate brand names: Andriol, Aveed, Jatenzo, Kyzatrex.
7-methoxyflavone has a moderate interaction with Testosterone Undecanoate. In vitro evidence shows that 7-methoxyflavone inhbits aromatase.
Read the full interaction report7-methoxyflavone and Testosterone Undecanoate
Here is the interaction we found between these two, with the evidence behind it.
TESTOSTERONE
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the idea behind this combo. 7-methoxyflavone is sold as a possible aromatase blocker, meaning it may slow the enzyme that normally turns some of your testosterone into estrogen. If you're already taking testosterone undecanoate (Jatenzo, Aveed, and similar), blocking that conversion could leave more testosterone, and tip the hormone balance a bit further. In theory that might nudge testosterone's effects and side effects upward, things like acne, oily skin, mood changes, fluid retention, or a higher red blood cell count.
I want to be honest though: this is based on lab data only, not real people, so it's more of a theoretical concern than a proven problem. Still, since testosterone dosing is carefully balanced and monitored, please run it by your doctor or pharmacist before adding this supplement.
- Ta N, Walle T. Aromatase inhibition by bioavailable flavones. J Steroid Biochem Mol Biol 2007;107(1-2):127-9.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
7-methoxyflavone Also Interacts With Other Medications
7-methoxyflavone has 11 moderate known drug interactions in our database — the Testosterone Undecanoate one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against 7-methoxyflavone
We haven’t checked that one against 7-methoxyflavone yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against 7-methoxyflavone. Pick one to open its full report.
Questions About 7-methoxyflavone or Testosterone Undecanoate
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers 7-methoxyflavone or Testosterone Undecanoate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Pharmacist Instructing To Reuse Single Dose Testosterone Vials ›
- Is Frozen Testosterone Still Safe To Use? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Testosterone Undecanoate
This page covers 7-methoxyflavone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Testosterone Undecanoate page lists 200 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).
By severity: 7 major · 150 moderate · 43 minor.
From our pharmacist’s overview on the Testosterone Undecanoate page
“The supplement list for testosterone undecanoate (Jatenzo, Aveed, Kyzatrex, Andriol) deserves real attention before you combine it with much of anything, and the seven major-rated entries are where I would start. Most of the 200 ingredients on file, 121 of them, can change how the body handles this hormone through the CYP3A4 enzyme; gr…”
Reviewed by 2 · Jul 18, 2026
Taking 7-methoxyflavone as Part of a Dietary Supplement Product? Check It for Interactions
We hold 20 real supplement products containing 7-methoxyflavone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 7-methoxyflavone. Your product may carry other ingredients that interact with Testosterone Undecanoate too, on top of 7-methoxyflavone — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where 7-methoxyflavone and Testosterone Undecanoate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#554 of 1,452 supplements looked up here in the last 7 days
#407 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About 7-methoxyflavone
What is 7-methoxyflavone?
- Boosting testosterone
- Reducing estrogen (aromatase inhibition)
- Athletic and bodybuilding performance
- Muscle building support
7-Methoxyflavone is a lab-made or plant-derived flavonoid marketed mainly in testosterone-boosting and bodybuilding supplements based on the idea that it blocks the aromatase enzyme. However, solid human evidence that it raises testosterone, improves performance, or builds muscle is essentially lacking, and its long-term safety has not been well studied. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
About Testosterone Injection
What Is Testosterone Injection Used For?
Brand names: Andriol, Aveed, Jatenzo, Kyzatrex
Testosterone injection is primarily used in men whose bodies do not produce enough testosterone on their own — a condition called hypogonadism. This includes primary hypogonadism (a problem with the testicles themselves, such as from injury, infection, or surgery) and hypogonadotropic hypogonadism (caused by problems in the brain's hormone signaling from the hypothalamus or pituitary gland). It is also used to stimulate puberty in carefully selected adolescent males with clearly delayed puberty who have not responded to other support.
Testosterone Enanthate Injection is also approved for use in women with advanced, inoperable metastatic breast cancer (specifically skeletal metastases) who are one to five years past menopause, or in premenopausal women with hormone-responsive breast cancer who have had their ovaries removed. This use should be directed by an oncologist. Aveed (testosterone undecanoate) is specifically approved for male hypogonadism only.
Other Drugs & 7-methoxyflavone
Browse every other medication we’ve checked against 7-methoxyflavone — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
11 interactions
No interaction 2,818 drugs checked — show the list
We also checked 7-methoxyflavone against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Valacyclovir ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Metformin ›
- Acyclovir ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Lamotrigine ›
- Fluoxetine ›
- Amphetamine ›
- Pregabalin ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
Showing the 60 most looked-up of 2,818 medications checked with no known interaction — see the full 7-methoxyflavone list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Taking 7-methoxyflavone and Testosterone Undecanoate Together: Common Questions
Can you take 7-methoxyflavone with Testosterone Undecanoate?
How serious is the 7-methoxyflavone and Testosterone Undecanoate interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.