Supplements for Leg Circulation Safe With Citalopram and Lisinopril

An older adult taking citalopram for mood and lisinopril for blood pressure wants to know whether any vitamins or supplements can help improve circulation in the legs.

3 min read Updated Jul 2026 163 views
Supplements for Leg Circulation Safe With Citalopram and Lisinopril
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Question time asked

I take citalopram 20 mg and lisinopril 10 mg. Which vitamins or supplements help leg circulation? I am in my eighties.

Jul 24, 2026
The quick answer
  • No supplement has strong proof that it meaningfully improves leg circulation, and the best first step is asking your doctor to evaluate why your legs feel this way since treatments like walking programs or compression stockings often help more than any pill.
  • Avoid ginkgo biloba, high-dose fish oil, garlic pills, and high-dose vitamin E with citalopram because these have mild blood-thinning properties that could add to the slight bleeding tendency citalopram can cause.
  • Avoid potassium supplements and potassium-based salt substitutes with lisinopril unless your doctor specifically recommends them, and be cautious with supplements like L-arginine that lower blood pressure since they could add to lisinopril's effect and raise the chance of dizziness or falls.
  • Horse chestnut seed extract, omega-3 fish oil, and vitamin B12 are options worth discussing with your doctor, though you should have your B12 level checked first since deficiency is common in older adults and can cause leg numbness and tingling that mimics circulation problems.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.
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Hello, and thank you for reaching out to HelloPharmacist!

I want to be upfront with you that although there are plenty of products that are marketed to improve circulation, no vitamin or supplement has strong proof that it meaningfully improves leg circulation, and a few of the popular ones deserve extra caution with the two medications you take.

Finding Out Why Your Legs Feel This Way

Before looking for a supplement to take, the most valuable step at your age is figuring out what's actually causing the circulation problem.

Poor leg circulation in someone in their eighties can come from very different things, such as peripheral artery disease (narrowed arteries in the legs), vein problems that cause swelling and heaviness, or even nerve issues that just feel like circulation trouble.

Each of these is managed differently, and some, like peripheral artery disease, are important for your doctor to know about because they affect heart health overall.

Interestingly, the single best-proven 'treatment' for leg circulation from artery disease isn't a pill at all, it's a structured exercise program, and compression stockings often help when veins are the issue.

Supplements People Use for Circulation

Among supplements, a few come up repeatedly.

Horse chestnut seed extract has modest evidence for vein-related leg swelling and heaviness. I'd say it's the most common ingredient I see in dietary supplements marketed for circulation.

Omega-3 fish oil supports general cardiovascular health, though its effect on leg circulation specifically is unimpressive.

Vitamin B12 is worth mentioning because deficiency is common in older adults and can cause leg numbness and tingling that mimics circulation problems, so having your level checked is a smart, low-cost move. B vitamins in general have even been studied directly alongside citalopram in older adults without safety problems.

Cautions With Citalopram and Lisinopril

Now for the important cautions.

Citalopram, like all SSRIs, can slightly increase bleeding tendency, and its labeling warns that combining it with anything else that thins the blood may add to that risk.

Several 'circulation' supplements, including ginkgo biloba, high-dose fish oil, garlic pills, and high-dose vitamin E, have mild blood-thinning properties, so I'd be cautious with those, especially ginkgo, which is probably the most heavily marketed circulation supplement out there.

With lisinopril, the main things to steer clear of are potassium supplements and potassium-based salt substitutes unless your doctor specifically recommends them, since ACE inhibitors already cause the body to hold on to potassium and the label calls for periodic potassium monitoring.

Also, supplements like L-arginine that are sold for blood flow can lower blood pressure on their own, which could add to lisinopril's effect and raise the chance of dizziness or falls, a real concern in your eighties.

Final Words

The bottom line is that no supplement is a proven fix for leg circulation, and the best first step is asking your doctor to evaluate why your legs feel this way, since treatments like walking programs or compression stockings often help more than any pill.

If you'd like to try something like horse chestnut, B12, or fish oil, run it by your doctor or pharmacist first given the citalopram and lisinopril. They may provide modest benefit, but it's important for you to be monitored appropriately.

Feel free to write back if you have a specific product in mind, we're happy to take a closer look!

References & sources
  1. Celexa Structured Product Labelin — DailyMed
  2. B vitamins to enhance treatment response to antidepressants in middle-aged and older adults: results from the B-VITAGE randomised, double-blind, placebo-controlled trial. — PubMed
  3. Zestril Structured Product Labeling — DailyMed
  4. Horse chestnut seed extract for chronic venous insufficiency — PubMed
  5. Impact of omega-3 polyunsaturated fatty acids on vascular function and blood pressure: Relevance for cardiovascular outcomes — PubMed
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Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

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