Medication interaction hub

What Supplements Interact with Dapsone?

Dapsone brand names: Dapsone, Avlosulfon, Aczone. Every interaction below applies to the brands too.

215 Interactions 7 Major 167 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated October 5, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Dapsone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Dapsone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Dapsone treats serious conditions, from dermatitis herpetiformis to leprosy, and its supplement list is one I'd want a patient to read closely rather than skim. Most entries touch how the body handles dapsone through the CYP3A4 enzyme, so grapefruit can raise its blood level while St. John's wort can lower it enough to undercut treatment. A second large group adds strain on the liver, which matters because dapsone itself can be hard on the liver, and heavy drinking belongs there too.

PABA stands apart because it directly blunts dapsone's antibacterial action and should be avoided outright. Smaller clusters add sun sensitivity, work against probiotic products, or reduce absorption of oral doses, so space those well apart from dapsone. Of the 215 ingredients on file, 7 rate major, and understanding those seven is where the effort pays off; the 167 moderates and 41 minors mostly follow the patterns above.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 167 Minor 41 No known interaction 1,237

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Dapsone: Top Interactions at a Glance

The most significant Dapsone supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 215 interacting ingredients — plus 1,237 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Dapsone + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Dapsonei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely Para-aminobenzoic Acid (paba) + Dapsonei

Theoretically, concomitant use of PABA and dapsone may decrease the effects of dapsone.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Dapsonei

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Probable Activated Charcoal + Dapsonei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Beer + Dapsonei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable St. John's Wort + Dapsonei

St.

Read the full interaction
The complete list

Every Supplement Checked Against Dapsone

All 1,452 ingredients in our database, ranked by severity — 215 with a Dapsone interaction on file and 1,237 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Dapsone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Turmeric with Dapsone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Turmeric + Dapsone answer

Can you take Turpentine Oil with Dapsone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some in vitro research shows that alpha-pinene, the major constituent of turpentine oil, does not increase the absorption of chlorpromazine...

Full Turpentine Oil + Dapsone answer

Can you take Uva Ursi with Dapsone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.

Full Uva Ursi + Dapsone answer

Can you take Vitamin A with Dapsone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disea...

Full Vitamin A + Dapsone answer

Can you take Vitamin E with Dapsone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Dapsone answer

Can you take White Pepper with Dapsone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that piperine, a constituent of white pepper, inhibits cytochrome P450 3A4 (CYP3A4).

Full White Pepper + Dapsone answer

Can you take Wild Cherry with Dapsone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.

Full Wild Cherry + Dapsone answer

Can you take Zedoary with Dapsone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zedoary might increase levels of drugs metabolized by CYP3A4.

Full Zedoary + Dapsone answer

Can you take Green Tea with Dapsone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Green Tea + Dapsone answer

Can you take Thyroid Extract with Dapsone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Dapsone answer

Can you take Aegeline with Dapsone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Aegeline + Dapsone answer

Can you take Agar with Dapsone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Dapsone answer

Can you take Alchemilla with Dapsone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. While no side effects have been reported from orally using Alchemilla, a clinical study titled "Treatment of Aphthous Stomatitis with Topica...

Full Alchemilla + Dapsone answer

Can you take Algin with Dapsone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Dapsone answer

Can you take Atractylodes with Dapsone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, atractylodes might increase the levels of CYP3A4 substrates.

Full Atractylodes + Dapsone answer

Can you take Bael with Dapsone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Bael and its constituents marmelosin and marmesinin inhibited cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Bael + Dapsone answer

Can you take Black Psyllium with Dapsone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Dapsone answer

Can you take Blond Psyllium with Dapsone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Dapsone answer

Can you take Breadfruit with Dapsone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, breadfruit might inhibit cytochrome P450 3A4 (CYP3A4) and increase levels of drugs metabolized by these enzymes; until more i...

Full Breadfruit + Dapsone answer

Can you take Carob with Dapsone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Dapsone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Dapsone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Dapsone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Dapsone sits in 7 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Dapsone through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Dapsone through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Dapsone through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Dapsone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Dapsone through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Dapsone through this category.

Dapsone (Avlosulfon) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Dapsone through this category.

About Dapsone

Dapsone is a sulfone medicine used as a tablet for dermatitis herpetiformis (an itchy, blistering skin condition) and leprosy, and as a topical gel for acne vulgaris.

Generic name: Dapsone  ·  Brand names: Dapsone, Avlosulfon, Aczone.

See the full Dapsone drug information

Related: does Dapsone deplete any nutrients?

Dapsone has 14 reported nutrient associations in the research literature — see the Dapsone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Dapsone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Dapsone.

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Pharmacist Counseling Corner

Dapsone & Supplements: Common Questions

What supplements interact with Dapsone?
More than you might expect — 215 in total, though they are far from equal: 7 are rated major, 167 moderate, and 41 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Para-aminobenzoic Acid (paba), Siberian Cocklebur.
Which Dapsone supplement interactions are the most serious?
Focus on the major group: Grapefruit, Para-aminobenzoic Acid (paba), Siberian Cocklebur, Activated Charcoal and Beer, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Dapsone?
Usually yes — most people on Dapsone can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Dapsone have the same supplement interactions as Dapsone?
Yes — Dapsone, Avlosulfon, Aczone all contain Dapsone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Dapsone deplete any vitamins or nutrients?
It might — Dapsone has 14 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Dapsone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Dapsone and my other medications?
This page covers Dapsone against supplements and herbal ingredients. Checking Dapsone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Dapsone drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 5, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.