Drug & supplement interaction

Rna And Dna + Testosterone

Testosterone brand names: Intrinsa, Testim, Androgel, Andropatch, Testogel, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Rna And Dna and Testosterone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Rna And Dna and Testosterone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Testosterone and Rna And Dna in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Rna And Dna at all — not against Testosterone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Rna And Dna safety at a glance

Rna And Dna overall Use caution Generally tolerated in small amounts, but evidence is weak and high intake may raise uric acid levels.
Pregnancy Possibly Unsafe When used orally as supplements. Some evidence suggests some orally ingested DNA might cross the placenta and be mutagenic. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally as supplements. Some evidence suggests some orally ingested DNA might cross the placenta and be mutagenic. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Testosterone and Rna And Dna? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Rna And Dna and Testosterone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Itching / Swelling Additional detail

    Rna And Dna

    “Orally, RNA and DNA are well tolerated when consumed in food or enteral nutrition. Nucleotides seem to be well tolerated when consumed in medicinal amounts for up to 14 days. No adverse effects have been reported. Subcutaneously, RNA can cause itching, redness, and swelling at the injection site.”

    Rna And Dna · Natural Medicines adverse-effect record, reported in pruritus.

    6 sources cited
    1. 5531. Daly JM, Lieberman MD, Goldfine J, et al. Enteral nutrition with supplemental arginine, RNA, and omega-3 fatty acids in patients after operation: immunologic, metabolic and clinical outcome. Surgery 1992;112:56-67.
    2. 5533. Kemen M, Senkal M, Homann HH, et al. Early postoperative enteral nutrition with arginine-omega-3 fatty acids and ribonucleic acid-supplemented diet vs placebo in cancer patients: an immunologic evaluation of impact. Crit Care Med 1995;23:652-9.
    3. 5534. Gianotti L, Braga M, Fortis C, et al. A prospective, randomized clinical trial on perioperative feeding with an arginine, omega-3-fatty acid, and RNA-enriched enteral diet: effect on host response and nutritional status. JPEN J Parenter Enteral Nutr 199 PubMed
    4. 5535. Saffle JR, Wiebke G, Jennings K, et al. Randomized trial of immune-enhancing enteral nutrition in burn patients. J Trauma 1997;42:793-802. PubMed
    5. 5536. Bower RH, Cerra FB, Bershadsky B, et al. Early enteral administration of a formula (Impact) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized clinical trial. Crit Ca
    6. 7819. Tepaske R, Velthuis H, Oudemans-van Straaten HM, et al. Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial. Lancet 2001;358:696-701. PubMed

    “Subcutaneously, an injection of RNA can cause itching, redness, and swelling at the injection site. In one review, these reactions occurred in 3 out of 83 patients.”

    Rna And Dna · Natural Medicines adverse-effect record, reported in pruritus.

    1 source cited
    1. 5538. Li L. Erythematous skin reaction to subcutaneous injection of ribonucleic acid. Contact Dermatitis 1999;41:239. PubMed

    Testosterone

    Listed in the ADVERSE REACTIONS section of the FDA label for Testosterone. Read the label on DailyMed ›

Effects for Testosterone come from the ADVERSE REACTIONS section of its FDA label; effects for Rna And Dna come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Rna And Dna in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally as supplements. Some evidence suggests some orally ingested DNA might cross the placenta and be mutagenic.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Rna And Dna or Testosterone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Rna And Dna or Testosterone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Testosterone

This page covers Rna And Dna only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Testosterone page lists 170 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Beer (major), Grapefruit (major), Siberian Cocklebur (major), St. John's Wort (major) and Wine (major).

By severity: 5 major · 129 moderate · 36 minor.

From our pharmacist’s overview on the Testosterone page

“The supplement list for testosterone therapy (Androgel, Testim, Nebido, and others) deserves real attention, mainly because five of its 170 entries are rated major and four of those are everyday items: grapefruit, St. John's wort, and alcohol in the form of beer or wine.”

Reviewed by 2 · Jul 18, 2026

Open the Testosterone interaction page

How much people look this up

Where Rna And Dna and Testosterone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Rna And Dna
Steady interest

#1,320 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Testosterone
Top 1%

#15 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Rna And Dna reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Rna And Dna and Testosterone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Rna And Dna

What is Rna And Dna?

  • Anti-aging
  • Energy and vitality
  • Immune support
  • Skin health
  • General cellular support

RNA and DNA supplements contain nucleic acids, usually taken from yeast or fish, and are marketed for anti-aging, energy, and immune support. There is very little solid human evidence that taking these by mouth provides any of these benefits, and the body breaks them down during digestion. They are best avoided by people with gout or high uric acid, and there is not enough safety data to recommend them during pregnancy or breastfeeding.

Nucleic acids (RNA and DNA) typically extracted from yeast, fish, or other animal sources · Tablets, capsules, powders, combination 'nucleic acid' supplements

An interaction check asks whether these two react with each other — it does not ask whether Rna And Dna is a good idea for someone in your situation. Here is what our Rna And Dna record says about it on its own.

Rna And Dna: dosing

There is no well-established standard dose for RNA and DNA supplements, and no clear evidence on how much, if any, is helpful. Products vary widely in their source and strength.If you choose to use one, follow the directions on the product label and do not exceed the recommended amount.

From our Rna And Dna monograph — the full record covers uses, side effects and every documented interaction.

Read the full Rna And Dna monograph & all interactions
Medication

About Testosterone

What Is Testosterone Used For?

Brand names: Intrinsa, Testim, Androgel, Andropatch, Testogel, Nebido, Delatestryl, Natesto, Vogelxo

Testosterone replacement therapy is used in adult males whose bodies do not produce enough of their own testosterone. This includes primary hypogonadism — where the testes themselves fail due to causes such as Klinefelter's syndrome, injury, chemotherapy, or surgical removal — and hypogonadotropic hypogonadism, where the brain's signaling system (the hypothalamus or pituitary gland) fails to trigger testosterone production.

Testopel (subcutaneous pellets) may also be used to stimulate puberty in carefully selected males with clearly delayed puberty. The safety and efficacy of testosterone for age-related (late-onset) hypogonadism have not been established for most products, including AndroGel, Testim, Jatenzo, Kyzatrex, Natesto, Depo-Testosterone, Testosterone Cypionate, and Xyosted.

Most-Reported Side Effects for Testosterone

From FAERS, the FDA’s public side-effect reporting system (34,758 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 1,854 reports
Myocardial infarction 1,728 reports
Cerebrovascular accident 1,290 reports
Deep vein thrombosis 1,240 reports
Anxiety 1,199 reports
See full Testosterone drug information
Keep checking

Other Drugs & Rna And Dna

Browse every other medication we’ve checked against Rna And Dna — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Rna And Dna against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Rna And Dna list.

See the full Rna And Dna interactions page
See every supplement checked against Testosterone, ranked by severity
Evidence & sources

Rna And Dna References

The 11 references that drive our Rna And Dna monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Daly JM, Lieberman MD, Goldfine J, et al. Enteral nutrition with supplemental arginine, RNA, and omega-3 fatty acids in patients after operation: immunologic, metabolic and clinical outcome. Surgery 1992;112:56-67.
  2. Kemen M, Senkal M, Homann HH, et al. Early postoperative enteral nutrition with arginine-omega-3 fatty acids and ribonucleic acid-supplemented diet vs placebo in cancer patients: an immunologic evaluation of impact. Crit Care Med 1995;23:652-9.
  3. Gianotti L, Braga M, Fortis C, et al. A prospective, randomized clinical trial on perioperative feeding with an arginine, omega-3-fatty acid, and RNA-enriched enteral diet: effect on host response and nutritional status. JPEN J Parenter Enteral Nutr 199 PubMed
  4. Saffle JR, Wiebke G, Jennings K, et al. Randomized trial of immune-enhancing enteral nutrition in burn patients. J Trauma 1997;42:793-802. PubMed
  5. Bower RH, Cerra FB, Bershadsky B, et al. Early enteral administration of a formula (Impact) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized clinical trial. Crit Ca
  6. Li L. Erythematous skin reaction to subcutaneous injection of ribonucleic acid. Contact Dermatitis 1999;41:239. PubMed
  7. Schubert R, Hohlweg U, Renz D, Doefler W. On the fate of orally ingested foreign DNA in mice: chromosomal association and placental transmission o the fetus. Mol Gen Genet 1998;259:569-76.
  8. Tepaske R, Velthuis H, Oudemans-van Straaten HM, et al. Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial. Lancet 2001;358:696-701. PubMed
  9. Dancey CP, Attree EA, Brown KF. Nucleotide supplementation: a randomised double-blind placebo controlled trial of IntestAidIB in people with Irritable Bowel Syndrome [ISRCTN67764449]. Nutr J. 2006;5:16. PubMed
  10. Ostojic SM, Idrizovic K, Stojanovic MD. Sublingual nucleotides prolong run time to exhaustion in young physically active men. Nutrients. 2013;5(11):4776-85. PubMed
  11. Sterczala AJ, DuPont WH, Comstock BA, et al. Physiological effects of nucleotide supplementation on resistance exercise stress in men and women. J Strength Cond Res. 2016;30(2):569-78. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Rna And Dna and Testosterone Together: Common Questions

Is it safe to take Rna And Dna with Testosterone?
We do not list a known interaction between Rna And Dna and Testosterone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Rna And Dna and Testosterone have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Testosterone interact with any supplements?
Yes. Testosterone has documented interactions with 170 supplements in our database — Rna And Dna is not one of them. The Testosterone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Rna And Dna monograph Uses, safety profile, and every drug interaction in one place Testosterone drug information The full plain-English guide to this medication Testosterone supplement interactions Every supplement checked against Testosterone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 11 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Testosterone and Rna And Dna?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.