Testosterone and Insulin Glulisine (Rdna Origin) Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Insulin Glulisine (Rdna Origin) Injection
Testosterone
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of hypoglycemia (CNS depression, seizures)
Interaction Deep Dive
Use caution when coadministering insulin and testosterone as this may result in changes in insulin sensitivity or glycemic control. Decreases in blood glucose may occur in patients with diabetes and may necessitate a reduction in insulin dosage12.
Why it happens (mechanism)
Metabolic effects of androgens reduce blood glucose
Common questions
Can I take Testosterone and Insulin Glulisine (Rdna Origin) Injection together?
Increased risk of hypoglycemia (CNS depression, seizures) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Testosterone and Insulin Glulisine (Rdna Origin) Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Testosterone or Insulin Glulisine (Rdna Origin) Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: AVEED(TM) intramuscular injection solution, testosterone undecanoate intramuscular injection solution. Endo Pharmaceuticals Solutions Inc. (per FDA), Malvern, PA, 2014.
- Product Information: AZMIRO intramuscular injection, testosterone cypionate intramuscular injection. Slayback Pharma LLC (per FDA), Princeton, NJ, 2024.
Keep reading about Insulin Glulisine (Rdna Origin) Injection
Keep reading about Testosterone
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist