Testosterone and Dabigatran Etexilate: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Testosterone
Dabigatran Etexilate
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of bleeding
Interaction Deep Dive
Concomitant use of testosterone and warfarin may result in an increased risk of bleeding. A number of case reports have demonstrated prolonged prothrombin time and hemorrhages with coadministration of oral anticoagulants and 17-alkylated androgens45678. Testosterone has been reported to suppress the clotting factors II, V, VII, and X, which may lead to bleeding in patients on concomitant anticoagulant therapy 3. If coadministration of testosterone and warfarin is deemed necessary, make INR determinations and increase prothrombin time monitoring, particularly when treatment with testosterone is initiated or discontinued 231.
Why it happens (mechanism)
Modification of coagulation factor, hepatic synthesis, and competitive inhibition of plasma protein binding by testosterone
Literature reports
2 reports — tap to read
a) Anabolic steroids have been well documented to cause important interactions with dicumarol, another anticoagulant. Anabolic steroids enhance the anticoagulant activity of dicumarol perhaps through reductions in clotting factor formation and increased clotting factor degradation. The 17-alpha-alkylated steroids (fluoxymesterone, oxandrolone, oxymetholone, methylTESTOSTERone, methandrostenolone, stanozolol) appear to be more likely to induce this reaction than the non-substituted steroids 45678.
b) Significant enhancement of the anticoagulant effects of warfarin was described in a 69-year-old woman following application of a vaginal ointment of testosterone propionate. The mechanism of interaction is unclear 4.
Common questions
Can I take Testosterone and Dabigatran Etexilate together?
An increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.
How serious is the Testosterone and Dabigatran Etexilate interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Testosterone or Dabigatran Etexilate need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (8)
- Product Information: AZMIRO intramuscular injection, testosterone cypionate intramuscular injection. Slayback Pharma LLC (per FDA), Princeton, NJ, 2024.
- Product Information: ANDROGEL(R) topical gel, testosterone topical gel. Unimed Pharmaceuticals,Inc, Marietta, GA, 2007. DailyMed
- Product Information: DELATESTRYL(R) IM injection, testosterone enanthate IM injection. Indevus Pharmaceuticals,Inc, Lexington, MA, 2007.
- Lorentz SM & Weibert RT: Potentiation of warfarin anticoagulation by topical testosterone ointment. Clin Pharm 1985; 4:332-334.
- Robinson BH, Hawkins JB, Ellis JE, et al: Decreased anticoagulant tolerance with oxymetholone. Lancet 1971; 1:1356. PubMed
- Longridge RG, Gillam PM, & Barton GM: Decreased anticoagulant tolerance with oxymetholone. Lancet 1971; 2:90. DOI
- Edwards MS & Curtis JR: Decreased anticoagulant tolerance with oxymetholone. Lancet 1971; 2:221. PubMed
- Schrogie JJ & Solomon HM: The anticoagulant response to bishydroxycoumarin. II. The effect of D-thyroxine, clofibrate, and norethandrolone. Clin Pharmacol Ther 1967; 8:70-77. DOI
Keep reading about Testosterone
Keep reading about Dabigatran Etexilate
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