Drug & supplement interaction

Fish Oil + Dapsone

Dapsone brand names: Dapsone, Avlosulfon, Aczone.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Fish Oil and Dapsone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Fish Oil and Dapsone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dapsone and Fish Oil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fish Oil safety at a glance

Fish Oil overall Generally safe Fish oil is generally well tolerated for most adults at typical supplement doses.

Pregnancy Likely Safe When used orally and appropriately. Intake of fish oil during pregnancy does not appear to adversely affect the fetus or nursing infant. One large clinical tria... Read the full pregnancy detail

Breastfeeding Likely Safe When used orally and appropriately. Intake of fish oil during pregnancy does not appear to adversely affect the fetus or nursing infant. One large clinical tria... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dapsone and Fish Oil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Dapsone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Dapsone is filed under 7 classifications — including antibiotic drugs, topical drugs, photosensitizing drugs. Fish Oil has documented interactions with 9 drug classes — the most serious being antihypertensive drugs (moderate), contraceptive drugs (moderate) and cyclosporine (neoral, sandimmune) (moderate) — and none of Dapsone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Fish Oil Does Interact With Other Medications

Fish Oil has 207 moderate, 120 minor known drug interactions in our database — Dapsone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 207 Minor 120 No known interaction 2,503 (incl. Dapsone)

Taking anything else?

Check Another of Your Medications Against Fish Oil

Covers the 2,830 medications we’ve checked against Fish Oil. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Fish Oil and Dapsone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

Anemia Worth acting on Additional detail
Fish Oil
“Orally, 3 grams or greater of omega-3 fatty acids daily may inhibit platelet aggregation and increase the risk of bleeding; however, there is little evidence of statistically significant bleeding risk at lower doses.”

Fish Oil · Natural Medicines adverse-effect record, reported in anemia.
6 sources cited

1313. FDA. Center for Food Safety and Applied Nutrition. Letter regarding dietary supplement health claim for omega-3 fatty acids and coronary heart disease. Available at: http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-Rpt0272-38-Appendix-D-Reference

8699. Pedersen HS, Mulvad G, Seidelin KN, et al. N-3 fatty acids as a risk factor for haemorrhagic stroke. Lancet 1999;353:812-3. PubMed

66500. Knapp, H. R. Dietary fatty acids in human thrombosis and hemostasis. Am J Clin Nutr 1997;65(5 Suppl):1687S-1698S. PubMed

66501. Archer, S. L., Green, D., Chamberlain, M., Dyer, A. R., and Liu, K. Association of dietary fish and n-3 fatty acid intake with hemostatic factors in the coronary artery risk development in young adults (CARDIA) study. Arterioscler Thromb.Vasc.Biol 1998;1 PubMed

66334. Weksler, B. B. Omega 3 fatty acids have multiple antithrombotic effects. World Rev Nutr Diet 1994;76:47-50. PubMed

101543. McNamara RK, Strawn JR, Tallman MJ, et al. Effects of fish oil monotherapy on depression and prefrontal neurochemistry in adolescents at high risk for bipolar I disorder: A 12-week placebo-controlled proton magnetic resonance spectroscopy trial. J Child A PubMed
Dapsone

Listed in the ADVERSE REACTIONS section of the FDA label for Dapsone. Read the label on DailyMed ›
Itching Additional detail
Fish Oil
“Orally, skin rashes, itching, and skin irritation have been reported.

A case of severe tissue inflammation and breast tissue necrosis has been reported for a female who injected fish oil from capsules subcutaneously for breast augmentation.”

Fish Oil · Natural Medicines adverse-effect record, reported in skin irritation.
6 sources cited

66498. Kuenzel U and Bertsch S. Clinical experiences with a standardized commercial fish oil product containing 33.5% omega-3 fatty acids - field trial with 3958 hyperlipemic patients in general practitioner practice. In: Chandra RK. Health Effects of Fish and F

66492. Sydenham E, Dangour AD Lim WS. Omega 3 fatty acid for the prevention of cognitive decline and dementia. Cochrane Database Syst Rev. 2012;6:CD005379. PubMed

66488. Schachter, HM, Reisman, J, Tran, K, Dales, B, Kourad, K, Barnes, D, Sampson, M, Morrison, A, Gaboury, I, and Blackman, J. Health effects of omega-3 fatty acids on asthma. Evid.Rep.Technol.Assess.(Summ.) 2004;(91):1-7.

89369. Souied EH, Delcourt C, Querques G, Bassols A, Merle B, Zourdani A, Smith T, Benlian P; Nutritional AMD Treatment 2 Study Group. Oral docosahexaenoic acid in the prevention of exudative age-related macular degeneration: the Nutritional AMD Treatment 2 stud DOI

104551. Suradom C, Suttajit S, Oon-Arom A, Maneeton B, Srisurapanont M. Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation for prevention and treatment of perinatal depression: a systematic review and meta-analysis of randomized-controlled trials. Nord PubMed

89371. Turk E, Karagulle E, Koksal H, Togan T, Erinanc OH, Dogru O, Moray G. Bilateral breast necrosis due to local injection of fish oil. Breast J 2013;19(2):196-8. PubMed
Dapsone

Listed in the ADVERSE REACTIONS section of the FDA label for Dapsone. Read the label on DailyMed ›
Stomach pain / A skin rash reported in 3.7% of FDA reports for Dapsone Additional detail

Fish Oil

“Orally and parenterally, fish oil is generally well-tolerated. Topically, no adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted.

Most Common Adverse Effects:

Orally: Abdominal pain, bad breath, fishy aftertaste, heartburn, increased low-density lipoprotein (LDL) cholesterol levels, loose stools, nausea, and rash.

Serious Adverse Effects (Rare):

Orally: Atrial…”

Fish Oil · Natural Medicines adverse-effect record, reported in atrial fibrillation.

Dapsone

Listed in the ADVERSE REACTIONS section of the FDA label for Dapsone, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›
Vomiting Additional detail
Fish Oil
“Orally, most adverse effects of omega-3 fatty acids are gastrointestinal in nature. Gastrointestinal upset is common with the use of fish oil supplements, occurring in up to 5% of patients in clinical trials, with nausea in up to 1.5% of patients. Diarrhea and loose stools may also occur, with potentially severe diarrhea at very high doses.”

Fish Oil · Natural Medicines adverse-effect record, reported in anorexia.
6 sources cited

12915. Wang C, Chung M, Lichtenstein A, et al. Effects of omega-3 fatty acids on cardiovascular disease. Evid Rep Technol Assess (Summ) 2004 Mar;(94):1-8.

65599. Maclean, C. H., Mojica, W. A., Morton, S. C., Pencharz, J., Hasenfeld, Garland R., Tu, W., Newberry, S. J., Jungvig, L. K., Grossman, J., Khanna, P., Rhodes, S., and Shekelle, P. Effects of omega-3 fatty acids on lipids and glycemic control in type II di

65728. Reisman, J., Schachter, H. M., Dales, R. E., Tran, K., Kourad, K., Barnes, D., Sampson, M., Morrison, A., Gaboury, I., and Blackman, J. Treating asthma with omega-3 fatty acids: where is the evidence? A systematic review. BMC.Complement Altern Med 2006;6 PubMed

65770. Lim, A. K., Manley, K. J., Roberts, M. A., and Fraenkel, M. B. Fish oil for kidney transplant recipients. Cochrane Database Syst Rev 2007;(2):CD005282. DOI

65780. Freund-Levi, Y., Basun, H., Cederholm, T., Faxen-Irving, G., Garlind, A., Grut, M., Vedin, I., Palmblad, J., Wahlund, L. O., and Eriksdotter-Jonhagen, M. Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptom

65904. Turnbull, T., Cullen-Drill, M., and Smaldone, A. Efficacy of omega-3 fatty acid supplementation on improvement of bipolar symptoms: a systematic review. Arch Psychiatr.Nurs 2008;22(5):305-311. PubMed
Dapsone

Listed in the ADVERSE REACTIONS section of the FDA label for Dapsone. Read the label on DailyMed ›
Headache Additional detail
Fish Oil
“Orally, fish oil may cause headache, dizziness, and inability to sleep. Also, restlessness and formication have been reported in less than 1% of studied cases of patients taking fish oil.”

Fish Oil · Natural Medicines adverse-effect record, reported in cluster headache.
6 sources cited

65599. Maclean, C. H., Mojica, W. A., Morton, S. C., Pencharz, J., Hasenfeld, Garland R., Tu, W., Newberry, S. J., Jungvig, L. K., Grossman, J., Khanna, P., Rhodes, S., and Shekelle, P. Effects of omega-3 fatty acids on lipids and glycemic control in type II di

65648. Schachter, H. M., Kourad, K., Merali, Z., Lumb, A., Tran, K., and Miguelez, M. Effects of omega-3 fatty acids on mental health. Evid.Rep.Technol.Assess.(Summ.) 2005;(116):1-11.

89359. Oliveira JM, Rondó PH, Yudkin JS, Souza JM, Pereira TN, Catalani AW, Picone CM, Segurado AA. Effects of fish oil on lipid profile and other metabolic outcomes in HIV-infected patients on antiretroviral therapy: a randomized placebo-controlled trial. Int J PubMed

103491. Nicholls SJ, Lincoff AM, Garcia M, et al. Effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk: The STRENGTH randomized clinical trial. JAMA. 2020e2022258.

104551. Suradom C, Suttajit S, Oon-Arom A, Maneeton B, Srisurapanont M. Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation for prevention and treatment of perinatal depression: a systematic review and meta-analysis of randomized-controlled trials. Nord PubMed

66498. Kuenzel U and Bertsch S. Clinical experiences with a standardized commercial fish oil product containing 33.5% omega-3 fatty acids - field trial with 3958 hyperlipemic patients in general practitioner practice. In: Chandra RK. Health Effects of Fish and F
Dapsone

Listed in the ADVERSE REACTIONS section of the FDA label for Dapsone. Read the label on DailyMed ›

Reported for Fish Oil but not commonly for Dapsone: stomach upset, a heart attack, an irregular heartbeat and a change in taste.

Effects for Dapsone come from the ADVERSE REACTIONS section of its FDA label; effects for Fish Oil come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 10,640 voluntary FDA FAERS reports for Dapsone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Fish Oil in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally and appropriately. Intake of fish oil during pregnancy does not appear to adversely affect the fetus or nursing infant. One large clinical trial shows that intake of fish oil from the 24th week of gestation increases the odds of the child having overweight and having metabolic syndrome measurements at age 10 when compared with placebo. More research is needed to confirm these findings. The adequate intake level of omega-3 fatty acids during pregnancy is 1.4 grams daily; the adequate intake level during lactation is 1.3 grams daily. If possible, people who are trying to become pregnant, as well as those who are pregnant or lactating, should avoid swordfish, king mackerel, and tilefish (also called golden bass or golden snapper), as these may contain high levels of methylmercury. Pregnant individuals should also limit consumption of other fatty fish to 12 ounces, or about 3-4 servings, per week.

Pregnancy And Lactation Possibly Unsafe

When fish oil from dietary sources are consumed in large amounts. Fatty fish can contain significant amounts of toxins such as mercury, polychlorinated biphenyls (PCBs), dioxin, and dioxin-related compounds. If possible, people who are trying to become pregnant, as well as those who are pregnant or lactating, should avoid swordfish, king mackerel, and tilefish (also called golden bass or golden snapper), as these may contain high levels of methylmercury. Pregnant individuals should also limit consumption of other fatty fish to 12 ounces, or about 3-4 servings, per week.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Fish Oil or Dapsone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Fish Oil or Dapsone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Supplements for Leg Circulation Safe With Citalopram and Lisinopril Answered by Dr. Brian Staiger, PharmD · July 2026 ›

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Dapsone

This page covers Fish Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dapsone page lists 215 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Para-aminobenzoic Acid (paba) (major) and Siberian Cocklebur (major).

By severity: 7 major · 167 moderate · 41 minor.

From our pharmacist’s overview on the Dapsone page

“Dapsone treats serious conditions, from dermatitis herpetiformis to leprosy, and its supplement list is one I'd want a patient to read closely rather than skim. Most entries touch how the body handles dapsone through the CYP3A4 enzyme, so grapefruit can raise its blood level while St.”

Reviewed by 2 · Jul 18, 2026

Open the Dapsone interaction page

One more smart check

Taking Fish Oil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,777 real supplement products containing Fish Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Fish Oil. Even though Fish Oil itself has no known interaction with Dapsone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Fish Oil and Dapsone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fish Oil

Top 5%

#58 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Dapsone

Top 10%

#175 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fish Oil reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Fish Oil and Dapsone records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Fish Oil

What is Fish Oil?

High triglycerides
Heart health
Joint pain and inflammation
Brain and eye health
Dry eyes

Fish oil provides omega-3 fatty acids (EPA and DHA) that are best known for lowering high triglyceride levels. The evidence for other heart and health benefits is mixed, and it is generally well tolerated. Talk with your pharmacist or doctor before starting it, especially if you take blood thinners or have a fish allergy.

Oil from fatty fish (such as mackerel, salmon, sardines, and anchovies) · Softgel capsules, liquid, gummies, and fortified foods

An interaction check asks whether these two react with each other — it does not ask whether Fish Oil is a good idea for someone in your situation. Here is what our Fish Oil record says about it on its own.

Fish Oil: dosing

There is no single standard dose of fish oil for everyone, and the right amount depends on why it is being used and the EPA/DHA content of the product. Higher, prescription-strength doses used for very high triglycerides should only be used under a doctor's supervision.

From our Fish Oil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fish Oil monograph & all interactions

Medication

About Dapsone

What Is Dapsone Used For?

Brand names: Dapsone, Avlosulfon, Aczone

Dapsone tablets are used to treat dermatitis herpetiformis (a chronic, intensely itchy blistering skin condition) and leprosy (all forms, except where proven resistance to dapsone exists). For leprosy, dapsone tablets are typically used in combination with other anti-leprosy medicines.

Aczone Gel (dapsone gel, 7.5%) and dapsone gel are indicated for the topical treatment of acne vulgaris in patients 9 years of age and older. This topical form is applied to the skin and is not used for leprosy or dermatitis herpetiformis.

Most-Reported Side Effects for Dapsone

From FAERS, the FDA’s public side-effect reporting system (10,640 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 487 reports

Methaemoglobinaemia 481 reports

Fatigue 477 reports

Fever 468 reports

Diarrhea 424 reports

See full Dapsone drug information

Keep checking

Other Drugs & Fish Oil

Browse every other medication we’ve checked against Fish Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

207Moderate

120Minor

2,502No known interaction

207 Moderate 120 Minor 2,502 No interaction

Moderate

207 interactions

Showing 60 of 207 moderate interactions — see all 207 on the Fish Oil page.

Minor

120 interactions

Showing 60 of 120 minor interactions — see all 120 on the Fish Oil page.

No interaction 2,502 drugs checked — show the list

We also checked Fish Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,502 medications checked with no known interaction — see the full Fish Oil list.

See the full Fish Oil interactions page

See every supplement checked against Dapsone, ranked by severity

Evidence & sources

Fish Oil References

The 157 references that drive our Fish Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Prisco D, Paniccia R, Bandinelli B, et al. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. Thromb Res 1998;1:105-12.
Allard JP, Kurian R, Aghdassi E, Muggli R, et al. Lipid peroxidation during n-3 fatty acid and vitamin E supplementation in humans. Lipids 1997;32:535-41.. PubMed
Toft I, Bonaa KH, Ingebretsen OC, et al. Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. Ann Intern Med 1995;123:911-8.
Onwude JL, Lilford RJ, Hjartardottir H, et al. A randomised double blind placebo controlled trial of fish oil in high risk pregnancy. Br J Obstet Gynaecol 1995;102:95-100. PubMed
Bulstra-Ramakers MT, Huisjes HJ, Visser GH. The effects of 3g eicosapentaenoic acid daily on recurrence of intrauterine growth retardation and pregnancy induced hypertension. Br J Obstet Gynaecol 1995;102:123-6. PubMed
Sacks FM, Hebert P, Appel LJ, et al. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the trials of hypertension prevention. J Hypertens 1994;12:209-13.
Vandongen R, Mori TA, Burke V, et al. Effects on blood pressure of omega 3 fats in subjects at increased risk of cardiovascular disease. Hypertension 1993;22:371-9. PubMed
Hawthorne AB, Daneshmend TK, Hawkey CJ, et al. Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial. Gut 1992;33:922-8. PubMed
D'Almeida A, Carter JP, Anatol A, Prost C. Effects of a combination of evening primrose oil (gamma linolenic acid) and fish oil (eicosapentaenoic + docahexaenoic acid) versus magnesium, and versus placebo in preventing pre-eclampsia. Women Health 1992;19 PubMed
FDA. Center for Food Safety and Applied Nutrition. Letter regarding dietary supplement health claim for omega-3 fatty acids and coronary heart disease. Available at: http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-Rpt0272-38-Appendix-D-Reference
Montori VM, Farmer A, Wollan PC, Dinneen SF. Fish oil supplementation in type 2 diabetes: a quantitative systemic review (abstract). Diabetes Care 2000;23:1407-15.
Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
Adler A, Holub BJ. Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men. Am J Clin Nutr 1997;65:445-50. PubMed
Higdon JV, Liu J, Du S, et al. Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as asses
Kastrup EK. Drug Facts and Comparisons. 1998 ed. St. Louis, MO: Facts and Comparisons, 1998.
Belluzzi A, Brignola C, Campieri M, et al. Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease. N Engl J Med 1996;334:1557-60. PubMed
Belluzzi A, Brignola C, Campieri M, et al. Effects of new fish oil derivative on fatty acid phospholipid-membrane pattern in a group of Crohn's disease patients. Dig Dis Sci 1994;39:2589-94. PubMed
Mahan LK, Escott-Stump S. Krause's Food, Nutrition, and Diet Therapy. 9th edition. W.B. Saunders Co., Philadelphia, PA, 1996.
Yetiv JZ. Clinical applications of fish oils. JAMA 1988;260:665-70. DOI
de Deckere EAM, Korver O, Verschuren PM, Katan MB. Health aspects of fish and n-3 polyunsaturated fatty acids from plant and marine origin. Eur J Clin Nutr 1998;52:749-53. PubMed
Sorensen NS, Marckmann P, Hoy CE, et al. Effect of fish-oil-enriched margarine on plasma lipids, low-density-lipoprotein particle composition, size, and susceptibility to oxidation. Am J Clin Nutr 1998;68:235-41. PubMed
Kelley DS, Rudolph IL. Effect of individual fatty acids of omega-6 and omega-3 type on human immune status and role of eicosanoids. Nutrition 2000;16:143-5.
Meydani SN, Dinarello CA. Influence of dietary fatty acids on cytokine production and its clinical implications. Nutr Clin Pract 1993;8:65-72. PubMed
Caicoya M. Fish consumption and stroke: a community case-control study in Asturias, Spain. Neuroepidemiology 2002;21:107-14. PubMed
Leaf A. On the reanalysis of the GISSI-Prevenzione. Circulation 2002;105:1874-5. PubMed
Dewailly E, Blanchet C, Lemieux S, et al. n-3 Fatty acids and cardiovascular disease risk factors among the Inuit of Nunavik. Am J Clin Nutr 2001;74:464-73. PubMed
Connor WE. n-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J Clin Nutr 2001;74;415-6. PubMed
Maresta A, Balduccelli M, Varani E, et al. Prevention of postcoronary angioplasty restenosis by omega-3 fatty acids: main results of the Esapent for Prevention of Restenosis Italian Study (ESPRIT). Am Heart J 143:E5. PubMed
Deutch B, Jorgensen EB, Hansen JC. n-3 PUFA from fish or seal oil reduce atherogenic risk indicators in Danish women. Nutr Res 2000;20:1065-77. DOI
Higgins S, McCarthy SN, Corridan BM, et al. Measurement of free cholesterol, cholesteryl esters and cholesteryl linoleate hydroperoxide in copper-oxidised low density lipoprotein in healthy volunteers supplemented with a low dose of n-3 polyunsaturated f
Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res 2001;21:309-41. DOI
Lacaille B, Julien P, Deshaies Y, et al. Responses of plasma lipoproteins and sex hormones to the consumption of lean fish incorporated in a prudent-type diet in normolipidemic men. J Am Coll Nutr 2000;19:745-53. PubMed
Pedersen HS, Mulvad G, Seidelin KN, et al. N-3 fatty acids as a risk factor for haemorrhagic stroke. Lancet 1999;353:812-3. PubMed
Higdon JV, Du SH, Lee YS, et al. Supplementation of postmenopausal women with fish oil does not increase overall oxidation of LDL ex vivo compared to dietary oils rich in oleate and linoleate. J Lipid Res 2001;42:407-18. DOI
Olsen SF, Sorensen JD, Secher NJ, et al. Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration. Lancet 1992;339:1003-7. PubMed
Ito Y, Suzuki K, Imai H, et al. Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. Cancer Lett 2001;163:171-8. PubMed
Bender NK, Kraynak MA, Chiquette E, et al. Effects of marine fish oils on the anticoagulation status of patients receiving chronic warfarin therapy. J Thromb Thrombolysis 1998;5:257-61.. PubMed
Suzukawa M, Abbey M, Howe PR, Nestel PJ. Effects of fish oil fatty acids on low density lipoprotein size, oxidizability, and uptake by macrophages. J Lipid Res 1995;36:473-84.. DOI
Su KP, Huang SY, Chiu CC, Shen WW. Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial. Eur Neuropsychopharmacol 2003;13:267-71..
Wang C, Chung M, Lichtenstein A, et al. Effects of omega-3 fatty acids on cardiovascular disease. Evid Rep Technol Assess (Summ) 2004 Mar;(94):1-8.
US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Seafood. Mercury levels in seafood species. Available at: http://www.cfsan.fda.gov/~frf/sea-mehg.html.
US Environmental Protection Agency. Fish Advisories web page. Available at: http://www.epa.gov/waterscience/fish.
Dunstan JA, Roper J, Mitoulas L, et al. The effect of supplementation with fish oil during pregnancy on breast milk immunoglobulin A, soluble CD14, cytokine levels and fatty acid composition. Clin Exp Allergy 2004;34:1237-42. PubMed
Lauritzen L, Jorgensen MH, Mikkelsen TB, et al. Maternal fish oil supplementation in lactation: effect on visual acuity and n-3 fatty acid content of infant erythrocytes. Lipids 2004;39:195-206. PubMed
Dunstan JA, Mori TA, Barden A et al. Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial. J Allergy Clin Immunol 2003;112:1178-84 PubMed
Olsen SF, Secher NJ, Tabor A, et al. Randomised clinical trials of fish oil supplementation in high risk pregnancies. Fish Oil Trials In Pregnancy (FOTIP) Team. BJOG 2000;107:382-95. PubMed
Stern AH. A review of the studies of the cardiovascular health effects of methylmercury with consideration of their suitability for risk assessment. Environ Res 2005;98:133-42. PubMed
Harris WS. Fish oil supplementation: evidence for health benefits. Cleve Clin J Med 2004;71:208-10, 212, 215-8 passim. PubMed
Raitt MH, Connor WE, Morris C, et al. Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators: a randomized controlled trial. JAMA 2005;293:2884-91. DOI
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Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Related: nutrient depletion

Dapsone Is Linked to Lower Levels of 7 Nutrients

Natural Medicines records Dapsone as a medicine that can lower these. This is not an interaction with Fish Oil — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:

Read the full Dapsone nutrient depletion report ›

Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.

Pharmacist Counseling Corner

Taking Fish Oil and Dapsone Together: Common Questions

Is it safe to take Fish Oil with Dapsone?

We do not list a known interaction between Fish Oil and Dapsone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Fish Oil and Dapsone have any of the same side effects?

Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

How was the Fish Oil and Dapsone combination checked?

Interactions in our licensed database are recorded against drug classes. Dapsone is filed under 7 classifications, and Fish Oil has documented interactions with 9 drug classes — none of Dapsone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Fish Oil interact with any other medications?

Yes. Fish Oil has 327 documented drug interactions in our database — Dapsone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Dapsone interact with any supplements?

Yes. Dapsone has documented interactions with 215 supplements in our database — Fish Oil is not one of them. The Dapsone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Still Have a Question About Dapsone and Fish Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.