Medication interaction hub

What Supplements Interact with Testosterone?

Testosterone brand names: Intrinsa, Testim, Androgel, Andropatch, Testogel, and others. Every interaction below applies to the brands too.

170 Interactions 5 Major 129 Moderate 36 Minor
Curated & coded by · Clinical Pharmacist · Updated October 5, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Testosterone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Testosterone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

The supplement list for testosterone therapy (Androgel, Testim, Nebido, and others) deserves real attention, mainly because five of its 170 entries are rated major and four of those are everyday items: grapefruit, St. John's wort, and alcohol in the form of beer or wine. Most of the interactions follow two patterns. The largest group, 121 ingredients, can push testosterone's blood level up or down by changing how the liver enzyme CYP3A4 breaks the drug down. Another 38 add stress to the liver itself, which matters because testosterone already carries some liver risk.

A smaller cluster is the muscle-building aisle, androgen precursors and testosterone boosters that pile hormone effects on top of the prescription and can worsen mood, heart, kidney, or liver problems. Beyond the five majors, 129 entries are moderate and 36 minor. Read the major entries first, then run whatever you take regularly past your pharmacist.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 129 Minor 36 No known interaction 1,282

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Testosterone: Top Interactions at a Glance

The Testosterone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 170 interacting ingredients — plus 1,282 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Testosterone Combinations Today

The Testosterone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Ostarine + Testosteronei

Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.

Read the full interaction Minor Likelihood Possible Hibiscus Sabdariffa + Testosteronei

Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Dimethylsulfoxide (dmso) + Testosteronei

Topical DMSO might increase the effects and adverse effects of topical drugs.

Read the full interaction Moderate Likelihood Possible Berberine + Testosteronei

Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Beer + Testosteronei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Minor Likelihood Possible Rhodiola + Testosteronei

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Testosterone

All 1,452 ingredients in our database, ranked by severity — 170 with a Testosterone interaction on file and 1,282 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Testosterone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ostarine with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.

Full Ostarine + Testosterone answer

Can you take Hibiscus Sabdariffa with Testosterone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP3A4 substrates.

Full Hibiscus Sabdariffa + Testosterone answer

Can you take Dimethylsulfoxide (dmso) with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Topical DMSO might increase the effects and adverse effects of topical drugs.

Full Dimethylsulfoxide (dmso) + Testosterone answer

Can you take Berberine with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Full Berberine + Testosterone answer

Can you take Beer with Testosterone?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Full Beer + Testosterone answer

Can you take Boswellia Serrata with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Full Boswellia Serrata + Testosterone answer

Can you take Buchu with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu contains pulegone, a known hepatotoxin.

Full Buchu + Testosterone answer

Can you take Bulbine Natalensis with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + Testosterone answer

Can you take Calamus with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Testosterone answer

Can you take Camphor with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of camphor with other hepatotoxic drugs might increase the risk of liver damage.

Full Camphor + Testosterone answer

Can you take Cannabis with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Full Cannabis + Testosterone answer

Can you take Cassia Cinnamon with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Cassia Cinnamon + Testosterone answer

Can you take Cat's Claw with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.

Full Cat's Claw + Testosterone answer

Can you take Ceylon Leadwort with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Ceylon Leadwort + Testosterone answer

Can you take Chanca Piedra with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.

Full Chanca Piedra + Testosterone answer

Can you take Chaparral with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Chaparral + Testosterone answer

Can you take Chokeberry with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.

Full Chokeberry + Testosterone answer

Can you take Clove with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.

Full Clove + Testosterone answer

Can you take Coleus with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.

Full Coleus + Testosterone answer

Can you take Comfrey with Testosterone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, comfrey might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Comfrey + Testosterone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Testosterone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Testosterone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Testosterone sits in 5 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Testosterone through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Testosterone through this category.

Testosterone 14 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

14 of the supplement ingredients on this page reach Testosterone through this category.

Androgens 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Testosterone through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Testosterone through this category.

About Testosterone

Testosterone is a hormone replacement used to treat low testosterone levels in men with hypogonadism caused by certain medical conditions.

Generic name: Testosterone  ·  Brand names: Intrinsa, Testim, Androgel, Andropatch, Testogel, Nebido, Delatestryl, Natesto, Vogelxo.

See the full Testosterone drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Testosterone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Testosterone.

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Pharmacist Counseling Corner

Testosterone & Supplements: Common Questions

What supplements interact with Testosterone?
In our interaction database, 170 supplement and herbal ingredients have an interaction with Testosterone on file — 5 rated major, 129 moderate, and 36 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Beer.
Which Testosterone supplement interactions are the most serious?
The 5 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Beer, St. John's Wort and Wine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Testosterone?
That depends entirely on which supplement. The honest answer for Testosterone is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Intrinsa have the same supplement interactions as Testosterone?
Yes — Intrinsa, Testim, Androgel, Andropatch, Testogel and other brands all contain Testosterone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Testosterone and my other medications?
This page covers Testosterone against supplements and herbal ingredients. Checking Testosterone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Testosterone drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 5, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.