Medication interaction hub

What Supplements Interact with Testosterone Enanthate?

Testosterone Enanthate brand name: Xyosted. Every interaction below applies to the brands too.

184 Interactions 6 Major 134 Moderate 44 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Testosterone Enanthate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Testosterone Enanthate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Beer and wine both carry major ratings on this list, because heavy alcohol use can compound the strain testosterone enanthate (Xyosted) already places on the liver. That liver theme runs through 38 of the 184 ingredients on file, Siberian cocklebur among them, and with six interactions rated major overall, this page deserves genuine care rather than a quick skim. The largest cluster, 121 ingredients from grapefruit to St. John's wort, works differently, pushing drug levels up or down by changing how the CYP3A4 enzyme processes medications.

Eighteen more entries are hormone-boosting supplements like 1-androsterone that stack extra androgen on top of your prescribed dose, raising the odds of mood, heart, kidney, or liver problems. Seventeen, activated charcoal included, can blunt absorption of pills, so keep them well spaced from any oral medicines. Most of the 134 moderate and 44 minor entries echo these same themes at lower stakes, but the liver entries are the ones to read closely first.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 134 Minor 44 No known interaction 1,268

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Testosterone Enanthate: Top Interactions at a Glance

The Testosterone Enanthate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 184 interacting ingredients — plus 1,268 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Testosterone Enanthate Combinations Today

The Testosterone Enanthate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Cordyceps + Testosterone Enanthatei

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.

Read the full interaction Moderate Likelihood Possible Black Pepper + Testosterone Enanthatei

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Coleus + Testosterone Enanthatei

Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Cannabis + Testosterone Enanthatei

Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction Minor Likelihood Possible L-arginine + Testosterone Enanthatei

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.

Read the full interaction Minor Likelihood Possible Valerian + Testosterone Enanthatei

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Testosterone Enanthate

All 1,452 ingredients in our database, ranked by severity — 184 with a Testosterone Enanthate interaction on file and 1,268 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Testosterone Enanthate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cordyceps with Testosterone Enanthate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concurrent use of cordyceps and testosterone might have additive effects.

Full Cordyceps + Testosterone Enanthate answer

Can you take Black Pepper with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Testosterone Enanthate answer

Can you take Coleus with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.

Full Coleus + Testosterone Enanthate answer

Can you take Cannabis with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Full Cannabis + Testosterone Enanthate answer

Can you take L-arginine with Testosterone Enanthate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of L-arginine and testosterone might have additive effects.

Full L-arginine + Testosterone Enanthate answer

Can you take Androstenediol with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Androstenediol is a precursor to testosterone and can increase levels of testosterone.

Full Androstenediol + Testosterone Enanthate answer

Can you take Ashwagandha with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.

Full Ashwagandha + Testosterone Enanthate answer

Can you take Astaxanthin with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Full Astaxanthin + Testosterone Enanthate answer

Can you take Ayahuasca with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase plasma concentrations of CYP3A4 substrates.

Full Ayahuasca + Testosterone Enanthate answer

Can you take Bacopa with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Full Bacopa + Testosterone Enanthate answer

Can you take Beet with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Testosterone Enanthate answer

Can you take Berberine with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Full Berberine + Testosterone Enanthate answer

Can you take Beta-methylphenethylamine (bmpea) with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.

Full Beta-methylphenethylamine (bmpea) + Testosterone Enanthate answer

Can you take Bishop's Weed with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Bishop's Weed + Testosterone Enanthate answer

Can you take Bitter Orange with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + Testosterone Enanthate answer

Can you take Black Cohosh with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.

Full Black Cohosh + Testosterone Enanthate answer

Can you take Bog Labrador Tea with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Testosterone Enanthate answer

Can you take Boldo with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.

Full Boldo + Testosterone Enanthate answer

Can you take Boswellia Serrata with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Full Boswellia Serrata + Testosterone Enanthate answer

Can you take Buchu with Testosterone Enanthate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu contains pulegone, a known hepatotoxin.

Full Buchu + Testosterone Enanthate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Testosterone Enanthate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Testosterone Enanthate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Testosterone Enanthate sits in 5 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Testosterone Enanthate through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Testosterone Enanthate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Testosterone Enanthate through this category.

Testosterone 14 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

14 of the supplement ingredients on this page reach Testosterone Enanthate through this category.

Androgens 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Testosterone Enanthate through this category.

About Testosterone Enanthate

An androgenic hormone injection used to treat low testosterone in men with hypogonadism and delayed puberty.

Generic name: Testosterone Enanthate  ·  Brand name: Xyosted.

See the full Testosterone Injection drug information
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Take a Supplement Product? Check the Whole Bottle Against Testosterone Enanthate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Testosterone Enanthate.

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Pharmacist Counseling Corner

Testosterone Enanthate & Supplements: Common Questions

What supplements interact with Testosterone Enanthate?
More than you might expect — 184 in total, though they are far from equal: 6 are rated major, 134 moderate, and 44 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Testosterone Enanthate supplement interactions are the most serious?
Focus on the major group: Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Testosterone Enanthate?
Usually yes — most people on Testosterone Enanthate can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Xyosted have the same supplement interactions as Testosterone Enanthate?
Yes — Xyosted all contain Testosterone Enanthate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Testosterone Enanthate and my other medications?
This page covers Testosterone Enanthate against supplements and herbal ingredients. Checking Testosterone Enanthate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Testosterone Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.