Ozone Therapy Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Ozone Therapy interacts with medications. The heart of this page is the interaction list — every drug Ozone Therapy is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Ozone Therapy is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Ozone Therapy against your medication
Add one medicationDrugs that interact with Ozone Therapy
0 medications have a known interaction with Ozone Therapy, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Ozone Therapy. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Ozone Therapy combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Ozone Therapy: Uses, Safety & Side Effects
Ozone therapy uses a reactive form of oxygen for a wide range of unproven health claims, and it is not a dietary supplement or herb. High-quality evidence for most uses is limited, and breathing ozone is harmful to the lungs. If you are considering it, talk to a licensed doctor or pharmacist first, since safety and benefit are not well established.
- Part used
- Medical ozone gas (a mixture of oxygen and ozone)
- Common forms
- Gas insufflation, ozonated water, ozonated oils, major and minor autohemotherapy (blood treatment), injections
- Wound and skin infections
- Joint and back pain
- Immune support
- Dental and gum care
- Chronic infections
- General 'detox' and wellness claims
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Ozone is a toxic gas if inhaled, and most uses lack strong proof of benefit, so professional medical oversight is essential.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Ozone therapy is not an herb or a plant-based supplement. It uses ozone, a gas made of three oxygen atoms (O₃). The same gas that forms part of the Earth's upper atmosphere can be created with a special medical device that passes oxygen through an electrical charge.
People and clinics use ozone therapy in many different ways. These include applying ozonated oils or water to the skin, blowing the gas into body openings (insufflation), injecting it, or removing a small amount of blood, mixing it with ozone, and returning it to the body (called autohemotherapy).
It is promoted for a wide range of conditions, from infections and wounds to pain and general wellness. It is important to know that ozone therapy is not approved by the U.S. FDA as a treatment for any medical condition, and the FDA has warned that ozone is a toxic gas with no known useful medical application in a general sense.
How it works
Ozone is a highly reactive form of oxygen. When it contacts tissues or fluids, it quickly reacts and forms other compounds, including reactive oxygen species and certain fat-related byproducts.
Supporters believe that these reactions may, in small controlled amounts, stimulate the body's own antioxidant defenses, affect immune signaling, and improve how oxygen is delivered or used by cells. Ozone is also known to kill microbes on contact, which is why it is used to disinfect water and surfaces.
It is important to understand that most of these proposed mechanisms come from laboratory and animal research. The same reactivity that may have effects can also damage healthy cells, especially in the lungs. How these effects translate to real benefits in people is still not well understood.
Does Ozone Therapy work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Ozone Therapy, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 21 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Back pain
Research has evaluated ozone therapy injections for back pain caused by a herniated disc. Most observational research has found that injecting ozone into a herniated disc is associated with reduced back pain. Preliminary clinical research and an analysis of preliminary clinical research also show that injecting 5-20 mL of ozone 20-30 mcg/mL into the herniated disc or injecting it into paravertebral muscles seems to improve back pain when compared with baseline or active control. Other preliminary clinical research shows that injecting ozone into the herniated disc is as effective as microdiscectomy for reducing back pain. Additionally, one small clinical study suggests that ozone therapy is most effective in males, patients with isolated radicular pain, patients with calcified disc herniation, and/or patients with symptoms lasting less than one year.
Insufficient Reliable Evidence To Rate Carpal tunnel syndrome
A small clinical study in patients with mild or moderate carpal tunnel syndrome shows that receiving a single local intraarticular ozone injection in addition to wearing a resting volar wrist splint for 8 weeks results in greater pain reduction (64%) when compared with only wearing the wrist splint (45%).
Insufficient Reliable Evidence To Rate Coronavirus disease 2019 (COVID-19)
Research on the use of ozone therapy, including nebulized ozone and ozone autohemotherapy, for the treatment of COVID-19 has yielded mixed findings. It is also unclear if ozone autohemotherapy is beneficial for long-term symptoms occurring after recovery from COVID-19.
Insufficient Reliable Evidence To Rate Dental caries
A small meta-analysis shows that ozone therapy has inconsistent antimicrobial effects when compared with chlorhexidine and sealants for the treatment of dental caries. The studies in this analysis were limited by risk of bias and imprecision of data.
Insufficient Reliable Evidence To Rate Diabetes
Preliminary clinical research shows that ozone therapy administered locally or through rectal insufflations of ozone gas improves blood glucose and markers of oxidative stress. A clinical study in adults with type 2 diabetes shows that receiving a topical oral ozone gas regimen along with conventional periodontal treatment every 3 months does not improve glycated hemoglobin (HbA1c) levels at 12 months when compared with conventional periodontal treatment alone. The validity of these findings is limited by the unblinded nature of the study.
Insufficient Reliable Evidence To Rate Diabetic foot ulcers
Topical non-invasive ozone therapy has been evaluated for use in the treatment of diabetic foot ulcers with mixed findings. Invasive ozone therapy combined with topical ozone therapy has shown some benefit.
Insufficient Reliable Evidence To Rate Fibromyalgia
Observational research in patients with fibromyalgia has found that receiving ozone therapy mostly via autohemotherapy and some by ozone rectal insufflations is associated with improved symptoms in 70% of patients when compared with baseline. The validity of this finding is limited by the lack of a comparator group.
Insufficient Reliable Evidence To Rate Gingivitis
A small clinical study in adults with plaque-induced gingivitis shows that combining gaseous ozone therapy with periodontal treatment is less effective for reducing gingival inflammation than periodontal treatment alone. Effects were similar between smokers and non-smokers. Similarly, a meta-analysis shows that adjuvant use of ozone therapy with nonsurgical periodontal treatment is no more effective for improving clinical attachment loss, periodontal parameters, or bacterial counts when compared with nonsurgical periodontal treatment alone or in combination with chlorhexidine. The validity of these findings is limited by the high heterogeneity of the included studies.
Insufficient Reliable Evidence To Rate Hearing loss
Preliminary clinical research shows that ozone therapy via autohemotherapy where 100 mL of a patient's blood is mixed with a 1:1 gaseous mixture of oxygen and ozone and reinjected via intravenous (IV) infusion twice weekly for 5 weeks might improve hearing loss compared to placebo in patients with sudden sensorineural hearing loss. This study is limited by incomplete reporting of results and flawed methodology.
Insufficient Reliable Evidence To Rate Herniated disc
Observational research in patients with persistent radicular pain refractory to conservative management and/or epidural steroid injection found that injecting ozone into the herniated disc is associated with a reduction in herniated disc surface area of about 20% in 75% of cases. Also, a small clinical study shows that injecting ozone into the herniated disc is as effective as microdiscectomy for reducing radicular leg pain and disability and improving overall health and mobility.
Insufficient Reliable Evidence To Rate HIV/AIDS
Preliminary clinical research shows that giving ozone via autohemotherapy three times weekly for 8 weeks does not improve immune response in patients with HIV.
Insufficient Reliable Evidence To Rate Intermittent claudication
Preliminary clinical research shows that receiving intravenous ozone therapy 60 mcg/mL in 500 mL of normal saline along with 30-minute aerosol oxygen-ozone baths to the lower legs daily for 10 days seems to improve walking distance compared to balneotherapy in patients with intermittent claudication.
Insufficient Reliable Evidence To Rate Meniere disease
Preliminary clinical research shows that inhaled ozone 8 mcg/mL therapy at 60 mL/minute for 10 minutes plus tympanic membrane pressure massage for 10 minutes daily for 10 days does not improve hearing loss compared to baseline in patients with Meniere's disease.
Insufficient Reliable Evidence To Rate Osteoarthritis
Meta-analyses of small, low-quality clinical studies in patients with knee osteoarthritis show that intra-articular ozone therapy improves pain for up to 6 months when compared with placebo. However, ozone therapy seems to be less effective than hyaluronic acid or platelet-rich plasma. The validity of these analyses is limited by a high risk of bias and short duration of the included studies.
Insufficient Reliable Evidence To Rate Periodontitis
Topical ozone therapy has been evaluated for use in the treatment of periodontitis with mixed findings. Two small clinical studies in patients with chronic periodontitis show that applying ozone as ozonated olive oil to gum pockets is as effective as chlorhexidine 0.2% or 1% for improving most periodontal measures. In one study, ozonated olive oil was applied once immediately after scaling and root planing and then once more one week thereafter. In the other, ozonated olive oil gel (Bioemmei Srl) was applied two weeks after professional oral hygiene. However, in one of these studies the improvements in clinical attachment and gingivitis indices were similar to chlorhexidine 1% at 1 month, but not at 3 months. Also, a small clinical study in patients with severe generalized periodontitis shows that applying gaseous ozone into periodontal pockets twice weekly for 2 weeks does not improve periodontal parameters when compared with baseline. This study was limited due to a lack of comparator group.
Insufficient Reliable Evidence To Rate Postherpetic neuralgia
A preliminary clinical study in patients with postherpetic neuralgia shows that receiving ozone 40 mL via autohemotherapy three times weekly for 2 weeks addition to pharmacotherapy seems to improve pain at 1 month and 3 months when compared with pharmacotherapy alone.
Insufficient Reliable Evidence To Rate Postoperative pain
A meta-analysis of small clinical trials in patients undergoing surgery for an impacted mandibular third molar shows that adjuvant ozone application modestly reduces pain and analgesic use for up to 7 days after surgery, but does not affect swelling or jaw movement restriction, when compared with no ozone treatment. In one of the studies included in the analysis, a specific ozone product (Ozone gel, Aqua Ozone) was applied to the tooth socket for 2 minutes twice daily for 3 days in addition to using analgesics. Other modes of application evaluated in the meta-analysis include the use of an extraoral ozone probe and ozonated water irrigation.
Insufficient Reliable Evidence To Rate Rheumatoid arthritis (RA)
Preliminary clinical research in patients with RA shows that adding ozone therapy as 25 mg/L to 40 mg/L via rectal insufflation for 5 days weekly for 4 weeks to methotrexate therapy seems to improve disease activity measures and pain when compared with methotrexate alone.
Insufficient Reliable Evidence To Rate Scleroderma
A small preliminary clinical trial in patients with digital ulcers related to systemic scleroderma shows that local ozone treatment modestly improves digital ulcer severity and hand function when compared with standard treatment alone. The hand was exposed to oxygen-ozone in a bag for 30 minutes daily for one week, followed by twice weekly for the next 3 weeks. Another small clinical study shows that exposing the digits to oxygen-ozone for 30 minutes daily for 20 days results in the healing of digital ulcers in 96% of participants, compared with 44% of those given standard treatment with calcium channel blockers alone. Digits were exposed to a total volume of 20-50 mL of ozone at 52 mcg/mL in a bag using an ozone generator device (Humazon Promedic). Exposure to ozone also reduced ulcer pain and the number and duration of Raynaud attacks.
Insufficient Reliable Evidence To Rate Temporomandibular disorders (TMD)
Limited research suggests that applying ozone topically may reduce pain in patients with TMD, but it does not appear to improve jaw mobility. Preliminary clinical research in patients with masticatory myofascial pain due to TMJ dysfunction shows that applying topical ozone therapy at 60% intensity to the site of greatest pain for 10 minutes three times per week for 2 weeks modestly reduces pain but does not improve jaw movement when compared with sham ozone therapy. Ozone therapy has also been compared to active controls such as medication and occlusal splints. A small clinical study shows that applying topical ozone therapy at 30% intensity for 10 minutes three times per week for one week improves pain to a greater degree when compared with taking ketoprofen 150 mg and thiocolchicoside 8 mg twice daily for 7 days; however, mouth opening is not improved. Another small clinical study in patients with TMD shows that receiving 60% ozone exposure to pain points for 10 minutes three times weekly for two weeks reduces pain to a similar degree as wearing an occlusal splint every night for four weeks. This study was limited due to small sample size and differences in treatment duration.
Insufficient Reliable Evidence To Rate Tinnitus
Preliminary clinical research shows that applying ozone autohemotherapy, where 100 mL of a patient's blood is mixed with a 1:1 gaseous mixture of oxygen and ozone, does not improve tinnitus compared to baseline and compared to a betahistidine control in patients with idiopathic tinnitus for at least 6 months.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
The biggest safety concern is that ozone gas is harmful to breathe. Inhaling it can irritate and damage the lungs and airways, cause coughing, chest pain, and shortness of breath, and may worsen asthma or other lung conditions. Ozone should never be inhaled.
Injecting ozone, or certain procedures done improperly, can lead to serious problems such as air or gas bubbles in the bloodstream (gas embolism), infections, and other complications. Because of this, any ozone procedure should only be done by a qualified, licensed healthcare provider using sterile technique.
People with bleeding disorders, certain enzyme deficiencies (such as G6PD deficiency), heart or lung disease, or weakened immune systems should be especially cautious and speak with a doctor first.
Pregnancy and breastfeeding: There is not enough reliable safety information, so ozone therapy should be avoided during pregnancy and while breastfeeding.
Side effects
Side effects depend on how ozone is used. Reported effects include:
- Burning, irritation, or discomfort at the site of application or injection
- Coughing, chest tightness, and breathing problems if the gas is inhaled
- Headache, fatigue, or feeling unwell after treatment
- Cramping or discomfort with rectal or other insufflation methods
Rare but serious problems can include gas embolism (gas bubbles in the blood), infections, and reactions in people with red blood cell enzyme disorders. Seek emergency care for sudden chest pain, severe shortness of breath, fainting, or signs of a serious reaction.
Ozone Therapy: Reported Adverse Effects
Documented safety reports on Ozone Therapy from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Ozone therapy, applied locally or rectally, has not been linked to serious adverse effects; however, a thorough evaluation of safety outcomes with these routes of administration has not been conducted.
Inhaled ozone therapy and ozone therapy injected into a herniated disc have been linked to cases of Anton syndrome, involving blindness secondary to ischemic stroke or secondary to encephalopathy, and also cases of heart attack, pulmonary embolism, and death. Intravenously, ozone infusion has been linked to pulmonary embolism and death.
- Re L, Mawsouf MN, Menendez S, et al. Ozone therapy: clinical and basic evidence of its therapeutic potential. Arch Med Res 2008;39:17-26.
- Bocci VA. Tropospheric ozone toxicity vs. usefulness of ozone therapy. Arch Med Res 2007;38:265-7.
- Santos GM, Pacheco RL, Bussadori SK, et al. Effectiveness and Safety of Ozone Therapy in Dental Caries Treatment: Systematic Review and Meta-analysis. J Evid Based Dent Pract 2020;20(4):101472.
- Avci S, Büyükcam F, Demir ÖF, Özkan S. Anton syndrome during oxygen-ozone therapy. Am J Emerg Med. 2015;33(6):856.e1-2.
- Vaiano AS, Valente C, De Benedetti G, Caramello G. Transient cortical blindness after intradiscal oxygen-ozone therapy. Indian J Ophthalmol. 2016;64(12):944-946.
- Chirchiglia D, Chirchiglia P, Stroscio C, Volpentesta G, Lavano A. Suspected Pulmonary Embolism after Oxygen-Ozone Therapy for Low Back Pain. J Neurol Surg A Cent Eur Neurosurg. 2019;80(6):503-506.
- He R, Huang Q, Yan X, Liu Y, Yang J, Chen X. A Case of Paradoxical Embolism Causing Anterior Spinal Cord Syndrome and Acute Myocardial Infarction Following the Intradiscal Oxygen-Ozone Therapy. Front Neurol. 2019;10:137.
- Nociti V, Picarelli C, Losavio FA, et al. Posterior Reversible Encephalopathy Syndrome After Intramuscular Oxygen-Ozone Therapy. Can J Neurol Sci. 2020;47(3):416-418.
- Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res 2006;37:425-35.
Cardiac arrest Cardiovascular
Inhaled ozone therapy and ozone therapy injected into a herniated disc have been associated with cases of Anton syndrome. Anton syndrome involves blindness secondary to ischemic stroke. The patient is typically unaware of the blindness due to cerebral damage. Intravenously, ozone infusion has been linked to pulmonary embolism and death. Ozone injected into the spine has been linked with cases of heart attack, pulmonary embolism, and death. In a case report, an 80-year-old female developed pulmonary embolism resulting in death after receiving two ozone injections into the spine near a herniated disc. In another case-report, a 66-year-old female developed a spinal cord infarction and ST-elevation myocardial infarction (STEMI) after receiving an ozone injection for disc herniation.
- Avci S, Büyükcam F, Demir ÖF, Özkan S. Anton syndrome during oxygen-ozone therapy. Am J Emerg Med. 2015;33(6):856.e1-2.
- Vaiano AS, Valente C, De Benedetti G, Caramello G. Transient cortical blindness after intradiscal oxygen-ozone therapy. Indian J Ophthalmol. 2016;64(12):944-946.
- Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res 2006;37:425-35.
- Chirchiglia D, Chirchiglia P, Stroscio C, Volpentesta G, Lavano A. Suspected Pulmonary Embolism after Oxygen-Ozone Therapy for Low Back Pain. J Neurol Surg A Cent Eur Neurosurg. 2019;80(6):503-506.
- He R, Huang Q, Yan X, Liu Y, Yang J, Chen X. A Case of Paradoxical Embolism Causing Anterior Spinal Cord Syndrome and Acute Myocardial Infarction Following the Intradiscal Oxygen-Ozone Therapy. Front Neurol. 2019;10:137.
Cluster headache Neurologic/CNS
Inhaled and injected ozone has been associated with blindness and encephalopathy. In a case report, a 36-year-old female presented with Anton syndrome, or ischemic stroke resulting in sudden bilateral blindness, nausea, vomiting and loss of strength after using inhalation ozone therapy for 1 week intended to help with hearing loss and tinnitus from Meniere disease. Reversal of blindness was not reported. In another case report, a 54-year-old male developed Anton syndrome and blindness after an ozone injection for disc herniation. The blindness was followed by severe frontal headache, vomiting, and nausea. In a case report, a healthy 66-year-old male presented to the emergency room with encephalopathy, fever, severe vision loss in both eyes, memory impairment, nausea, and vomiting after receiving an intramuscular paravertebral cervical injection of 20 mL containing ozone and lidocaine 2%.
- Avci S, Büyükcam F, Demir ÖF, Özkan S. Anton syndrome during oxygen-ozone therapy. Am J Emerg Med. 2015;33(6):856.e1-2.
- Vaiano AS, Valente C, De Benedetti G, Caramello G. Transient cortical blindness after intradiscal oxygen-ozone therapy. Indian J Ophthalmol. 2016;64(12):944-946.
- Nociti V, Picarelli C, Losavio FA, et al. Posterior Reversible Encephalopathy Syndrome After Intramuscular Oxygen-Ozone Therapy. Can J Neurol Sci. 2020;47(3):416-418.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no standardized, proven dose for ozone therapy, and it varies widely between providers and methods. Concentrations, volumes, and treatment schedules are not well established by high-quality research.
Because ozone is reactive and potentially harmful, you should never try to make or use it at home. If you are considering ozone therapy, only do so under the supervision of a licensed, experienced healthcare professional, and discuss it with your own doctor or pharmacist first to make sure it is appropriate and safe for you.
Ozone Therapy & Pregnancy
Ozone Therapy & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 39 references that drive our Ozone Therapy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Re L, Mawsouf MN, Menendez S, et al. Ozone therapy: clinical and basic evidence of its therapeutic potential. Arch Med Res 2008;39:17-26. PubMed
- Bocci VA. Tropospheric ozone toxicity vs. usefulness of ozone therapy. Arch Med Res 2007;38:265-7. PubMed
- Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res 2006;37:425-35. PubMed
- Tafil-Klawe M, Wozniak A, Drewa T, et al. Ozone therapy and the activity of selected lysosomal enzymes in blood serum of patients with lower limb ischaemia associated with obliterative atheromatosis. Med Sci Monit 2002;8(7):CR520-5.
- Ragab A, Shreef E, Behiry E, et al. Randomised, double-blinded, placebo-controlled, clinical trial of ozone therapy as treatment of sudden sensorineural hearing loss. J Laryngol Otol 2009;123(1):54-60. PubMed
- Garber GE, Cameron DW, Hawley-Foss N, et al. The use of ozone-treated blood in the therapy of HIV infection and immune disease: a pilot study of safety and efficacy. AIDS 1991;5(8):981-4. PubMed
- Andreula CF, Simonetti L, De Santis F, et al. Minimally invasive oxygen-ozone therapy for lumbar disk herniation. AJNR Am J Neuroradiol 2003;24(5):996-1000.
- Pawlak-Osinska K, Kazmierczak H, Kazmierczak W, Szpoper M. Ozone therapy and pressure-pulse therapy in Meniere's disease. Int Tinnitus J 2004;10(1):54-7.
- Avci S, Büyükcam F, Demir ÖF, Özkan S. Anton syndrome during oxygen-ozone therapy. Am J Emerg Med. 2015;33(6):856.e1-2. PubMed
- Celakil T, Muric A, Gokcen Roehlig B, Evlioglu G, Keskin H. Effect of high-frequency bio-oxidative ozone therapy for masticatory muscle pain: a double-blind randomised clinical trial. J Oral Rehabil. 2017;44(6):442-451. PubMed
- Dogan M, Ozdemir Dogan D, Düger C, et al. Effects of high-frequency bio-oxidative ozone therapy in temporomandibular disorder-related pain. Med Princ Pract. 2014;23(6):507-10. PubMed
- León Fernández OS, Viebahn-Haensler R, Cabreja GL, et al. Medical ozone increases methotrexate clinical response and improves cellular redox balance in patients with rheumatoid arthritis. Eur J Pharmacol. 2016;789:313-318. PubMed
- Magalhaes FN, Dotta L, Sasse A, Teixera MJ, Fonoff ET. Ozone therapy as a treatment for low back pain secondary to herniated disc: a systematic review and meta-analysis of randomized controlled trials. Pain Physician. 2012;15(2):E115-29. DOI
- Sivalingam VP, Panneerselvam E, Raja KV, Gopi G. Does Topical Ozone Therapy Improve Patient Comfort After Surgical Removal of Impacted Mandibular Third Molar? A Randomized Controlled Trial. J Oral Maxillofac Surg. 2017;75(1):51.e1-51.e9. PubMed
- Sönmez O, Külahli I, Vural A, Sahin MI, Aydin M. The evaluation of ozone and betahistine in the treatment of tinnitus. Eur Arch Otorhinolaryngol. 2013;270(7):1999-2006. PubMed
- Vaiano AS, Valente C, De Benedetti G, Caramello G. Transient cortical blindness after intradiscal oxygen-ozone therapy. Indian J Ophthalmol. 2016;64(12):944-946. PubMed
- Zhang Y, Ma Y, Jiang J, Ding T, Wang J. Treatment of the lumbar disc herniation with intradiscal and intraforaminal injection of oxygen-ozone. J Back Musculoskelet Rehabil. 2013;26(3):317-22. PubMed
- Arias-Vázquez PI, Tovilla-Zárate CA, Hernández-Díaz Y, et al. Short-Term Therapeutic Effects of Ozone in the Management of Pain in Knee Osteoarthritis: A Meta-Analysis.PM R. 2019;11(8):879-887. PubMed
- Bahrami MH, Raeissadat SA, Nezamabadi M, Hojjati F, Rahimi-Dehgolan S. Interesting effectiveness of ozone injection for carpal tunnel syndrome treatment: a randomized controlled trial. Orthop Res Rev. 2019;11:61-67.
- Celakil T, Muric A, Gökcen Roehlig B, Evlioglu G. Management of pain in TMD patients: Bio-oxidative ozone therapy versus occlusal splints. Cranio. 2019;37(2):85-93. PubMed
- Chirchiglia D, Chirchiglia P, Stroscio C, Volpentesta G, Lavano A. Suspected Pulmonary Embolism after Oxygen-Ozone Therapy for Low Back Pain. J Neurol Surg A Cent Eur Neurosurg. 2019;80(6):503-506. PubMed
- de Sire A, Stagno D, Minetto MA, Cisari C, Baricich A, Invernizzi M. Long-term effects of intra-articular oxygen-ozone therapy versus hyaluronic acid in older people affected by knee osteoarthritis: A randomized single-blind extension study. J Back Muscul PubMed
- Gandhi KK, Cappetta EG, Pavaskar R. Effectiveness of the adjunctive use of ozone and chlorhexidine in patients with chronic periodontitis. BDJ Open. 2019;5:17. PubMed
- He R, Huang Q, Yan X, Liu Y, Yang J, Chen X. A Case of Paradoxical Embolism Causing Anterior Spinal Cord Syndrome and Acute Myocardial Infarction Following the Intradiscal Oxygen-Ozone Therapy. Front Neurol. 2019;10:137. PubMed
- Hu B, Zheng J, Liu Q, Yang Y, Zhang Y. The effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia. J Pain Res. 2018;11:1637-1643. PubMed
- Nociti V, Picarelli C, Losavio FA, et al. Posterior Reversible Encephalopathy Syndrome After Intramuscular Oxygen-Ozone Therapy. Can J Neurol Sci. 2020;47(3):416-418. PubMed
- Noori-Zadeh A, Bakhtiyari S, Khooz R, Haghani K, Darabi S. Intra-articular ozone therapy efficiently attenuates pain in knee osteoarthritic subjects: A systematic review and meta-analysis. Complement Ther Med. 2019;42:240-247. PubMed
- Tasdemir Z, Oskaybas MN, Alkan AB, Cakmak O. The effects of ozone therapy on periodontal therapy: A randomized placebo-controlled clinical trial. Oral Dis. 2019;25(4):1195-1202. PubMed
- Tirelli U, Cirrito C, Pavanello M, Piasentin C, Lleshi A, Taibi R. Ozone therapy in 65 patients with fibromyalgia: an effective therapy. Eur Rev Med Pharmacol Sci. 2019;23(4):1786-1788.
- Rapone B, Ferrara E, Corsalini M, et al. The Effect of Gaseous Ozone Therapy in Conjunction with Periodontal Treatment on Glycated Hemoglobin Level in Subjects with Type 2 Diabetes Mellitus: An Unmasked Randomized Controlled Trial. Int J Environ Res Publi PubMed
- Santos GM, Pacheco RL, Bussadori SK, et al. Effectiveness and Safety of Ozone Therapy in Dental Caries Treatment: Systematic Review and Meta-analysis. J Evid Based Dent Pract 2020;20(4):101472. PubMed
- Talmaç AC, Çalisir M. Efficacy of gaseous ozone in smoking and non-smoking gingivitis patients. Ir J Med Sci 2021;190(1):325-333. PubMed
- Moraschini V, Kischinhevsky ICC, Calasans-Maia MD, et al. Ineffectiveness of ozone therapy in nonsurgical periodontal treatment: a systematic review and metaanalysis of randomized clinical trials. Clin Oral Investig 2020;24(6):1877-1888. PubMed
- Simon C, Le Corroller T, Pauly V, Creze M, Champsaur P, Guenoun D. Intradiscal oxygen-ozone therapy for the treatment of symptomatic lumbar disc herniation: A preliminary study. J Neuroradiol 2022;49(2):180-186. PubMed
- Chaudhry K, Rustagi N, Bali R, et al. Efficacy of adjuvant ozone therapy in reducing postsurgical complications following impacted mandibular third-molar surgery: A systematic review and meta-analysis. J Am Dent Assoc 2021;152(10):842-854. PubMed
- Kaymaz S, Karasu U, Alkan H, et al. Efficacy of local oxygen-ozone therapy for the treatment of digital ulcers refractory to medical therapy in systemic sclerosis: A randomized controlled study. Mod Rheumatol 2021.
- Kelekis A, Bonaldi G, Cianfoni A, et al. Intradiscal oxygen-ozone chemonucleolysis versus microdiscectomy for lumbar disc herniation radiculopathy: a non-inferiority randomized control trial. Spine J 2022;(6):895-909. PubMed
- Colombo M, Gallo S, Garofoli A, Poggio C, Arciola CR, Scribante A. Ozone gel in chronic periodontal disease: A randomized clinical trial on the anti-inflammatory effects of ozone application. Biology (Basel) 2021;10(7):625. PubMed
- Hassanien M, Rashad S, Mohamed N, Elawamy A, Ghaly MS. Non-invasive Oxygen-Ozone therapy in treating digital ulcers of patients with systemic sclerosis. Acta Reumatol Port. 2018;43(3):210-216.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Ozone Therapy: Common Questions
What is Ozone Therapy used for, and does it work?
Does Ozone Therapy interact with prescription medications?
How are Ozone Therapy interactions rated?
Is it safe to take Ozone Therapy with my medications?
Where does this Ozone Therapy interaction information come from?
What is Ozone Therapy used for?
Is Ozone Therapy safe?
Is Ozone Therapy approved by the FDA?
Can I use Ozone Therapy while pregnant or breastfeeding?
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