Drug & supplement interaction

Uva Ursi + Testosterone Undecanoate

Testosterone Undecanoate brand names: Andriol, Aveed, Jatenzo, Kyzatrex.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Uva Ursi has a moderate interaction with Testosterone Undecanoate. Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Uva Ursi and Testosterone Undecanoate

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

Why this applies to Testosterone Undecanoate

Testosterone Undecanoate falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group Uva Ursi interacts with.

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for oral testosterone undecanoate (like Jatenzo or Kyzatrex): your liver uses an enzyme called CYP3A4 to help process this hormone. In lab dishes, uva ursi seems to slow that same enzyme down. If that happened in your body, your testosterone levels could drift a little higher than expected, which might mean more of the usual effects like acne, mood swings, fluid retention, or changes in blood counts.

But here's the honest part: this is only a test-tube finding. It has never actually been shown to happen in people, so I wouldn't lose sleep over it. Since uva ursi is meant only for short-term use anyway, just give your pharmacist or doctor a heads-up before pairing the two.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Uva Ursi Also Interacts With Other Medications

Uva Ursi has 739 moderate, 63 minor known drug interactions in our database — the Testosterone Undecanoate one above is one of them. If you take anything else, check it against the full list below.

Moderate 739 Minor 63 No known interaction 2,028 (incl. Testosterone Undecanoate)
Taking anything else?

Check Another of Your Medications Against Uva Ursi

Covers the 2,830 medications we’ve checked against Uva Ursi. Pick one to open its full report.

From our Q&A

Questions About Uva Ursi or Testosterone Undecanoate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Uva Ursi or Testosterone Undecanoate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Testosterone Undecanoate

This page covers Uva Ursi only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Testosterone Undecanoate page lists 200 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 7 major · 150 moderate · 43 minor.

From our pharmacist’s overview on the Testosterone Undecanoate page

“The supplement list for testosterone undecanoate (Jatenzo, Aveed, Kyzatrex, Andriol) deserves real attention before you combine it with much of anything, and the seven major-rated entries are where I would start. Most of the 200 ingredients on file, 121 of them, can change how the body handles this hormone through the CYP3A4 enzyme; gr…”

Reviewed by 2 · Jul 18, 2026

Open the Testosterone Undecanoate interaction page

One more smart check

Taking Uva Ursi as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,423 real supplement products containing Uva Ursi, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Uva Ursi. Your product may carry other ingredients that interact with Testosterone Undecanoate too, on top of Uva Ursi — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Uva Ursi and Testosterone Undecanoate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Uva Ursi
Top 25%

#162 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Testosterone Undecanoate
Top 25%

#403 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Uva Ursi

What is Uva Ursi?

Uva Ursi
  • Urinary tract infections
  • Urinary discomfort
  • Mild diuretic
  • Kidney stones
  • Skin conditions

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people is limited, and because high doses or long-term use may be harmful to the liver and could be toxic, it should only be used short-term and with guidance from a healthcare professional. Avoid it during pregnancy and breastfeeding.

Read the full Uva Ursi monograph & all interactions
Medication

About Testosterone Injection

What Is Testosterone Injection Used For?

Brand names: Andriol, Aveed, Jatenzo, Kyzatrex

Testosterone injection is primarily used in men whose bodies do not produce enough testosterone on their own — a condition called hypogonadism. This includes primary hypogonadism (a problem with the testicles themselves, such as from injury, infection, or surgery) and hypogonadotropic hypogonadism (caused by problems in the brain's hormone signaling from the hypothalamus or pituitary gland). It is also used to stimulate puberty in carefully selected adolescent males with clearly delayed puberty who have not responded to other support.

Testosterone Enanthate Injection is also approved for use in women with advanced, inoperable metastatic breast cancer (specifically skeletal metastases) who are one to five years past menopause, or in premenopausal women with hormone-responsive breast cancer who have had their ovaries removed. This use should be directed by an oncologist. Aveed (testosterone undecanoate) is specifically approved for male hypogonadism only.

See full Testosterone Injection drug information
Keep checking

Other Drugs & Uva Ursi

Browse every other medication we’ve checked against Uva Ursi — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
739Moderate
63Minor
2,027No known interaction
739 Moderate 63 Minor 2,027 No interaction
Moderate

739 interactions

Showing 60 of 739 moderate interactions — see all 739 on the Uva Ursi page.

Minor

63 interactions

Showing 60 of 63 minor interactions — see all 63 on the Uva Ursi page.

No interaction 2,027 drugs checked — show the list

We also checked Uva Ursi against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,027 medications checked with no known interaction — see the full Uva Ursi list.

See the full Uva Ursi interactions page
See every supplement checked against Testosterone Undecanoate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Uva Ursi monograph › Uses, safety, and every drug interaction in one place Testosterone Undecanoate supplement interactions › Every supplement checked against Testosterone Undecanoate, ranked by severity Testosterone Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Uva Ursi and Testosterone Undecanoate Together: Common Questions

Can you take Uva Ursi with Testosterone Undecanoate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Uva Ursi and Testosterone Undecanoate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Testosterone Undecanoate and Uva Ursi?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.