Drug Interaction Report

Testosterone and Cyclosporine Injection: Interaction Details

A pharmacist-reviewed analysis of the Testosterone and Cyclosporine Injection interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Testosterone

Androderm Androgel Aveed Azmiro Depo-testosterone Fortesta Jatenzo Jatenzo®
+

Cyclosporine Injection

Atopica Cequa Cyclavance Gengraf Modulis Neoral Optimmune Restasis
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Moderate
Can be significant — usually manageable with monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 51 documented Testosterone interactions, 40 are rated moderate — including this one.
Onset
delayed
Evidence
theoretical
Severity
Moderate

What happens

An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias)

Interaction Deep Dive

Concomitant administration of cycloSPORINE and anabolic steroids may result in increased cycloSPORINE blood levels and toxicity231.

Why it happens (mechanism)

Decreased cycloSPORINE metabolism

Literature reports

1 report — tap to read

a) Concomitant administration of cycloSPORINE and anabolic steroids may result in increased cycloSPORINE blood levels and toxicity. This effect has been observed in 2 case studies with methyltestosterone and in 1 case study with danazol 123.

Common questions

Can I take Testosterone and Cyclosporine Injection together?

An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Always confirm with your pharmacist or prescriber before making any change.

How serious is the Testosterone and Cyclosporine Injection interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "delayed". Effects tend to build up gradually over days to weeks.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Questions for your pharmacist

  • Does my dose of Testosterone or Cyclosporine Injection need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there anything you'd monitor while I'm on both?

References (3)

  1. Moller BB & Ekelun B: Toxicity of cyclosporine during treatment with androgen (letter). N Engl J Med 1985; 133:1416.
  2. Goffin E, Pirson Y, Geubel A, et al: Cyclosporine-methyltestosterone interaction. Nephron 1991; 59:174-175. PubMed
  3. Ross WB, Roberts D, & Griffin PJ: Cyclosporin interaction with danazol and norethisterone (letter). Lancet 1986; 1:330. DOI
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Testosterone

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All Testosterone interactions (51) Testosterone drug information
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Cyclosporine Injection

Keep reading about Cyclosporine Injection

All Cyclosporine Injection interactions (545) Cyclosporine Injection drug information
Also serious with: Ezetimibe Grazoprevir Sitaxsentan Simvastatin
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Testosterone + Beer Grapefruit Siberian Cocklebur St. John's Wort Wine 1-androsterone 19-nor-dhea 4-androsterone + 162 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.