Testosterone

51 interactions 1 explained in plain English

Also sold as: Androderm Androgel Aveed Azmiro Depo-testosterone Fortesta Jatenzo Jatenzo® Kyzatrex Natesto Testim Testopel Tlando Undecatrex Vogelxo Xyosted

About Testosterone

Testosterone is a hormone replacement used to treat low testosterone levels in men with hypogonadism caused by certain medical conditions. Read the full Testosterone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Insulin Glulisine (Rdna Origin) Injection Azathioprine Methotrexate Injection Methotrexate Edoxaban Mercaptopurine

11 Major 40 Moderate

All (51) Major (11) Moderate (40)

Major

Testosterone Apixaban Eliquis Explained An increased risk of bleeding Details Testosterone Azathioprine Azasan An increased risk of hepatotoxicity Details Testosterone Dabigatran Pradaxa® An increased risk of bleeding Details Testosterone Dabigatran Etexilate An increased risk of bleeding Details Testosterone Edoxaban Savaysa An increased risk of bleeding Details Testosterone Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Increased risk of hypoglycemia (CNS depression, seizures) Details Testosterone Insulin Detemir (Rdna Origin) Injection Levemir Increased risk of hypoglycemia (CNS depression, seizures) Details Testosterone Insulin Glulisine (Rdna Origin) Injection Apidra Increased risk of hypoglycemia (CNS depression, seizures) Details Testosterone Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Testosterone Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Testosterone Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Testosterone Beclomethasone Nasal Spray Beconase Increased risk of edema Details Testosterone Beclomethasone Oral Inhalation Beclovent® Increased risk of edema Details Testosterone Budesonide Entocort Increased risk of edema Details Testosterone Budesonide Nasal Spray Rhinocort Increased risk of edema Details Testosterone Budesonide Oral Inhalation Pulmicort Increased risk of edema Details Testosterone Ciclesonide Nasal Spray Omnaris Increased risk of edema Details Testosterone Ciclesonide Oral Inhalation Alvesco Increased risk of edema Details Testosterone Clobetasol Byqlovi Increased risk of edema Details Testosterone Clobetasol Topical Clobex® Increased risk of edema Details Testosterone Cyclosporine Injection Atopica An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Testosterone Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Testosterone Deflazacort Emflaza Increased risk of edema Details Testosterone Desonide Desowen Increased risk of edema Details Testosterone Desonide Topical Desonate® Increased risk of edema Details Testosterone Desoximetasone Topicort Increased risk of edema Details Testosterone Desoximetasone Topical Topicort Increased risk of edema Details Testosterone Dexamethasone Injection Decadron Increased risk of edema Details Testosterone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of edema Details Testosterone Diflorasone Topical Apexicon Increased risk of edema Details Testosterone Difluprednate Ophthalmic Durezol Increased risk of edema Details Testosterone Fludrocortisone Acetate Florinef® Increased risk of edema Details Testosterone Flunisolide Nasal Spray Nasalide® Increased risk of edema Details Testosterone Flunisolide Oral Inhalation AeroBid® Inhaler System Increased risk of edema Details Testosterone Fluocinolone Capex Increased risk of edema Details Testosterone Fluocinolone Topical Capex® Shampoo Increased risk of edema Details Testosterone Fluocinonide Vanos Increased risk of edema Details Testosterone Fluocinonide Topical Dermacin® Increased risk of edema Details Testosterone Flurandrenolide Topical Cordran Increased risk of edema Details Testosterone Glimepiride Amaryl Increased blood glucose lowering effect and increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.