FDA-filed SPL labeling · retrieved through openFDA

Cyclosporine

Cyclosporine is a powerful immune-suppressing medication used to prevent organ rejection after transplants and to treat severe rheumatoid arthritis and psoriasis.

Brand names GengrafNeoralSandimmune CapsulesSandimmune Oral SolutionOptimmune +11 more
Drug class ⓘ Calcineurin Inhibitor Immunosuppressant
Rx Forms 4 Routes Oral · Ophthalmic · Intravenous · Ophthalmic, Topical +1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 11 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveAug 10, 2026
Clinical labels in scope ⓘ11
AvailabilityRx
Earliest approval/marketing year ⓘ1983
FDA-listed product records ⓘ159
Boxed warningYes
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 23, 2026
Other forms & routes:
Injection Ophthalmic
⭐ Cyclosporine at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Cyclosporine is a potent immunosuppressant that can prevent transplant rejection and control severe autoimmune conditions, but it requires very close medical oversight. Regular blood monitoring is essential to catch kidney problems or dangerously high drug levels early. Never switch cyclosporine formulations, skip doses, or add new medications without talking to your transplant team or prescriber first.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Cyclosporine carries serious risks that require expert medical supervision. Because it suppresses the immune system, it can make you significantly more vulnerable to infections and raise your risk of developing lymphoma (a blood cancer) or other cancers — especially when used alongside other immunosuppressive drugs after a transplant.

Cyclosporine also comes in different formulations that are not interchangeable — switching between them without a doctor's guidance can cause your blood levels to be too high (leading to toxicity) or too low (risking organ rejection). Blood levels must be monitored regularly. This medication should only be prescribed and managed by physicians specifically experienced in immunosuppressive therapy, and patients should be cared for at facilities with the proper monitoring resources.

Read the full warning on DailyMed →

📖 Cyclosporine: Patient Information Guide

A plain-language walkthrough of Cyclosporine — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Cyclosporine is used for several serious conditions where the immune system needs to be kept in check:

  • Organ transplantation — prevents rejection after kidney, liver, or heart transplants, often combined with other immunosuppressive drugs
  • Rheumatoid arthritis — for severe, active cases that haven't responded adequately to methotrexate alone
  • Severe plaque psoriasis — for adults with extensive or disabling psoriasis who have tried and failed other systemic treatments, or for whom those treatments aren't an option
⚙️How it works▾

Cyclosporine targets specific immune cells called T-lymphocytes — particularly the T-helper cells that direct immune attacks. It blocks these cells at an early stage of their growth cycle, preventing them from multiplying and from releasing inflammatory proteins like interleukin-2. The result is a controlled dampening of the immune response: enough to stop the body from attacking a transplanted organ or inflamed tissue, but without shutting down functions like the infection-fighting activity of other immune cells such as macrophages.

Importantly, cyclosporine does not suppress the bone marrow, which means it doesn't cause the blood cell production problems seen with some other immunosuppressants. Its effects are specific and reversible — targeting the immune overreaction rather than broadly wiping out immune function.

💊How it's taken▾

Cyclosporine is taken by mouth, either as a capsule or a liquid solution, typically twice daily. It's critical to take it at the same times every day and to keep your routine consistent around meals — if you normally take it with food, always take it with food.

  • The liquid solution can be mixed with orange juice or apple juice (not grapefruit juice)
  • Avoid all grapefruit and grapefruit juice — they raise cyclosporine blood levels and can cause toxicity
  • Do not switch between the modified and non-modified formulations without your doctor's supervision — they are not interchangeable
  • If you miss a dose, contact your care team for guidance rather than doubling up
🤒Side effects — in detail▾

Cyclosporine has a number of side effects that your doctor will monitor for during treatment:

  • Kidney function changes (the most common and important concern)
  • High blood pressure
  • Tremor or shaking
  • Increased hair growth on the body
  • Gum overgrowth (gums may become swollen or enlarged)
  • Low magnesium levels in the blood
  • Elevated liver enzymes

Serious reactions — including significant kidney damage, new infections, signs of cancer, or seizures — require immediate medical attention. Don't wait to call your doctor if something feels wrong.

⚠️Warnings & precautions▾
  • Kidney damage: Cyclosporine can cause serious, sometimes permanent kidney damage. This risk increases with higher doses and longer use. Serum creatinine is monitored regularly to catch problems early.
  • Increased infection risk: Because the immune system is suppressed, even common infections can become serious. Report any fever, chills, or unusual symptoms promptly.
  • Cancer risk: Long-term immune suppression raises the risk of lymphoma and other cancers, especially when multiple immunosuppressive agents are used together.
  • Liver toxicity: Cyclosporine can also harm the liver, particularly at higher doses. Liver function is monitored throughout treatment.
  • Formulation mix-up risk: The modified formulation (this drug) and older Sandimmune formulations are NOT interchangeable — swapping them can cause blood levels to be too high or too low, with serious consequences.
🔀What it interacts with▾

Cyclosporine interacts with many drugs and foods — always keep your entire care team updated on everything you take:

  • Grapefruit and grapefruit juice — blocks the enzyme that clears cyclosporine, raising blood levels to potentially toxic amounts
  • Methotrexate — cyclosporine significantly increases methotrexate levels in the blood, raising toxicity risk
  • Diclofenac (an NSAID pain reliever) — blood levels of diclofenac are notably increased when taken with cyclosporine
  • Nephrotoxic drugs (kidney-harming medications) — combining these with cyclosporine compounds kidney damage risk
  • Other immunosuppressants — using them together further raises the risk of serious infections and cancer
  • PUVA, UVB light, coal tar, and radiation therapy — absolutely must not be used together with cyclosporine in psoriasis patients

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Anyone with abnormal kidney function should discuss this carefully with their doctor — cyclosporine can worsen it; rheumatoid arthritis and psoriasis patients with kidney problems generally should not take it
  • People with uncontrolled high blood pressure should not take cyclosporine for RA or psoriasis until it's controlled
  • Anyone with a current or past cancer (malignancy) should tell their doctor before starting
  • Older adults require especially close monitoring because kidney function naturally declines with age
  • People with severe liver disease may need dose adjustments since the liver processes cyclosporine
  • Tell your doctor about all medications, including over-the-counter drugs and supplements
  • Anyone with a known allergy to cyclosporine or any ingredient in the formulation must not take it
🚑If you take too much▾

Taking too much cyclosporine can cause vomiting, drowsiness, headache, rapid heartbeat, and temporary kidney or liver problems. If an overdose is suspected, call the Poison Help line at 1-800-222-1222 right away. Cyclosporine is not effectively removed by dialysis or activated charcoal, so getting expert guidance quickly matters.

📡Pharmacodynamics — effects in the body▾

Cyclosporine selectively suppresses the immune system by inhibiting T-lymphocytes — especially T-helper cells — at an early stage of their activation cycle. It blocks the production and release of interleukin-2 and other immune-signaling proteins (lymphokines) that would otherwise drive immune attacks on transplanted organs or inflamed tissue. Notably, it does not affect the bone marrow and does not impair the phagocytic (pathogen-engulfing) activity of other immune cells, making its immune suppression more targeted than some alternatives.

🔬Pharmacokinetics — how your body processes it▾

After taking cyclosporine by mouth, absorption is incomplete and varies quite a bit from person to person and between formulations. The body processes it primarily through the liver, and it is eliminated mainly through bile into the stool — only about 6% leaves the body through urine. The drug has a half-life (the time for blood levels to fall by half) of roughly 8 to 18 hours. Because absorption varies so much between individuals, blood level monitoring is essential to ensure the dose is in the right range — not too low (risking rejection or treatment failure) and not too high (risking toxicity).

📦How to store it▾

Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) 100 mg — Off-white, oblong, soft gelatin capsules. Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) Store and Dispense In the original container at 20° to 25…

📄 Written from Cyclosporine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

229

Supplements & herbs that interact with Cyclosporine

229 supplements and herbal products have documented interactions with Cyclosporine in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 9
  • Moderate · 182
  • Minor · 38
ACTIVATED CHARCOAL Major ASARABACCA Major BEER Major BERBERINE Major GRAPEFRUIT Major SIBERIAN COCKLEBUR Major ST. JOHN'S WORT Major TREE TURMERIC Major +221 more
Every supplement checked against Cyclosporine — ranked by severity The full interaction hub: 9 major · 182 moderate · 38 minor · every one linked to its full report. Check Cyclosporine against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

1

Nutrient depletion considerations

Cyclosporine has been associated with lower levels of 1 nutrient in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

MAGNESIUM Moderate Depletion
See the full Cyclosporine nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Cyclosporine — the kind of thing our pharmacy team would talk through with you at the counter.

Why do I need blood tests so often while taking cyclosporine? ▾
Cyclosporine levels in your blood can vary quite a bit, and both too much and too little can cause real problems — too high raises the risk of kidney damage, and too low means the drug might not be protecting your transplant or controlling your condition. Your doctor checks your blood regularly to make sure the level stays in the right zone for you specifically. Think of it as fine-tuning your dose to keep you safe.
Can I eat grapefruit while taking cyclosporine? ▾
No — grapefruit and grapefruit juice are a hard no with cyclosporine. They block a key enzyme in your body that normally clears cyclosporine, which can cause your blood levels to climb much higher than intended and put you at risk for serious side effects like kidney damage. Stick to orange juice or apple juice if you're taking the liquid form.
My skin is getting hairier and my gums look swollen — is this from cyclosporine? ▾
Yes, both of those are known side effects. Increased hair growth (especially on the face and body) and gum overgrowth are common with cyclosporine. They're not dangerous on their own, but let your doctor know — good dental hygiene can help with the gum issue, and your doctor may want to monitor how things progress. Don't stop the medication on your own without talking to your care team first.
Does cyclosporine make me more likely to get sick? ▾
Yes, it does lower your immune defenses, which is exactly how it works — but that also means your body has a harder time fighting off infections. You should take everyday precautions like handwashing seriously, and report any fever, chills, or signs of infection to your doctor promptly. Over the long term, there is also a small increased risk of certain cancers, particularly lymphoma, which is something your care team will monitor for.
I was told not to switch between cyclosporine brands. Why does that matter? ▾
Different formulations of cyclosporine are not equivalent — meaning the same labeled dose from one product may deliver meaningfully different amounts of drug into your bloodstream compared to another. Switching without medical supervision could result in levels that are too high (causing toxicity) or too low (risking organ rejection or loss of disease control). If a change is ever needed, your doctor will adjust the dose and monitor your blood levels carefully through the transition.
Can I take over-the-counter pain relievers like ibuprofen or naproxen while on cyclosporine? ▾
You should check with your doctor before taking any pain relievers, including over-the-counter ones. Some anti-inflammatory drugs can add stress to the kidneys, which is already a concern with cyclosporine. Your doctor can help you choose the safest option for managing pain while you're on this medication.
Is Cyclosporine available over the counter? ▾
Cyclosporine is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
When was Cyclosporine first available? ▾
Cyclosporine has been available in the United States since at least 1983, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Cyclosporine? ▾
Cyclosporine is supplied by 45 manufacturers listed in the FDA NDC Directory, including Novartis Pharmaceuticals Corporation, Apotex Corp., Teva Pharmaceuticals USA, Inc..

💬 Answers drafted from Cyclosporine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

📊Cyclosporine supplement interactions229 checked — ranked by severity 🌿Drug & Supplement CheckerCyclosporine vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Cyclosporine NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Cyclosporine comes

Cyclosporine is available in 4 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Capsule

By mouth
Brands Gengraf Neoral Sandimmune
Available strengths 3 strengths
25 mg 50 mg 100 mg
77 FDA-listed product records ⓘ

Eye drops

In the eye · On the skin
Brands Cequa Restasis Restasis MultiDose Verkazia Vevye
Available strengths 4 strengths
0.0009 mg/mL 0.5 mg/mL 0.0009 g/mL 1 mg/mL
40 FDA-listed product records ⓘ

Oral solution

By mouth
Brands Gengraf Neoral Sandimmune
Available strengths 1 strength
100 mg/mL
10 FDA-listed product records ⓘ

Injection

By injection · Into a vein
Brands Sandimmune
Available strengths 1 strength
50 mg/mL
9 FDA-listed product records ⓘ

📊 Cyclosporine across the U.S. market

How Cyclosporine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

4
Dose forms ⓘ
45
Manufacturers
11
Brand names
159
FDA-listed product records ⓘ
1983
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (23) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Novartis Pharmaceuticals Corporation19%
Apotex Corp.10%
Teva Pharmaceuticals USA, Inc.7%
Strides Pharma Science Limited6%
Sun Pharmaceutical Industries, Inc.5%
AbbVie Inc.4%
Other makers49%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Cyclosporine is used

A general measure of how commonly Cyclosporine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Cyclosporine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

403,927
Medicaid prescriptions filled (Q1–Q4 2025)
$268.4M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Cyclosporine prescribed? Of the 1,596 medications we measure, Cyclosporine ranks #287 by Medicaid prescriptions — more than 82% of them.

Where Cyclosporine ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #287 of 1,596
#282 Acetaminophen, Butalbi... 425,589 Rx #283 Varenicline 417,684 Rx #284 Human Insulin Injectio... 414,373 Rx #285 Loperamide 409,237 Rx #286 Tacrolimus Topical 408,485 Rx #287 Cyclosporine 403,927 Rx #288 Betamethasone 403,381 Rx #289 Betamethasone Topical 402,754 Rx #290 Midazolam 401,717 Rx #291 Zonisamide 395,289 Rx #292 Methimazole 378,542 Rx

Utilization by Cyclosporine product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 0.4 mL / 0.5 mg/mL ophthalmic suspension is the most-dispensed Cyclosporine product — about 81% of these Medicaid prescriptions.

0.4 ML cyclosporine 0.5 MG/ML Ophthalmic Suspension Most dispensed

328,030 Medicaid prescriptions (Q1–Q4 2025) 81% of Cyclosporine prescriptions shown $226.6M gross reimbursement (before rebates) ≈ $691 per prescription (gross)

Summed across the 12 of 28 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2572292

cyclosporine 0.9 MG/ML Ophthalmic Solution

31,524 Medicaid prescriptions (Q1–Q4 2025) 8% of Cyclosporine prescriptions shown $23.3M gross reimbursement (before rebates) ≈ $740 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2055021

cyclosporine, modified 25 MG Oral Capsule

11,203 Medicaid prescriptions (Q1–Q4 2025) 3% of Cyclosporine prescriptions shown $950,603 gross reimbursement (before rebates) ≈ $85 per prescription (gross)

Summed across the 4 of 14 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 835894

cyclosporine 1 MG/ML Ophthalmic Solution

9,829 Medicaid prescriptions (Q1–Q4 2025) 2% of Cyclosporine prescriptions shown $7.6M gross reimbursement (before rebates) ≈ $778 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2639936

cyclosporine, modified 100 MG Oral Capsule

7,570 Medicaid prescriptions (Q1–Q4 2025) 2% of Cyclosporine prescriptions shown $1.1M gross reimbursement (before rebates) ≈ $142 per prescription (gross)

Summed across the 5 of 12 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 241834

cyclosporine 0.5 MG/ML Ophthalmic Suspension

7,386 Medicaid prescriptions (Q1–Q4 2025) 2% of Cyclosporine prescriptions shown $4.8M gross reimbursement (before rebates) ≈ $644 per prescription (gross)

Summed across the 1 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 351291

cyclosporine 100 MG Oral Capsule

2,191 Medicaid prescriptions (Q1–Q4 2025) <1% of Cyclosporine prescriptions shown $1.4M gross reimbursement (before rebates) ≈ $635 per prescription (gross)

Summed across the 2 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 328160

cyclosporine 25 MG Oral Capsule

2,025 Medicaid prescriptions (Q1–Q4 2025) <1% of Cyclosporine prescriptions shown $812,521 gross reimbursement (before rebates) ≈ $401 per prescription (gross)

Summed across the 2 of 10 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197553

cyclosporine, modified 50 MG Oral Capsule

1,783 Medicaid prescriptions (Q1–Q4 2025) <1% of Cyclosporine prescriptions shown $185,843 gross reimbursement (before rebates) ≈ $104 per prescription (gross)

Summed across the 2 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 835925

cyclosporine, modified 100 MG/ML Oral Solution

1,604 Medicaid prescriptions (Q1–Q4 2025) <1% of Cyclosporine prescriptions shown $262,165 gross reimbursement (before rebates) ≈ $163 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 835886

cyclosporine 1 MG/ML Ophthalmic Suspension

759 Medicaid prescriptions (Q1–Q4 2025) <1% of Cyclosporine prescriptions shown $1.4M gross reimbursement (before rebates) ≈ $1,852 per prescription (gross)

Summed across the 1 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2590608

Other Cyclosporine products — combination packs and listings not yet matched to a specific clinical product (kept visible so every prescription is accounted for)

23 Medicaid prescriptions (Q1–Q4 2025) <1% of Cyclosporine prescriptions shown $18,260 gross reimbursement (before rebates) ≈ $794 per prescription (gross)

Summed across the 1 of 45 listed NDC products with Medicaid activity.

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Cyclosporine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 33 of 139 listed Cyclosporine NDCs with Medicaid activity.

🔍 Compare Cyclosporine products

A representative set of FDA-listed product records for Cyclosporine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 159 of 159 products — FDA National Drug Code Directory. See every product, package size and price: browse all 159 Cyclosporine NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Cyclosporine RxCUI 3008 6 dose forms · 16 strengths
  1. Dose form (SCDF) Injection RxCUI 1732364 In current FDA listings
    Clinical drug / strength (SCD) 5 ML cyclosporine 50 MG/ML RxCUI 205175
  2. Dose form (SCDF) Ophthalmic Ointment RxCUI 1093173 No current FDA listing
    Clinical drug / strength (SCD) 0.002 MG/MG RxCUI 1093174
  3. Dose form (SCDF) Ophthalmic Solution RxCUI 2055020 In current FDA listings
    Clinical drug / strength (SCD) 0.9 MG/ML RxCUI 2055021 1 MG/ML RxCUI 2639936
  5. Dose form (SCDF) Oral Capsule RxCUI 371666 In current FDA listings
    Clinical drug / strength (SCD) modified 10 MG RxCUI 835919 modified 100 MG RxCUI 241834 modified 25 MG RxCUI 835894 modified 50 MG RxCUI 835925 25 MG RxCUI 197553 50 MG RxCUI 205168 100 MG RxCUI 328160
  6. Dose form (SCDF) Oral Solution RxCUI 371667 In current FDA listings
    Clinical drug / strength (SCD) modified 100 MG/ML RxCUI 835886 100 MG/ML RxCUI 309632

Look up RxCUI 3008 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Gengraf Neoral Sandimmune Capsules Sandimmune Oral Solution Optimmune Atopica Sandimmune Cequa Cyclavance Restasis Verkazia Vevye Sporimune Modulis Cyclosporine Modified Restasis MultiDose

🏭 Manufacturers & labelers

Novartis Pharmaceuticals Corporation 29 Apotex Corp. 15 Teva Pharmaceuticals USA, Inc. 11 Strides Pharma Science Limited 9 Sun Pharmaceutical Industries, Inc. 8 AbbVie Inc. 6 Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. 6 Catalent Pharma Solutions, LLC 6 Allergan, Inc. 6 A-S Medication Solutions 4 American Health Packaging 4 Lupin Pharmaceuticals, Inc. 3 Santen Incorporated 3 Kvk-tech, Inc. 3 Joyang Laboratories 3 Apotex Corp 3 Harrow Eye, LLC 3 Curia Italy S.r.l. 3 Dr. Reddy's Laboratories Inc 2 Concord Biotech Limited 2 Bryant Ranch Prepack 2 Mayne Pharma Inc. 2 Professional Compounding Centers of America 2 Patheon Softgels Inc 2

…and 16 more on the FDA NDC directory.

RxNorm drug class

Cyclosporine belongs to the Calcineurin Inhibitor Immunosuppressant class.

Pharmacologic class Calcineurin Inhibitor Immunosuppressant
Drug family (ATC) Calcineurin inhibitors, Other ophthalmologicals
How it works Calcineurin Inhibitors, Cytochrome P450 3A4 Inhibitors, P-Glycoprotein Inhibitors

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Aug 10, 2026
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Cyclosporine.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Cyclosporine after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
11
NDC products indexed
159
Distinct labelers/manufacturers represented
45
Linked representative label ⓘ
Novartis Pharmaceuticals Corporation
Linked label effective
Aug 10, 2026
Composite sections available
20
Linked SPL Set ID
94461af3-11f1-4670-95d4-2965b9538ae3
Linked SPL Document ID
47367e3d-2d79-49bd-849c-5557ef605b27
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 11 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Novartis Pharmaceuticals Corporation is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.