Medication interaction hub

What Supplements Interact with Testosterone Undecanoate?

Testosterone Undecanoate brand names: Andriol, Aveed, Jatenzo, Kyzatrex. Every interaction below applies to the brands too.

200 Interactions 7 Major 150 Moderate 43 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Testosterone Undecanoate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Testosterone Undecanoate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

The supplement list for testosterone undecanoate (Jatenzo, Aveed, Kyzatrex, Andriol) deserves real attention before you combine it with much of anything, and the seven major-rated entries are where I would start. Most of the 200 ingredients on file, 121 of them, can change how the body handles this hormone through the CYP3A4 enzyme; grapefruit pushes drug levels up while St. John's wort drives them down. Another 38, including regular beer or wine, add strain on the liver, which matters because oral testosterone already asks a lot of that organ.

Beyond those seven, 150 entries carry a moderate rating and 43 a minor one. Activated charcoal (itself rated major) and bulk fibers like glucomannan can blunt absorption of pills taken by mouth, so keep them well separated from an oral dose. A smaller cluster acts on thyroid hormone, and a handful of testosterone-boosting botanicals may simply stack their effects onto the drug itself.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 150 Minor 43 No known interaction 1,252

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Testosterone Undecanoate: Top Interactions at a Glance

The Testosterone Undecanoate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 200 interacting ingredients — plus 1,252 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Testosterone Undecanoate Combinations Today

The Testosterone Undecanoate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Bulbine Natalensis + Testosterone Undecanoatei

Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Minor Likelihood Possible Cordyceps + Testosterone Undecanoatei

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.

Read the full interaction Moderate Likelihood Possible Turmeric + Testosterone Undecanoatei

Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Read the full interaction Moderate Likelihood Possible Ascophyllum Nodosum + Testosterone Undecanoatei

Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.

Read the full interaction Moderate Likelihood Probable L-carnitine + Testosterone Undecanoatei

Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.

Read the full interaction Moderate Likelihood Possible Bacopa + Testosterone Undecanoatei

Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Testosterone Undecanoate

All 1,452 ingredients in our database, ranked by severity — 200 with a Testosterone Undecanoate interaction on file and 1,252 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Testosterone Undecanoate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bulbine Natalensis with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + Testosterone Undecanoate answer

Can you take Cordyceps with Testosterone Undecanoate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concurrent use of cordyceps and testosterone might have additive effects.

Full Cordyceps + Testosterone Undecanoate answer

Can you take Turmeric with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Turmeric + Testosterone Undecanoate answer

Can you take Ascophyllum Nodosum with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.

Full Ascophyllum Nodosum + Testosterone Undecanoate answer

Can you take L-carnitine with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.

Full L-carnitine + Testosterone Undecanoate answer

Can you take Danshen with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.

Full Danshen + Testosterone Undecanoate answer

Can you take Devil's Claw with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Testosterone Undecanoate answer

Can you take Dhea with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Testosterone Undecanoate answer

Can you take Diosmin with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Full Diosmin + Testosterone Undecanoate answer

Can you take Dulse with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, due to its iodine content, dulse might alter the effects of thyroid hormone.

Full Dulse + Testosterone Undecanoate answer

Can you take Echinacea with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Full Echinacea + Testosterone Undecanoate answer

Can you take Ephedra with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Ephedra + Testosterone Undecanoate answer

Can you take Epistane with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Epistane + Testosterone Undecanoate answer

Can you take Equol with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, equol might increase the levels and clinical effects of testosterone.

Full Equol + Testosterone Undecanoate answer

Can you take Eucalyptus with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Full Eucalyptus + Testosterone Undecanoate answer

Can you take European Barberry with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.

Full European Barberry + Testosterone Undecanoate answer

Can you take Evodia with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.

Full Evodia + Testosterone Undecanoate answer

Can you take False Unicorn with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full False Unicorn + Testosterone Undecanoate answer

Can you take Fennel with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Testosterone Undecanoate answer

Can you take Feverfew with Testosterone Undecanoate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.

Full Feverfew + Testosterone Undecanoate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Testosterone Undecanoate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Testosterone Undecanoate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Testosterone Undecanoate sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Testosterone Undecanoate through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Testosterone Undecanoate through this category.

Thyroid Hormone 21 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

21 of the supplement ingredients on this page reach Testosterone Undecanoate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Testosterone Undecanoate through this category.

Testosterone 14 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

14 of the supplement ingredients on this page reach Testosterone Undecanoate through this category.

Androgens 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Testosterone Undecanoate through this category.

About Testosterone Undecanoate

An androgenic hormone injection used to treat low testosterone in men with hypogonadism and delayed puberty.

Generic name: Testosterone Undecanoate  ·  Brand names: Andriol, Aveed, Jatenzo, Kyzatrex.

See the full Testosterone Injection drug information
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Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Testosterone Undecanoate.

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Pharmacist Counseling Corner

Testosterone Undecanoate & Supplements: Common Questions

What supplements interact with Testosterone Undecanoate?
More than you might expect — 200 in total, though they are far from equal: 7 are rated major, 150 moderate, and 43 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Testosterone Undecanoate supplement interactions are the most serious?
The 7 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Testosterone Undecanoate?
Usually yes — most people on Testosterone Undecanoate can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Andriol have the same supplement interactions as Testosterone Undecanoate?
Yes — Andriol, Aveed, Jatenzo, Kyzatrex all contain Testosterone Undecanoate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Testosterone Undecanoate and my other medications?
This page covers Testosterone Undecanoate against supplements and herbal ingredients. Checking Testosterone Undecanoate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Testosterone Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.